Clinical trials: Paclitaxel-induced Peripheral Neuropathy
Breast Cancer, Peripheral Neuropathy
Acupuncture to Reduce Chemotherapy-induced Peripheral Neuropathy Severity During Neoadjuvant or Adjuvant Weekly Paclitaxel Chemotherapy in Breast Cancer Patients
The purpose of this study is to find out the effects of acupuncture on reducing nerve damage. Acupuncture is a medical technique of inserting very thin needles into the "energy points" on the body with the aim to restore health…
- Trial name
- NCT02364726
- Testing
- Acupuncture, Neuropathic Pain Scale (NPS) questionnaire, FACT/GOG-Ntx questionnaire
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Oncology Pain, Chemotherapy-induced Peripheral Neuropathy
The Potential Protective Role of Venlafaxine Versus Memantine in Paclitaxel Induced Peripheral Neuropathy
This is a double blinded two-arm randomized case-only interventional trial. A total of 60 patients who are to receive Paclitaxel to be included and allocated in two groups.
- Trial name
- NCT04737967
- Testing
- Venlafaxine, Memantine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mendel AI
Peripheral Neuropathy, Secondary to Drugs or Chemicals, Oxaliplatin Induced Peripheral Neuropathy in Cancer Patients
Effect of Exercise on Chemotherapy-Induced Peripheral Neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN) is a common and often persistent adverse effect of oxaliplatin- and paclitaxel-based chemotherapy.
- Conditions
- Peripheral Neuropathy, Secondary to Drugs or Chemicals, Oxaliplatin Induced Peripheral Neuropathy in Cancer Patients, Paclitaxel Induced Neuropathy
- Trial name
- EX-CIPN (NCT07399561)
- Testing
- Exercise Intervention, Usual Care
- Where
- South Korea
- Volunteers
- 140 people
- Sponsor
- National Cancer Center, Korea
Peripheral Neuropathy, Breast Cancer
Efficacy of Cilostazol in Prevention of Peripheral Neuropathy
There are several mechanisms concerning pathophysiology of paclitaxel induced peripheral neuropathy. One of the main mechanisms is induction of Schwann cell dedifferentiation by paclitaxel.
- Trial name
- NCT05298696
- Testing
- Cilostazol
- Where
- Egypt
- Volunteers
- 71 people
- Sponsor
- Mansoura University
Real Time Pressure Controller, Breast Cancer
A Study of the Effect of Real-time Pressure Controllers on Subjective and Objective Symptoms of Peripheral Neuropathy Induced by Albumin Paclitaxel
The purpose of the real-time pressure controller proposed in this experiment is to overcome the deficiencies of the existing technology and provide a pressure filling device for the prevention of chemotherapy-induced peripheral…
- Conditions
- Real Time Pressure Controller, Breast Cancer, Albumin Paclitaxel, Peripheral Neuropathy
- Trial name
- NCT07019233
- Testing
- Real Time Pressure Controller
- Where
- China
- Volunteers
- 118 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Chemotherapy-induced Peripheral Neuropathy, CIPN - Chemotherapy-Induced Peripheral Neuropathy
High-concentration Capsaicin Patch for the Prevention of Paclitaxel-induced Peripheral Neuropathy
This research study is for participants who are receiving paclitaxel infusion as part of their cancer treatment. The purpose of this study is to test the effectiveness of the Food and Drug Administration (FDA) approved…
- Trial name
- NCT07834281
- Testing
- High Concentration Capsaicin Patch (HCCP)
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Case Comprehensive Cancer Center
Breast Cancer, Peripheral Neuropathy
NBP in Women With Metastatic Breast Cancer to Prevent Nab-paclitaxel Induced Toxic Neuropathy
Phase 2, randomized, double-blind, Placebo-Controlled, Multiple Dose Study for the treatment of Patients with Metastatic Breast Cancer.
- Trial name
- NCT04675450
- Testing
- NBP Softgel Capsules
- Volunteers
- healthy volunteers welcome
- Sponsor
- Conjupro Biotherapeutics, Inc.
Cervical Carcinoma, Fallopian Tube Carcinoma
Cryocompression With or Without Cilostazol for the Prevention of Paclitaxel-induced Neuropathy in Patients With Gynecological Cancers
The phase II trial evaluates the effectiveness of cryocompression therapy alone or in combination with cilostazol in preventing paclitaxel-induced peripheral neuropathy (numbness, pain or tingling in the feet and hands) for…
- Conditions
- Cervical Carcinoma, Fallopian Tube Carcinoma, Malignant Solid Neoplasm, Malignant Uterine Neoplasm
- Trial name
- NCT06492070
- Testing
- Best Practice, Cilostazol, Cryocompression Therapy
- Where
- 3 sites in United States
- Volunteers
- 70 people
- Sponsor
- Emory University
Peripheral Neuropathy Due to Chemotherapy
Trimetazidine Efficacy in Attenuating Paclitaxel-Induced Peripheral Neuropathy
This proof-of-concept study evaluated the effect of Trimetazidine on the incidence of paclitaxel-induced peripheral neuropathy in patients with breast cancer.
- Trial name
- NCT06459193
- Testing
- Trimetazidine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Minia University
Peripheral Neuropathy, Breast Cancer
Efficacy of Metformin as Preventive Treatment in Paclitaxel Induced Peripheral Neuropathy in Breast Cancer Patients
At present, there are no FDA-approved treatments for chemotherapy-induced neuropathy. Discrete neuro anti-inflammatory effects of metformin support its repurposing as a neuroprotective agent in patients with neurodegenerative…
- Trial name
- NCT05351021
- Testing
- Metformin
- Where
- Egypt
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Cognition Disorders, Polyneuropathies
Chemotherapy-induced Cognitive Alterations in Recruits With Ovarian and Breast Cancer
Neurotoxic phenomena are among the most common and difficult to treat side effects of chemotherapy. The development of chemotherapy induced peripheral neuropathy (CIPN) is a well-recognized adverse reaction in the peripheral…
- Trial name
- CICARO (NCT02753036)
- Testing
- Chemotherapy
- Where
- Germany
- Volunteers
- 72 people
- Sponsor
- Charite University, Berlin, Germany
Peripheral Neuropathy Due to Chemotherapy
Acupuncture for Peripheral Neuropathy Induced by Paclitaxel in Early Stage Breast Cancer
The present study aims to evaluate the effectiveness of acupuncture in the treatment of chemotherapy drug paclitaxel induced peripheral neuropathy in patients with early stage breast cancer
- Trial name
- NCT04461977
- Testing
- True acupuncture
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Instituto Brasileiro de Controle do Cancer
Peripheral Neuropathy, Chemotherapy-induced, Disease Management
A Controlled Clinical Trial Assessing the Efficacy of Vitamin B Prophylaxis in Attenuating Paclitaxel-induced Neuropathy and the Imperative Use of Gabapentin in Diabetic Ovarian Cancer Patients and the Potential Effect on Disease Response.
The goal of this clinical trial is to learn if vitamin B prophylaxis is effective in attenuating chemotherapy-induced peripheral neuropathy in adult ovarian cancer patients.
- Trial name
- NCT07191587
- Testing
- Vitamin B Complex
- Where
- Egypt
- Volunteers
- 146 people
- Sponsor
- National Cancer Institute, Egypt
Chemotherapy-induced Peripheral Neuropathy (CIPN)
GM1 Prophylaxis for Nab-paclitaxel-associated Chemotherapy-induced Peripheral Neuropathy (CIPN) in Patients With Breast Cancer
This study is a randomized, double-blind, multicenter, placebo-controlled phase III clinical trial, aiming to evaluate the efficacy and safety of GM1 in preventing chemotherapy-induced peripheral neuropathy in breast cancer…
- Trial name
- NCT06994507
- Testing
- GM1
- Where
- China
- Volunteers
- 352 people
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8
Docetaxel or Paclitaxel in Reducing Chemotherapy-Induced Peripheral Neuropathy in African American Patients With Stage I-III Breast Cancer
This phase II trial studies how well docetaxel or paclitaxel work in reducing chemotherapy-induced peripheral neuropathy in African American patients with stages I-III breast cancer.
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
- Trial name
- NCT04001829
- Testing
- Docetaxel, Paclitaxel, Quality-of-Life Assessment
- Where
- 482 sites in United States
- Volunteers
- 249 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Chemotherapy-induced Peripheral Neuropathy
Pentoxifylline Role Against Chemotherapy-induced Neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating side effect of neurotoxic cancer treatment. Estimated to occur in up to 80% of paclitaxel-treated patients with breast cancer, neuropathy symptoms can…
- Trial name
- NCT06562998
- Testing
- Pentoxifylline
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Beni-Suef University
Breast Cancer, Peripheral Neuropathy Due to Chemotherapy
Evaluation of the Effect of Amantadine in the Prevention of Paclitaxel-Induced Peripheral Neuropathy in Breast Cancer Patients
This randomized, controlled, open-label trial will evaluate the efficacy and safety of amantadine, an NMDA receptor antagonist with antioxidant and anti-inflammatory properties, in preventing paclitaxel-induced peripheral…
- Conditions
- Breast Cancer, Peripheral Neuropathy Due to Chemotherapy, VAS Score
- Trial name
- NCT07889115
- Testing
- Amantadine (oral)
- Volunteers
- 80 people
- Sponsor
- Al-Azhar University
Chemotherapy Induced Peripheral Neuropathy (CIPN)
Stibium Metallicum Praeparatum D6 Versus Placebo in the Reduction of Paclitaxel-induced Peripheral Neurotoxicity
Chemotherapy induced peripheral neuropathy (CIPN) is one of the most limiting side effects of chemotherapy and often leads to adaptations in the protocol of the chemotherapy including dose reduction or even discontinuation of…
- Trial name
- STING-CIPN (NCT04715542)
- Testing
- Stibium metallicum praeparatum 6x
- Volunteers
- 86 people
- Sponsor
- University of Bern
Breast Cancer, Chemotherapy-Induced Peripheral Neuropathy
TENS, Compression, and Cryotherapy for Paclitaxel-Induced Peripheral Neuropathy in Women With Breast Cancer
This single-center, four-arm, parallel-group randomized controlled trial evaluates transcutaneous electrical nerve stimulation (TENS), compression, and cryotherapy for the management of chemotherapy-induced peripheral neuropathy…
- Trial name
- NCT07817979
- Testing
- Transcutaneous Electrical Nerve Stimulation, Cryotherapy, Compression Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Cumhuriyet University
Paclitaxel Adverse Reaction, Neuropathy;Peripheral
ABCB1 SNPs as Predictors of PIPN
The study aim is to determine the allele frequencies of 1236 G>A and 3435 G>A in ABCB1 and study their association with the incidence and severity of paclitaxel-induced peripheral neuropathy while adjusting for other baseline…
- Conditions
- Paclitaxel Adverse Reaction, Neuropathy;Peripheral, Breast Cancer
- Trial name
- NCT05093023
- Testing
- Real-Time PCR
- Where
- Egypt
- Volunteers
- 92 people
- Sponsor
- Ain Shams University