Clinical trials: Paclitaxel-induced Peripheral Neuropathy
Cryotherapy Effect, Peripheral Neuropathy
The Use of Cryotherapy to Prevent Paclitaxel-induced Peripheral Neuropathy and Nail Changes in Women With Breast Cancer
This study will determine the efficacy of cryotherapy to prevent paclitaxel-induced peripheral neuropathy and nail changes in women with breast cancer.
- Conditions
- Cryotherapy Effect, Peripheral Neuropathy, Nail Toxicity
- Trial name
- NCT04558034
- Testing
- cryotherapy
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Parkview Health
Breast Cancer
Regional Cryotherapy in Preventing Paclitaxel Induced Peripheral Neuropathy in Breast Cancer Patients
The trial will be preceded by a pilot phase study in 5 patients. This will then be followed by the randomized 1:1 phase II trial testing the utility of regional cryotherapy in preventing or reducing paclitaxel-induced peripheral…
- Trial name
- NCT03429972
- Testing
- Elasto-Gel™, Paclitaxel
- Where
- Singapore
- Volunteers
- 51 people
- Sponsor
- National Cancer Centre, Singapore
Chemotherapy-induced Peripheral Neuropathy
Study of SIR2501 in Solid Tumor Patients Receiving Paclitaxel
This Phase 2, open-label study will evaluate the safety, tolerability, and pharmacokinetics of SIR2501 in adults with solid tumors who are scheduled to receive paclitaxel-based chemotherapy.
- Trial name
- NCT07765446
- Testing
- SIR2501
- Where
- 5 sites in United States
- Volunteers
- 18 people
- Sponsor
- Sironax USA, Inc.
Breast Cancer Female, Peripheral Neuropathy
"Prevention of Paclitaxel-Induced Peripheral Neuropathy in Breast Cancer Patients"
The aim of this study is to evaluate the effect of pentoxifylline 400 mg twice daily administration on the prevention of paclitaxel-Induced peripheral neuropathy in breast cancer patients.
- Trial name
- NCT05189535
- Testing
- Pentoxifylline, Paclitaxel
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Ain Shams University
Acute Pain, Breast Carcinoma
Minocycline Hydrochloride in Reducing Chemotherapy-Induced Peripheral Neuropathy and Acute Pain in Patients With Breast Cancer Undergoing Treatment With Paclitaxel
This randomized pilot trial studies how well minocycline hydrochloride works in reducing chemotherapy-induced peripheral neuropathy and acute pain in patients with breast cancer undergoing treatment with paclitaxel.
- Conditions
- Acute Pain, Breast Carcinoma, Peripheral Neuropathy
- Trial name
- NCT02297412
- Testing
- Minocycline Hydrochloride, Quality-of-Life Assessment, Questionnaire Administration
- Where
- 12 sites in United States
- Volunteers
- 47 people
- Sponsor
- Academic and Community Cancer Research United
Breast Cancer, Chemotherapy-induced Peripheral Neuropathy (CIPN)
Chinese Medicinal Component Relieves CIPN and Mitochondria Function
A randomized controlled trial was designed and conducted to confirm whether oral administration of the herb Moutan Cortex, which contains paeonol, can alleviate peripheral neuropathy in paclitaxel-treated cancer patients.
- Trial name
- NCT07693374
- Testing
- Moutan cortex
- Where
- Taiwan
- Sponsor
- Taiwan Municipal An-Nan Hospital-China Medical University
Chemotherapy-induced Peripheral Neuropathy (CIPN)
PREventing CHemotherapy Induced Neuropathy (PreChIN)
The project is designed to study the use of localized hypothermia alone, or with compression to the limbs during chemotherapy infusion for the prevention of chemotherapy induced peripheral neuropathy (CIPN).
- Trial name
- NCT03299582
- Testing
- Hypothermia, Cryocompression
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Chemotherapy-induced Peripheral Neuropathy
A Feasibility Study Investigating Chemotherapy-induced Neuropathy Using Multi-frequency Tactilometry and Patient-reported Outcomes (PRO)
Chemotherapy induced peripheral neuropathy (CIPN) is among the most feared side effects to cancer treatment. The development of CIPN can lead to discontinuation or omission of antineoplastic drugs, possibly affecting efficacy of…
- Trial name
- CINCAN-1 (NCT04167319)
- Testing
- QST and PRO measurements during treatment
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- Zealand University Hospital
CIPN - Chemotherapy-Induced Peripheral Neuropathy
Study to Investigate the Chemotherapy-Induced Peripheral Neuropathy (CIPN) Onset-Suppressing Effect and Safety of ONO-2910 in Patients With Breast Cancer Receiving Weekly Paclitaxel
To investigate the safety and CIPN onset-suppressing effect of ONO-2910 in participants receiving paclitaxel (PTX) weekly as chemotherapy for breast cancer in Japan.
- Trial name
- NCT06538272
- Testing
- ONO-2910
- Where
- 30 sites in Japan
- Volunteers
- 210 people
- Sponsor
- Ono Pharmaceutical Co., Ltd.
Breast Neoplasms, Breast Diseases
Evaluation of BNP7787 for the Prevention of Neurotoxicity in Metastatic Breast Cancer Patients Receiving Weekly Paclitaxel
The purpose of this study is to determine whether BNP7787 is effective in preventing or reducing neurotoxicity (nerve damage) caused by paclitaxel (Taxol®).
- Conditions
- Breast Neoplasms, Breast Diseases, Metastases, Neoplasm
- Trial name
- NCT00039780
- Testing
- BNP7787
- Volunteers
- 764 people
- Sponsor
- BioNumerik Pharmaceuticals, Inc.
Neuropathy Associated With Dysproteinaemias
Relationship Between Serum Interleukin-20 Level and Paclitaxel-associated Neuropathy
This study aims to investigate the correlation between paclitaxel-induced neuropathy and the measurement values of serum IL-20 levels at baseline and during chemotherapy in patients who will receive neoadjuvant or adjuvant…
- Trial name
- NEUROTOX (NCT05622617)
- Testing
- no intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Namik Kemal University
Peripheral Neuropathy
Early Detection of Taxane-Induced Neuropathy in Women With Breast Cancer
Purpose: The purpose of the study is to test a new way of measuring nerve damage in women with breast cancer receiving chemotherapy drug paclitaxel (Taxol).
- Trial name
- NCT02549534
- Testing
- Axon Reflexes, Axon Flares, Self-Reported Signs & Symptoms of CIPN
- Where
- 2 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Indiana University
Cancer, Lung, Colon Neoplasm
Exploration of Circulating microRNAs as Biomarkers of Chemo-induced Peripheral Neuropathy: a Study in Cancer Patients
This study aims to find out whether certain molecules in the blood, called microRNAs, are linked to how often and how severely people develop nerve damage from chemotherapy.
- Conditions
- Cancer, Lung, Colon Neoplasm, Neuropathy;Peripheral
- Trial name
- miR-CIPN#1 (NCT07427537)
- Testing
- Assessment of blood concentrations of microRNAs, Chemotherapy-induced peripheral neuropathy (CIPN) - grade, Pain assessement
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Clermont-Ferrand
Chemotherapy-induced Peripheral Neuropathy
A New Diagnostic Method to Assess Paclitaxel-Induced Peripheral Neuropathy
To assess the impact of Paclitaxel treatment on the nerve excitability of the small and large nerve fibers
- Trial name
- PacTox (NCT04237194)
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Carsten Dahl Mørch
Breast Cancer Female, Neuropathic Pain
Prevalence of Paclitaxel Induced CIPN-Related Pain and CIPN in Indian Patients With Breast Cancer
Since its introduction in the 1970s, Paclitaxel has been used as an effective anticancer agent against lung, breast, ovarian, leukopenia and liver cancer.
- Trial name
- NCT03022162
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Tata Memorial Centre
Breast Cancer Patients, Chemotherapy Induced Peripheral Neuropathy (CIPN)
The Effect of Cold Salt Water Foot Bath on the Development Of Chemotherapy-Induced Peripheral Neuropathy
This prospective, randomised, controlled study was designed to evaluate the effectiveness of salt and unsalted cold water foot baths in preventing chemotherapy-induced peripheral neuropathy (CIPN) in patients receiving…
- Conditions
- Breast Cancer Patients, Chemotherapy Induced Peripheral Neuropathy (CIPN), Paclitaxel-induced Peripheral Neuropathy
- Trial name
- NCT06964802
- Testing
- Cold salt water foot bath, Cold water foot bath
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Tuba Eryiğit
Paclitaxel-induced Peripheral Neuropathy
Efficacy of Surgical Glove-Compression Therapy As a Prevention of Paclitaxel-Induced Peripheral Neuropathy
The aim of this randomized controlled trial (RCT) is to compare the incidence of paclitaxel-induced grade 2 or higher sensory peripheral neuropathy, evaluated using the CTCAE version 5.0, between patients receiving surgical…
- Trial name
- NCT06763575
- Testing
- Surgical Glove-Compression Therapy, non-compressive plastic gloves
- Where
- Thailand
- Volunteers
- 36 people
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Breast Cancer, Stage I Breast Cancer
Acupuncture in Treating Nerve Pain in Patients With Stage I, Stage II, or Stage III Breast Cancer Who Are Receiving Paclitaxel
RATIONALE: Acupuncture may help relieve nerve pain caused by chemotherapy. PURPOSE: This randomized clinical trial is studying how well acupuncture works in treating nerve pain in patients with stage I, stage II, and stage III…
- Conditions
- Breast Cancer, Stage I Breast Cancer, Stage II Breast Cancer, Stage IIIA Breast Cancer
- Trial name
- NCT01050075
- Testing
- acupuncture therapy, questionnaire administration, management of therapy complications
- Where
- 2 sites in United States
- Volunteers
- 7 people
- Sponsor
- City of Hope Medical Center
Chemotherapy-induced Peripheral Neuropathy
A Study of Topical Pirenzepine or Placebo in Oncology Patients With Chemotherapy Induced Peripheral Neuropathy
This is a randomized, double-blind, placebo-controlled adaptive study of the safety, tolerability, and exploratory efficacy of once-daily topical WST-057 administered for up to 19 weeks (or up to 24 weeks for subjects who…
- Trial name
- NCT05488873
- Testing
- WST-057 Active
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- WinSanTor, Inc
Chemotherapy-induced Peripheral Neuropathy
Role of Curcumin in Paclitaxel Induced PN
Paclitaxel induced peripheral neuropathy is the most common and serious side effect associated with Paclitaxel treatment in breast cancer patients receiving Paclitaxel.
- Trial name
- NCT05966441
- Testing
- Curcumin, Paclitaxel
- Volunteers
- 80 people
- Sponsor
- Ain Shams University