Clinical trials: Pain, Medication
Migraine, Migraine With Aura
RimegepAnt effectIvenesS and tolErability as Migraine Preventive Treatment
The purpose of this prospective and multicentric study is to evaluate the effectiveness and tolerability of rimegepant as preventive migraine treatment in a cohort of episodic or chronic migraine patients.
- Conditions
- Migraine, Migraine With Aura, Migraine Without Aura
- Trial name
- RAISE (NCT06409832)
- Testing
- Rimegepant 75 mg
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- University of Florence
Intervention Studies, ASA Physical Status I
Biological, Radiographic and Clinical Evaluation of Various Inter-Visit Root Canal Dressings in Retreatment Cases
The aim of this clinical trial is to evaluate anti-inflammatory effect of various intracanal medications: 1. Calcium Hydroxide Slurry mixed with 3% Sodium Hypochlorite 2. Calcium Silicate 3.
- Conditions
- Intervention Studies, ASA Physical Status I, Intracanal Medication, Periapical Abscess
- Trial name
- RCT (NCT07641933)
- Testing
- Calcium Silicate Intracanal Medication, Calcium Hydroxide Slurry mixed with Sodium Hypochlorite Intracanal Medication, Calcium Hydroxide (Ca(OH)2) Intracanal Medication
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Acute Pain, Anxiety
Effects of Complementary Therapies Delivered Via Mobile Technologies
The purpose of this study is to determine the effects of complementary therapies delivered via mobile technologies have a therapeutic effect on surgical patients' anxiety, pain, and self-efficacy in healing reports before…
- Conditions
- Acute Pain, Anxiety, Self Efficacy
- Trial name
- NCT02236455
- Testing
- Audio Relaxation Technique, Medical Music Intervention, Nature Therapy without Music
- Where
- Iceland
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of San Francisco
Cancer, Pain
Validation of a Screening Scale for Misuse of Opioid Analgesics
In oncology, pain is one of the main symptoms of discomfort. It has a significant impact on the quality of life.The use of opioid analgesics is recommended for the treatment of moderate to severe cancer pain.The misuse of opioid…
- Conditions
- Cancer, Pain, Opioid Analgesic Adverse Reaction
- Trial name
- VPOMIONCOL (NCT05761587)
- Testing
- Questionnaires
- Where
- 2 sites in France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Clermont-Ferrand
Musculoskeletal Pain, Neuropathic Pain
Virtual Reality (VR) Self-Hypnosis Software
This single-site study of self-hypnosis software using an off-the-shelf virtual reality (VR) device (OculusGo™) to determine the software's safety, usability, and preliminary efficacy in pain relief for HIV-associated chronic…
- Conditions
- Musculoskeletal Pain, Neuropathic Pain, Neuralgia
- Trial name
- NCT06398847
- Testing
- Virtual Reality headset
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Postoperative Pain, Nerve Block
Comparison of 2 Different Methods in Infraclavicular Block
Background :The investigators wanted to see if dexamethasone, which is routinely used as an adjuvant tool by different anesthesiologists in the orthopedics operating room, can really start the effect of other local anesthetics…
- Conditions
- Postoperative Pain, Nerve Block, Analgesics
- Trial name
- NCT06402149
- Testing
- dexamethasone
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara City Hospital Bilkent
Postoperative Pain Following Coronary Artery Bypass Grafting (CABG)
Combined SPSP and TTP Blocks for Postoperative Analgesia Post-CABG
After heart bypass surgery (coronary artery bypass grafting, CABG), the breastbone is divided to reach the heart, which causes significant pain. Pain can make deep breathing and coughing difficult and may slow recovery.
- Trial name
- PACT (NCT07658521)
- Testing
- Bilateral Posterior Superior Plane Block, Bilateral Transversus Thoracic Plane, Conventional Systemic Analgesia
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
OPLL, Medicine, Korean Traditional
Long Term Follow-Up of Post Neck Pain Patients Accompanying Ossification of Posterior Longitudinal Ligament Treated With Integrated Complementary and Alternative Medicine: Observational Study
The purpose of this study is to reveal the effectiveness and safety of integrative Korean medicine for Ossification of Posterior Longitudinal Ligament(OPLL) by observation inpatients treated with integrative Korean medicine.
- Trial name
- NCT04446221
- Testing
- phone survey
- Where
- South Korea
- Volunteers
- 78 people
- Sponsor
- Jaseng Medical Foundation
Anesthetic, Sedative or Analgesic Complications in Labor or Delivery
Trial of Onset of Epidural Pain Relief With Low Dose Bupivacaine and Different Doses of Fentanyl in Laboring Women
Epidural analgesia is the most effective form of labor pain relief. Low doses of local anesthetic (freezing solutions) in combination with opioids (narcotics) are commonly used as epidural solutions to provide pain relief.
- Trial name
- NCT02004899
- Testing
- Fentanyl
- Where
- Canada
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Pain, Delayed Onset Muscle Soreness
An Investigator Initiated, Within-Subject, Proof of Concept Study to Assess the Efficacy and Safety of Voltaren Gel in Subjects With DOMS
The purpose of this study is to evaluate analgesic efficacy of Topical Voltaren Gel (diclofenac sodium gel) 1% applied QID compared to Placebo in Subjects Experiencing Delayed Onset Muscle Soreness.
- Trial name
- NCT02087748
- Testing
- 1% diclofenac sodium gel
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Lotus Clinical Research, LLC
Pain, Postoperative
Analgesic Efficacy of Bilateral US Guided TTPB vs ESPB in Pediatric Patients Undergoing Corrective Cardiac Surgeries
Corrective cardiac surgeries include a bundle of major surgeries that take place in pediatric patients and require imperative perioperative pain control; hence, the art of healing starts from trying to diminish or abolish pain.
- Trial name
- NCT05559684
- Testing
- Erector spinae plane block, Transversus thoracis plane block
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Opioid Analgesic Treatment Response, Chronic Pain
Predictive Markers of the Effects of Opioid Therapy
The overall goal of the ABILITY study is to help improve pain diagnostics and treatment by developing an implementable clinical computerised decision support system based on individual patient characteristics.
- Trial name
- ABILITY (NCT02308306)
- Where
- 5 sites in Belgium, Denmark and 1 more
- Volunteers
- 62 people
- Sponsor
- University of Aarhus
Pain
Art Therapy Pain Management Adolescents Pediatric ED
This project is studying adolescents between the ages of 12 to 18 years that come to the emergency department and are in pain. We want to find out how well art therapy is able to decrease the pain they are experiencing.
- Trial name
- NCT03755687
- Testing
- Art Therapy Intervention
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Columbia University
Low Back Pain
Identification of Risk Factors for Recurrence of Low Back Pain and Occupational Repercussions
Low back pain (LBP) is the leading cause of disability and one of the most common reasons for physician visits in primary care, with a 33 % rate of recurrence during the first year, converting LBP into a chronic condition.
- Trial name
- LORET (NCT05286333)
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Fondation Ildys
Osteoarthritis, Total Knee Replacement
Adductor Canal Block
The investigators aim to investigate whether the addition of a surgeon-administered adductor canal blockade to a multimodal periarticular injection cocktail provides additional pain relief for patients undergoing total knee…
- Trial name
- NCT04513145
- Testing
- Ropivacaine injection, Saline Injection, Total Knee Arthroplasty
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- OrthoCarolina Research Institute, Inc.
Fear
The Effects of Acetaminophen on Fear
This study investigates the effects of acetaminophen on behavioral, physiological, and self-report fear responses.
- Trial name
- NCT05396677
- Testing
- Acetaminophen
- Where
- Canada
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- University of Guelph
ACL Repair, Meniscectomy
Efficacy Study of Continuous Intraarticular Infusion in Patients Undergoing Arthroscopic Knee and Shoulder Operations
The aim of this study is to determine whether the continuous intraarticular infusion of local anesthetics in the postoperative period can improve analgesia and patients satisfaction after knee and shoulder arthroscopy.
- Conditions
- ACL Repair, Meniscectomy, Bankart Repair
- Trial name
- NCT00314457
- Testing
- Bupivacaine
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Children's Hospital of Philadelphia
Pain, Acute
The Efficacy of Acu-TENS as an Adjunct Analgesic During USG-MVA
Objectives: To prospectively evaluate the potential of acu-TENS to reduce the pain experienced by women undergoing ultrasound-guided manual vacuum aspiration (USG-MVA) and evaluate its safety profile.
- Trial name
- NCT06411054
- Testing
- Acu-TENS
- Where
- Hong Kong
- Volunteers
- 108 people
- Sponsor
- Chinese University of Hong Kong
Analgesia, Burns
Analgesic Effect of Esketamine in DCSB in Adultscontrolled Study
Patients with severe and above degree burns are often complicated with inhalation injury and systemic infection. During debridement and dressing change in such patients, doctors will be more cautious in using analgesics.
- Trial name
- NCT05603975
- Testing
- Esketamine 0.1mg/kg intravenous injection, Normal saline
- Volunteers
- 52 people
- Sponsor
- Shenzhen Second People's Hospital
Acute Radicular Back Pain, Cannabis
Effect of Cannabis Extract on Acute Radicular Pain and on Analgesic Requirement
Clinical evidence about the effects of cannabis in the management of acute pain is rather scarce, mostly consisting of case report-based opinions on adverse events during or after general anesthesia after smoking cannabis…
- Trial name
- NCT04816994
- Testing
- Single-dose of cannabis oil, Control
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Hadassah Medical Organization
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