Clinical trials: Pain, Medication
Hip Surgery, Postoperative Analgesia
Postoperative Analgesic Efficacy of PENG and QLB Blocks in Hip Surgeries
This prospective, randomized, single-blinded study compares the postoperative analgesic efficacy of the Pericapsular Nerve Group (PENG) block and Quadratus Lumborum Block (QLB) in hip surgeries under spinal anesthesia.
- Trial name
- PENG vs QLB (NCT06653894)
- Testing
- PENG block with 0.25% bupivacaine., anterior quadratus lumborum block
- Where
- Turkey (Türkiye)
- Volunteers
- 73 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Diabetic Neuropathy, Painful
A Study in Painful Diabetic Neuropathy
This study will investigate the efficacy of a combination treatment of duloxetine + pregabalin compared with the maximal dose of each drug in monotherapy, in patients with diabetic peripheral neuropathic pain (DPNP) who have not…
- Trial name
- COMBO-DN (NCT01089556)
- Testing
- Duloxetine, Pregabalin
- Where
- 54 sites in Australia, Canada and 14 more
- Volunteers
- 811 people
- Sponsor
- Eli Lilly and Company
Coronary Artery Disease, Stable Angina
Study Comparing Ticagrelor With Aspirin for Prevention of Vascular Events in Patients Undergoing CABG
The primary objective of this study ist to test the hypothesis that ticagrelor is superior to Aspirin (ASA) fort he prevention of major cardio- and cerebrovascular events (MACCE) in patients undergoing artery bypass operation.
- Conditions
- Coronary Artery Disease, Stable Angina, Acute Coronary Syndrome
- Trial name
- TiCAB (NCT01755520)
- Testing
- Ticagrelor, Aspirin
- Where
- 29 sites in Austria, Germany and 1 more
- Volunteers
- 1,893 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Chronic Pain
Central Analgesic Drugs for the Treatment of Chronic Pain
Chronic pain is defined as pain that persists after healing of the wound that caused it, and can occur even in the absence of any obvious pathological trigger.
- Trial name
- NCT02223442
- Volunteers
- 300 people
- Sponsor
- University of Parma
Pain, Postoperative, Postoperative Pain
Intraperitoneal Aerosolized Delivery of a Local Anesthetic for Post Operative Pain Management. A Double Blind, Randomised Controlled Clinical Trial.
The purpose of this study is to determine the effectiveness of aerosolized pain medication (.5% bupivicaine) delivered into the peritoneal cavity after laparoscopic gastric bypass surgery.
- Conditions
- Pain, Postoperative, Postoperative Pain, Abdominal Pain, Obesity
- Trial name
- NCT00286286
- Testing
- Intraperitoneal Aerosolization System, IntraMyst
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Northgate Technologies
Postoperative Pain, Acute
Dexamedatomidine vs. Dexamethasone in Rhomboidal Intercostal Plain Block and Subserratus Block in Breast Surgery
The aim of this study is to evaluate the analgesic efficacy and safety of adding dexmedetomidine and dexamethasone to bupivacaine in rhomboidal intercostal and subserratus (RISS) block for patients undergoing modified radical…
- Trial name
- NCT05385523
- Testing
- Rhomboid Intercostal and Sub-Serratus block technique (RISS), General Anaesthesia, dexamedatomidine
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Armed Forces College of Medicine, Cairo, Egypt
Coronary Artery Disease, Myocardial Ischemia
Safety and Efficacy Study of the Amaranth Medical APTITUDE Bioresorbable Drug-Eluting Coronary Stent
The purpose of this study is to evaluate the safety and performance of a new version of a coronary artery stent for treating blockages in the arteries supplying blood to the heart muscle.
- Trial name
- RENASCENT II (NCT02568462)
- Testing
- AmM APTITUDE Bioresorbable Drug-Eluting Coronary Scaffold
- Where
- 12 sites in Colombia, Italy
- Volunteers
- 60 people
- Sponsor
- Amaranth Medical Inc.
Pancreatic Cancer Pain, Intrathecal Analgesic
Evaluating the Effectiveness of AIT in the Treatment of Pain Related to Pancreatic Cancer
The aim of this clinical trial is to assess the effectiveness of intratracheal analgesia on pain intensity in cancer patients, from the start of treatment up to 3 months. It will also investigate the safety of this technique.
- Conditions
- Pancreatic Cancer Pain, Intrathecal Analgesic, Intrathecal Administration of the Drug, Pancreatic Carcinoma
- Trial name
- PIT (NCT07733427)
- Testing
- Intrathecal catheter connected to an implantable pump, Administration of medication, including analgesics, via an intrathecal catheter connected to an implantable pump or via periodic injections
- Where
- 3 sites in France
- Volunteers
- 40 people
- Sponsor
- Clinique Bizet
HIV Infections, Peripheral Nervous System Diseases
Study of NGX-4010 for Treatment of Painful HIV-Associated Neuropathy
The purpose of the study is to determine if an investigational drug, NGX-4010 (high-concentration capsaicin patch), is safe, tolerable and effective in treating painful HIV-associated neuropathy.
- Conditions
- HIV Infections, Peripheral Nervous System Diseases, Pain
- Trial name
- NCT00085761
- Testing
- Capsaicin Dermal Patch
- Where
- 2 sites in United States
- Sponsor
- NeurogesX
Osteoarthritis
A Study of Etoricoxib in Participants With Osteoarthritis Not Responding to Analgesic Drugs (MK-0663-142)
This two-part study will evaluate the effectiveness of etoricoxib in controlling pain in participants with osteoarthritis who are experiencing inadequate response to their current treatments.
- Trial name
- RESPOND-EUROPE (NCT01429168)
- Testing
- Etoricoxib
- Sponsor
- Organon and Co
Coronary Heart Disease, Angina Pectoris
Safety Study of Kudiezi (a Chinese Medicine Injection) Used in Hospitals in China
This study was advocated by Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences in October 2011.
- Trial name
- RSCMI-Ⅱ (NCT01612559)
- Volunteers
- 30,000 people
- Sponsor
- China Academy of Chinese Medical Sciences
ESPB With Dexmetomidine May Provide Analgesia
Analgesic Efficacy of Adding Different Doses of Dexmedetomidine as Adjuvants With Bupivacaine vs.Bupivacaine Only in Ultrasound-guided Erector Spinae Plane Block in Morbidly Obese Patients Undergoing Laparoscopic Bariatric Surgery. A Randomized Controlled Double Blinded Study.
Analgesic Efficacy of adding different doses of dexmedetomidine as adjuvants with bupivacaine vs. bupivacaine only in ultrasound-guided erector spinae plane block in morbidly obese patients undergoing Laparoscopic Bariatric…
- Trial name
- NCT07380503
- Testing
- Analgesic Efficacy of adding different doses of dexmedetomidine
- Where
- Egypt
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pain, Postoperative
Analgesic Efficacy, Safety and Tolerability of Two Paracetamol-containing Solutions in Post-Surgical Dental Pain
The aim of the study is to evaluate the therapeutic efficacy and safety of two different paracetamol-containing solutions in postoperative dental pain.
- Trial name
- NCT00406679
- Testing
- Paracetamol (acetaminophen) solution experimental, paracetamol (acetaminophen) solution commercial
- Where
- 2 sites in United Kingdom
- Volunteers
- 135 people
- Sponsor
- Baxter Healthcare Corporation
Pain
Investigation of Analgesic and Anti-hyperalgesic Effect of Opioids in Experimental Pain
To compare the analgesic and anti-hyperalgesic effect of Buprenorphine and Fentanyl against experimental pain in skin, muscle and bone. The study will be performed with healthy volunteers.
- Trial name
- NCT00647127
- Testing
- Buprenorphine, Fentanyl
- Where
- Denmark
- Volunteers
- 22 people
- Sponsor
- University of Aarhus
Musculoskeletal Pain
Analgesic Effect of a Biophotonic Foot Massage Cream
This study aims to evaluate the effectiveness of a biophotonic cosmetic massage cream in reducing musculoskeletal foot pain in adults.
- Trial name
- No acronym (NCT07501273)
- Testing
- Biophotonic cosmetic massage cream
- Volunteers
- 170 people
- Sponsor
- University of Seville
Chronic Rhinosinusitis with Nasal Polyps, Aspirin-exacerbated Respiratory Disease
Effect of Celecoxib on Postoperative Analgesia and Disease Severity in AERD Patients with CRS
This is a proposed randomized prospective study to evaluate both the anti-inflammatory and analgesic effects of a COX-2 inhibitor, celecoxib, in patients with aspirin-exacerbated respiratory disease and Chronic rhinosinusitis…
- Trial name
- NCT04147013
- Testing
- Celecoxib
- Where
- 2 sites in Canada, Saudi Arabia
- Volunteers
- 44 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Opioid Use and Disposal
Impacting the Disposal of Unused Opioid
The purpose of this study is to compare the rates of proper opioid disposal in patients receiving an educational brochure compared to an automated text message delivered directly to patients' cell phones alongside the brochure…
- Trial name
- NCT04044105
- Testing
- Pamphlet education, Pamphlet education + texts
- Where
- United States
- Volunteers
- 563 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Fibromyalgia
Analgesic Effect of Music Listening During Pain Elicitation in Fibromyalgia
Patients with fibromyalgia (FM) are more sensitive to things that cause pain. Music lowers self-reported pain in patients with chronic pain.
- Trial name
- FMMusic (NCT04059042)
- Testing
- Music Listening
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Kansas Medical Center
Pediatric Anxiety
Non-Wearable Audiovisual Distraction for Children's Medical Anxiety in the ED
Pediatric emergency department (ED) visits often cause significant anxiety and stress for young patients due to unfamiliar environments and invasive medical procedures.
- Trial name
- NCT07761637
- Testing
- Non-Wearable Audiovisual Distraction, Routine ED Care
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- National Taiwan University Hospital
Acute Pain, İnjection
Comparison of the Efficacy of Shotblocker and Acupressure in Reducing Pain Due to Intramuscular Injection
Various non-pharmacological approaches are used in the relief of pain caused by intramuscular injection. Shotblocher and acupressure, which are among these methods, are easy to apply.More evidence-based studies are needed to…
- Conditions
- Acute Pain, İnjection, Acupressure, Alternative Medicine
- Trial name
- NCT05456945
- Testing
- acupressure application, Shotblocher
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ataturk University
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