Clinical trials: Pain, Face
Pain, Postoperative
Study to Find Out the Optimal Dose of Caffeine in the Combination Tablet of Naproxen Sodium and Caffeine in Patients Experiencing Moderate to Severe Pain After Having Wisdom Teeth Removed
The researchers in this study wanted to find out the optimal dose of Caffeine in the combination tablet of Naproxen Sodium and Caffeine that works in patients experiencing moderate to severe pain after having wisdom teeth…
- Trial name
- NCT04132336
- Testing
- Naproxen sodium/Caffeine (BAY2880376), Naproxen sodium (Aleve), Caffeine
- Where
- United States
- Volunteers
- 193 people
- Sponsor
- Bayer
Acute Pain
A Study to Assess Efficacy and Tolerability of Ketoprofen 40 mg Granules vs Placebo
Primary objective: To assess the efficacy of OKITASK® 40 mg granules versus Placebo in patients with acute pain syndrome after removal of one molar tooth by comparing AUC0-6h of posttreatment pain profile measured by VAS.
- Trial name
- KSL0117 (NCT03836807)
- Testing
- OKITASK®
- Where
- 3 sites in Russia
- Volunteers
- 70 people
- Sponsor
- Dompé Farmaceutici S.p.A
Post-surgical Dental Pain
Post-operative Dental Pain Study Comparing Analgesic Efficacy
GlaxoSmithKline will be conducting this trial to compare analgesics efficacy of paracetamol 1000mg vs 500mg . The post-surgical dental pain model will be used to evaluate the analgesic efficacy of paracetamol.
- Trial name
- NCT01082081
- Testing
- Paracetamol 1000 mg, Paracetamol 500 mg
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- GlaxoSmithKline
Pain
S-Caine™ Peel (Skin Numbing Cream) to Treat Pain During Skin Filler Injection in the Face
Injection of dermal filler is used as an aesthetic treatment to fill in unwanted wrinkles and scars. There can be substantial pain associated with dermal filler injections.
- Trial name
- NCT00110760
- Testing
- S-Caine™ Peel (lidocaine and tetracaine cream 7%/7%)
- Where
- 3 sites in United States
- Volunteers
- 70 people
- Sponsor
- ZARS Pharma Inc.
Temporomandibular Joint Disorders, Facial Pain
Device for Alleviating Temporomandibular Joint (TMJ) Pain
The goal of this clinical trial is to evaluate the safety and effectiveness of the investigational BTL-043 device in alleviating Temporomandibular Joint (TMJ) pain in adults aged 22 years and older.
- Conditions
- Temporomandibular Joint Disorders, Facial Pain, Temporomandibular Joint Dysfunction Syndrome
- Trial name
- NCT07624539
- Testing
- Treatment with BTL-043
- Where
- 3 sites in United States
- Volunteers
- 31 people
- Sponsor
- BTL Industries Ltd.
Pain
A Dental Pain Study to Test the Effectiveness of a New Pain Reliever Medicine
To assess the safety and effectiveness one dose of a new pain reliever medicine (JNJ-10450232 at either the 250 or 1000 mg strength) compared with placebo (sugar pill) or acetaminophen 1000 mg after surgical removal of third…
- Trial name
- NCT02209181
- Testing
- JNJ-10450232 / Not yet marketed, acetaminophen / Tylenol
- Where
- United States
- Volunteers
- 269 people
- Sponsor
- McNeil Consumer Healthcare Division of McNEIL-PPC, Inc.
Dental Pain
Phase 2 Study of Indomethacin Capsules to Treat Dental Pain
The purpose of this study is to determine whether Indomethacin Test Formulation Capsules are safe and effective for the treatment of dental pain.
- Trial name
- NCT00964431
- Testing
- Celecoxib 400 mg, Indomethacin Test (lower dose), Indomethacin Test (upper dose)
- Where
- United States
- Volunteers
- 203 people
- Sponsor
- Iroko Pharmaceuticals, LLC
Toothache
Assessing the Analgesic Efficacy of Naproxen Sodium in Postsurgical Dental Pain.
To evaluate the analgesic efficacy of a single, oral dose of a naproxen sodium extended-release tablet, compared to placebo in postsurgical dental pain.
- Trial name
- NCT00720057
- Testing
- Naproxen Sodium ER (BAYH6689)
- Where
- 3 sites in United States
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- Bayer
Dental Pain
A Study of ARRY-371797 in Subjects Undergoing Third Molar Extraction
This is a Phase 2 study designed to test the ability of investigational study drug ARRY-371797 to reduce pain in a postoperative pain model (third molar extraction), and to further evaluate the drug's safety.
- Trial name
- NCT00663767
- Testing
- ARRY-371797, p38 inhibitor; oral, Celecoxib, COX-2 inhibitor; oral
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- Pfizer
Dental Pain
Evaluation of EXPAREL for Prolonged Postsurgical Analgesia in Subjects Undergoing Third Molar Extraction
This is a Phase 3, randomized, double-blind, placebo-controlled study in subjects scheduled to undergo elective bilateral third molar extraction under local anesthesia.
- Trial name
- NCT02517905
- Testing
- Bupivacaine liposome
- Where
- United States
- Volunteers
- 166 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Trigeminal Neuralgia
A Study to Validate a Pain Diary for Patient With Trigeminal Neuralgia
The aim of the study is to establish the validity of a patient reported diary in TN . The following objectives have been identified: 1.
- Trial name
- NCT06019338
- Testing
- Pain Diary use
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 30 people
- Sponsor
- Noema Pharma AG
Atypical Facial Pain, Persistent Idiopathic Facial Pain
Efficacy and Safety of ATNC05 in Treatment of Atypical Facial Pain
The purpose of the study is to test the efficacy of ATNC05 in the treatment of Atypical Facial Pain (AFP), also known as Persistent Idiopathic Facial Pain (PIFP).
- Conditions
- Atypical Facial Pain, Persistent Idiopathic Facial Pain, Atypical Trigeminal Neuralgia, Neuropathic Orofacial Pain
- Trial name
- AFP (NCT01920087)
- Testing
- ATNC05
- Where
- United States
- Sponsor
- Allodynic Therapeutics, Inc
Dental Anxiety, Dental Pain
Nonpharmacologic Reduction of Periprocedural Distress and Drug Use
Objectives of this Phase I pilot trial are to provide data towards assessing and facilitating feasibility of a larger scale Phase II trial in which the effects of a calmative Comfort Talk® app can be unequivocally evaluated.
- Conditions
- Dental Anxiety, Dental Pain, Drug Use, Opioid Use
- Trial name
- NCT03328208
- Testing
- Comfort Talk® app, White Noise app
- Where
- 2 sites in United States
- Volunteers
- 72 people
- Sponsor
- Hypnalgesics, LLC
Dental Pain
Study of Acetaminophen (ACE) in Post-operative Dental Pain
This is a dental pain study evaluating the efficacy and safety of a single dose of test acetaminophen (ACE) (1000 mg) compared to commercial acetaminophen (1000 mg), ibuprofen (IBU) (400 mg), and placebo over a 6 hour period.
- Trial name
- NCT02320708
- Testing
- Acetaminophen (ACE) (1000 mg), Commercial ACE (1000 mg), Commercial Ibuprofen (IBU) (400 mg)
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Johnson & Johnson Healthcare Products Division of McNEIL-PPC, Inc.
Pain
Acetaminophen/Naproxen Sodium Dose Ranging Study
Study assessing the relative efficacy of five strengths of a fixed combination of acetaminophen and naproxen sodium is being investigated to help inform selection of dose(s) for further development and to evaluate the safety of a…
- Trial name
- NCT04447040
- Testing
- Acetaminophen/naproxen sodium Dose A, Acetaminophen/naproxen sodium Dose B, Acetaminophen/naproxen sodium Dose C
- Where
- United States
- Volunteers
- 304 people
- Sponsor
- Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division
Pain, Aging
RHA® Redensity With New Anesthetic Agent Perioral Rhytids (PAS)
This is a randomized, controlled, double-blinded, within-subject (split-face), multicenter, prospective study to investigate whether RHA® Redensity with new anesthetic agent is non-inferior to RHA® Redensity with lidocaine in…
- Trial name
- NCT06378086
- Testing
- RHA® Redensity with new anesthetic agent, RHA® Redensity with lidocaine
- Where
- 3 sites in United States, Puerto Rico
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Teoxane SA
Dental Pain
Dental Pain Study of Analgesics in Patients Undergoing Molar Removal
Accessing the efficacy and safety of pregabalin when used alone and in combo with acetaminophen in a dental pain model. To test whether pre-operative dose of pregabalin increases the time to significant post-operative pain (NRS ≥…
- Trial name
- NVK009-0001 (NCT03652818)
- Testing
- Pre-Op pregabalin, Post-Op pregabalin
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Nevakar, Inc.
Neuropathic Pain, Facial Pain
Motor Cortex Stimulation for Chronic Neuropathic Pain
The purpose of this study is to evaluate the efficacy of cortical stimulation (CS) as an adjunctive treatment for chronic neuropathic pain.
- Conditions
- Neuropathic Pain, Facial Pain, Post-stroke Pain, Brachial Plexus Avulsion
- Trial name
- NCT01554332
- Testing
- Motor Cortex Stimulation using SJM EonC Stimulator
- Where
- Brazil
- Volunteers
- 38 people
- Sponsor
- Abbott Medical Devices
Pain Disorders
Crossover, Single Dose Randomized, Bioequivalence of Ketoprofen Lysine Salt Immediate Release vs Oral Solution
Objectives: The objective of the study was to investigate the bioequivalence between two formulations containing ketoprofen lysine salt (KLS) when administered as single oral doses in two consecutive study periods to healthy male…
- Trial name
- NCT02350296
- Testing
- KSL 40 mg, OKi® 80 mg
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dompé Farmaceutici S.p.A
Pain
Multiple Dose Dental Pain Study Of Ibuprofen Extended Release
The study hypothesis is that single and multiple doses of ibuprofen 600 mg ER caplets provide analgesic efficacy superior to placebo over 12-hour dosing intervals.
- Trial name
- NCT01266161
- Testing
- Ibuprofen 600 mg ER
- Where
- 2 sites in United States
- Volunteers
- 106 people
- Sponsor
- Pfizer