Clinical trials: Pain, Medication
Limb Deformity
Analgesic Efficacy of Two Doses of Dexmedetomidine as Adjuncts to Lidocaine for Intravenous Regional Anesthesia
Intravenous Regional Anesthesia (IVRA) was first used by August Bier in 1908. This technique is easy to administer, reliable and cost-effective for short surgical procedures of the extremities performed on an ambulatory basis…
- Trial name
- NCT03399474
- Testing
- Lidocaine Hydrochloride 2%, Dexmedetomidine 0.5 ug/kg, Dexmedetomidine Injection 0.25 ug/kg
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Chronic Pain
A Study Evaluating the Drug-Drug Interaction Between KL0011034 Injection and Alfentanil Hydrochloride Injection
To evaluate the pharmacokinetic interaction of KL0011034 injection in combination with alfentanil hydrochloride injection.To evaluate the safety and tolerability of KL0011034 injection in combination with alfentanil hydrochloride…
- Trial name
- NCT07710560
- Testing
- KL0011034 injection, Alfentanil Hydrochloride Injection
- Where
- China
- Volunteers
- 27 people
- Sponsor
- Hunan Kelun Pharmaceutical Co., Ltd.
Osteoarthritis: Shoulder
Local Intraoperative Analgesic Injection Versus Single Injection Interscalene Nerve Block in Patients Undergoing TSA
A non-blinded randomized controlled trial, in which participants undergoing primary reverse or total shoulder arthroplasty are randomly assigned to one of two treatment groups.
- Trial name
- NCT02695758
- Testing
- Interscalene brachial plexus block, bupivacaine extended-release liposome injection
- Volunteers
- 156 people
- Sponsor
- Rothman Institute Orthopaedics
Osteoarthritis, Rheumatoid Arthritis
Safety Study of HZT-501 in Patients Who Require Long-Term Daily Non-steroidal Anti-inflammatory Drug Treatment
The purpose of this study is to evaluate the safety of long-term treatment with HZT-501, a fixed-dose combination oral tablet of 800 mg ibuprofen and 26.6 mg famotidine for patients that require long-term NSAID treatment.
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Chronic Low Back Pain, Chronic Regional Pain Syndrome
- Trial name
- NCT00984815
- Testing
- HZT-501
- Where
- 4 sites in United States
- Volunteers
- 86 people
- Sponsor
- Amgen
Pain, Analgesics
Mentholated Cream Containing Oxygenated Glycerol Triesters on Acute Pain of the Muscles and Joints
A single center trial to evaluate the efficacy, tolerance, and acceptability of Oxygenated Glycerol Triesters (OGT) mentholated cream on acute musculoskeletal pain in normal healthy adult volunteers suffering from a recent…
- Trial name
- NCT01387750
- Testing
- Mentholated Cream, Mentholated Cream with OGT
- Volunteers
- 71 people
- Sponsor
- NEMA Research, Inc.
Chronic Non-specific Neck Pain
Efficacy and Safety of Acupuncture Combined With Chinese Herbal Fumigation for Chronic Non-Specific Neck Pain
Chronic non-specific neck pain is a common musculoskeletal disorder that significantly affects quality of life and functional ability.
- Trial name
- NCT07515690
- Testing
- Acupuncture, Wenyang Tongluo Fumigation Formula
- Where
- Malaysia
- Volunteers
- 120 people
- Sponsor
- Universiti Tunku Abdul Rahman
Analgesia, Children, Only
The Use of Midazolam as Adjuvant to Bupivacaine Intrathecal Anesthesia for Children Undergoing Lower Abdominal Surgeries.
The study will be carried on children undergoing lower abdominal surgeries. Patients will be randomly categorized into two study groups.
- Conditions
- Analgesia, Children, Only, Bupivacaine, Midazolam
- Trial name
- NCT04718259
- Testing
- intrathecal bupivacaine, midazolam
- Where
- Saudi Arabia
- Volunteers
- 120 people
- Sponsor
- Tanta University
Low Back Pain
A Trial Comparing Three Orthobiologic Therapies on Atrophied Multifidus Muscles in Patients With Low Back Pain
To evaluate and compare the effectiveness of 3 different injection treatments on multifidus atrophy and lower back pain.
- Trial name
- NCT03618979
- Testing
- PPP treatment, PRP treatment, PRP and PL Combo treatment
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Regenexx, LLC
Chronic Neck Pain
Analgesic Current Therapies for Chronic Neck Pain
Does the use of analgesic current therapies increase the effectiveness of neck stabilization exercises for improving pain, disability, mood, and quality of life in chronic neck pain? a randomized, controlled, single-blind study
- Trial name
- NCT03121859
- Testing
- Neck stabilization exercise, TENS, IFC
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people
- Sponsor
- Hilal Yeşil
Osteopathic Manipulative Treatment
By Potentially Adding a Century Old Therapeutic Measure to Pain Treatment Regimens Called Osteopathic Manipulative Treatment, Can Help Decrease Muscle and Bone Pain and the Usage of Opioid Pain Medication.
Osteopathic Manipulative Treatment (OMT) has been used to successfully treat patients for over a hundred years. Even though there have been many subjective clinical results, there is still little research measuring the actual…
- Trial name
- NCT06930196
- Testing
- Counterstrain, Muscle Energy, High Velocity Low Amplitude
- Where
- United States
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- Skagit Regional Health
Chronic Pain
Reduced Opioid Analgesic Requirements Via Improved Endogenous Opioid Function
Chronic Pain (CP) management has increasingly utilized long-term opioid analgesic therapy, a change associated with increased opioid abuse (via greater exposure in vulnerable individuals), non-pain health consequences (hormone…
- Trial name
- NCT02469077
- Testing
- 6 week aerobic exercise intervention, Morphine, naloxone
- Where
- 2 sites in United States
- Volunteers
- 117 people
- Sponsor
- Vanderbilt University Medical Center
Pain, Beta-endorphin
Double-blind, Randomized Controlled Study to Assess the Analgesic Effect of 2 g of Magnesium Dipyrone (Metamizol) and Changes in Plasma Beta-endorphin Immunoreactivity Values in Patients Undergoing Elective Inguinal Herniorrhaphy Under Epidural Anesthesia.
A double-blind, randomized controlled study is designed to assess the analgesic effect of a single intravenous dose of 2 g of magnesium dipyrone (metamizol) and whether the administration of the active drug will be associated…
- Conditions
- Pain, Beta-endorphin, Dipyrone, Hernia Surgery
- Trial name
- NCT04595877
- Testing
- Dipyrone administration, Pain assessment, beta-endorphin immunoreactivity
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Antonio Martín Duce
Caesarean Section, Postoperative Analgesia
Analgesic Effects of Intrathecal Morphine and Transversalis Plane Block After Cesarean Delivery
A comparison of postoperative pain levels, patient satisfaction, and side effects is planned between patients who received morphine during spinal anesthesia for cesarean section and patients who did not receive morphine but…
- Trial name
- NCT07490795
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 117 people
- Sponsor
- Vezirköprü State Hospital
Pain, Hyperalgesia
Analgesic Effect of Oxytocin Receptor Modulation
Carbetocin is a synthetic analogue of the hormone Oxytocin and is routinely used in obstetric anesthesiology to control uterine bleeding after cesarean section.
- Conditions
- Pain, Hyperalgesia, Central Sensitization
- Trial name
- NCT01918475
- Testing
- Carbetocin
- Where
- Switzerland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Acute Low Back Pain
A Pharmacodynamic/Pharmacokinetic Study to Determine the Onset of Analgesic Effect and Plasma Levels of Tramadol in Patients With Acute Low Back Pain Receiving a Single 200 mg Dose of Tramadol Contramid® Once-a-Day
The primary objective of this study is to determine the time of onset of analgesic effect of Tramadol Contramid® Once-A-Day (OAD) in acute low back pain.
- Trial name
- NCT00952068
- Testing
- Tramadol Contramid® OAD 200mg
- Volunteers
- 47 people
- Sponsor
- Labopharm Inc.
Inguinal or Ovarian Hernia, Hydrocele
Transversus Abdominis Plane Block in Pediatrics: Volume or Concentration ?
The transversus abdominis plane (TAP) block provide a local anesthesia drug diffusion between the transverse abdominis muscle and the internal oblique muscle.
- Conditions
- Inguinal or Ovarian Hernia, Hydrocele, Cord Kyst, Local Analgesia Block
- Trial name
- TAP Bloc (NCT02064088)
- Testing
- Injection of 0,2 ml/kg of 0,2% levobupivacaine for small volume group, Injection of 0,4 ml/kg of 0,1% lévobupivacaine for high volume group
- Where
- France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Montpellier
Anxiety, Postoperative Pain
Evaluation of the Postoperative Agitation Prevention and Analgesic Efficacy of Perioperative Dexmedetomidine Infusion in a Pediatric Patient Group to Undergo Dental Treatment
Dexmedetomidine is a drug known for its pain-relieving and restlessness-reducing effects. The purpose of this run is to use the association between this use during surgery and the attrition of post-operative pain and discomfort.
- Conditions
- Anxiety, Postoperative Pain, Nausea
- Trial name
- NCT06097169
- Testing
- Fentanyl, Dexmedetomidine
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Medipol University
Liver Cancer
The Effect of Analgesic Modalities on Long Term Outcomes Following Open Liver Resection
The LIVER (Local Infiltration Versus Epidural after Liver Resection) and LIVER 2 (Local Infiltration Versus Epidural after Liver Resection 2) studies were randomised controlled trials that compared epidural analgesia with local…
- Trial name
- LIVER 3 (NCT03813953)
- Testing
- Liver resection
- Where
- United Kingdom
- Volunteers
- 160 people
- Sponsor
- University of Edinburgh
Pain, Postoperative, Osteoarthritis, Knee
Analgesic Efficacy of Pre-operative Dose of Ketorolac and Gabapentin
Evaluation of the analgesic efficacy of a pre-operative dose of ketorolac and gabapentin in reducing post-operative pain scores in patients undergoing TKA
- Trial name
- NCT07047040
- Testing
- Ketorolac Tromethamine 30 MG/ML Prefilled Syringe, Gabapentin, Empty Medication Capsules
- Where
- Egypt
- Volunteers
- 86 people
- Sponsor
- Assiut University
Hip Surgeries
Quadratus Lumborum Block by Paraspinous Sagittal Shift Approach With Different Concentrations Of Bupivacaine in Hip Surgeries
The aim of this study is to evaluate the optimum concentration of bupivacaine in Paraspinous Sagittal Shift Approach for Quadratus Lumborum Block in hip Surgeries
- Trial name
- NCT04628689
- Testing
- quadratus lumborum block by paraspinous sagittal shift approach
- Where
- Egypt
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
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