Clinical trials: PTSD and Alcohol Use Disorder, open to volunteers
PTSD, Alcohol; Use, Problem
Evaluating Signs of Safety: A Deaf-Accessible Therapy Toolkit for AUD and Trauma
The U.S. Deaf community - a group of more than one million Americans who communicate using American Sign Language (ASL) - experiences nearly triple the rate of lifetime problem drinking and twice the rate of trauma exposure…
- Trial name
- NCT06278922
- Testing
- Seeking Safety + Signs of Safety toolkit, Treatment as usual
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- University of Massachusetts, Worcester
PTSD, Depression
Local Participatory Systems Dynamics to Increase Reach of Evidence Based Addiction and Mental Health Care
The most common reasons Veterans seek VA addiction and mental health care is for help with opioid and alcohol misuse, depression and PTSD.
- Conditions
- PTSD, Depression, Alcohol Use Disorder, Opioid Use Disorder
- Trial name
- NCT04356274
- Testing
- Participatory System Dynamics (PSD), Audit and Feedback (AF)
- Where
- United States
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Palo Alto Veterans Institute for Research
Post Traumatic Stress Disorder PTSD, Hazardous Alcohol Use
Multimodal Intervention for Individuals With Posttraumatic Stress Disorder (PTSD) and Hazardous Alcohol Use
This project will test the effectiveness of a stepped-care talk therapy model for patients with PTSD and Hazardous Alcohol use (HAU).
- Trial name
- NCT07903974
- Testing
- Written Exposure Therapy (WET), Clinician Supported PTSD Coach App (CS-PTSD), Phone follow up
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Michigan
PTSD, AUD
PTSD and Alcohol Couples Treatment for Veterans
Treatment of post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) treatment for Veterans is challenging for Veterans.
- Trial name
- PACT-V (NCT07388654)
- Testing
- COPE + BFIT
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- VA Office of Research and Development
Depression - Major Depressive Disorder, Anxiety
Deaf CBT-TS to Reduce Suicide Risk
The goal of this clinical trial is to learn if a short, Zoom-based intervention, Cognitive Behavioral Therapy for Treatment-Seeking for Deaf Individuals (Deaf CBT-TS) can change beliefs about mental health treatment and increase…
- Conditions
- Depression - Major Depressive Disorder, Anxiety, PTSD - Post Traumatic Stress Disorder, Insomnia
- Trial name
- NCT07279363
- Testing
- Deaf CBT-TS
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of Rochester
Alcohol Use Disorder (AUD), Post Traumatic Stress Disorder (PTSD)
Suvorexant for Treatment of AUD and PTSD
This study is to determine if suvorexant (SUV) will reduce insomnia in 76 men and women veteran and non-veterans between the ages 21-65 with posttraumatic stress disorder (PTSD) symptoms and alcohol use disorder (AUD).
- Conditions
- Alcohol Use Disorder (AUD), Post Traumatic Stress Disorder (PTSD), Insomnia
- Trial name
- SUV (NCT06679062)
- Testing
- Suvorexant
- Where
- 2 sites in United States
- Volunteers
- 76 people
- Sponsor
- Pharmacotherapies for Alcohol and Substance Use Disorders Alliance
Intimate Partner Violence
Evaluating Interventions for Intimate Partner Violence Use in Washington State
Intimate partner violence (IPV), specifically physical and psychological aggression toward an intimate partner, represents a public health crisis that affects millions of Americans each year.
- Trial name
- NCT06526247
- Testing
- Strength at Home (SAH), Treatment as usual for IPV
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- Boston University
PTSD - Post Traumatic Stress Disorder, PTSD and Alcohol Use Disorder
Effectiveness, Implementation, and Cost of Cognitive Processing Therapy in Prisons
Addiction and trauma exposure are common among the 5.5 million people (1 in 47 adults) in the U.S. who are in prison or under supervision.
- Conditions
- PTSD - Post Traumatic Stress Disorder, PTSD and Alcohol Use Disorder, PTSD and Trauma-related Symptoms, Substance Use Disorder (SUD)
- Trial name
- STRIDES2 (NCT06923423)
- Testing
- Group Cognitive Processing Therapy (CPT), Control Group Individual trauma focused self-help via workbook
- Where
- 6 sites in United States
- Volunteers
- 640 people
- Sponsor
- University of Arkansas
Posttraumatic Stress Disorder, Alcohol Use Disorder
Integration of Cognitive Processing Therapy and Relapse Prevention for Alcohol Use Disorder and PTSD
The goal of this clinical trial is to test the efficacy of a novel integrative cognitive-behavioral intervention in patients with posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD).
- Trial name
- CPT+RP (NCT05959434)
- Testing
- Cognitive Processing Therapy + Relapse Prevention, Relapse Prevention
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Texas A&M University
Post-Traumatic Stress Disorder, PTSD, Alcohol Use Disorder (AUD)
Imaging Phosphodiesterase 4B (PDE4B) in People With Psychiatric Disorders With Positron Emission Tomography (PET) and the Radiotracer [18F]PF974
Imaging PDE4B in people with psychiatric disorders with PET and the radiotracer [18F]PF974
- Trial name
- NCT07488819
- Testing
- PF974
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Yale University
Major Depressive Episode (MDE), Major Depressive Disorder (MDD)
LHC-CIDI-5 in Hong Kong
The World Health Organization Composite International Diagnostic Interview-5th (CIDI-5) is a standardized diagnostic tool used to assess the prevalence of mental and substance use disorders over varying time frames (30 days, 12…
- Conditions
- Major Depressive Episode (MDE), Major Depressive Disorder (MDD), Persistent Depressive Disorder (PDD), Suicidal Ideation
- Trial name
- NCT06804525
- Testing
- CIDI-5, LHC-CIDI-5
- Where
- Hong Kong
- Volunteers
- 2,500 people
- Sponsor
- The University of Hong Kong
Domestic Violence, Post Traumatic Stress Disorder
Evaluation of a Trauma-Informed Partner Violence Intervention Program
The goal of this study is to conduct a randomized controlled trial (RCT) comparing outcomes between two programs to reduce intimate partner violence (IPV)- the Strength at Home (SAH) program and a standard, state-approved IPV…
- Trial name
- NCT06803043
- Testing
- SAH, TAU
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Boston University
PTSD, Alcohol Use Disorder
Peer Delivered, Emotion Regulation-Focused Mental Health Prevention Training for Fire Fighter Trainees
The goal of this clinical trial is to determine if a peer-delivered emotion regulation training (Brief-Unified Protocol) workshop is effective for preventing posttraumatic stress and other psychological health symptoms in…
- Conditions
- PTSD, Alcohol Use Disorder, Depression, Anxiety
- Trial name
- PEER UP (NCT06290778)
- Testing
- Brief Unified Protocol, Psychoeducation
- Where
- United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Post Traumatic Stress Disorder, Alcohol Use Disorder
Leveraging Biomarkers for Personalized Treatment of Alcohol Use Disorder Comorbid With PTSD
This is a double-blind, 2-group randomized controlled trial evaluating the effects of topiramate versus placebo in patients with comorbid PTSD and moderate-to-severe AUD.
- Trial name
- NCT03667846
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- NYU Langone Health
Post-Traumatic Stress Disorder, Alcohol Drinking
Approach-Avoidance and Alcohol Challenge Study in PTSD
Individuals with posttraumatic stress disorder (PTSD) have greater prevalence of alcohol use disorders (AUDs), with this comorbidity associated with worse illness outcomes, yet there remains limited mechanistic understanding of…
- Trial name
- PACS (NCT06002633)
- Testing
- Alcohol
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Alcohol Use Disorder (AUD), Post Traumatic Stress Disorder (PTSD)
Effect of Sublingual Formulation of Dexmedetomidine Hydrochloride (HCl) (BXCL501) - Outpatient Study
The overall objective of the proposed study is to determine if Dexmedetomidine HCl (BXCL501) is safe for treatment of alcohol use disorder (AUD) with comorbid posttraumatic stress disorder (PTSD) in an outpatient setting and also…
- Trial name
- NCT06335407
- Testing
- Dexmedetomidine (DEX) for sublingual (SL) administration (BXCL501) - 40µg, Dexmedetomidine (DEX) for sublingual (SL) administration (BXCL501) - 80µg
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Pharmacotherapies for Alcohol and Substance Use Disorders Alliance
Post Traumatic Stress Disorder, Alcohol Use Disorder
MDMA-Assisted Therapy for Veterans With PTSD and Alcohol Use Disorder
The study investigators are conducting the first randomized placebo-controlled trial of MDMA-assisted therapy with a comorbid sample of military Veterans with a co-occurring diagnosis of Alcohol Use Disorder (AUD) and…
- Trial name
- MAP VETS (NCT07118839)
- Testing
- Full Dose MDMA, MDMA-Assisted psychotherapy
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- VA Office of Research and Development
Alcohol Use Disorder (AUD), PTSD
Recovery Through Inhibitory Learning, Self-Efficacy Building, Problem Solving, and Community Building
This is a two-part study to develop and test a brief, virtual therapy program for lesbian, gay, bisexual, transgender, and queer (LGBTQ+) people who have experienced trauma and use alcohol.
- Trial name
- RISE (NCT07217795)
- Testing
- CBT + expressive writing, Wait-List Control
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Rhode Island
Anxiety Disorders and Symptoms, PTSD and Trauma-related Symptoms
Personalizing Treatment Delivery
Anxiety and anxiety-related disorders frequently co-occur with alcohol use problems resulting in an enormous humanitarian and economic cost to society.
- Conditions
- Anxiety Disorders and Symptoms, PTSD and Trauma-related Symptoms, Alcohol; Use, Problem; Alcohol Use Disorder
- Trial name
- NCT05821634
- Testing
- Personalized intervention condition: Cognitive behavioral therapy skills, Therapeutic control condition: Cognitive behavioral therapy skills, Tracking control condition: Supportive counseling
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Rutgers, The State University of New Jersey
Alcohol Use Disorder (AUD), Post Traumatic Stress Disorder (PTSD)
Pregnenolone to Target Concurrent PTSD and Stress Induced Alcohol Use in Veterans: A Dose Finding Study
The purpose of this research study is to find out how Zulresso®/brexanolone influences Posttraumatic Stress Disorder (PTSD) symptoms and alcohol use.
- Trial name
- NCT06580444
- Testing
- Brexanolone
- Volunteers
- 40 people
- Sponsor
- Pharmacotherapies for Alcohol and Substance Use Disorders Alliance