Clinical trials: Pain, Medication
Pain, Postoperative, Analgesic Adverse Reaction
Neodolpasse® Infusion Solution Versus Diclofenac 75 mg Infusion in the Treatment of Postoperative Pain After Elective Knee Surgery
The clinical study is planned as a double-blind, randomised, placebo-controlled, parallel-group, single-centre exploratory clinical study with the aim to investigate the analgesic efficacy of the Neodolpasse® Infusion Solution in…
- Conditions
- Pain, Postoperative, Analgesic Adverse Reaction, Cruciate Ligament Rupture
- Trial name
- NCT03493490
- Testing
- Neodolpasse, Diclofenac
- Where
- Austria
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Pain, Diabetic Neuropathy
Study to Evaluate the Analgesic Efficacy of 28 Days' Oral Administration of AZD2066 Compared With Placebo in Patients With Painful Diabetic Neuropathy
The purpose of this study is to investigate if AZD2066 can relieve the pain arising from painful diabetic neuropathy compared to placebo.
- Trial name
- NCT00857623
- Testing
- AZD2066
- Where
- 19 sites in United States
- Volunteers
- 127 people
- Sponsor
- AstraZeneca
Ketamine Causing Adverse Effects in Therapeutic Use
Comparing Three Different Doses of Intrathecal Ketamine
The aim of this study is to compare the postoperative analgesic effect of three different doses of intrathecal ketamine as an adjuvant to bupivacaine in patients undergoing knee arthroscopy.
- Trial name
- NCT05074823
- Testing
- Ketamine 0.1 mg, Ketamine 0.2 mg, Ketamine 0.3 mg
- Where
- Egypt
- Volunteers
- 105 people
- Sponsor
- Assiut University
Pulp Necrosis, Postoperative Pain
Evaluation of Post-operative Pain and Bacterial Load Reduction After Application of Three Intra-canal Medications (Cocoa Husk Versus Calcium Hydroxide With and Without Cocoa) in Necrotic Mandibular First Molar.
The study will aim to evaluate the postoperative pain and bacterial load after application of two intracanal medications in mandibular first molar teeth with necrotic pulp.
- Trial name
- NCT07790796
- Testing
- Root canal treatment with intracanal medication by calcium hydroxide for one week., Root canal treatment with intracanal medication by cocoa husk for one week, Root canal treatment with intracanal medication by calcium hydroxide with cocoa husk for one week.
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Renal Calculus
Comparison Between Tramadol Hcl and Other Analgesics in the Treatment of Renal Colic
The purpose of this study is to determine whether Tramadol Hcl is as effective as Voltaren a non-steroidal antiinflammatory drug, and Dipyrone in amelioration of the pain caused by acute renal colic.
- Trial name
- NCT00310908
- Testing
- Tramadol Hcl
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Hadassah Medical Organization
Chronic Low Back Pain (CLBP), Low Back Pain
Chronic Low Back Pain and Osteopathic Manipulation Treatment
The goal of this clinical trial is to learn if adding Osteopathic Manipulative Therapy (OMT) to the usual medical care provided at the VA (usual VA care) improves treatment outcomes in individuals with chronic low back pain…
- Trial name
- NCT07161661
- Testing
- Usual VA Care, Osteopathic manipulative treatment
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Edward Hines Jr. VA Hospital
Acute Pain, Fever
Safety and Efficacy of Intravenous Acetaminophen (IV APAP) in Adult Inpatients
The study will be investigating safety and efficacy administration of repeated dose of IV Acetaminophen (IV APAP) over five days for the treatment of acute pain or fever in adult patients.
- Trial name
- NCT00598559
- Testing
- IV Acetaminophen
- Where
- 14 sites in United States
- Volunteers
- 213 people
- Sponsor
- Mallinckrodt
Other Peripheral Nerve Disease
Comparison of the Analgesic Effect of Different Local Anesthetics in Interscalene Nerve Block for Shoulder Surgery
Several reports have compared the duration of action of levobupivacaine and ropivacaine as local anesthetic. The most widely used method for sensory function evaluation is though means of a pinprick test.
- Trial name
- NCT02691442
- Testing
- Ropivacaine 0.75%, Levobupivacaine 0.5%, Levobupivacaine 0.5% + epinephrin 1/200000
- Volunteers
- 30 people
- Sponsor
- University Hospital, Antwerp
Chronic Pain
Veterans' Pain Care Organizational Improvement Comparative Effectiveness Study
Background and significance: Treatment with opioid pain medications (like hydrocodone and morphine) is common for severe pain, but studies show these medications may not always help and can cause serious problems.
- Trial name
- VOICE (NCT03026790)
- Testing
- Medication management, Non-pharmacological pain management, Buprenorphine-Naloxone
- Where
- United States
- Volunteers
- 820 people
- Sponsor
- University of Minnesota
Cancer Pain
Effect of Adding Ultrasound Guided IPACK Block to Adductor Canal Block for Postoperative Pain in Knee Tumor Excision
the aim of this study is to determine the analgesic effect of iPACK in combination to ACB after the excision of tumors around the Knee regarding the following: Time to the 1st rescue analgesia. Postoperative morphine consumption.
- Trial name
- NCT07382297
- Testing
- adductor canal block with iPACK, control group
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- National Cancer Institute, Egypt
Fibromyalgia
L-Tyrosine Supplementation in Patients With Fibromyalgia
Patients in the study, who have a diagnosis of fibromyalgia, will be randomly assigned to take the amino acid L-tyrosine or placebo (blank pill) for 3 weeks.
- Trial name
- NCT01219049
- Testing
- Tyrosine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Postoperative Pain
Caudal Block v/s Local Wound Infiltration for Pain Control in Pediatric Patients After Operation for Inguinal Hernia
This randomized controlled trial aims to compare the analgesic efficacy of local wound infiltration with Ropivacaine versus Caudal Block with Ropivacaine in pediatric patients undergoing surgery for inguinal hernia
- Trial name
- NCT07747038
- Testing
- Caudal Block with Ropivacaine Intervention, Local Wound Infiltration with Ropivacaine Intervention, Intravenous Paracetamol Suspension Intervention
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Fatima Memorial Hospital
Surgery
Analgesic Efficacy of Us Guided Fascia Iliaca Block Versus Caudal Block in Pediatric Graft Surgeries
The study is aimed to determine which of the two methods , either the fascia iliaca block or the caudal block is better in managing the post operative pain and by which decreasing the consumption of analgesic drugs post…
- Trial name
- NCT06427174
- Testing
- Fascia iliaca block, Caudal block
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Cleft Palate
Suprazygomatic Block in Cleft Palate Surgery in Children
Cleft palate (CP) is a common congenital malformation, with an incidence ranging from 0.1 to 1.1 per 1000 births depending on the population group (liau et al, 2010).
- Trial name
- NCT03412474
- Testing
- Bupivacaine, Dexmedetomidine, paracetamol
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Sciatica Acute, Sciatica
COMPARISON OF EFFICACY OF DIFFERENT DRUG COMBINATIONS IN ACUTE SCIATICA
The goal of this clinical trial is to compare different combinations of diclofenac with diclofenac monotherapy in acute sciatica.
- Trial name
- EDCLAS (NCT05626140)
- Testing
- Lacosamide 50 MG Oral Tablet [Vimpat], Codeine Phosphate, Diclofenac Sodium
- Where
- Pakistan
- Volunteers
- 120 people
- Sponsor
- Pakistan Institute of Medical Sciences
Pain
Effect of Complementary and Alternative Medicine on Pain Among Inpatients
The proposed study has 3 aims: 1) quantitatively describe a model for delivering complementary and alternative medicine (CAM) therapies to understand the selection of patients and CAM therapies used for pain management, 2)…
- Trial name
- NCT02190240
- Where
- United States
- Volunteers
- 4,422 people
- Sponsor
- Allina Health System
Multimorbidity
Preventing Decompensation Among Multimorbid Outpatients in Residential Care. A Cohort Study With a Six-month Follow-up.
Background :The European General Practitioners Research Network (EGPRN) designed and validated a comprehensive definition of multimorbidity using a systematic literature review and qualitative research throughout Europe.
- Trial name
- FDPM (NCT03088982)
- Testing
- Questionnaire
- Volunteers
- 64 people
- Sponsor
- University Hospital, Brest
Chemotherapy-induced Peripheral Neuropathy, Pain, Neuropathic
Ozone Therapy in Chemotherapy-induced Peripheral Neuropathy: RCT (O3NPIQ)
The main objective of this clinical trial is to evaluate the effectiveness and cost-effectiveness of adding ozone therapy to the clinical management of patients with pain secondary to chemotherapy-induced peripheral neuropathy
- Conditions
- Chemotherapy-induced Peripheral Neuropathy, Pain, Neuropathic, Pain Syndrome
- Trial name
- O3NPIQ (NCT04299893)
- Testing
- Ozone, Oxygen
- Where
- 2 sites in Spain
- Volunteers
- 42 people
- Sponsor
- Bernardino Clavo, MD, PhD
Kidney Stones
Comparison of RIRS Versus PCNL Methods, According to Postoperative Pain and Analgesic Demand in 2 to 4 cm Renal Stones
Purpose: to investigate the postoperative outcomes of Retrograde intrarenal surgery versus percutaneous nephrolithotomy in 2 to 4 cm kidney stones.
- Trial name
- NCT02430168
- Testing
- Percutaneous nephrolithotomy, Retrograde intrarenal surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Diskapi Teaching and Research Hospital
Healthy, Inflammation
Using a Narcotic to Enhance the Numbing Effect of the Local Anesthetic Lidocaine on Inflamed Molar Teeth
The effectiveness of local anesthetics is reduced if inflammation is present, making it difficult to control pain during such procedures as root canals and wisdom teeth removal.
- Conditions
- Healthy, Inflammation, Mouth Disease, Pain
- Trial name
- NCT00001952
- Where
- United States
- Volunteers
- 275 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)