Clinical trials: Pain, Medication
Pain, Analgesics, Opioid
A Study of OROS Hydromorphone HCL vs Morphine in Cancer Pain Patients.
The purpose of this study was to demonstrate the clinical equivalence of hydromorphone and morphine (immediate-release [IR] and sustained-release [SR] formulations) using the "worst pain in the past 24 hours" item of the Brief…
- Trial name
- NCT00410540
- Testing
- OROS hydromorphone HCL ; Morphine sulfate
- Volunteers
- 202 people
- Sponsor
- Alza Corporation, DE, USA
Coronary Disease, Heart Diseases
Safety and Clinical Performance of the Freesolve Resorbable Magnesium Scaffold (RMS) System in Subjects With Coronary Artery Lesions
The objective of this study is to assess the safety and efficacy of the Freesolve resorbable magnesium scaffold (RMS) in the treatment of subjects with up to two de novo lesions in native coronary arteries compared to the Xience…
- Conditions
- Coronary Disease, Heart Diseases, Cardiovascular Diseases, Arteriosclerosis
- Trial name
- BIOMAG-III (NCT07258290)
- Testing
- Freesolve RMS, Xience DES
- Where
- 3 sites in United States, Latvia
- Volunteers
- 1,859 people
- Sponsor
- Teleflex
Opioid-induced Constipation
Risk of Major Adverse Cardiovascular Events for Naldemedine & Other Medications for Opioid Induced Constipation
The research objective is to characterize the risk of a major adverse cardiovascular event (MACE) among new users of naldemedine versus new users of lubiprostone and new users of naloxegol as comparator opioid induced…
- Trial name
- NCT03720613
- Testing
- Naldemedine, Lubiprostone, Naloxegol
- Where
- United States
- Volunteers
- 34,532 people
- Sponsor
- BioDelivery Sciences International
Pain, Postoperative
Addition of Muscle Relaxants in a Multimodal Analgesic Regimen for Analgesia After Primary Total Knee Arthroplasty
This is a prospective, cluster-randomized, two-arm, comparative study aimed at determining whether addition of tizanidine ( an oral muscle relaxant) to a multimodal pain regimen following primary TKA reduces opioid consumption.
- Trial name
- NCT04574791
- Testing
- TiZANidine 2 MG Oral Capsule
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Pain, Abuse, Drug
Cannabis Effects as a Function of Sex
The purpose of this research is to assess the impact of cannabis on the analgesic and abuse-related effects between men and women
- Trial name
- CanSex (NCT04385082)
- Testing
- Active Cannabis
- Where
- United States
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Pain, Postoperative
Rhomboid Intercostal Block Compared With Thoracic Paravertebral Block in Breast Cancer Surgeries
Postoperative pain is a significant problem following breast surgery . If not treated in time, it may lead to delayed wound healing, respiratory depression, hemodynamic disorders, anxiety,other complications, and finally lead to…
- Trial name
- NCT06781346
- Testing
- Rhomboid Intercostal Block, Thoracic Paravertebral Block
- Where
- Egypt
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Fayoum University Hospital
Pain, Postoperative
Randomized Study Comparing the Use of Epidural Analgesia to Intravenous Narcotics for Laparoscopic Colorectal Resection.
Laparoscopic colorectal surgery (LCS) has gained wide acceptance in the treatment of various pathology from diverticular disease to colon cancer.
- Trial name
- NCT02086123
- Testing
- Epidural Analgesia, Parenteral Analgesia (Intravenous)
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- University of California, Irvine
Fibromyalgia, Hyperbaric Oxygen
Hyperbaric Oxygen Compared to Pharmaceutical Therapies for Fibromyalgia Syndrome
The investigators have previously studied the efficacy of hyperbaric oxygen therapy (HBOT) as a treatment for Fibromyalgia syndrome (FMS) in a prospective, active control, crossover clinical trial.
- Trial name
- FMSRCT (NCT03325959)
- Testing
- Hyperbaric oxygen therapy (HBOT) treatment, Cymbalta / Lyrica treatment, Crossover Hyperbaric oxygen therapy
- Where
- Israel
- Volunteers
- 76 people
- Sponsor
- Assaf-Harofeh Medical Center
Postoperative Analgesia, Laparoscopic Hysterectomy
Preemptive Analgesia in Laparoscopic Hysterectomy
The aim of this study is to evaluate the effects of ibuprofen and paracetamol administered for pre-emptive analgesia to patients undergoing laparoscopic hysterectomy on pain scores during the first 24 hours postoperatively, the…
- Trial name
- NCT07401927
- Testing
- Ibuprofen, Parasetamol
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Giresun University
Chronic Pain
A Study to Evaluate the Drug-Drug Interaction Between KL0011034 Injection and Alfentanil Hydrochloride Injection in Participants With Moderate-to-Severe Non-Cancer Chronic Pain
This study will evaluate the drug-drug interaction between KL0011034 Injection and Alfentanil Hydrochloride Injection in participants with moderate-to-severe non-cancer chronic pain. The study consists of two parts.
- Trial name
- NCT07751094
- Testing
- KL0011034 injection, Alfentanil Hydrochloride Injection
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- The Third Xiangya Hospital of Central South University
Arthroplasty, Knee Replacement, Pain Control
Self Medication With Oral Morphine After Total Knee Arthroplasty.
The study aims to compare two post operative pain management strategy's, traditional nurse dispensed pain control versus patient self medication.
- Trial name
- NCT01226186
- Testing
- Nurse dispensed oral morphine., Patient self medication of oral morphine.
- Where
- United Kingdom
- Volunteers
- 144 people
- Sponsor
- The Royal Bournemouth Hospital
Inguinal Herniorrhaphy, Pain, Postoperative
Post-Operative Analgesic Effects of Local Wound Infiltration With Ketorolac After Inguinal Herniorrhaphy
Inguinal hernia is one of the most common diseases worldwide, including Thailand. Patients who underwent treatment of inguinal hernia (herniorrhaphy) found surgical site pain.There are many procedures to relieve pain after…
- Trial name
- NCT03534505
- Testing
- Ketorolac group, Bupivacaine group
- Where
- Thailand
- Volunteers
- 10 people
- Sponsor
- Mahidol University
Postoperative Pain
Bilateral Erector Spinae Plane Block After Elective Cesarean Section
The aim of work is to assess and compare the analgesic efficacy of bilateral erector spinae plane block with that of bilateral transversus abdominis plane block after elective cesarean section.
- Trial name
- NCT04016688
- Testing
- ESPB and TAP block
- Where
- 3 sites in Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Postoperative Pain, Dental Implant
Laser Photobiomodulation After Dental Implant Surgery: A Comparison of 650 nm and 810 nm Diode Lasers
The goal of this clinical trial is to evaluate the effectiveness of laser light therapy, known as photobiomodulation (PBM), in reducing pain after dental implant surgery.
- Trial name
- NCT06988722
- Testing
- 650 nm Diode Laser PBM, 810 nm Diode Laser PBM
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- National Institute of Laser Enhanced Sciences
Gastric Cancer
Comparison of the Analgesic Effect Between Intrathecal Morphine and IV-fentanyl Patient Controlled Analgesia (ITM-IVPCA) and Epidural PCA (PCEA) in Patients Undergoing Gastrectomy -Randomized Allocation Study-
The present study was designed to assess analgesic capacity of intrathecal administration of morphine combined with intravenous fentanyl patient-controlled analgesia (ITM-PCA) compared to patient controlled epidural analgesia…
- Trial name
- NCT01234272
- Testing
- morphine, Ropivacaine
- Where
- South Korea
- Volunteers
- 59 people
- Sponsor
- Yonsei University
Nonspecific Pain Post Traumatic Injury
MAST Trial: Multi-modal Analgesic Strategies in Trauma
This is a comparative effectiveness study of current pain management strategies in acutely injured trauma patients. Two different multi-modal, opioid minimizing analgesic strategies will be compared [original multimodal pain…
- Trial name
- MAST (NCT03472469)
- Testing
- Acetaminophen IV/PO, Acetaminophen PO, Ketorolac
- Where
- United States
- Volunteers
- 1,561 people
- Sponsor
- The University of Texas Health Science Center, Houston
Neuralgia, Neuropathic Peripheral Pain
Efficacy of Valproate in Peripheral Neuropathic Pain
The purpose of this study is to determine whether valproate is effective and well tolerated in the treatment of neuropathic peripheral pain. The drug is administered by intravenous route followed by oral route during 4 weeks.
- Trial name
- NCT00221637
- Testing
- Sodium Valproate
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Bordeaux
Fibromyalgia Syndrome
Osteopathic Medicine in Fibromyalgia Syndrome
The purpose of this study is to evaluate the analgesic effects of a 6 weeks osteopathic treatment on patients with fibromyalgia.
- Trial name
- FIBROPATHIC (NCT02343237)
- Testing
- Osteopathic treatment, Factitious osteopathic treatment
- Where
- France
- Volunteers
- 101 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Postoperative Pain
Serratus Intercostal Plane Block Versus Port Infiltration in Laparoscopic Cholecystectomy
Most patients undergoing laparoscopic cholecystectomy (LC) experience moderate to severe pain in the first 24 hours after surgery.
- Trial name
- NCT07193472
- Testing
- serratus intercostal plane block as analgesic technique
- Where
- Spain
- Volunteers
- 128 people
- Sponsor
- Hospital del Rio Hortega
Percutaneous Electrolysis, Pain
Analgesic Mechanisms of Percutaneous Electrolysis
Percutaneous electrolysis is based on the application of a galvanic current through an acupuncture needle. The underlying mechanisms that explain the efficacy of this technique are not completely well understood.
- Conditions
- Percutaneous Electrolysis, Pain, Analgesia, Pain Modulation
- Trial name
- NCT05097937
- Testing
- Low intensity percutaneous electrolysis, High intensity percutaneous electrolysis
- Where
- Spain
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
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