Clinical trials: Pain, Medication
Cancer Pain
Study to Evaluate Effectiveness and Tolerability of OROS Hydromorphone for Cancer Pain Treatment in Korean Patients
The purpose of this study is to evaluate the effectiveness and tolerability of Once-Daily OROS ("Osmotic Release Oral System" [a controlled release oral medication delivery system in the form of a tablet]) hydromorphone for…
- Trial name
- NCT01621100
- Testing
- OROS hydromorphone
- Where
- 6 sites in South Korea
- Volunteers
- 106 people
- Sponsor
- Janssen Korea, Ltd., Korea
Pain, Postoperative, Pain Uterus
Effects of Tapentadol Versus Oxycodone After Hysterectomy.
Opioids remain the first-line drugs for the treatment of moderate to severe postoperative pain, but the use is limited by well-known side-effects, most of which are dose-dependent.
- Conditions
- Pain, Postoperative, Pain Uterus, Pain, Acute, Opioid Use
- Trial name
- NCT03314792
- Testing
- Tapentadol, Oxycodone
- Where
- Norway
- Volunteers
- 86 people
- Sponsor
- Oslo University Hospital
Acute Coronary Syndromes
Study to Learn When Platelets Return to Normal After One Loading Dose of Anti-platelet Drugs in Patients With Symptoms of Acute Coronary Syndromes
To investigate how platelets recover to normal function in subjects who have symptoms of a heart attack or unstable angina and who get a loading dose of prasugrel or clopidogrel for planned coronary angiography.
- Trial name
- NCT01107899
- Testing
- clopidogrel, prasugrel
- Where
- Germany
- Volunteers
- 29 people
- Sponsor
- Eli Lilly and Company
Opioid-Refractory Chronic Cancer-Related Pain
The Role of Coadministration of Lidocaine and Ketamine in Opioid-Refractory Chronic Cancer-Related Pain.
This is a randomized, double-blinded, placebo-controlled, cross-over trial examining the effect of a series of two weekly intravenous infusions of lidocaine 4 mg/kg and ketamine 0.2 mg/kg in patients with moderate to severe…
- Trial name
- NCT07408193
- Testing
- Lidocaine and Ketamine Infusion
- Where
- Greece
- Volunteers
- 24 people
- Sponsor
- National and Kapodistrian University of Athens
Chronic Pain, Back Pain
CARES (Comprehensive Analgesic, Recovery, and Education Support) for Surgery Trial
The goal of this clinical trial is to learn whether a combined behavioral and pharmacologic intervention can help reduce opioid use, improve pain recovery, and prevent opioid misuse after surgery in adults undergoing elective…
- Conditions
- Chronic Pain, Back Pain, Neck Pain, Opioid Misuse
- Trial name
- CARES (NCT06027099)
- Testing
- Tizanidine, MI-Opioid Taper, Enhanced Usual Care
- Where
- 4 sites in United States
- Volunteers
- 375 people
- Sponsor
- Stanford University
Breast Cancer, Postoperative Pain
Comparison of Postoperative Analgesic Efficacy of Two Different Blocks in Modified Radical Mastectomy Surgery
Postoperative pain following modified radical mastectomy remains a significant clinical challenge and may delay recovery, impair patient comfort, and increase opioid consumption.
- Trial name
- mastectomy (NCT07737132)
- Testing
- Ultrasound-Guided Serratus Posterior Superior Intercostal Plane Block (SPSIPB), Ultrasound-Guided Serratus Anterior Plane Block (SAPB)
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Pharmacoresistant Neuropathic Pain
Analgesic Effect of Non Invasive Stimulation : Comparison of rTMS and tDCS Efficacy
The aim of this study is to compare analgesic efficacy of two non invasive techniques based on motor cortex stimulation in neuropathic pain patients.
- Trial name
- NI-MCS (NCT01800136)
- Testing
- Repetitive Transcranial Magnetic Stimulation and Transcranial Direct Current Stimulation
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Hospices Civils de Lyon
Obesity
Erector Spina Plane Block in Laparoscopic Sleeve Gastrectomy Surgery
The aim of the study is to evaluate the effect of erector spina plane (ESP) block on pulmonary functions and postoperative analgesic consumption in patients undergoing bariatric surgery.
- Trial name
- NCT04039321
- Testing
- ESPB group, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Antalya Training and Research Hospital
Post-Operative Pain
Evaluate the Analgesic Efficacy and Safety of VVZ-149 Injection for Post-operative Pain Following Gastrectomy
VVZ-149 is a novel analgesic drug candidate that shows a potential analgesic activity inhibiting GlyT2 and 5HT2A simultaneously.
- Trial name
- NCT02522598
- Testing
- VVZ-149 injections
- Where
- South Korea
- Volunteers
- 38 people
- Sponsor
- Vivozon, Inc.
Low Back Pain
Pregnancy-Related Low Back Pain and Complementary and Alternative Medicine (CAM) Treatment
This study compares three treatments for low back pain that started during pregnancy. The study hypothesizes that exercise, spinal manipulation, and a mind-body technique called neuroemotional technique (NET) equally affect pain…
- Trial name
- NCT00937365
- Testing
- Exercise, Spinal Manipulation, Neuroemotional Technique (NET)
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Appendicitis
Perioperative Pain Management of Pediatric Appendectomy Patients
Acute appendicitis is the most common illness that brings pediatric patients to the hospital for surgical treatment. Abdominal pain is the symptom because of which the patients go to the hospital.
- Trial name
- umpikipu (NCT02580487)
- Testing
- appendicectomy
- Where
- Finland
- Volunteers
- 178 people
- Sponsor
- Kuopio University Hospital
Effect of Drug
Comparing Trypsin-Chymotrypsin and Naproxen Sodium for Post-endodontic Treatment Pain
This study aims to compare the pain reduction efficacy of Trypsin-Chymotrypsin and Naproxen sodium after root canal treatment in patients with symptomatic irreversible pulpitis.
- Trial name
- NCT06562816
- Testing
- Trypsin-Chymotrypsin, Naproxen Sodium 550mg
- Where
- Pakistan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Overweight, Glucose Metabolism Disorders
The Physical Activity and Nutrition in Children (PANIC) Study
The Physical Activity and Nutrition in Children (PANIC) Study is a single-centre controlled trial on the effects of a combined physical activity and dietary intervention on cardiometabolic risk factors and other health outcomes…
- Conditions
- Overweight, Glucose Metabolism Disorders, Lipid Metabolism Disorders, Blood Pressure
- Trial name
- PANIC (NCT01803776)
- Testing
- lifestyle counseling
- Where
- Finland
- Volunteers
- 504 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Pain, Acute
Nebulized Ketamine to Nebulized Fentanyl for Treating Acute Painful Conditions in the ED
In situations where intravenous access is not readily available or is unobtainable and the intranasal route is not feasible, another non-invasive route of ketamine administration, such as inhalation via breath-actuated Nebulizer…
- Trial name
- KETAFEN (NCT06364540)
- Testing
- Ketamine, Fentanyl
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Antonios Likourezos
Pain, Pain, Postoperative
Cryoablation of Intercostal Nerves for Post-Operative Pain Management in Opioid-Tolerant Patients
The main objective study is to compare the use of the cryoSPHERE probe to the standard-of-care method for pain management of patients receiving robotic-assisted thoracoscopic surgery, including reductions in opioid pain…
- Trial name
- NCT05276258
- Testing
- cryoSPHERE Ablation, Bupivacaine
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- The Methodist Hospital Research Institute
Pain
To Investigate the Impact of Analgesic Management Guided by qNOX Monitoring on the Comfort and Prognosis of Mechanically Ventilated ICU Patients
Purpose: To explore the effect of analgesic management under the guidance of qNOX monitoring on the comfort level and prognosis of patients with mechanical ventilation in ICU.
- Trial name
- NCT05912855
- Testing
- qNOX
- Volunteers
- 110 people
- Sponsor
- Tianjin Medical University General Hospital
Sickle Cell Disease
Evaluation of Different Dose Regimens of Aes-103 Given for 28 Days to Subjects With Stable Sickle Cell Disease
Sickle cell disease (SCD) is a genetic blood disorder characterized by the presence of sickle-shaped red blood cells. In the U.S. and the U.K. this occurs primarily in persons of African origin.
- Trial name
- NCT01987908
- Testing
- Aes-103
- Where
- United Kingdom
- Volunteers
- 35 people
- Sponsor
- Baxalta now part of Shire
Coronary Artery Disease, Chest Pain
Coronary Obstruction Detection by Molecular Personalized Gene Expression (Corus CAD or ASGES)
To validate the use of Corus CAD (Age/Sex/Gene Expression score - ASGES) blood assay in subjects who are referred for the work-up of coronary artery disease.
- Conditions
- Coronary Artery Disease, Chest Pain, Cardiovascular Diseases, Coronary Heart Disease
- Trial name
- COMPASS (NCT01117506)
- Testing
- Corus CAD (ASGES)
- Where
- 7 sites in United States
- Volunteers
- 581 people
- Sponsor
- CardioDx
Fever, Heart Rate
The Effect of Methods Used in Oral Antipyretic Administration on the Vital Findings of the Child With Fever
Fever, one of the most common clinical journeys of childhood, makes up a fraction of emergency room admissions. About us-30. High fever, which is one of the first schools in infancy and childhood, can cause health problems such…
- Conditions
- Fever, Heart Rate, Respiratory Rate, Pain
- Trial name
- NCT05366049
- Testing
- using a medicine pacifier to give acetaminophen
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Postoperative Pain
Analgesic Efficacy of an Opioid-free Postoperative Pain Management Strategy Versus a Conventional Opioid-based Strategy Following Video-assisted Thoracoscopic Lobectomy
Investigators have designed a randomized controlled trial. Utilizing an open-label, randomized, controlled study methodology, this trial aims to explore a opioid-free, safe, and effective analgesic approach for thoracic surgery.
- Trial name
- NCT06570538
- Testing
- Ropivacaine, Sufentanil
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Affiliated Cancer Hospital & Institute of Guangzhou Medical University
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