Clinical trials: Pain, Medication
Osteoarthritis, Knee, Healthy
Generate a Pharmacodynamic Model of Oxytocin for Peripheral Analgesic Effects
This is a study of participants that will receive an intravenous (IV) infusion of oxytocin (naturally occurring hormone that is made in the brain).
- Trial name
- NCT04431206
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Endometriosis-related Pain, Endometriosis
Enriched Environments in Endometriosis
The investigators propose to conduct a randomized behavioral trial that will produce a clinically useful multi-level integrative medicine model to be used in stress- and inflammation-related disorders that can easily be…
- Conditions
- Endometriosis-related Pain, Endometriosis, Pelvic Pain, Quality of Life
- Trial name
- NCT04179149
- Testing
- Environmental enrichment
- Where
- Puerto Rico
- Volunteers
- 56 people
- Sponsor
- Ponce Medical School Foundation, Inc.
Post Operative Pain
Post-Operative Analgesic Efficacy Of Ultrasound Guided Pericapsular Nerve Group Block Versus Combined Suprascapular And Axillary (Circumflex) Nerve Block For Patients Undergoing Shoulder Arthroscopy
Recently, the Combined suprascapular nerve block and axillary nerve block (SSNB+ANB) was proposed to provide anesthesia and postoperative analgesia for shoulder surgery as a safe alternative to interscalene block.
- Trial name
- NCT05791058
- Testing
- ultrasound guided pericapsular nerve group shoulder block, ultrasound guided suprascapular and axillary nerve block, general anesthesia without nerve block
- Volunteers
- 75 people
- Sponsor
- Ain Shams University
Osteoarthritis, Hip, Osteoarthritis, Knee
A Study Evaluating Pain Relief and Safety of Orally Administered CR845 in Patients With Osteoarthritis of Hip or Knee
The study schedule consists of a Screening Period (up to 14 days), a blinded 4- week Titration-to-Effect Period with weekly visits, a blinded 4-week Maintenance Treatment Period at the optimal dose level determined for each…
- Conditions
- Osteoarthritis, Hip, Osteoarthritis, Knee, Arthritis, Joint Diseases
- Trial name
- NCT02944448
- Testing
- CR845 tablet 1 mg, CR845 tablet 2.5 mg, CR845 tablet 5 mg
- Where
- 35 sites in United States
- Volunteers
- 761 people
- Sponsor
- Cara Therapeutics, Inc.
Pain, Postoperative
Methadone for Postoperative Pain
The aim of this study is to compare the efficacy of methadone versus morphine in dealing with postoperative pain, in laparoscopic cholecystectomy under total intravenous anesthesia (TIVA); Efficacy is defined in terms of the…
- Trial name
- NCT01833715
- Testing
- Morphine, Methadone, TIVA
- Where
- Chile
- Volunteers
- 86 people
- Sponsor
- Universidad de Valparaiso
Osteoporosis
Analgesic Effects of the Gastrolith, in Osteoporotic Patients Suffering From Recent Skeletal Pain Caused by Vertebral Fractures
This study aims to evaluate the safety and analgesic effect (efficacy) of Gastrolith powder (GASP) on skeletal pain caused by osteoporotic vertebral compression fractures (OVCF) versus placebo, primarily as assessed by the…
- Trial name
- NCT01482858
- Testing
- Gastrolith
- Where
- 5 sites in Israel
- Sponsor
- Amorphical Ltd.
Spine Surgery, Postoperative Pain Management
Intraoperative Placement of Vancomycin-impregnated Calcium Sulfate Beads Conjugated With Analgesics to Improve Spine Surgery Outcomes
The goal of this clinical trial is to learn if using calcium sulfate beads that contain vancomycin (an antibiotic) and pain-relieving medicines during spine surgery can improve recovery compared to standard care with intravenous…
- Trial name
- NCT07201987
- Testing
- Vancomycin (local, via calcium sulfate beads), Morphine (local, via calcium sulfate beads), Bupivacaine (local, via calcium sulfate beads)
- Volunteers
- 100 people
- Sponsor
- Ganesh M. Shankar
Chronic Pain, Addiction Opiate
Cross-cultural Validation of a Screening Scale for the Misuse of Opioid Analgesics in Primary Care
Objective: Analgesic Opioids misuse among patients with chronic pain ranges from 0% to 50%. The general practitioner is the first prescriber of opioid analgesics Our objective was to validate in primary care the POMI…
- Trial name
- VAMOS (NCT05431985)
- Where
- 5 sites in France
- Volunteers
- 160 people
- Sponsor
- University Hospital, Clermont-Ferrand
Bone Pain Flare, Bone Metastasis
Non Steroidal Anti-inflammatory Drugs in the Prevention of Bone Pain Flares After Palliative Radiotherapy
Solid tumors have the tendency to spread to other organs in around 26% of cases, with many cases involving the bone causing severe bone destruction and pain that reduces patients' quality of life.
- Trial name
- NCT06903585
- Testing
- Naproxen (Proxen S), Esomeprazole 20mg once daily
- Where
- Lebanon
- Volunteers
- 385 people
- Sponsor
- American University of Beirut Medical Center
Shoulder Injury
Ropivacaine Block Alone or With Perineural or Systemic Dexamethasone for Pain in Shoulder Surgery
Pre-operative perineural injection of dexamethasone mixed with local anesthetic in peripheral nerve blockade for orthopedic surgery has been shown to prolong the length of analgesia, improve visual analog pain scores, decrease…
- Trial name
- NCT01450007
- Testing
- Ropivacaine, Dexamethasone, Normal saline
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Mayo Clinic
Patient Compliance, Medication Adherence
Impact of Information Prescriptions on Medication Adherence in Emergency Department (ED) Patients
The main objectives of this research are: 1. To identify factors that influence medication adherence rates in Emergency Department (ED) patients. 2.
- Conditions
- Patient Compliance, Medication Adherence, Medication Non-Adherence
- Trial name
- NCT01174706
- Testing
- Information prescriptions
- Where
- 3 sites in United States
- Volunteers
- 3,940 people
- Sponsor
- Johns Hopkins University
Chronic Pain
Accuracy of Point of Care (POC) or In-office Urine Drug Testing (Immunoassay) in Chronic Pain Patients
Accuracy of Point of Care (POC) or In-office Urine Drug Testing (Immunoassay) in Chronic Pain Patients: A Prospective Analysis of Immunoassay and Liquid Chromatography Tandem Mass Spectometry (LC/MS/MS)
- Trial name
- NCT01052155
- Testing
- Urine Drug Testing
- Volunteers
- 1,000 people
- Sponsor
- Pain Management Center of Paducah
Umbilical Hernia, Postoperative Pain Management
Ultrasound-Guided Transversus Abdominis Plane Block Versus Epidural Block for Umbilical Hernia Analgesia
This observational study aims to compare the postoperative analgesic effectiveness of ultrasound-guided transversus abdominis plane (TAP) block and single-dose epidural anesthesia in patients undergoing umbilical hernia surgery.
- Trial name
- NCT07327463
- Testing
- Ultrasound-Guided Transversus Abdominis Plane Block, Single-Dose Epidural Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Sakarya University
Pain, Postoperative
A Randomized Control Trial Comparing Analgesic Benefits of Ultrasound-guided Single vs Continuous Quadratus Lumborum Blocks (QLB)vs Intrathecal Morphine(ITM) for Post Cesarean Section Pain
the purpose of this study is to compare opioid consumption in morphine equivalents between the groups that received postoperative analgesia with intrathecal morphine versus US guided QL blocks versus US guided QL catheters
- Trial name
- NCT04368364
- Testing
- Intrathecal morphine sulfate (ITM), Bupivacaine hydrochloride, ropivacaine hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Persistent Spinal Pain Syndrome Type 2, Spinal Cord Stimulation
Pain Medication Tapering for Patients With Persistent Spinal Pain Syndrome Type 2, Treated With Spinal Cord Stimulation.
The primary objective of the study is to examine whether there is a difference in disability after 12 months of Spinal Cord Stimulation (SCS) in patients with Persistent Spinal Pain Syndrome Type 2 (PSPS T2) after receiving a…
- Trial name
- PIANISSIMO (NCT05861609)
- Testing
- Usual care, Standardized pain medication tapering, Personalized pain medication tapering
- Where
- 3 sites in Belgium
- Volunteers
- 195 people
- Sponsor
- Moens Maarten
Pain Threshold, Conscious Sedation
Correlation Between Pain Threshold and Analgesic Consumption in Transvaginal Oocyte Aspiration Patients
Nowadays, in vitro fertilization (IVF) is an important component of modern infertility treatment. One of the critical stages of the IVF process is oocyte (egg) retrieval, which requires both anesthesia and analgesia; this…
- Conditions
- Pain Threshold, Conscious Sedation, Oocyte Retrieval
- Trial name
- NCT07262216
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Burcu ayvazoğlu
Endometriosis, Endometriosis-related Pain
Metabolomic Profile in Women With and Without Endometriosis
The pathogenesis of endometriosis is very complex as several factors, including genetic, environmental and lifestyle-related factors, are involved in the development, progression and maintenance of the disease.
- Conditions
- Endometriosis, Endometriosis-related Pain, Infertility
- Trial name
- METABOLENDO (NCT05496218)
- Testing
- Blood samples
- Where
- Italy
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Pain, Postoperative
Phase II Clinical Trial to Evaluate the Efficacy and Safety of LPM3480392 Injection for Moderate to Severe Pain After Abdominal Surgery
A randomized, double-blind, placebo/positive drug parallel controlled design was used to evaluate the preliminary efficacy and safety of intravenous infusion of LPM3480392 injection using different dosing regimens in subjects…
- Trial name
- NCT06204120
- Testing
- LPM3480392 Injection, morphine hydrochloride injection
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Luye Pharma Group Ltd.
Depressive Disorder, Treatment-Resistant, Stress Disorders, Post-Traumatic
Ketamine Infusions for PTSD and Treatment-Resistant Depression
The relationship between depression and trauma is well established. Co-occuring depression and post-traumatic stress disorder (PTSD) are associated with more severe symptoms and lower levels of functioning.
- Trial name
- NCT02577250
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Post Operative Pain
Comparison of Analgesic Efficacy of Suprainguinal Fascia Iliaca and Quadro-iliac Blocks in Hip Fracture Surgery
This prospective, randomized, double-masked trial compared two ultrasound-guided regional analgesic techniques, suprainguinal fascia iliaca block (SIFI) and quadro-iliac plane block (QIPB), in adults undergoing surgery for hip…
- Trial name
- NCT07546903
- Testing
- Suprainguinal Fascia Iliaca Block, Quadro-Iliac Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 85 people
- Sponsor
- Hitit University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.