Clinical trials: Pain, Medication
Knee Surgery
Comparison of Analgesic Efficacy and Impact on Motor Function in Knee Replacement Surgery: 0.1% Naropeine Tri-block Versus 0.5% Naropeine iPACK Saphenous Block - A Prospective Randomised Trial
Over the last two decades, perioperative analgesia has evolved. Spinal and epidural anaesthesia, once common, have been gradually phased out due to their side effects.
- Trial name
- ProBlocs (NCT07578688)
- Testing
- Tri-bloc, iPACK saphène
- Where
- France
- Volunteers
- 120 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Analgesic Drugs, Antinociceptive Agents
Analgesic Effects of Midazolam in Human Volunteers
This study evaluates analgesic properties of midazolam compared to placebo and fentanyl. Each participant will receive all three drugs (midazolam, fentanyl, placebo) on three different occasions (study visits) and the effect on…
- Trial name
- GabA01 (NCT02629146)
- Testing
- Midazolam, Fentanyl, Isotonic saline
- Where
- Austria
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Wilhelminenspital Vienna
Pain
A Study Evaluating the Impact of a Painkiller Product on Quality-of-Life and Daily Functioning
The aim of this study is to generate real-world, consumer reported evidence on the perceived impact of headache relief with Panadol/Dolex on Quality of Life (QoL) and daily functioning.
- Trial name
- NCT07909590
- Testing
- Paracetamol
- Where
- Singapore
- Volunteers
- 2,100 people
- Sponsor
- HALEON
Mechanical Ventilation, Pediatric Acute Respiratory Failure
Optimizing Pain Treatment in Children On Mechanical Ventilation
In this clinical trial, investigators want to learn more about using non-opioid pain medications for children with acute respiratory failure.
- Conditions
- Mechanical Ventilation, Pediatric Acute Respiratory Failure, Analgesics, Opioid, Sedation and Analgesia
- Trial name
- OPTICOM (NCT06994442)
- Testing
- Acetaminophen, Ketorolac
- Where
- 16 sites in United States
- Volunteers
- 644 people
- Sponsor
- Weill Medical College of Cornell University
Pain
Bioavailability of Oxymorphone Hydrochloride 40 mg Extended Release Tablets Under Fed Conditions
The purpose of this study is to demonstrate the relative bioequivalence of oxymorphone hydrochloride extended release tablets (Sandoz) with Opana extended release oxymorphone hydrochloride tablets.
- Trial name
- NCT00857142
- Testing
- oxymorphone hydrochloride, Opana
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Sandoz
Chronic Apical Periodontitis
Adjunctive Oral Probiotics in Endodontic Retreatment: Effects on Postoperative Pain and RANKL/OPG Levels
This study aimed to evaluate the effect of oral administration of probiotics as an adjunctive treatment to local intracanal medicaments, namely propolis and calcium hydroxide or empty canal, on the levels of receptor activator of…
- Trial name
- RANKL/OPG (NCT07683520)
- Testing
- Linex Adult®, Ca(OH)2 as intracanal medicament, propolis intracanal medication
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Ain Shams University
Fibromyalgia, Pregabalin
The Efficacy and Safety of Pregabalin Combined With Desvenlafaxine in Patients With Fibromyalgia
Fibromyalgia (FM) is a chronic pain syndrome characterized by widespread pain, fatigue, and emotional disorders. Its onset is related to factors such as central sensitization and imbalance of neurotransmitters.
- Conditions
- Fibromyalgia, Pregabalin, Pain
- Trial name
- NCT07171320
- Testing
- Pregabalin, Pregabalin with desvenlafaxine
- Where
- China
- Volunteers
- 384 people
- Sponsor
- Beijing Tiantan Hospital
Coronary Disease, Intracranial Embolism
A Registry Study of Shuxuening Injection Used in Hospitals in China
The purpose of this study is get to know what and how Shuxuening injection in hospital results in adverse events or adverse drug reactions from a cohort event monitoring.
- Conditions
- Coronary Disease, Intracranial Embolism, Stroke, Angina Pectoris
- Trial name
- RSCMI-VII (NCT01752946)
- Volunteers
- 30,000 people
- Sponsor
- China Academy of Chinese Medical Sciences
Angina Pectoris
Neurostimulation to Treat Refractory Angina Pectoris Pain
The therapy under investigation involves an implanted Medtronic neurostimulation system to relieve symptoms of angina pectoris pain.
- Trial name
- STARTSTIM (NCT00200070)
- Testing
- Spinal Cord Stimulation
- Where
- 8 sites in United States, Canada
- Volunteers
- 228 people
- Sponsor
- MedtronicNeuro
Peripheral Nerve Block, Cholecystectomy, Laparoscopic
External Oblique Plane Block and Subcostal Tap Block for Laparoscopic Cholecystectomy
The study aims to compare the efficacy of the external oblique plane block and the subcostal plane block in providing pain relief during perioperative anaesthetic management.
- Conditions
- Peripheral Nerve Block, Cholecystectomy, Laparoscopic, Pain After Surgery
- Trial name
- NCT07061262
- Testing
- External Oblique Intercostal Plane Block, Subcostal TAP block and spinal anesthesia group (STAP)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Haseki Training and Research Hospital
Dysmenorrhea Primary, Pain, Menstrual
Extracorporeal Shock Wave Therapy in the Treatment of Primary Dysmenorrhea
Primary dysmenorrhea (PD) is a common female disease during menstruating. Although nonsteroidal anti-inflammatory drug is an effective treatment, there are concerns about side effects.
- Trial name
- NCT03121170
- Testing
- extracorporeal shock wave therapy, hot compress paste
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Ruirui Xing
Pain, Acute, Pain, Procedural
Pain Modality Treatment After Hemorrhoidectomy
Hemorrhoidectomy is one of the operations that causes the greatest intensity of pain. Treatment of postoperative pain is essential for the well-being of the patient.
- Trial name
- NCT04953182
- Testing
- Pain scale registry
- Volunteers
- 5,335 people
- Sponsor
- Assuta Medical Center
Pain
Study to Assess the Kinetic of the Analgesic Effect and Tolerability of Eschscholtzia Californica Versus Ibuprofen and Placebo in the Treatment of Pain After Surgery of the Third Molar
Study to determine the kinetic of the analgesic effect of 500 mg and 1000 mg of Eschscholtzia Californica per os and placebo in patients undergoing dental surgery over an observation period of 6 hours.
- Trial name
- NCT02187588
- Testing
- Eschscholtzia Californica - low dose, Eschscholtzia Californica - high dose, Ibuprofen
- Volunteers
- 200 people
- Sponsor
- Boehringer Ingelheim
Inguinal Hernia, Postoperative Pain
Safety, Tolerability, PK, and Analgesic Effect of INL-001 in Children Following Open Inguinal Hernia Repair
A multicenter, single-dose study in children 12 to <17 years of age, 6 to <12 years of age, and 2 to <6 years of age who are scheduled for elective open inguinal hernia repair.
- Trial name
- NCT03262688
- Testing
- Bupivacaine HCl collagen-matrix implant, Bupivacaine HCl infiltration
- Where
- 11 sites in United States
- Volunteers
- 159 people
- Sponsor
- Innocoll
Acute Pain
ANI Versus Standard Care in Surgical Patients Receiving Balanced Sevoflurane-Fentanyl Anesthesia
This study aims to be a randomized, controlled study of ANI-guided opioid administration versus standard clinical practice in surgical patients undergoing general anesthesia with balanced sevoflurane-fentanyl.
- Trial name
- NCT03684590
- Testing
- ANI-guided opioid administration, Standard opioid administration
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Temporomandibular Disorder
Evaluation of the Efficacy of Different Drugs in the Treatment of the Pain in Patients With Temporomandibular Disorder
The most important step in the treatment of TMJ (temporomandibular joint) disease in clinical dentistry is diagnosis and planning.
- Trial name
- NCT05529290
- Testing
- Dexketoprofen Trometamol + Thiocolchicoside, Dexketoprofen Trometamol + Paracetamol, Dexketoprofen Trometamol (25mg)
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Leprosy
Auricular Electroacupuncture and Auricular Acupuncture With Health Education for Pain in Leprosy
This randomized controlled pilot study evaluated the effects of auricular electroacupuncture and auricular acupuncture combined with health education on pain management in adults diagnosed with leprosy or who had completed…
- Trial name
- NCT07862413
- Testing
- Auricular Electroacupuncture, Auricular Acupuncture, Health Education
- Where
- Brazil
- Volunteers
- 16 people
- Sponsor
- Universidade Federal de Pernambuco
Laparoscopic Cholecystectomy
Dexamethasone-Enhanced TAP Block in Lapchole
The transversus abdominis plane (TAP) block is widely used as part of analgesia for abdominal surgeries such as laparoscopic cholecystectomy. While bupivacaine is commonly used for TAP blocks with reported success.
- Trial name
- NCT07182110
- Testing
- Dexamethasone enhanced TAP Block, Marcaine- 0.25%
- Where
- Lebanon
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Makassed General Hospital
Pain, Postoperative
Perioperative Pain Management for Lumbar Spine Surgery
Perioperative pain management is crucial for patients undergoing elective lumbar spine surgery. Moderate to severe postoperative pain can significantly impact recovery, worsen patient outcomes, and potentially lead to chronic…
- Trial name
- NCT06662318
- Testing
- Fentanyl Citrate, Dexmedetomidine, Lidocaine Hydrochloride
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Benha University
Postpartum Disorder
Efficacy of Ginger Extract (Compare Between the Ginger Preparation of Ancient Concept of Thai Traditional Practitioner, Standard Drug and Placebo) by Using Pain Score to Evaluate After Pain of Three Groups of First Normal Postpartum Women.
Introduction A common problem in women after childbirth is bleeding (5-8 percent). This is one of the leading causes of maternal death in Thailand.
- Trial name
- NCT03617900
- Testing
- Ginger, Paracetamol
- Where
- Thailand
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Thammasat University
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