Clinical trials: Pain, Medication
Femoral Neck Fractures, Intertrochanteric Fractures
Opioid-Free Pain Treatment in Trauma Patients
Analgesic drug study that will compare pain outcomes of opioid analgesia and opioid-free analgesia in post-operative orthopedic patients.
- Conditions
- Femoral Neck Fractures, Intertrochanteric Fractures, Femoral Shaft Fracture, Distal Femur Fracture
- Trial name
- NCT06078371
- Testing
- Opioid-free pain treatment
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Kansas Medical Center
Chronic Pain, Intractable Pain
Transitioning to a Valve -Gated Intrathecal Drug Delivery System (IDDS)
Flowonix Prometra® II Programmable Pump may require a smaller dose of drug when converting from other commercially available intrathecal drug delivery systems (IDDS).
- Conditions
- Chronic Pain, Intractable Pain, Back Pain
- Trial name
- TRANSIT (NCT03876158)
- Testing
- Prometra II Programmable Pump system(Flowonix Medical)
- Where
- United States
- Sponsor
- Rush University Medical Center
Foot and Ankle Procedures
Efficacy of Popliteal Nerve Blocks With and Without Dexamethasone on the Duration of Analgesia for Foot & Ankle Surgery
The purpose of this research study to evaluate the effects of dexamethasone as an addition to peripheral nerve block (Put the nerve to sleep with Bupivacaine a numbing medication) on length of pain relief (analgesia)…
- Trial name
- NCT01975285
- Testing
- Dexamethasone, Saline
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Cedars-Sinai Medical Center
Colo-rectal Cancer
Does Omission of NSAIDs After Colorectal Cancer Operation Affect the Consumption of Opioids?
Patients undergoing an operation for colorectal cancer are normally treated with non-steroid-anti-inflammatory-drugs (NSAIDs) e.g. ibuprofen as pain medication after the operation.
- Trial name
- NCT04448652
- Testing
- NSAID
- Where
- Denmark
- Volunteers
- 502 people
- Sponsor
- Zealand University Hospital
Stable Angina, Unstable Angina
Clinical Performance of CRE8 Drug Eluting Stent in All Comer Population
The aim of this study is to evaluate safety and efficacy performances of CRE8 Drug Eluting Stent, in patients comparable to the everyday's clinical practice population, with a specific focus on diabetics, that will be part of a…
- Conditions
- Stable Angina, Unstable Angina, Acute Myocardial Infarction
- Trial name
- PARTICIPATE (NCT01556126)
- Testing
- Amphilimus Eluting Stent (CRE8)
- Where
- 23 sites in Austria, Belgium and 4 more
- Volunteers
- 1,191 people
- Sponsor
- CID - Carbostent & Implantable Devices
Infant, Newborn Diseases
Reduced Infant Response To A Routine Care Procedure After Glucose 25% Analgesia
Glucose has analgesic and calming effects in newborns. To date, it is not known whether the beneficial effects extend to care giving procedures that are performed after painful procedures.
- Trial name
- NCT01289808
- Testing
- Glucose 25%
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- The Baruch Padeh Medical Center, Poriya
Chronic Primary Pain, Musculoskeletal Pain
Facilitators and Barriers in Neuroscience-based Pain Education Programmes in Primary Care Physiotherapy
The new approach in pain neuroscience education (PNE) requires specific training for the physiotherapists in charge of applying it.
- Conditions
- Chronic Primary Pain, Musculoskeletal Pain, Fibromyalgia
- Trial name
- NCT05860816
- Testing
- Survey
- Where
- Spain
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Castilla-León Health Service
Low Back Pain, Chronic Pain
SMART Stepped Care Management for Low Back Pain in the Military Health System
This study will be sequential, randomization trial where patients with chronic low back pain are initially randomized to receive 1 of 2 treatments (physical therapy OR Move 2 Health).
- Conditions
- Low Back Pain, Chronic Pain, Military Personnel, Veterans
- Trial name
- SMART LBP (NCT04172038)
- Testing
- Physical Therapy, Move 2 Health (M2H), MORE Mindfulness
- Where
- 4 sites in United States
- Volunteers
- 850 people
- Sponsor
- Brooke Army Medical Center
Coronary Heart Disease, Stable Angina Pectoris
Studies of Traditional Chinese Medicine Clinical Efficacy Evaluation Index
The purpose of the trial is to take stable angina pectoris of coronary heart disease (CHD) as examples to build a standard evaluation system for efficacy of traditional Chinese medicine (TCM). 1.
- Trial name
- NCT01502943
- Testing
- Louxiangdan Tongxin granules, Chixiangshen Tongxin granules, Western basis treatment
- Where
- 10 sites in China
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Liaoning University of Traditional Chinese Medicine
Moderate to Severe Postoperative Pain
Comparison of the Efficacy and Safety of Q8003 Versus Its Individual Components in Bunionectomy Patients
This is a randomized, double-blind, multicenter, fixed dose factorial study of Q8003 12 mg/8 mg versus its individual morphine sulfate and oxycodone hydrochloride components for the management of acute moderate to severe…
- Trial name
- NCT01016808
- Testing
- Q8003, Morphine sulfate, Oxycodone HCl
- Where
- 5 sites in United States
- Volunteers
- 522 people
- Sponsor
- QRxPharma Inc.
Arthritis, Tendonitis
Prospective Analgesic Compound Efficacy (PACE) Study
A 24-week observational prospective study on the efficacy of topical non-steroidal anti-inflammatory drugs for the relief of pain.
- Conditions
- Arthritis, Tendonitis, Gout, Radiculopathy
- Trial name
- PACE (NCT02403687)
- Testing
- baclofen 2%, Bupivacaine hydrochloride 1%, Cyclobenzaprine hydrochloride 2%
- Volunteers
- 300 people
- Sponsor
- Express Specialty Pharmacy
Pain, Acute
Analgesic Efficacy of Orally Administered VTS-K for Pain Management
A combination of ketamine and aspirin for the treatment of acute MSK pain in the ED would confer multimodal analgesia, with the contributions of aspirin and ketamine to an opioid sparing effect.
- Trial name
- NCT04702555
- Testing
- VTS-K
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Antonios Likourezos
Pain, Postoperative
Comparison of Local Anesthetic Dose in PENG Block Performed in Total Hip Replacement Operations
The investigators research was designed as a single-center, prospective, randomized double-blind study. The patients undergoing total hip replacement surgery in Istanbul University Istanbul Medicine Faculty Department of…
- Trial name
- NCT04900116
- Testing
- Bupivacaine HCl 0.5 % in 20 ML Injection, Bupivacaine HCl 0.25 % in 20 ML Injection, Bupivacaine HCl 0.125 % in 20 ML Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Breast Cancer
Analgesic Efficacy of Maxigesic in Breast Cancer Surgery
The present study aims to find a perioperative analgesic method that provides sufficient analgesia while reducing immune compromise in cancer surgery. This study is to investigate the analgesic effect and safety of Maxigesic inj.
- Trial name
- NCT06174363
- Testing
- Maxigesic, 0.9% saline solution
- Where
- South Korea
- Volunteers
- 84 people
- Sponsor
- Yonsei University
Upper Extremity Problem
Comparison of Selective Trunk and Supraclavicular Brachial Plexus Blocks
There are different methods in brachial plexus blocks for hand, wrist, forearm, and elbow operations. In this study, the anesthetic efficacy of the ultrasound-guided selective truncus methods and the supraclavicular methods for…
- Trial name
- NCT06004648
- Testing
- Upper extremity surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 92 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Opioid Use, Post Operative Pain
Comparing Intrathecal Morphine With Erector Spina Plane Block in Open Gastrectomy Surgery
Open gastrectomy causes severe postoperative pain due to wide surgical incisions, retraction of the abdominal wall and direct manipulation of the visceral organs.
- Conditions
- Opioid Use, Post Operative Pain, Pain Assessment Scales
- Trial name
- NCT05706285
- Testing
- Regional Block Comparison
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- Marmara University
Pain
Bupivacaine Injections Into Uterosacral Ligaments During Robotic Assisted Total Hysterectomies
Will patients that receive injections of Marcaine into the uterine nerve via the uterosacral ligaments experience less pain postoperatively, need less narcotic pain medication and return to activities of daily living sooner.
- Trial name
- NCT02230735
- Testing
- Bipivacaine 0.5% with epinephrine, Normal Saline
- Where
- United States
- Sponsor
- Souza, Amanda, M.D.
Postoperative Pain Following Radical Cystectomy
Efficacy and Safety of Peri-operative Pregabalin After Radical Cystectomy
This study compares analgesic efficacy, and safety of three different doses of peri-operative pregabaline to placebo following radical cystectomy.
- Trial name
- NCT02724293
- Testing
- pregabaline 300 mg once., pregabaline 300 mg twice., pregabaline 600 mg once.
- Volunteers
- 60 people
- Sponsor
- Assiut University
Adolescent Idiopathic Scoliosis, Analgesia
Intravenous Lignocaine as an Analgesic Adjunct in Adolescent Idiopathic Scoliosis Surgery
This is a single-center study comparing the effect of intravenous (IV) Lignocaine given throughout posterior spinal fusion surgery on the reduction of morphine usage during postoperative period in adolescent idiopathic scoliosis…
- Trial name
- IGNITE-AIS (NCT04931433)
- Testing
- Lignocaine, Normal saline
- Where
- Malaysia
- Volunteers
- 115 people
- Sponsor
- University of Malaya
Pain, Postoperative
Evaluate Efficacy and Safety of Extended Release (ER) Naproxen Sodium
The objective is to evaluate pain relief of the extended release naproxen sodium 660 mg tablet compared to commercial naproxen sodium 220 mg tablet over 24 hours in patients with postsurgical dental pain.
- Trial name
- VERNE (NCT01389284)
- Testing
- Naproxen Sodium ER (BAYH6689), Naproxen Sodium IR (Aleve, BAYH6689)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Bayer
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