Clinical trials: PTSD - Post Traumatic Stress Disorder
Stress Disorders, Post-Traumatic, PTSD
Ketamine as a Rapid Treatment for Post-traumatic Stress Disorder (PTSD)
The objective of the proposed study is to test if a single IV dose of ketamine (0.5 mg/kg) decreases symptoms of PTSD.
- Conditions
- Stress Disorders, Post-Traumatic, PTSD, Depression, Anxiety Disorder
- Trial name
- KetPTSD (NCT00749203)
- Testing
- Midazolam, Ketamine
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Dennis Charney
PTSD, TBI (Traumatic Brain Injury)
Top-Down Executive Control in Traumatic Brain Injury (TBI), PTSD and Combined
This research investigates processes involved with one being able to focus on relevant information and ignore non-relevant information in veterans with PTSD and those with a history of traumatic brain injury.
- Trial name
- NCT01072006
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
PTSD
Neural Circuits in Women With Abuse and Posttraumatic Stress Disorder
The purpose of this study was to assess the effects of the medication paroxetine on symptoms of posttraumatic stress disorder (PTSD) and the brain in women with a history of PTSD related to childhood abuse.
- Trial name
- NCT01681849
- Testing
- Paroxetine, Positron Emission Tomography (PET) Imaging
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Emory University
Posttraumatic Stress Disorder, PTSD
D-cycloserine Adjunctive Treatment for Posttraumatic Stress Disorder (PTSD) in Adolescents
The purpose of this study is to show whether D-cycloserine in combination with cognitive behavioral therapy (CBT) is more effective than CBT plus placebo to reduce symptoms of posttraumatic stress disorder (PTSD) in 13-18…
- Trial name
- NCT01157429
- Testing
- D-cycloserine, CBT
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Tulane University School of Medicine
Non PTSD, PTSD
Neurobiology of Sleep and Sleep Treatment Response in Returning Veterans
The overarching objectives of this study are: 1) To investigate the neurobiology of posttraumatic stress disorder (PTSD) during Rapid Eye Movement (REM) and Non-Rapid Eye Movement (NREM) sleep relative to wakefulness; 2) To…
- Trial name
- NOSSTIP (NCT01637584)
- Testing
- Prazosin
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Posttraumatic Stress Disorder (PTSD)
Two Stepped Care Models for Posttraumatic Stress Disorder (PTSD) Among Cambodian Refugees With PTSD
This project aims to investigate the efficacy of two models to treat Posttraumatic Stress Disorder (PTSD) for Cambodian refugees in primary care.
- Trial name
- NCT01542372
- Testing
- Medication augmentation, CBT
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Massachusetts General Hospital
Posttraumatic Stress Disorders, PTSD
Effect of D-cycloserine on Treatment of Posttraumatic Stress Disorder (PTSD) in Youth
The purpose of this study is to show whether D-cycloserine in combination with cognitive behavioral therapy (CBT) is more effective than CBT plus placebo to reduce symptoms of posttraumatic stress disorder (PTSD) in 7-12 year old…
- Trial name
- NCT01157416
- Testing
- D-cycloserine, CBT
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Tulane University School of Medicine
Major Depressive Disorder, Post-Traumatic Stress Disorder (PTSD)
PET Imaging of mGLuR5 With Drug Challenge
This study is designed to look at that involvement of a process in the brain called the glutamate system in depression. Participants will undergo a screening session, up to two functional Magnetic Resonance Imaging (fMRI) scans…
- Trial name
- NCT01691092
- Testing
- Ketamine
- Where
- 3 sites in United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Yale University
PTSD
Veterans Telemedicine Outreach for PTSD Services
Post-Traumatic Stress Disorder (PTSD) is considered a major public health problem in the U.S. due to its high prevalence and high rates of disability associated with the disorder.
- Trial name
- VTOPS (NCT00645047)
- Testing
- Telemedicine CBT, In-Person CBT
- Where
- United States
- Volunteers
- 207 people
- Sponsor
- VA Office of Research and Development
PTSD
PTSD Coach App Evaluation
PTSD Coach is a mobile application (app) that aims to teach individuals self-management strategies for symptoms of Post-traumatic Stress Disorder (PTSD). PTSD is a major public health concern.
- Trial name
- NCT02445196
- Testing
- PTSD Coach, Smartphone
- Volunteers
- 120 people
- Sponsor
- Craig Barr Taylor
PTSD, TBI
Study of PTSD in Military Veterans Who Have Suffered Traumatic Brain Injuries
Treatment for veterans who have had a traumatic brain injury (TBI) and who are suffering from post traumatic stress syndrome (PTSD) is varied with varied outcomes.
- Trial name
- PTSD-TBI (NCT02003352)
- Testing
- Functional Neurological Rehabilitation
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Carrick Institute for Graduate Studies
Post-traumatic Stress Disorder, PTSD
Brexpiprazole as an Adjunctive Treatment to Paroxetine or Sertraline in Adult Patients Suffering From Post-traumatic Stress Disorder (PTSD)
To evaluate the efficacy of brexpiprazole as adjunctive treatment to paroxetine (PAR) or sertraline (SER) on PTSD symptoms.
- Trial name
- NCT01987960
- Testing
- Brexpiprazole
- Where
- 59 sites in United States, Estonia and 7 more
- Volunteers
- 417 people
- Sponsor
- H. Lundbeck A/S
PTSD, Substance Addiction
Integrated vs Sequential Treatment for PTSD and Addiction
The investigators are examining different treatment strategies of helping patients with PTSD and addiction.
- Trial name
- NCT01211106
- Testing
- Prolonged Exposure, Motivational Enhancement Therapy
- Where
- 2 sites in United States
- Volunteers
- 183 people
- Sponsor
- VA Office of Research and Development
PTSD, Panic Attacks
Exposure Therapy for Veterans With PTSD and Panic Attacks (Phase 1)
To evaluate the feasibility, acceptability and effectiveness of Multiple Channel Exposure Therapy-Veterans (MCET-V) as a treatment for returning service members with comorbid posttraumatic stress disorder (PTSD) and panic…
- Trial name
- NCT01551199
- Testing
- Multiple Channel Exposure Therapy- Veterans
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- VA Office of Research and Development
PTSD, Anxiety
EEG Biofeedback Therapy as an Adjunct Treatment for PTSD
The proposed study, "Placebo-controlled study of EEG biofeedback therapy as an adjunct treatment for PTSD, evaluating symptoms and EEG dynamics", will investigate the brain dynamics associated with PTSD symptom reduction…
- Conditions
- PTSD, Anxiety, Trauma, Sleep Disorders
- Trial name
- NCT01591408
- Testing
- EEG biofeedback
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- United States Naval Medical Center, San Diego
PTSD, Alcohol Abuse
Helping Families Help Veterans With PTSD and Alcohol Abuse: An RCT of VA-CRAFT
This project begins to evaluate the effectiveness of a web-based family outreach tool that is designed to promote treatment engagement among Veterans with posttraumatic stress disorder (PTSD) or alcohol use disorders (AUDs) but…
- Trial name
- NCT01678196
- Testing
- VA-CRAFT, Control
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- VA Office of Research and Development
Hepatitis C, Depression
Integrated Care for Patients With High Risk Substance Use and Psychiatric Disorder With Chronic Direct Acting Antiviral Treatment
To determine the effect of an integrated care protocol on antiviral treatment and sustained virologic response (SVR) rates following initiation of direct acting antiviral therapies (DAA) treatments in 2011.
- Conditions
- Hepatitis C, Depression, PTSD, Substance Use Disorder
- Trial name
- NCT02648022
- Testing
- Brief mental health interventions and case management
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- VA Office of Research and Development
Alcohol Dependence, PTSD
Neuromodulation of Trauma Memories in PTSD & Alcohol Dependence
The purpose of this study is to examine the effect of propranolol versus placebo on craving, distress and cue reactivity to trauma and alcohol cues.
- Trial name
- NCT01055171
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Alcoholism, Depression
Naltrexone & SSRI in Alcoholics With Depression/PTSD
The purpose of this study is to evaluate the efficacy of naltrexone in combination with an SSRI to reduce alcohol consumption in alcoholic patients with comorbid PTSD and depression.
- Conditions
- Alcoholism, Depression, PTSD
- Trial name
- NCT00338962
- Testing
- paroxetine, desipramine, Naltrexone
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Yale University
PTSD
Clinician-Supported PTSD Coach vs. Self-Managed PTSD Coach
PTSD Coach is a mobile application (app) that aims to teach individuals self-management strategies for symptoms of Post-traumatic Stress Disorder (PTSD).
- Trial name
- NCT02400710
- Testing
- Clinician-Supported PTSD Coach, Self-Managed PTSD Coach
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Syracuse VA Medical Center