Clinical trials: Pain, Medication
Pain
Nicotine Patch as an Analgesic Adjuvant After Surgery
Effect of nicotine patch as an adjutant for acute pain after surgery.
- Trial name
- NCT00440830
- Testing
- nicotine patch
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Columbia University
Cleft Palate
Efficacy of Oral Versus Intravenous Acetaminophen for Primary Pediatric Cleft Palate Repair
The purpose of this investigator-initiated study is to determine whether acetaminophen is an effective pain reliever for primary cleft palate repair in children and possesses opioid sparing effects.
- Trial name
- NCT01500109
- Testing
- Oral acetaminophen, Ofirmev®, Opioid only
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Loma Linda University
Acute Postoperative Pain, Chest Wall Surgery
Prospective Feasibility, Analgesic Effectiveness, and Safety Study of a Visual Analog Scale-Guided Multimodal Pain Algorithm After Posterior Rib Remodeling With Osteosynthesis
This prospective single-group study will evaluate a visual analog scale-guided multimodal analgesia algorithm during the first five days after posterior rib remodeling with osteosynthesis.
- Trial name
- NCT07805928
- Testing
- VAS-Guided Multimodal Analgesia Algorithm, Ultrasound-Guided Thoracic Wall Regional Block
- Where
- Colombia
- Volunteers
- 160 people
- Sponsor
- Research Inc
Coronary Artery Diseases
BIOFLOW III Satellite-Italy Orsiro Stent System
Clinical evaluation of the Orsiro LESS in subjects requiring coronary revascularization with Drug Eluting Stents (DES). 500 subjects will be enrolled in this registry.
- Trial name
- NCT02028728
- Where
- 18 sites in Italy
- Volunteers
- 609 people
- Sponsor
- Biotronik Italia S.p.A.
Critical Illness, Pain
Treatment of Procedural Pain Associated With Turning in Patients With Mechanical Ventilation
Background: Few studies have addressed the situation of procedural pain and the use of preemptive analgesia for turning in patients under mechanical ventilation.
- Trial name
- NCT01950000
- Testing
- Fentanyl
- Where
- Spain
- Volunteers
- 75 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Breast Cancer
Role of Preoperative Tapentadol in Reduction of Perioperative Analgesic Requirement After Breast Conservative Surgery in Cancer Patients.
This study evaluated the preemptive analgesic efficacy of Tapentadol in reducing peri operative analgesic requirements among patients undergoing breast cancer surgery.
- Trial name
- NCT07320781
- Testing
- Tapentadol
- Where
- Pakistan
- Volunteers
- 70 people
- Sponsor
- Shaukat Khanum Memorial Cancer Hospital & Research Centre
Acute Coronary Syndrome, Stable Chronic Angina
Angiographic Control Vs. Ischemia-driven Management of Patients Treated with PCI on Left Main with Drug-eluting Stents
The present study aims to compare a planned angiographic control (PAC) follow-up strategy vs. conservative management for patients treated with drug-eluting stents on unprotected left main artery in a prospective, randomized…
- Conditions
- Acute Coronary Syndrome, Stable Chronic Angina, Coronary Artery Disease, Left Main Coronary Artery Disease
- Trial name
- PULSE (NCT04144881)
- Testing
- coronary computed tomography
- Where
- 3 sites in Italy
- Volunteers
- 606 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Low Back Pain
Linking Altered Central Pain Processing and Genetic Polymorphism to Drug Efficacy in Chronic Low Back Pain (Predictio)
Drug therapy in patients with chronic low back pain is a major challenge for physicians. One of the problems is the lacking knowledge in prediction of drug efficacy in a chosen patient.
- Trial name
- Predictio (NCT01179828)
- Testing
- Oxycodone 15mg, Clobazam, Imipramine
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Headache
Facilitating Migraine Medication Adherence and Optimizing Medication Use
The present research will pilot-test a new state-of-the-art Internet-based intervention targeting adherence facilitation and optimization of medication use, and will be evaluated to assess its utility in facilitating adherence…
- Trial name
- NCT02473692
- Testing
- Online Migraine Treatment Optimization
- Sponsor
- Wake Forest University Health Sciences
Pain
Bioavailability of Oxymorphone Hydrochloride 40 mg Extended Release Tablets Under Fasted Conditions
The purpose of this study is to demonstrate the relative bioequivalence of oxymorphone hydrochloride extended-release tablets (Sandoz) with Opana extended release oxymorphone hydrochloride tablets.
- Trial name
- NCT00857428
- Testing
- oxymorphone
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sandoz
Pain After Surgery
RISS Versus Lower Thoracic ESP Block for Analgesia After Laparoscopic Abdominal Surgery: A Randomized Trial
The goal of this clinical trial is to investigate the analgesic efficacy of ultrasound-guided Romboid Intercostal and Subserratus (RISS) block versus lower thoracic Erector Spinae Plane (ESP) block after laparoscopic abdominal…
- Trial name
- NCT07593300
- Testing
- Group A (n=35): Ultrasound-guided RISS block (RISS):, Group B (n=35): Ultrasound-guided lower thoracic ESP block
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Misr University for Science and Technology
Pain
Implementing Genomics in Practice (IGNITE) Proof of Concept Study: Genotyping in Family Medicine Clinics
This study will examine the effect of having genotype information on pain management and pain control for patients treated in family medicine clinics.
- Trial name
- IGNITE (NCT02335307)
- Testing
- CYP2D6 genotyping, Pain assessment questionnaire, Physician assessment
- Where
- 11 sites in United States
- Volunteers
- 505 people
- Sponsor
- University of Florida
Pain, Postoperative
PECS I Block for Breast Subpectoral Implant Surgery
Breast augmentation surgery can cause important postoperative pain, especially when bilateral subpectoral implants are used. The investigators hypothesized that a technique of regional analgesia, the pectoral nerve block type I…
- Trial name
- NCT02849236
- Testing
- Ropivacaine (PECS bloc)
- Where
- France
- Volunteers
- 56 people
- Sponsor
- University Hospital, Lille
Cerebral Palsy, Postoperative Pain
Combined Popliteal and Adductor Canal Blocks for Postoperative Analgesia in Children With Cerebral Palsy
This prospective, randomized, controlled trial aims to evaluate the postoperative analgesic efficacy of combined ultrasound-guided popliteal sciatic nerve block and adductor canal block in children with cerebral palsy undergoing…
- Trial name
- NCT07801365
- Testing
- Adductor Canal Block + Popliteal Sciatic Nerve Block Group, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Chronic Headache, Analgesic Rebound Headache
Propofol Injection for Daily Headache
Hypothesis A single subanesthetic dose of propofol will result in improved pain and quality of life for the next 30 days in persons with chronic daily headache (CDH) Specific objectives To measure the effect of a single infusion…
- Conditions
- Chronic Headache, Analgesic Rebound Headache, Chronic Daily Headache, Headache, Intractable
- Trial name
- NCT00228267
- Testing
- Propofol
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- University of Alberta
Adverse Effects
The Pharmacokinetics of 4% Lidocaine Gel When Applied Topically to the Breasts
The purpose of this study is to test the hypothesis that one-time application of 4% lidocaine gel (TOPICAINE) on the skin of the breasts and chest wall as recommended for pre-medication to reduce discomfort during screening…
- Trial name
- NCT00925353
- Testing
- 4% lidocaine gel
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Mountain States Tumor and Medical Research Institute
Opioid Abuse (Disorder), Opioid Analgesia
Reducing Opioid Use After Upper Extremity Surgery: Testing Lower Prescriptions and Pill Quantity
The goal of this clinical trial is to evaluate strategies for optimizing postoperative multimodal pain regimens and reducing opioid dependency in patients undergoing upper extremity surgery.
- Conditions
- Opioid Abuse (Disorder), Opioid Analgesia, Opioid Analgesic Adverse Reaction, Opioid Consumption
- Trial name
- NCT07750639
- Testing
- Naproxen, Acetaminophen, oxycodone
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- AdventHealth
Post-Operative Pain, Third Molar Extraction
Efficacy and Safety of Intranasal Morphine for Pain After Third Molar Extraction
This study involves approximately 200 patients designed to evaluate the efficacy and safety of intranasal (IN) morphine 7.5 mg and 15 mg, intravenous morphine (IV) 7.5 mg, immediate release oral (PO) morphine 60 mg or placebo in…
- Trial name
- NCT00390312
- Testing
- Intranasal Morphine 15 mg, Immediate Release Oral Morphine 60 mg, Intravenous morphine
- Volunteers
- 225 people
- Sponsor
- Javelin Pharmaceuticals
Postoperative Pain
Posterior Quadratus Lumborum Block Using 0.125% Versus 0.25% Bupivacaine for Analgesia in Children Undergoing LPEC
The aim of the present study is to evaluate and compare the analgesic efficiency of the difference concentration between 0.125% and 0.25% bupivacaine provided by ultrasound guided posterior quadratus lumborum block undergoing…
- Trial name
- NCT04998071
- Testing
- Bupivacaine hydrochloride
- Where
- Thailand
- Volunteers
- 50 people
- Sponsor
- Queen Sirikit National Institute of Child Health
Low Back Pain, Pregnancy
Osteopathic Manipulative Medicine in Pregnancy: Physiologic and Clinical Effects
The purpose of this study is to determine to what extent and by what physiological mechanisms Osteopathic Manipulative Medicine (OMM) affects selected conditions related to pregnancy, labor and delivery.
- Trial name
- NCT00426244
- Testing
- Osteopathic Manipulative Treatment
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of North Texas Health Science Center
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