Clinical trials: PTSD, open to volunteers
Major Depression
Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression
The purpose of this multi-site randomized controlled trial is to evaluate the efficacy and risks of psilocybin for the treatment of depression in U.S.
- Trial name
- PIVOT (NCT07226232)
- Testing
- Psilocybin
- Where
- 5 sites in United States
- Volunteers
- 240 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder
Focused Ultrasound for PTSD in Veterans
The goal of this study is to develop a new, non-invasive brain stimulation modality called low intensity focused ultrasound (FUS) as a psychiatric rehabilitation treatment for posttraumatic stress disorder (PTSD).
- Trial name
- PTSD FUS (NCT06820138)
- Testing
- Brainsonix Ultrasound Device
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- VA Office of Research and Development
PTSD - Post Traumatic Stress Disorder
ONE-P TMS First Responders
The aim of this study is to examine the feasibility and tolerability of a one-day protocol of repetitive transcranial magnetic stimulation with D-cycloserine (DCS) as an augmentation strategy in first responders who have PTSD.
- Trial name
- ONE-P_FR (NCT07773935)
- Testing
- D-Cycloserine (DCS), Intermittent Theta Burst Stimulation (iTBS)
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Fidel Vila-Rodriguez, MD, PhD, FRCPC, DFAPA
Post Traumatic Stress Disorder PTSD, Quality of Life
Effectiveness of Trauma Treatment in the Specialist Health Care Services
Post-traumatic stress disorder (PTSD) is a common mental illness. Treatments for PTSD are regarded as highly effective, but a large-scale, prospective, longitudinal randomized controlled trial comparing the effectiveness of these…
- Conditions
- Post Traumatic Stress Disorder PTSD, Quality of Life, Functional Outcome, Complex Post-Traumatic Stress Disorder
- Trial name
- NCT06691347
- Testing
- Eye movement desensitization and reprocessing, Cognitive therapy for PTSD
- Where
- Norway
- Volunteers
- 270 people
- Sponsor
- Vestre Viken Hospital Trust
Fibromyalgia (FM), Posttraumatic Stress Disorder (PTSD)
Treatment of Fibromyalgia and PTSD With Live and Inactive Vagus Nerve Stimulation With PEPC
Fibromyalgia (FM) pain and PTSD are highly prevalent and comorbid with associated increased risk of negative physical and mental health outcomes, including higher risk for opioid use and suicide.
- Trial name
- SWIFT-RELIEVE (NCT07718984)
- Testing
- tAN plus PEPC
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- VA Office of Research and Development
Acute Stress Reaction
Promoting Improved Functioning Among People Experiencing Stressful Situations
The iCOVER intervention was developed to rapidly restore functioning in individuals experiencing an Acute Stress Reaction (ASR). iCOVER is undergoing widespread adoption but has not been tested for efficacy.
- Trial name
- iCOVER (NCT06482567)
- Testing
- iCOVER, Physical Presence with Reassurance
- Where
- 5 sites in United States
- Volunteers
- 450 people
- Sponsor
- University of North Carolina, Chapel Hill
Perinatal Mental Health, Reproductive Behavior
Women's Reproductive Choices and Mental Health During Pregnancy and After Birth in Wartime Ukraine
The goal of this observational study is to learn how war affects reproductive decisions and perinatal mental health in Ukrainian women.
- Conditions
- Perinatal Mental Health, Reproductive Behavior, Women, Cohort Studies
- Trial name
- NCT07551934
- Testing
- Psychological Assessment, Routine Clinical Data Collection
- Where
- Ukraine
- Volunteers
- 328 people, healthy volunteers welcome
- Sponsor
- Taras Shevchenko National University of Kyiv
PTSD, Post-traumatic Stress Disorder
Induction of Dreaming With EEG and Anesthesia for Post-traumatic Stress Disorder
The goal of this study is to test whether anesthesia-induced experiences can help alleviate symptoms of PTSD in an (1) open-label trial (Phase I) and (2) single-center double-blind, randomized, active-comparator (dose-controlled)…
- Trial name
- IDEA_PTSD (NCT06577636)
- Testing
- Propofol
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Stanford University
Anxiety
Transcranial Alternating Current Stimulation (tACS) for the Treatment of Anxiety in Veterans: An Open-Label Pilot Study
Transcranial alternating current stimulation (tACS) in a wearable brain stimulation device that delivers a low intensity, pulsed, alternating current via scalp electrodes.
- Trial name
- NCT07288008
- Testing
- Transcranial alternating current stimulator
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Birmingham VA Health Care System
Post Traumatic Stress Disorder
Stepped Care for Posttraumatic Stress Disorder Study
Less than 20% of people with PTSD receive any treatment. This study extends a program of research by the investigator focused on developing adaptive (stepped) interventions for PTSD.
- Trial name
- STEPPS (NCT06947538)
- Testing
- webSTAIR, WebSTAIR plus coaching, Clinician administered Brief STAIR
- Where
- United States
- Volunteers
- 428 people
- Sponsor
- Boston Medical Center
Autonomic Nervous System Disease, Concussive Injury
Randomized Controlled Trial of Treatment to Optimize Heart Rate Variability for Persistent Post-Concussion Symptoms
Many combat veterans (c-Vs), service members (SMs) and civilians with mild traumatic brain injury (mTBI, also termed concussion) suffer from persistent post-concussion symptoms (PPCS) that degrade physical and cognitive…
- Conditions
- Autonomic Nervous System Disease, Concussive Injury, Mild Traumatic Brain Injury, Post Traumatic Stress Disorder
- Trial name
- NCT07071350
- Testing
- HRV Coherence Ratio, NSI, Pittsburgh Sleep Quality Index (PSQI)
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Virginia Commonwealth University
Brain Injury, Cognition
Comparing Telehealth to In-person a Combined Metacognitive Training in Veterans With mTBI/PTSD
Veterans with mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD) commonly experience cognitive impairments including attention and executive function deficits that interfere with their ability to engage…
- Conditions
- Brain Injury, Cognition, PTSD, Intervention
- Trial name
- NCT05380050
- Testing
- Goal Management Training plus Attention Training, Brain Health Workshop and National Geographic Movies
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- VA Office of Research and Development
Anxiety, Posttraumatic Stress Disorder
School-based Practices in Arts and Resilience for Kids
This proposal will implement and test feasibility and efficacy of school-based art therapy and yoga/mindfulness programming to reduce mental health disparities and foster resilience in youth.
- Conditions
- Anxiety, Posttraumatic Stress Disorder, Trauma
- Trial name
- SPARK (NCT06945497)
- Testing
- Art Therapy, Yoga/Mindfulness
- Where
- 2 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Wayne State University