Clinical trials: Pain, Experimental
Autonomic Nervous System Modulation, Pain Perception
Pain Perception and the Autonomic Nervous System
In this study, we want to investigate how pain processing and sensation are related to a certain part of the nervous system, the so-called autonomic nervous system.
- Conditions
- Autonomic Nervous System Modulation, Pain Perception, Pain Sensitivity, Central Sensitization
- Trial name
- NCT06667895
- Testing
- respiratory gated taVNS, random burst stimulation, continuous stimulation
- Where
- Switzerland
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Schweinhardt Petra
Chronic Pain
To Evaluate the Food Effect and the Absorption Profile of Ibuprofen Modified-Release Tablets 800 mg
An open-label, randomized, 3-way crossover study to evaluate the pharmacokinetics of investigational product "Ibuprofen Modified-Release Tablets 800 mg" in comparison to the reference standard "Ibuprofen Regular-Release Tablets…
- Trial name
- NCT05329454
- Testing
- Ibuprofen Tablets
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Overseas Pharmaceuticals, Ltd.
Pain
Effect of Opioids on Experimental Hyperalgesia in Oesophagus, Skin and Muscles
The study is a multi-modal multi-tissue human experimental pain study in 24 healthy volunteers. The study is a randomized cross-over study. The effect of 2 opioids will be compared on pain stimuli in skin, muscle an oesophagus.
- Trial name
- AEO-2007-01 (NCT00489684)
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Muscle Pain
Cocoa Intake and Muscle Pain Sensation
This experimental randomized, double-blind, and controlled study included fifteen young, healthy, and pain-free men and 15 age-matched women. It lasted for three visits with at least one-week washout.
- Trial name
- NCT05378984
- Testing
- before - hypertonic saline 5%, after - hypertonic saline 5%
- Where
- Sweden
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Experimental Pain in Healthy Human Subjects
Tonic Pain and Transauricular Vagal Nerve Stimulation
This study aims to explore the effect of burst-taVNS (electric stimulation of the concha cymba) on tonic (capsaicin-induced skin pain) and acute (pressure pain sensitivity) experimental pain and cardioception.
- Trial name
- NCT07325058
- Testing
- taVNS, Earlobe Stimulation
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Symptomatic Apical Periodontitis, Temporomandibular Disorders (TMDs)
Effect of Anterior Disc Displacement With Reduction on Postoperative Pain After Root Canal Treatment
The aim of this study is to evaluate the impact of anterior disc displacement with reduction (ADDR) on postoperative pain following root canal treatment in patients diagnosed with symptomatic apical periodontitis.
- Conditions
- Symptomatic Apical Periodontitis, Temporomandibular Disorders (TMDs), Anterior Disc Displacement
- Trial name
- TMD-POSTOP (NCT07329413)
- Testing
- Single-Visit Conventional Root Canal Treatment Using Nickel-Titanium Rotary Instruments (Endoart Smart Gold), Ibuprofen 400 mg (if necessary)
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Recep Tayyip Erdogan University
Low Back Pain, Lumbar Spinal Fusion
Back to Life - Early Rehabilitation Therapy for Patients Undergoing Lumbar Spinal Fusion
Aim This study aims to assess the effectiveness of an early intervention comprising individually tailored physiotherapy, including dialogue, education, and graded activity, following lumbar spinal fusion surgery.
- Trial name
- Back to Life (NCT07378735)
- Testing
- SOGA - Socratic dialogue and Graded Activity, SOGA - SOcratic dialougue and Graded-Activity, SOGA - SOcratic dialogue and Graded-Activity
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Coronary Angiography (CAG)
Effects of White Noise and Earplugs on Patients' Physiological Parameters, Pain, Comfort and Procedure Satisfaction
Coronary artery disease (CAD) is the leading cause of mortality and morbidity worldwide. Coronary Angiography (CAG) is an invasive method used in the diagnosis and treatment of CAD.
- Trial name
- NCT06725875
- Testing
- White Noise Group, Earplug group
- Volunteers
- 90 people
- Sponsor
- Di̇lek Soylu
Pain
Effects of GABA-a-Agonists on Pain Mechanisms: An Experimental Study in Healthy Volunteers
The investigators will use an intradermal capsaicin injection in the forearm to induce a state of localized pain. This localized pain will be measured by different means, and analysed locally and distally by so called…
- Trial name
- NCT01011036
- Testing
- clobazam, clonazepam, tolterodine
- Where
- Switzerland
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Chronic Low-back Pain
Osteopathic Single CAse Research for Patients With Chronic Low Back Pain
This study aims to collect primary data from patients with low back pain to assess the effect of standard osteopathic management and biopsychosocially-informed osteopathic care using a Single-Case Experimental Design.
- Trial name
- OSCAR (NCT05120921)
- Testing
- Osteopathic Manual Treatment, Self-management, Reassurance
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- University College of Osteopathy
Pain
A Prospective Randomized Comparison of Fentanyl, Methadone and Morphine for Epidural Analgesia in an Experimental Pain Model
The aims of this study are to provide pharmacokinetic-pharmacodynamic data to quantify the analgesic and side effect profiles of epidural methadone, fentanyl and morphine.
- Trial name
- NCT00848419
- Testing
- Epidural administration of bolus
- Sponsor
- Hadassah Medical Organization
Endometriosis (Diagnosis)
Impact of Food Supplementation on Quality of Life in Patients With Endometriosis and Pelvic Pain.
This study examines whether the food supplement Doliral can improve quality of life and reduce pelvic pain in women with endometriosis, compared with placebo, over several weeks.
- Trial name
- ENDOLIRAL (NCT07393958)
- Testing
- Food supplement (T1675)
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Arafarma Group, S.A.
Anemia, Sickle Cell
MBSR for Pain Catastrophizing in SCD
Significance: The purpose of this exploratory study is to test the feasibility, accessibility, and effects of a mindfulness-based stress reduction program (MBSR) on reducing pain catastrophizing in persons with sickle cell…
- Trial name
- NCT02394587
- Testing
- Mindfulness-based Stress Reduction
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Suicide, Attempted
Teachable Moment Brief Intervention for Suicide Attempt Survivors in an Inpatient Setting
This study is looking at the helpfulness of a brief treatment targeting suicidality (Teachable Moment Brief Intervention [TMBI]) and experimental pain responses in an inpatient population as well as collecting comparison data…
- Trial name
- TMBI-IP (NCT03600532)
- Testing
- Teachable Moment Brief Intervention (TMBI)
- Where
- 2 sites in United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Tulsa
Chronic Primary Pain
Personalising Psychotherapy for Chronic Primary Pain Using Network Analysis
The goal of this single case experimental design study with multiple baselines is to use network analysis to personalise cognitive behaviour therapy for chronic primary pain (CPP) and base the selection of individual treatment…
- Trial name
- NCT06179784
- Testing
- Cognitive Behaviour Therapy including third-wave
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- Prof. Dr. Julia Glombiewski
Acute Pain
Does the Understanding of Placebo Mechanisms Compensate for the Loss of Efficacy Associated With Open Label Placebo
The investigators are investigating whether, when given detailed information about underlying placebo mechanisms and pain, subjects will have a response similar to that of those subjected to a procedure in which they receive a…
- Trial name
- PLACETHIC (NCT03934138)
- Testing
- Informative movie on hand washing
- Where
- 2 sites in France
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Laboratoire TIMC-IMAG
Healthy, Placebo Effect
Experimental Pain Reporting Accuracy and Placebo Response
Good clinical care relies on precise evaluation of patients' conditions. Chronic pain and other neurological and psychiatric diagnoses pose challenges because their assessment depends on subjective patient-reported outcome…
- Conditions
- Healthy, Placebo Effect, Pain
- Trial name
- NCT03950999
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Haifa