Clinical trials: PTSD, completed
Posttraumatic Stress Disorder (PTSD)
DElivery of Self Training and Education for Stressful Situations-Primary Care Version
This study will compare a cognitive-behavioral online self-management intervention designed for primary care treatment of war-related PTSD to a control intervention, "optimized usual primary care PTSD treatment".
- Trial name
- DESTRESS-PC (NCT01474057)
- Testing
- DESTRESS-PC, Optimized Usual Primary Care PTSD treatment
- Where
- 4 sites in United States
- Volunteers
- 133 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
PostTraumatic Stress Disorder
A Smartphone Intervention With Telemedicine Support for Management of Post-traumatic Stress Disorder: A Randomized Trial
This study tests whether people receiving clinician support to use a mobile application on their smartphone can manage their post-traumatic stress disorder (PTSD) symptoms better than those who do not.
- Trial name
- NCT02956902
- Testing
- Clinician supported smartphone application intervention
- Volunteers
- 67 people
- Sponsor
- Ontario Shores Centre for Mental Health Sciences
Post-traumatic Stress Disorder, Miscarriage
Improving Mental Health Following Early PREgnancy Loss Using a Brief Cognitive Task
This is a randomised controlled trial designed to investigate the impact of a brief-cognitive task based intervention on intrusive memories, mental health symptoms and daily functioning, in women following an early pregnancy loss.
- Conditions
- Post-traumatic Stress Disorder, Miscarriage, Ectopic Pregnancy, Pregnancy Loss
- Trial name
- IMPREL (NCT05039853)
- Testing
- Brief cognitive task-based intervention
- Where
- United Kingdom
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Psychologic Manipulation
Cognitive Processing Therapy vs. Sertraline for the Treatment of PTSD & SUD in Egyptian Patients
The present research was aimed at comparing the effects of Cognitive Processing Therapy (CPT) with the effects of Sertraline in treating patients who have dual diagnosis PTSD \& SUD.
- Trial name
- NCT03469128
- Testing
- Cognitive processing therapy, Sertraline
- Volunteers
- 150 people
- Sponsor
- British University In Egypt
Stress Disorders, Post-Traumatic
Evaluation of GSK561679 in Women With Post-Traumatic Stress Disorder
This study will test the hypothesis of whether an antagonist at the corticotropin releasing factor type 1 (CRF1) receptor (i.e. GSK561679) is superior to placebo in reducing symptoms of post-traumatic stress disorder (PTSD).
- Trial name
- NCT01018992
- Testing
- GSK561679
- Where
- 4 sites in United States
- Volunteers
- 267 people
- Sponsor
- Emory University
PTSD - Post Traumatic Stress Disorder, Depression/Anxiety
An Integrative, Digital Health Approach to Veteran-Centered PTSD Care
The goal of this study is to test the effectiveness of a stress self-management mobile health system (smartphone app + wearable sensor) alongside an intense physical cycling intervention to reduce symptoms of stress in a veteran…
- Trial name
- NCT06993012
- Testing
- Mobile Health Stress Self Management System, Intensive Cycling Activity
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Nightmares, Insomnia
Treating Insomnia & Nightmares After Trauma: Impact on Symptoms & Quality of Life
Exposure to trauma, especially when it manifests as Posttraumatic Stress Disorder (PTSD), results in numerous negative consequences for patients, families, and society.
- Conditions
- Nightmares, Insomnia, Posttraumatic Stress Disorder
- Trial name
- NCT01009112
- Testing
- PTSD + IRT/CBT-I, PTSD + Supportive Care Therapy
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of California, San Diego
Posttraumatic Stress Disorder, Pregnancy Related
Online Intervention to Promote Resilience to Traumatic Stress During Pregnancy
The investigators will design, construct, and pilot a prototype of a trauma-informed online intervention, which will be called "SunnysideFlex," that functionally integrates a web-based intervention targeting skills to decrease…
- Trial name
- NCT04992767
- Testing
- Sunnyside, SunnysideFlex
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Post-traumatic Stress Disorders
A Simple Cognitive Task to Reduce the Build-Up of Flashbacks After a Road Traffic Accident
This research study is designed to investigate the effects of a simple cognitive task (a memory reactivation cue following by playing the computer game "Tetris") on flashbacks and other post-traumatic stress symptoms after a road…
- Trial name
- SCARTA (NCT02080351)
- Testing
- Simple cognitive task
- Where
- United Kingdom
- Volunteers
- 71 people
- Sponsor
- University of Oxford
Post-Traumatic Stress Disorder
Effect of Propranolol on Preventing Posttraumatic Stress Disorder
This study will assess the effectiveness of taking propranolol soon after a traumatizing incident in reducing the incidence and severity of posttraumatic stress disorder in acutely traumatized individuals.
- Trial name
- NCT00158262
- Testing
- Propranolol
- Where
- 2 sites in United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
HIV/AIDS, Depression
Tailored Response to Psychiatric Comorbidity to Improve HIV Care Engagement in the United States
This pilot randomized clinical trial will randomize 60 participants 1:1 to either enhanced usual care or to adapted Common Elements Treatment Approach (CETA), a counseling intervention for HIV care engagement plus depression…
- Conditions
- HIV/AIDS, Depression, Anxiety, Post-traumatic Stress Disorder
- Trial name
- TRACE (NCT04163341)
- Testing
- Adapted Common Elements Treatment Approach
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Michael J Mugavero, MD
Post Traumatic Stress Disorder (PTSD), Addiction
Clinical Trial for Alcohol Use Disorder and Post Traumatic Stress Disorder (PTSD)
This is a randomized controlled Phase II clinical trial designed to evaluate the effects of N-acetylcysteine (NAC) in reducing Alcohol Use Disorder (AUD) severity and Post Traumatic Stress Disorder (PTSD) symptomatology among…
- Conditions
- Post Traumatic Stress Disorder (PTSD), Addiction, Alcohol Abuse
- Trial name
- NCT02966873
- Testing
- N-Acetylcysteine (NAC) Treatment, Cognitive Behavioral Therapy (CBT), Functional magnetic resonance imaging (fMRI)
- Where
- 2 sites in United States
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Anxiety Disorders, Depressive Disorder
Transdiagnostic Treatment Personalization
The primary purpose of this study is to explore whether the efficiency of treatment for anxiety and depressive disorders can be increased using two discrete strategies: personalized skill ordering and 2) treatment discontinuation…
- Conditions
- Anxiety Disorders, Depressive Disorder, Post Traumatic Stress Disorder, Obsessive-Compulsive Disorder
- Trial name
- NCT04584879
- Testing
- Standard UP Treatment, Capitalization UP Treatment, Compensation UP Treatment
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Shannon E. Sauer-Zavala
Post-Traumatic Stress Disorder
Levetiracetam in Post-Traumatic Stress Disorder
The purpose of this study is to evaluate the short-term efficacy and safety of levetiracetam in post-traumatic stress disorder (PTSD) and to evaluate continuation effects of levetiracetam in preventing PTSD relapse.
- Trial name
- PTSD (NCT00413296)
- Testing
- levetiracetam, Levetriracetam
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Duke University
Posttraumatic Stress Disorders
Cognitive Behavioral Therapy to Improve Work and Wellness in Veterans With Mental Illness
Vocational instability in Veterans with serious mental illness (SMI) is pervasive, costly, and harmful. Over 75% of Veterans with SMI are unemployed, resulting in economic difficulties and trouble meeting basic needs.
- Trial name
- WORKWELL (NCT04504903)
- Testing
- Cognitive Behavioral Therapy For Work Success (CBTw), Psychoeducation
- Where
- 3 sites in United States
- Volunteers
- 294 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder
Investigating a Novel Sensory-based Program for Veterans With PTSD
SENSE-PTSD is an randomized controlled trial (RCT) which will evaluate the feasibility and efficacy of a novel, sensory-based psychoeducational program for improving psychological, functional, sensory, and cognitive outcomes in…
- Trial name
- SENSE-PTSD (NCT05766241)
- Testing
- Sensory Strategies Training
- Where
- Canada
- Volunteers
- 89 people
- Sponsor
- McMaster University
Distress, PTSD
Scaling-up Psychological Interventions With Syrian Refugees in Switzerland (STRENGTHS_CH): RCT
The current refugee crisis across the Middle East and Europe has large effects on individual refugees' psychological well-being, as well as on the healthcare systems of countries hosting refugees.
- Conditions
- Distress, PTSD, Anxiety, Depression
- Trial name
- NCT04574466
- Testing
- Problem Management Plus
- Where
- Switzerland
- Volunteers
- 54 people
- Sponsor
- University of Zurich
HIV Infections, AIDS
The CORE Buprenorphine Project - An HIV Primary Care Program Demonstration
The goal of this study is to develop and evaluate an innovative model of care to better serve patients who are both HIV-infected and opioid-dependent.
- Conditions
- HIV Infections, AIDS, Opiate Dependence, Post-Traumatic Stress Disorders
- Trial name
- BUP (NCT00227357)
- Testing
- On-site - buprenorphine/naloxone (Suboxone), Off-site - methadone or no agonist
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Ruth M. Rothstein CORE Center
Posttraumatic Stress Disorder, Shame
NET for SGBV Survivors in Eastern DR Congo
Throughout the last 10 years Narrative Exposure Therapy (NET) has evolved as one of the most effective, culturally sensitive trauma interventions.
- Trial name
- NCT02989987
- Testing
- Narrative Exposure Therapy, Social Support
- Where
- Germany
- Volunteers
- 201 people
- Sponsor
- University of Konstanz
Domestic Violence, Psychological Distress
GBV, Primary Trauma & Trauma Resilience & Understanding Self-help Therapy Utilization in Uganda
The goal of this community-based interventional study was to determine the effectiveness of the 'Trauma Resilience \& Understanding Self-help Therapy' (TRUST) in managing domestic violence \& primary trauma among formerly…
- Conditions
- Domestic Violence, Psychological Distress, Post-Traumatic Stress Disorder, Suicidality
- Trial name
- GBV (NCT06073964)
- Testing
- Trauma Resilience & Understanding Self-help Therapy
- Where
- Uganda
- Volunteers
- 284 people
- Sponsor
- Kampala International University