Clinical trials: PTSD Symptoms, active
PTSD and Trauma-related Symptoms, Cognitive Decline in Older Adults
Acute Effects of Estradiol Administration on Brain Function During Fear Learning
The goal of current study is to better understand how fear is processed in the brain and how these processes are influenced by cognition and hormones.
- Conditions
- PTSD and Trauma-related Symptoms, Cognitive Decline in Older Adults, Post Menopausal Women
- Trial name
- EstroFearGen (NCT07737613)
- Testing
- estradiol
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Psychological Disorder, Critical Illness
Feasibility and Preliminary Effects of a Spiritual Care Strategy on Psychological Disorders in Critically Ill Patients
Studies in hospitalized patients have shown that a large percentage of them consider religion or spirituality to be an important factor in enabling them to cope with a serious illness.
- Trial name
- NCT06048783
- Testing
- Program of systematic and periodic spiritual accompaniment and care
- Volunteers
- 30 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Post Traumatic Stress Disorder, Depression
Being Safe, Healthy, And Positively Empowered (BSHAPE) Intervention Study
The purpose of the study is to evaluate a trauma informed digital multicomponent intervention design to improve health and safety outcomes for women with lifetime exposures to violence and co-occurring PTSD and/or depression…
- Conditions
- Post Traumatic Stress Disorder, Depression, Violence
- Trial name
- BSHAPE (NCT07227337)
- Testing
- BSHAPE, Control (general wellness)
- Where
- United States
- Volunteers
- 676 people
- Sponsor
- Johns Hopkins University
Chronic Pain, PTSD - Post Traumatic Stress Disorder
Virtual Reality and Cranial Nerve Non-invasive Neuromodulation to Improve Quality of Life for Veterans
Veterans in Canada are twice as likely as the general population to experience chronic pain. This pain is often linked to post-traumatic stress disorder (PTSD), and both have a major impact on their quality of life.
- Conditions
- Chronic Pain, PTSD - Post Traumatic Stress Disorder, Quality of Life (QOL)
- Trial name
- VR & CN-NINM (NCT07137845)
- Testing
- Virtual reality, Cranial nerve non-invasive neuromodulation (CN-NINM)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Université de Sherbrooke
PTSD, Depression
Local Participatory Systems Dynamics to Increase Reach of Evidence Based Addiction and Mental Health Care
The most common reasons Veterans seek VA addiction and mental health care is for help with opioid and alcohol misuse, depression and PTSD.
- Conditions
- PTSD, Depression, Alcohol Use Disorder, Opioid Use Disorder
- Trial name
- NCT04356274
- Testing
- Participatory System Dynamics (PSD), Audit and Feedback (AF)
- Where
- United States
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Palo Alto Veterans Institute for Research
PTSD and Trauma-related Symptoms, PTSD
A Pilot Research Project on Outcome of Trauma Informed Stabilization Treatment (TIST) for Adults with Complex Trauma Symptoms After Childhood Trauma, At the Department of Trauma Treatment, Modum Bad, Norway
The purpose of the study is to examine the effects of residential group and individual Trauma Informed Stabilization Treatment (TIST) for complex symptoms in adult survivors of childhood trauma in a naturalistic observational…
- Trial name
- NCT06719167
- Testing
- Psychoterapy
- Where
- Norway
- Volunteers
- 32 people
- Sponsor
- Modum Bad
Parent-Child Relations
Strength at Home - Parents RCT
The goal of this clinical trial is to compare the effect of the Strength at Home Parents intervention to treatment as usual in veterans enrolled for care at VA facilities in VISN 17 on parenting stress and parenting behaviors.
- Trial name
- NCT06309329
- Testing
- Strength at Home Parents, VA treatment as usual
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- VISN 17 Center of Excellence
Posttraumatic Stress Disorder (PTSD), Substance Use Disorder (SUD)
The Many Roads to Trauma Recovery: A Clinical Trial Comparing Empirically Supported Treatments for Veterans With Co-Morbid Posttraumatic Stress and Substance Use Disorder Symptoms
Veterans with co-morbid posttraumatic stress disorder (PTSD) and substance use disorders (SUDs) are at substantial risk of developing hypertension and cardiovascular diseases that often lead to premature death, with some evidence…
- Trial name
- NCT07756723
- Testing
- Trauma Informed Heart Rate Variability Biofeedback, Present Centered Therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Coatesville VA Medical Center
Depression, Post Traumatic Stress Disorder
The Canadian Depression Research and Intervention Network (CDRIN) Maritimes Registry
While effective interventions for depression exist, their success rates are unsatisfactory and their provision is haphazard. The Canadian Depression Research and Intervention Network (CDRIN) Maritimes Depression Hub will improve…
- Conditions
- Depression, Post Traumatic Stress Disorder, Bipolar Disorder, Mood Disorder
- Trial name
- NCT02443636
- Where
- Canada
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
PTSD, Post Traumatic Stress Disorder
Wayne State Warriors Marijuana Clinical Research Program: Cannabinoid Adjunct to Prolonged Exposure & Recovery
The overall strategy is to recruit veterans with PTSD who report minimal current cannabis use but are interested in or considering therapeutic cannabis to manage mental health symptoms (anxiety, depression, PTSD and/or…
- Conditions
- PTSD, Post Traumatic Stress Disorder, Suicide, Cannabis Use
- Trial name
- CAPER (NCT06222268)
- Testing
- Cannabidiol (CBD) only, Delta-9-tetrahydrocannabinol (THC) only, THC:CBD 1:1
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- Leslie Lundahl
Schizophrenia, Psychosis
Enhancing Rehabilitation for Veterans With Serious Mental Illness
This study addresses the critical need for innovative therapeutic interventions in Veterans with serious mental illnesses (SMI) receiving care in VA Psychosocial Rehabilitation and Recovery Centers (PRRCs).
- Conditions
- Schizophrenia, Psychosis, Serious Mental Illness, PTSD
- Trial name
- NCT06586164
- Testing
- Targeted Cognitive Training
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- VA Office of Research and Development
Post Traumatic Stress Disorder
Effects of Stellate Ganglion Block in Post-traumatic Stress Disorder
This study will enroll patients meeting Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria for post-traumatic stress disorder (PTSD).
- Trial name
- NCT05391971
- Testing
- Bupivacaine, Saline
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- NYU Langone Health
Posttraumatic Stress Disorder
Multimodal Image Analysis and Guidance of Neuromodulation for Trauma-Related Symptoms
MAGNETS is a prospective, randomized, parallel-design, sham-controlled clinical trial of accelerated, functional magnetic resonance imaging (fMRI)-guided intermittent theta burst stimulation (iTBS) to the right dorsolateral…
- Trial name
- MAGNETS (NCT06449326)
- Testing
- Active Intermittent theta burst stimulation
- Where
- 2 sites in United States
- Volunteers
- 64 people
- Sponsor
- University of New Mexico
Borderline Personality Disorder (BPD), PTSD - Post Traumatic Stress Disorder
Pilot Study for the Evaluation of a New Psychotherapeutic Treatment for Borderline Personality Disorder Patients With Post-traumatic Stress Symptoms
Borderline Personality Disorder (BPD) is a serious mental health condition that often co-occurs with Complex PTSD (CPTSD), making treatment more challenging.
- Trial name
- MBT-TF (NCT07305155)
- Testing
- Standard Mentalization-Based Treatment, Trauma-Focused Mentalization-Based Treatment
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Eva Rüfenacht
Post-Traumatic Stress Disorder (PTSD), Depression
Transforming Trauma Care
This study evaluates the implementation and clinical effectiveness of the Trauma Resilience and Recovery Program (TRRP 2.0), a technology-enhanced behavioral health intervention designed for trauma center patients.
- Conditions
- Post-Traumatic Stress Disorder (PTSD), Depression, Substance Use Disorder, Traumatic Injury
- Trial name
- NCT07829510
- Testing
- Trauma Resilience and Recovery Program Portal 2.0 (TRRP 2.0)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Post Traumatic Stress Disorder, Diminished Pleasure
Psychotherapy Effects on Reward Processing in PTSD
The purpose of this study is to identify how trauma-focused psychotherapy changes the function of brain circuitry in posttraumatic stress disorder (PTSD) and how this mediates improvements in the diminished ability to experience…
- Conditions
- Post Traumatic Stress Disorder, Diminished Pleasure, Anhedonia, PTSD
- Trial name
- PERPP (NCT06096740)
- Testing
- Cognitive Processing Therapy
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Texas at Austin
Autism Spectrum Disorder, PTSD and Trauma-related Symptoms
TF-CBT for Autistic Youth Pilot Implementation - Open Pilot
Compared to the general population, autistic youth are at increased risk for both exposure to potentially traumatic events and trauma-related symptoms following trauma exposure.
- Conditions
- Autism Spectrum Disorder, PTSD and Trauma-related Symptoms, Autism, Trauma and Stressor Related Disorders
- Trial name
- NCT07420478
- Testing
- Trauma-Focused Cognitive Behavioral Therapy, modified for autistic youth
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Posttraumatic Stress Symptoms, Burnout
FLOAT for Healthcare PTSS
This early-stage pilot trial aims to examine the feasibility, tolerability, and safety of Floatation-REST, or Reduced Environmental Stimulation Therapy via floatation in frontline healthcare workers, first responders, and…
- Conditions
- Posttraumatic Stress Symptoms, Burnout, Burnout, Healthcare Workers, First Responders
- Trial name
- PTSS FLOAT (NCT07710417)
- Testing
- Floatation-REST, Documentary
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Laureate Institute for Brain Research, Inc.
Stress Disorders, Post-Traumatic, Pain, Chronic
Mantram Repetition Versus Health Education for Veterans With PTSD and Chronic Pain
Approximately 450,000 Veterans Health Administration service users have both posttraumatic stress disorder (PTSD) and chronic pain (CP); treatments that efficiently target both PTSD and CP are limited, and new interventions…
- Trial name
- NCT07725588
- Testing
- Mantram Repetition Program for PTSD + Pain, Health Education while Living with Pain
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- VA Office of Research and Development
Postpartum Complication, Posttraumatic Stress Symptoms
Labor Education to Reduce Postpartum Traumatic Stress
The goal of this randomized controlled trial is determine if education on common events in labor in nulliparous women can reduce the postpartum traumatic symptoms.
- Trial name
- LEPT (NCT06992791)
- Testing
- Prenatal Education on Childbirth
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego