Clinical trials: Pain, Medication
Pain, Postoperative
Analgesic Efficacy of Interscalene Nerve Block Versus Local Infiltration Analgesia Following Total Shoulder Arthroplasty
Total shoulder arthroplasty (TSA) is considered to be a major surgical procedure resulting in severe postoperative pain, especially in the first 48 hours after surgery.
- Trial name
- NCT02876055
- Testing
- Single shot interscalene nerve block, Continuous interscalene nerve block, Local Infiltration Analgesia (LIA)
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Hysterectomy, Myomectomy
Effect of Perioperative iv Dexmedetomidine vs. Lidocaine on Postoperative Pain, Analgesic Consumption and Recovery After Abdominal Gynaecological Surgery
Postoperative pain continues to be inadequately managed and is the most common reason for the delay in discharge and unplanned hospital admission after surgery. Opioids remain the mainstay for postoperative analgesia.
- Trial name
- NCT03363425
- Testing
- Lidocaine Iv, Dexmedetomidine, Normal saline
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Athens
Empathy
Mental Effects of Analgesic Drugs: Paracetamol and Ibuprofen
The objective of the present study is to study paracetamol effects on social pain and empathy under standardized international conditions (ICH-GCP) for planning, conduction and reporting of clinical pharmaceutical studies in…
- Trial name
- MEAD (NCT04424420)
- Testing
- Paracetamol, Ibuprofen
- Where
- Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Prof. Jürgen Brockmöller
Foot and Ankle Procedures
Efficacy of Popliteal Nerve Blocks With and Without Dexamethasone on the Duration of Analgesia for Foot & Ankle Surgery
The purpose of this research study to evaluate the effects of dexamethasone as an addition to peripheral nerve block (Put the nerve to sleep with Bupivacaine a numbing medication) on length of pain relief (analgesia)…
- Trial name
- NCT01975285
- Testing
- Dexamethasone, Saline
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Cedars-Sinai Medical Center
Analgesia Disorder
Study of PHN131 in Patients After Surgery
The purpose of this study is to assess the effectiveness, safety and pharmacokinetics of Oral Nalbuphine in the treatment of postoperative pain following hemorrhoidectomy.
- Trial name
- NCT02193620
- Testing
- PHN131 soft capsule with Nalbuphine HCl 60 mg/cap, Diclofenac
- Where
- Taiwan
- Volunteers
- 106 people
- Sponsor
- PhytoHealth Corporation
Safety and Efficacy, Scalp Nerve Block
Safety and Analgesic Efficacy of a Modified Auriculotemporal Nerve Block
1. Efficacy of a modified auriculotemporal nerve blockade for patients undergoing supratentorial craniotomy 2. Safety of a modified auriculotemporal nerve blockade for patients undergoing supratentorial craniotomy
- Trial name
- NCT05556889
- Testing
- a modified auriculotemporal nerve blockade, Traditional auriculotemporal nerve blockade
- Where
- China
- Volunteers
- 252 people
- Sponsor
- Tongji Hospital
Laparoscopic Cholecystectomy
Intraperitoneal Analgesia After Laparoscopic Cholecystectomy
Although laparoscopic cholecystectomy is associated with less pain than contemporary open procedures; it is definitely not pain free and the magnitude of postoperative shoulder and abdominal pain in the early postoperative period…
- Trial name
- NCT00950625
- Testing
- lignocaine, bupevacaine
- Where
- Pakistan
- Volunteers
- 200 people
- Sponsor
- Aga Khan University
Arthroplasty, Replacement, Hip
Multimodal Analgesic Regimen for Total Hip Arthroplasty: An Initiative to Minimize Postoperative Opioid Use
This study examines whether patients undergoing total hip replacement surgery can manage their pain effectively while using fewer opioid pain medications. Participants will be randomly assigned to one of two groups.
- Trial name
- NCT07672808
- Testing
- Standard Multimodal Analgesic Regimen with Opioid Prescription, Opioid-Reduced Multimodal Analgesic Regimen with Printed Prescription
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Henry Ford Health System
Pain
A Study to Evaluate the Pharmacokinetic Drug-drug Interactions Between VX-548, Midazolam, and Digoxin
The purpose of this study is to evaluate the pharmacokinetics of midazolam and digoxin in the absence and presence of VX-548.
- Trial name
- NCT05541471
- Testing
- VX-548, Midazolam, Digoxin
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Vertex Pharmaceuticals Incorporated
Analgesia
The Analgesic Effect of Auditory Inputs and Its Relation to Psychological and Neurobiological Mechanisms
The study investigates the analgesic effect of different auditory inputs. Employing a within-subject design, the study includes healthy participants that are exposed to thermal stimuli while listening to three different auditory…
- Trial name
- NCT03410563
- Testing
- Auditory inputs
- Where
- Denmark
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Sickle Cell Disease
Prevalence of Problematic Use of Equimolar Mixture of Oxygen and Nitrous Oxide and Analgesics in the Sickle-cell Disease
The use of analgesics can lead to cases of drug abuse and dependence. It can also cause pseudo-addiction in patients suffering from pain.
- Trial name
- PHEDRE (NCT02580565)
- Testing
- telephone interview
- Where
- France
- Volunteers
- 1,004 people
- Sponsor
- Nantes University Hospital
Pain, Postoperative
Postoperative Analgesic Efficacy of Adjuvant Quadratus Lumborum Block in Open Inguinal Hernia Surgery
Evaluation of Postoperative Analgesic Efficacy of Adjuvant Use in Quadratus Lumborum Blocks
- Trial name
- NCT06664164
- Testing
- ANTERİOR QUADRATUS LUMBORUM BLOCK, ANTERİOR QUADRATUS LUMBORUM BLOCK WİTH ADJUVANT
- Where
- Turkey (Türkiye)
- Volunteers
- 67 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Pain, Postoperative, Analgesia
Ultrasound-Guided Bilateral Transversalis Fascia Plane Block With vs Without Dexamethasone for Cesarean Delivery
Cesarean delivery is one of the most frequently performed surgical procedures worldwide, and effective postoperative pain management is essential to facilitate early mobilization, maternal-infant bonding, breastfeeding, and…
- Trial name
- NCT07736989
- Where
- Turkey (Türkiye)
- Volunteers
- 93 people
- Sponsor
- Bahçeşehir University
Neonatal Abstinence Syndrome
Non-Opiate Treatment After Prenatal Opiate Exposure to Prevent Postnatal Injury to the Young Brain
The long term goals of our research are to establish the best pharmacological treatment for NAS and determine how pharmacologic treatment of NAS affects long-term developmental outcomes.
- Trial name
- No-POPPY (NCT03396588)
- Testing
- Clonidine, Morphine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Henrietta Bada
Rheumatoid Arthritis, Sickness Behavior
7 Tesla MRI Brain Imaging to Decipher Filgotinib's Mode of Analgesic Action in Rheumatoid Arthritis
This is an experimental medicine, single-centre, observational test-retest study to evaluate Filgotinib's mechanism of analgesic action in RA patients.
- Conditions
- Rheumatoid Arthritis, Sickness Behavior, Inflammatory Disease, Autoimmune
- Trial name
- TEMPO (NCT05697159)
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- NHS Greater Glasgow and Clyde
Hip or Knee Replacement
'M'-Technique, Guided Imagery, or Standard of Care on Anxiety and Pain Pre- & Post-operatively in Elective Joint Replacement Patients
In the M-TIJRP protocol the investigators will utilize two Integrative Medicine modalities in a randomized, controlled study using either the 'M'-Technique® developed by Jane Buckle, PhD or Diane L.
- Trial name
- M•TIJRP (NCT01874379)
- Testing
- 'M'-Technique®, Guided Imagery, Standard of Care
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- Saint Clare's Health System
Acute Pain, Hyperalgesia
IV Acetaminophen as an Adjunct Analgesic in Cardiac Surgery
Patients undergoing cardiac surgery experience significant postoperative pain, which may impact postoperative outcomes. The aim of this single center, double-blind, randomized, placebo controlled trial is to determine if…
- Trial name
- CarDolMev (NCT01544062)
- Testing
- IV acetaminophen
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of Washington
Muscle Soreness
A Study to Evaluate the Analgesic Properties of Topically Applied Menthol in Marathon Participants
The purpose of the research study is to better understand the factors that impact pain experience in adult (18+ years) marathon runners participating in the 2026 Chicago Marathon and to better understand if topically applied…
- Trial name
- NCT07873242
- Testing
- Observational, Non-Interventional Study
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Reckitt Benckiser Healthcare (UK) Limited
Endodontic Disease
Postoperative Pain and Incidence of Extrusion Following the Use of Two Intra-canal Medications in Retreatment of Single Rooted Teeth
This study aims to compare the postoperative pain and incidence of extrusion of two intracanal medications in the retreatment of single-rooted teeth.
- Trial name
- NCT06913673
- Testing
- Bio-c Temp, Metapex
- Volunteers
- 30 people
- Sponsor
- Minia University
ST Elevation Myocardial Infarction, Non ST Segment Elevation Acute Coronary Syndrome
ANalgesic Efficacy and Safety of MOrphiNe Versus Methoxyflurane in Patients With Acute Myocardial Infarction
The purpose of this study is to evaluate analgesic efficacy of inhaled methoxyflurane vs intravenous morphine in patients presenting with acute ST-elevation (STEMI) / non ST-elevation acute coronary syndrome (NSTE-ACS)
- Trial name
- ANEMON (NCT04476173)
- Testing
- Methoxyflurane - Penthrox, Morphine
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Collegium Medicum w Bydgoszczy