Clinical trials: Pain, Medication
Pain, Postoperative
Comparison of Analgesic Duration of Popliteal Block Versus Ankle Block in Patients Undergoing Forefoot Surgery
Pain after forefoot surgery can be important and regional anesthesia plays a crucial role in post-operative pain control. Several techniques can be used to achieve surgical anesthesia as well as postoperative analgesia.
- Trial name
- NCT03683342
- Testing
- Ankle Block, Sciatic nerve block
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Pain, Abuse, Drug
Analgesic and Subjective Effects of Terpenes
The purpose of this research is to assess the analgesic and subjective effects of terpenes administered alone and in combination of THC.
- Trial name
- NCT04451863
- Testing
- Low THC, High THC, Low Myrcene
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Thoracic Sympathectomy
Analgesic Effect of Erector Spinae Versus Serratus Anterior Plane Block for Thoracoscopic Sympathectomy
Thoracic incisions are painful and associated with chronic post-surgical pain and inadequate analgesia is associated with poorer postoperative outcomes.
- Trial name
- NCT04486014
- Testing
- Erector spinae plane block, Serratus anterior plane block
- Where
- Egypt
- Volunteers
- 110 people
- Sponsor
- Mansoura University
Pain Perception
The Effect of Combined Oral and Topical Analgesics to Reduce Pain Perception During Electrodiagnostic Testing
Electromyography (EMG) is a useful test for diagnosis and monitoring of lower motor neuron disorders. It is mostly done in conjunction with a Nerve Conduction Study (NCS).
- Trial name
- COMFORTEMG (NCT04337814)
- Testing
- EMLA Cream, Ibuprofen
- Where
- Pakistan
- Volunteers
- 113 people
- Sponsor
- Aga Khan University Hospital, Pakistan
Osteo Arthritis Knee
Evaluation of the Effect of Different Doses of Ozone Therapy on Pain and Function of Patients With Knee Osteoarthritis
This study is designed as a randomized clinical trial that will be conducted in Hazrat Rasool Akram Hospital in Tehran. Patients with knee osteoarthritis were selected based on the study entry criteria and written consent was…
- Trial name
- NCT06088706
- Testing
- Intra-articular injection of ozone
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Ahmad Nazari
Pre-emptive, Postoperative Pain
Ultrasound-Guided Mid-Point Transverse Process to Pleura Block for Thoracotomy Incisions
This study is designed to investigate the analgesic efficacy of pre-emptive ultrasound-guided midpoint transverse process to pleura (MTP) block for posterolateral thoracotomy in cardiothoracic surgeries.
- Conditions
- Pre-emptive, Postoperative Pain, Thoracotomy
- Trial name
- NCT05044858
- Testing
- Midpoint transverse process block group
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Tanta University
Primary Dysmenorrhea
Chinese Herbal Sachet Inhalation for Primary Dysmenorrhea in Female College Students
Primary dysmenorrhea (painful menstrual periods without an underlying disease) is very common in female college students and can affect sleep, mood, study and daily life.
- Trial name
- NCT07778849
- Testing
- Traditional Chinese herbal sachet (aromatic inhalation)
- Where
- China
- Volunteers
- 82 people
- Sponsor
- Macao Polytechnic University
Postoperative Pain, Breast Cancer
Analgesic Efficacy of Erector Spinae Plane Block After Breast Cancer Surgery
Erector spinae plane block(ESPB), which is firstly used for thoracic neuropathic pain, is newly developed and highly promising fascial plane block for providing postoperative analgesia for a great deal of surgeries including…
- Trial name
- NCT04512391
- Testing
- Ultrasound guided Erector Spinae Plane Block (ESPB)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- TC Erciyes University
Pain, Chronic Pain
Lidocaine 5% Medicated Plaster in Chronic Neuropathic Postoperative Pain
The purpose of this trial is to investigate the efficacy and safety of lidocaine 5% medicated plaster in localized chronic post-operative neuropathic pain in comparison to placebo plaster.
- Conditions
- Pain, Chronic Pain, Neuropathic Pain, Postoperative Pain
- Trial name
- NCT01155986
- Testing
- Lidocaine 5% medicated plaster
- Where
- 22 sites in France
- Volunteers
- 74 people
- Sponsor
- Grünenthal GmbH
Analgesic Adverse Reaction
Psoas Compartment Block (PCB) Versus L.A Infiltration and Remifentanil Infusion During EVAR
Endovascular aneurysm repair (EVAR) was introduced in 1990 for the first time as a minimally invasive procedure instead of the conventional open surgical repair, with the aim to decrease morbidity and mortality .
- Trial name
- NCT03443518
- Testing
- Psoas Compartment Block (PCB), Local Anesthesia infiltration, Normal saline 0.9% IV infusion
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 30 people
- Sponsor
- Dr. Erfan and Bagedo General Hospital
Post Operative Pain, Bradycardia
Postoperative Analgesic Effectiveness of Bupivacaine With and Without Dexmedetomidine in Patients With Abdominal Surgery
Abdominal surgeries are major surgical procedures that are performed at any teaching hospital. Pain control is major concern in the intra-operative as well as post-operative period in these patients.
- Conditions
- Post Operative Pain, Bradycardia, Hypotension, Nausea
- Trial name
- NCT06531603
- Testing
- bupivacaine wound infilteration, Bupivacaine plus dexmedetomidine wound infilteration
- Where
- Pakistan
- Volunteers
- 64 people
- Sponsor
- Sahiwal medical college sahiwal
Premature Birth, Newborn
Pain Management in Neonatal Intensive Care Units by Studying the Autonomic Balance
Fight against the pain caused by the disease or by the diagnostic and therapeutic procedures is a daily and essential concern for the caregiver neonatologist.
- Trial name
- NIPE-DOL (NCT02764424)
- Testing
- NIPE (MDoloris®)
- Where
- France
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Migraine, Migraine With Aura
Gepant treAtments: EffectIveNess and tolERability (GAINER)
The purpose of this prospective and multicentric study is to evaluate the effectiveness and tolerability of rimegepant as acute migraine treatment in a cohort of episodic or chronic migraine patients.
- Conditions
- Migraine, Migraine With Aura, Migraine Without Aura, Chronic Migraine
- Trial name
- GAINER (NCT05903027)
- Testing
- Rimegepant 75 MG Disintegrating Oral Tablet
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- University of Florence
Tonsillectomy, Adenotonsillectomy
Celecoxib for Pediatric Adenotonsillectomy
The investigators' study will involve the administration of either placebo or celecoxib to children aged 2 to 18 years of age undergoing tonsillectomy and assessing pain relief, impact on quality of life and side effect profile.
- Conditions
- Tonsillectomy, Adenotonsillectomy, Pain, Postoperative
- Trial name
- NCT00849966
- Testing
- Celebrex suspension
- Where
- Canada
- Volunteers
- 282 people
- Sponsor
- Children's Hospital of Eastern Ontario
Diabetic Neuropathic Pain
A Study Comparing the Efficacy and Safety of ABT-652 to Placebo in Subjects With Diabetic Neuropathic Pain
To evaluate the safety and efficacy of ABT-652 compared to Placebo in subjects with diabetic neuropathic pain. People with diabetes can, over time develop nerve damage throughout the body with symptoms such as pain, tingling, or…
- Trial name
- NCT01579279
- Testing
- ABT-652 6 mg, ABT-652 12 mg, ABT-652 12 mg - 18 mg
- Where
- 8 sites in United States
- Volunteers
- 1 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Periapical Abscess
Comparison of Two Combinations of Opioid and Non-opioid Analgesics for Acute Periradicular Abscess
Aim: The aim of this study was to compare the analgesic efficacy of two combinations of opioid and non-opioid analgesics for acute periradicular abscesses.
- Trial name
- NCT02750696
- Testing
- Fixed-dose oral tablet of codeine/ acetaminophen every 4 hours for 3 days, Fixed-dose oral tablet of tramadol/ acetaminophen every 4 hours for 3 days
- Volunteers
- 27 people
- Sponsor
- Federal University of Rio Grande do Sul
Herpes Zoster, Postherpetic Neuralgia
Acupuncture in Herpes Zoster Neuralgia (ACUZoster)
Symptoms that herald herpes zoster include pruritus, dysesthesia and pain along the distribution of the involved dermatome. The most distressing symptom is typically pain and the most feared complication is postherpetic neuralgia…
- Conditions
- Herpes Zoster, Postherpetic Neuralgia, Pain
- Trial name
- ACUZoster (NCT00885586)
- Testing
- gabapentine, Acupuncture
- Where
- Germany
- Volunteers
- 68 people
- Sponsor
- Dominik Irnich
Pain
Efficacy and Pharmacokinetic-Pharmacodynamic Relationship of Intranasally Administered Sufentanil, Ketamine, and CT001
A randomised, double-blind, parallel-group, study comparing the analgesic effect of intranasal CT001 to intranasal sufentanil, intranasal ketamine or placebo for treatment of acute pain in adults undergoing surgical removal of an…
- Trial name
- NCT05508594
- Testing
- CT001, Sufentanil, Ketamine
- Where
- Denmark
- Volunteers
- 220 people
- Sponsor
- Cessatech A/S
Opioid Use Disorder
Naltrexone for Use in Conjunction With Buprenorphine in Adults With Opioid Use Disorder Prior to First Dose of VIVITROL® (Naltrexone for Extended-Release Injectable Suspension)
This study will evaluate the safety, effectiveness and tolerance of low doses of oral naltrexone along with buprenorphine to treat opioid use disorder prior to the first injection of VIVITROL.
- Trial name
- NCT02537574
- Testing
- NTX/BUP, NTX/PBO-B, PBO-N/PBO-B
- Where
- 20 sites in United States
- Volunteers
- 380 people
- Sponsor
- Alkermes, Inc.
Pain, Postoperative
Randomized Study Comparing the Use of Epidural Analgesia to Intravenous Narcotics for Laparoscopic Colorectal Resection.
Laparoscopic colorectal surgery (LCS) has gained wide acceptance in the treatment of various pathology from diverticular disease to colon cancer.
- Trial name
- NCT02086123
- Testing
- Epidural Analgesia, Parenteral Analgesia (Intravenous)
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- University of California, Irvine
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