Clinical trials: Paediatric
Paediatric Asthma, Paediatric Dysfunctional Breathing
Quality of Life - Effects of a Physical Therapy Intervention to for Children and Adolescents With Asthma
Many children and adolescents with asthma have dysfunctional breathing, e.g. they use mainly upper chest muscles to breath and do not engage the diaphragma muscle when breathing.
- Trial name
- NCT07397676
- Testing
- Breathing training, Standrad advice about physical activity
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Karolinska University Hospital
Paediatric B Cell-related Autoimmune Diseases, Autoimmune Diseases
Exploratory Clinical Study of Second-generation CD19/BCMA Chimeric Antigen Receptor NK Cell Injection in Treating Paediatric B Cell-related Autoimmune Diseases
Evaluating the efficacy and safety of anti-CD19/BCMA CAR-NK Cells in Paediatric B cell-related autoimmune diseases
- Conditions
- Paediatric B Cell-related Autoimmune Diseases, Autoimmune Diseases, CAR
- Trial name
- NCT07283315
- Testing
- anti-CD19/BCMA CAR NK cells (KN5601-K)
- Where
- China
- Volunteers
- 12 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Paediatrics
Acceptability, Gastrointestinal Tolerance, Compliance and Palatability Study.
Acceptability, compliance and palatability study.
- Trial name
- NCT07210658
- Testing
- Oral nutritional supplementation
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Société des Produits Nestlé (SPN)
Paediatric Outpatient Surgery
Reduction of Preoperative Anxiety in Children: Electronic Tab vs Midazolam
Rationale: The most frequently used means to prevent pre-anaesthetic anxiety in children is a drug premedication. Midazolam, a benzodiazepine, is mainly used.
- Trial name
- IPAD (NCT02192710)
- Testing
- electronic tab, Midazolam oral intake
- Where
- France
- Volunteers
- 118 people
- Sponsor
- Hospices Civils de Lyon
Anesthesia, Supraglottic Airway Efficiency
Clinical Efficacy Evaluation of Supraglottic Airway Device SafeLM™ in Paediatric Population
The goal of this interventional study is to evaluate the clinical efficacy of SafeLM™, a video laryngeal mask airway device in paediatric population. The main questions it aims to answer are: 1.
- Conditions
- Anesthesia, Supraglottic Airway Efficiency, Paediatric Airway Management
- Trial name
- NCT07266389
- Testing
- SafeLM™ as the airway management device during general anaesthesia
- Where
- 2 sites in Malaysia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Anaesthesia Conduction, Paediatric and Adult Patients
Sustainable Anaesthesia Practices in EUROPE - a Prospective International Cohort Study
In response to the climate crises, Societies of Anaesthesiology around the globe call for action to reduce the carbon footprint of daily clinical work.
- Conditions
- Anaesthesia Conduction, Paediatric and Adult Patients, Carbon Footprint in Anesthetic
- Trial name
- SUSTAIN-EUROPE (NCT07252973)
- Testing
- Anaesthesia technique
- Volunteers
- 2,000 people
- Sponsor
- European Society of Anaesthesiology
Paediatric Stroke
High Dose Steroids in Children With Stroke
This clinical trial deals with focal cerebral arteriopathy and childhood stroke, a rare but devastating condition. Focal cerebral arteriopathy (FCA) is an inflammatory vessel wall disease provoked by infection and there is…
- Trial name
- PASTA (NCT04873583)
- Testing
- Methylprednisolone, Prednisolone
- Where
- 35 sites in Australia, Austria and 6 more
- Volunteers
- 70 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Paediatric Surgery, Anaemia
South African Paediatric Surgical Outcomes Study 2
Preoperative anaemia has been shown to be associated with worse outcomes after surgery in both adults and children. Limited research has been done on how common preoperative iron-deficiency anaemia (IDA) is in children and how…
- Conditions
- Paediatric Surgery, Anaemia, Iron Deficiency Anemia, Iron
- Trial name
- SAPSOS2 (NCT05681871)
- Testing
- Ferrous gluconate syrup or ferrous fumarate/folic acid tablets
- Where
- 2 sites in South Africa
- Volunteers
- 755 people
- Sponsor
- University of Cape Town
Paediatric Oncology, Nurses
RCT to Evaluate the Efficacy of the NSSCEP in Reducing Burnout Among Jordanian Pediatric Oncology Nurses
The goal of this clinical trial is to learn if the Nurses' Stress Self-Care Educational Program (NSSCEP) can reduce burnout and occupational stress in Jordanian pediatric oncology nurses.
- Conditions
- Paediatric Oncology, Nurses, Burnout, Occupational Stress
- Trial name
- NSSCEP (NCT07175103)
- Testing
- Nurses' Stress Self-Care Educational Program (NSSCEP), General Technical Skills Program
- Where
- Jordan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
Infrared, Thermography
Infrared Thermography for Prediction of Successful Erector Spinae Plane Block in Unilateral Inguinal Hernia Surgery in Paediatric Patients
This study aims to evaluate the accuracy of temperature change (ΔT) measurements using infrared thermography to predict a successful erector spinae plane block in pediatric patients undergoing inguinal hernia repair under general…
- Conditions
- Infrared, Thermography, Prediction, Erector Spinae Plane Block
- Trial name
- NCT07161375
- Testing
- Infrared Thermography
- Where
- Egypt
- Volunteers
- 69 people
- Sponsor
- Cairo University
Stem Cell Transplant, Late Effect
Monitoring Neurocognitive Dysfunction and the Impact of Metabolism and Physical Capacity After Paediatric HSCT
Today the overall survival of childhood cancers has increased to above 85%. This increase is partially caused by treatment with bone marrow transplantation.
- Conditions
- Stem Cell Transplant, Late Effect, Neurocognitive Dysfunction, Paediatric Patients
- Trial name
- MindMe (NCT07140445)
- Where
- Denmark
- Volunteers
- 175 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Pancreatitis, Acute, Pain, Acute
Comparison of the Effectiveness of Paracetamol With Ibuprofen or Paracetamol With Metamizole in Treating Pain in Acute Pancreatitis in Children
The aim of the study is to assess the effectiveness and tolerance of pain treatment in AP in children using intravenous paracetamol in combination with ibuprofen or paracetamol in combination with metamizole.
- Conditions
- Pancreatitis, Acute, Pain, Acute, Pancreatic Disease, Pancreatic Diseases
- Trial name
- NCT07024199
- Testing
- The initial pain assessment, Drug administration according to protocol (paracetamol + ibuprofen OR paracetamol + metamizol), The effectiveness of the treatment
- Where
- Poland
- Volunteers
- 78 people
- Sponsor
- Medical University of Warsaw
Paediatric Dentistry, Dental Caries in Children
The Success Rate and Acceptability of Conventional and Modified Hall Crowns Among Children and Parents
This is a clinical trial that aims to compare the success rate, child and parent acceptance of conventional Hall crown technique (CHT) to modified Hall crown technique (MHT)in treating carious primary molars.
- Conditions
- Paediatric Dentistry, Dental Caries in Children, Dental Treatment
- Trial name
- Hallcrowns (NCT06545279)
- Testing
- Hall Crown Technique, Modified Hall Technique
- Where
- Jordan
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Survey on Patient and Parental Perceptions of EEG-monitoring During Paediatric Anaesthesia Care
Survey on Patient and Parental Perceptions of EEG-monitoring During Paediatric Anaesthesia Care
Electroencephalographic (EEG) monitoring during general anaesthesia (GA) is not typically part of standard care during GA. The recent availability of non-invasive commercial EEG monitors for children has made EEG monitoring more…
- Trial name
- NCT06937398
- Where
- Singapore
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Chronic Hepatitis B in Adults and Paediatric Patients
Bioequivalence Study of Two Products of Tenofovir Alafenamide 25 mg Film Tablet in Healthy, Adult, Human Subjects
To compare the bioavailability and characterize the pharmacokinetic profile of the sponsor's test product relative to that of reference product after single oral dose, fully replicate, bioequivalence study in normal, healthy…
- Trial name
- NCT06592300
- Testing
- Tenofovir Alafenamide Film coated Tablet, Vemlidy® film-coated tablets
- Where
- India
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Humanis Saglık Anonim Sirketi
Inguinal Hernia, Surgery
Analgesia Evaluation of an Ultrasound-guided Technique for Inguinal Hernia Surgery in Children in Children
The basis for the transversalis fascia plane (TFP) block involves infiltration of local anaesthetic blocking the ilioinguinal and iliohypogastric nerve which are located between the fascia of the transversus abdominis muscle and…
- Conditions
- Inguinal Hernia, Surgery, Paediatric
- Trial name
- NCT06883370
- Testing
- ultrasound-guided transversals fascia plane block with ropivacaine
- Where
- Malaysia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Paediatric Surgery, Perioperative/Postoperative Complications
An African, Multi-centre Evaluation of Patient Care and Clinical Outcomes for Paediatric Patients Undergoing Surgery
Access to safe surgery is a basic human right. This is highlighted by the work of the Lancet Commission on Global Surgery. There is a large burden of surgical disease in the paediatric surgical population with a large unmet need.
- Conditions
- Paediatric Surgery, Perioperative/Postoperative Complications, Perioperative Outcomes, Hospital Mortality
- Trial name
- ASOS-Paeds (NCT05061407)
- Where
- 2 sites in South Africa, Sudan
- Volunteers
- 8,625 people
- Sponsor
- University of KwaZulu
Underweight, Paediatrics
Impact of Bi-26 Supplementation on Weight Gain in Underweight Infants
The burden of disease experienced by underweight children is significant, particularly in low- and middle-income countries. Gut dysbiosis, an imbalance in microbial composition, is thought to play a role in nutrient malabsorption…
- Trial name
- NCT05952076
- Testing
- B. infantis Bi-26
- Where
- 5 sites in Pakistan
- Volunteers
- 40 people
- Sponsor
- Gates Medical Research Institute
Paediatric Inflammatory Multisystem Syndrome-Temporally Associated With SARS-CoV-2 (PIMS-TS)
Randomised Evaluation of COVID-19 Therapy (RECOVERY) in Children With PIMS-TS in Switzerland (SWISSPED-RECOVERY)
The study is to provide reliable estimates of the effect of study treatment on hospital length of stay through to 28 days after randomisation.
- Trial name
- NCT04826588
- Testing
- Methylprednisolone sodium succinate 10 mg/kg intravenously, Human normal immunoglobulin (IVIg)
- Where
- 10 sites in Switzerland
- Volunteers
- 76 people
- Sponsor
- University Children's Hospital Basel
Paediatric Airway
Ultrasound Evaluation of Laryngeal Mask Airway (LMA) Placement in Pediatric Patients and Its Relationship to Postoperative Complications
This study was designed to improve understanding of some respiratory reactions that can occur after surgery, such as difficulty breathing or persistent cough.
- Trial name
- LMAUSPED (NCT06712732)
- Volunteers
- 340 people
- Sponsor
- University Of Perugia