Clinical trials: Pain, Acute
Primary Inguinal Hernia
The Effect of Preemptive Regional Anesthesia (TAP-block) on Acute and Chronic Pain After Transabdominal Preperitoneal Inguinal Hernia Repair (TAPP)
The study is devoted to the impact of preemptive regional Transversus abdominal plane block on the postoperative acute and chronic pain after elective Transabdominal preperitoneal (TAPP) inguinal hernia repair.
- Trial name
- ERA-TAPP (NCT06406959)
- Testing
- Transversus abdominal plane block (TAP block)
- Where
- Russia
- Volunteers
- 78 people
- Sponsor
- Pirogov Russian National Research Medical University
Pain, Acute, Pain, Postoperative
Intraoperative Methadone in Children Undergoing Surgery
A prospective double-blind, randomized controlled trial investigating the effect of a single-dose of intraoperative methadone on postoperative pain and opioid consumption in 96 children undergoing open urological surgery.
- Conditions
- Pain, Acute, Pain, Postoperative, Children, Only
- Trial name
- METACEBO (NCT04680286)
- Testing
- Methadone Hydrochloride
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- University of Aarhus
Healthy, Tooth Extraction
Capsaicin to Control Pain Following Third Molar Extraction
Capsaicin to Control Pain Following Third Molar Extraction Summary: This study will test the effectiveness of the drug capsaicin in controlling pain after third molar (wisdom tooth) extraction.
- Trial name
- NCT00088686
- Testing
- Capsaicin (Intramucosal Injection)
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Intensive Care Unit, Cardiac Surgery
The Effect of Light Therapy on Post-Surgical Pain
Researchers aim to demonstrate that the use of phototherapy is feasible and may reduce acute postoperative pain based on recent literature.
- Trial name
- NCT05853731
- Testing
- Green light emitting diode, White light emitting diode
- Where
- United States
- Sponsor
- Mayo Clinic
Acute Low Back Pain (Low Back Pain for Less Than 3 Months)
Preventing the Transition From Acute to Persistent Disabling Low Back Pain Through Cognitive Functional Therapy
Acute low back pain often resolves spontaneously, but some patients develop persistent pain and disability. The goal of this clinical trial is to determine whether Cognitive Functional Therapy (CFT), compared with usual care, can…
- Trial name
- FIN-BACK (NCT07877454)
- Testing
- Cognitive Functional Therapy (CFT), Usual Care
- Where
- Finland
- Volunteers
- 461 people
- Sponsor
- University of Oulu
Angina (Stable), INOCA (Ischemia With Non Obstructive Coronary Artery Disease)
Diagnostic and Clinical Management of Non-Obstructive Myocardial Ischemia in Patients With Long Covid-19 Syndrome and New Onset Chest Pain
Long Covid-19 INOCA is an investigator-initiated, prospective, randomized, sham-controlled, single center study. Its objective is to investigate the benefits of tailored medical therapy according to the results of the coronary…
- Conditions
- Angina (Stable), INOCA (Ischemia With Non Obstructive Coronary Artery Disease), Long COVID-19 Syndrome
- Trial name
- NCT07559994
- Testing
- Coronary functional test
- Where
- Spain
- Volunteers
- 108 people
- Sponsor
- Fundacion Investigacion Interhospitalaria Cardiovascular
Abdominal Pain, Acute Pain
Diagnostic Performance of Low-Dose CT for Acute Abdominal Conditions
The goal of this non-inferiority observational study is to assess the diagnostic performance of low-dose CT with deep learning image reconstruction (DLIR) in adult participants with acute abdominal conditions.
- Conditions
- Abdominal Pain, Acute Pain, Acute Cholecystitis, Acute Appendicitis
- Trial name
- DETECT_Acute (NCT05651360)
- Testing
- low-dose CT
- Where
- 2 sites in Denmark, Norway
- Volunteers
- 246 people
- Sponsor
- Oslo University Hospital
Pain, Acute, Hip Arthropathy
Effect of Combinations of Paracetamol, Ibuprofen, and Dexamethasone on Patient-Controlled Morphine Consumption in the First 24 Hours After Total Hip Arthroplasty
Multimodal pain management is essential for recovery after surgery, aiming to target different pain mechanisms to minimize opioid usage and opioid-related adverse effects.
- Conditions
- Pain, Acute, Hip Arthropathy, Analgesia, Postoperative Pain
- Trial name
- RECIPE (NCT04123873)
- Testing
- Paracetamol, Ibuprofen, Dexamethasone
- Where
- 7 sites in Denmark
- Volunteers
- 1,060 people
- Sponsor
- Naestved Hospital
Chronic Pain, Acute Pain
Pilot Study on the Effects of Low-Level Laser Therapy Treatment for Acute and Persistent Discomfort
This study will examine the effectiveness of Low-Level Laser Therapy (LLLT) for the management of pain in various locations of the body.
- Trial name
- NCT04774783
- Testing
- Low-Level Laser Therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Arkansas Colleges of Health Education
Hypertonic Saline, Isotonic Saline
Activation of miRNA and Proteins After Acute Experimental Pain. (miRNA: Micro RNA)
In this experiment, the investigators would like to test the following: 1. Does acute pain induced by hypertonic injection cause changes in plasma miRNA and protein expression ? 2.
- Trial name
- miRNA (NCT04439994)
- Testing
- hypertonic saline, Saline injection, Blood sampling
- Where
- 2 sites in Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Burns, Acute Pain
VR-PAT During Home Burn Dressings - Multisite
This study will evaluate the effectiveness of smartphone Virtual Reality Pain Alleviation Therapy (VR-PAT) as a pain distraction tool during repeated at-home burn dressing changes among 100 children (age 6-17 years) with a burn…
- Conditions
- Burns, Acute Pain, Procedural Pain, Injuries
- Trial name
- NCT05673551
- Testing
- VR-PAT
- Where
- 2 sites in United States
- Volunteers
- 220 people
- Sponsor
- Nationwide Children's Hospital
Symptomatic Irreversible Pulpitis
Vital Pulp Therapy Versus Root Canal Treatment for Irreversible Pulpitis With Incipient Apical Periodontitis Diagnosed Using Artificial Intelligence This Keeps: the Main Intervention (Vital Pulp Therapy) the Comparison (Root Canal Treatment) the Condition (Irreversible Pulpitis With Incipient Apic
This study evaluates postoperative pain and treatment outcomes following vital pulp therapy and root canal treatment in patients with symptomatic teeth.
- Trial name
- NCT07549620
- Testing
- Vital Pulp Therapy, Root Canal Treatment
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Ain Shams University
Microbial Substitution, Tryptophan Metabolism Alterations
Impact of Gut Microbiota and Tryptophan Metabolites on Acute Pain in Lumbar Disc Herniation Surgery Patients
It is well-established that the gut microbiota plays a crucial role in various pain mechanisms, including visceral pain, inflammatory pain, headache, neuropathic pain, and opioid tolerance.
- Conditions
- Microbial Substitution, Tryptophan Metabolism Alterations, Postoperative Pain, Acute
- Trial name
- NCT06502223
- Testing
- Pain Perception in Patients Undergoing Lumbar Disc Herniation Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 37 people
- Sponsor
- Dokuz Eylul University
Non-ST-elevation Myocardial Infarction (NSTEMI)
Hs-cTnI Diagnosis of NSTE-ACS Patients in China
This study is to validate 1-hour and 3-hours diagnostic strategy using Architect high-sensitivity cardiac troponin I (hs-cTnI) in Chinese patients with suspected Non-ST-elevation Myocardial Infarction (NSTEMI).
- Trial name
- HEADLINES (NCT03734796)
- Where
- China
- Volunteers
- 2,400 people
- Sponsor
- China National Center for Cardiovascular Diseases
Total Abdominal Hysterectomy ,Pain , Acute Postoperative,Gabapentin , Celecoxib
Preoperative Analgesia in Non-gynecological Cancerous Women Who Underwent Elective Total Abdominal Hysterectomy
Comparison of effectiveness of preoperative Gabapentin with Celecoxib in reducing acute postoperative pain in abdominal hysterectomy, A randomized double blind controlled trial
- Trial name
- NCT03672162
- Testing
- Total abdominal hysterectomy
- Where
- Thailand
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Ankle Sprain
Safety and Efficacy of Generic Diclofenac Epolamine Acute Pain Due to Minor Ankle Sprain
To demonstrate the therapeutic efficacy of a generic diclofenac epolamine patch against Flector patch in the treatment of pain in subjects with minor ankle sprain
- Trial name
- NCT02324270
- Testing
- Diclofenac epolamine
- Where
- 31 sites in United States
- Volunteers
- 658 people, healthy volunteers welcome
- Sponsor
- Actavis Inc.
Colectomy, Open Surgery
Perioperative Intravenous Nimodipine Trial
The role of perioperative IV administration of nimodipine, an L-type calcium channel antagonist which is capable of crossing the blood-brain barrier, on peri-operative opioid and anesthetics requirements, pain intensity…
- Conditions
- Colectomy, Open Surgery, Pain, Pain, Postoperative
- Trial name
- NCT07048522
- Testing
- Nimodipine, Isotonic Saline
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- University of Ioannina
Pain, Acute, Anesthesia, Local
Intracervical Anesthesia and Pain Associated With Intrauterine Contraceptive Insertion
The primary aim of our study is to evaluate the effect of intracervical anesthesia on pain scores immediately following levonorgestrel-releasing intrauterine system (LNG-IUS) insertion in nulligravida women.
- Conditions
- Pain, Acute, Anesthesia, Local, IUD Insertion Complication
- Trial name
- NCT03111342
- Testing
- Anesthesia, Dry-needling
- Where
- Brazil
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Pain
Comparison of Two Dosage Strengths of Transdermal Fentanyl Versus Transdermal Buprenorphine and Placebo in Acute Pain Models in Healthy Volunteers.
The primary objective of this pilot trial is to identify pain model(s) which allow(s) to compare and differentiate the analgesic effects between transdermal fentanyl 25µg/h, transdermal fentanyl 12µg/h and placebo in a dose…
- Trial name
- NCT00886002
- Testing
- Fentanyl; Buprenorphine; Naloxone
- Volunteers
- 20 people
- Sponsor
- Janssen-Cilag A.G., Switzerland
Chronic Pain
Subdissociative Dose Ketamine for Treatment of Acute Pain in Subjects With Chronic Pain
This is a prospective, randomized controlled trial which will be conducted to determine whether sub-dissociative dose ketamine (SDDK) can improve pain control in subjects with chronic pain syndrome presenting to the emergency…
- Trial name
- NCT02920528
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center