Clinical trials: Pain, Musculoskeletal
Patellofemoral Pain Syndrome, Patellar Instability
Assessment of the Safety and Performance of a Patellofemoral Brace
Decathlon has developed kneeSOFT500 product, which is a medical device intended to be used on the knee to keep a physical activity on a regular basis in case of patellofemoral pain syndrome or patellar instability.
- Trial name
- NCT04653753
- Testing
- kneeSOFT500
- Where
- 4 sites in France
- Volunteers
- 30 people
- Sponsor
- Decathlon SE
Temporomandibular Joint Disorders, Facial Pain
Device for Alleviating Temporomandibular Joint (TMJ) Pain
The goal of this clinical trial is to evaluate the safety and effectiveness of the investigational BTL-043 device in alleviating Temporomandibular Joint (TMJ) pain in adults aged 22 years and older.
- Conditions
- Temporomandibular Joint Disorders, Facial Pain, Temporomandibular Joint Dysfunction Syndrome
- Trial name
- NCT07624539
- Testing
- Treatment with BTL-043
- Where
- 3 sites in United States
- Volunteers
- 31 people
- Sponsor
- BTL Industries Ltd.
Chronic Musculo-skeletal Pain
Effects of Pulsed Electromagnetic Field on Autonomic Function in Patients With Chronic Musculoskeletal Pain
Previously it has been demonstrated that exposing the heart to electromagnetic field during exercise stress test improves the recovery following the stress test.
- Trial name
- NCT01944917
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Aerotel Ltd
Neuralgia, Myalgia
Safety and Efficacy of Cunermuspir on Energy, Strength, and Fatigue in Patients With Nerve or Muscle Pain
Male and female participants were selected based on chronic neuromuscular pain. Patients were instructed to take two doses of the placebo or cuprous nicotinic acid chelate Cunermusmir twice a day for 28 days.
- Trial name
- NCT04737278
- Testing
- Cunermuspir
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- Mitosynergy LLC
Degenerative Disc Disease, Disc Degeneration
Clinical Trial Evaluating the Safety and Efficacy of Nucleus Pulposus Allograft in Participants With Degenerative Disc Disease
VIA Disc NP is a non-surgical intervention intended to supplement nucleus pulposus tissue in degenerated intervertebral discs. This is a randomized, sham-controlled, multi-center, double-blind clinical trial with an open label…
- Conditions
- Degenerative Disc Disease, Disc Degeneration, Lumbar Discogenic Pain
- Trial name
- RESTORE (NCT06778447)
- Testing
- VIA Disc NP
- Where
- 19 sites in United States
- Volunteers
- 325 people
- Sponsor
- VIVEX Biologics, Inc.
Osteoarthritis, Hip
ReNu™ Injection to Treat Hip Osteoarthritis Study
A pilot study to evaluate changes in hip function and pain in patients with osteoarthritis receiving the ReNu™ Hip Injection.
- Trial name
- NCT03063099
- Testing
- ReNu™ Injection
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- NuTech Medical, Inc
Osteoarthritis
Buprenorphine Transdermal Patch in Subjects With Osteoarthritis Pain Requiring Opioids. Includes a 52-Week Safety Extension.
The original objective of this study was to assess the safety and efficacy of the buprenorphine transdermal system (BTDS) (5, 10, and 20) in comparison to placebo transdermal system in subjects with moderate to severe…
- Trial name
- NCT00315458
- Testing
- Buprenorphine transdermal patch
- Where
- 48 sites in United States
- Volunteers
- 107 people
- Sponsor
- Purdue Pharma LP
Sprain, Strain
Efficacy and Safety of Ketoprofen Topical Patch 20% in the Treatment of Pain Associated With Ankle Sprain or Strain
The purpose of this study is to evaluate the effect of a ketoprofen topical patch on the pain associated with ankle sprain or strain.
- Trial name
- NCT00351104
- Testing
- Ketoprofen Topical Patch 20%
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Alkemira SA
Temporomandibular Disorder, Orofacial Pain
An Open Label Study Assessing REN Treatment in Headache Management in Temporomandibular Disorders
Temporomandibular disorders (TMD) encompass a group of conditions involving the masticatory muscles, temporomandibular joint (TMJ), and associated structures.
- Trial name
- NCT07639944
- Testing
- Nerivio treatment
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- Theranica
Osteoarthritis, Knee, Pain
New Hydroxyethyl Cellulose Hydrogel for the Treatment of the Pain of Knee Arthrosis
Prospective, multicenter study, unmasked, single-arm, to study the safety and efficacy of a new hydroxyethyl cellulose hydrogel for the treatment of the knee pain caused by osteoarthritis.
- Trial name
- PROMGEL-OA (NCT04061733)
- Testing
- Hydrogel injection
- Where
- 3 sites in Argentina
- Volunteers
- 50 people
- Sponsor
- Promedon
Osteoarthritis
Safety and Efficacy of the Buprenorphine Transdermal Delivery System in Subjects With Osteoarthritis Pain.
The objective of this study is to assess the safety and efficacy of the buprenorphine transdermal system (5, 10, and 20 mg) in comparison to placebo transdermal system in subjects with osteoarthritis pain.
- Trial name
- NCT00314652
- Testing
- Buprenorphine transdermal delivery system
- Where
- 22 sites in United States
- Volunteers
- 260 people
- Sponsor
- Purdue Pharma LP
Osteoarthritis of Knee
Study to Assess the Effect of E-OA-07 on Acute Pain Response in Subjects Suffering From Knee OA
The repetitive motions associated with active life and many sports can increase the wear and tear to the joints that leads to decrease in flexibility and joint pain finally heading its way to osteoarthritis.
- Trial name
- Osteolanc (NCT02417506)
- Testing
- E-OA-07 (Lanconone), Ibuprofen
- Where
- India
- Volunteers
- 72 people
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Osteoarthritis
A Comparative Study of Tramadol Hydrochloride Plus Acetaminophen Tablets Maintenance Versus Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Maintenance in Participants With Knee Osteoarthritis
The purpose of this study is to compare the effectiveness of tramadol hydrochloride 37.5 milligram (mg) plus acetaminophen 325 mg maintenance with that of non-steroidal anti-inflammatory drugs (NSAIDs) maintenance in participants…
- Trial name
- NCT00635349
- Testing
- Meloxicam, Aceclofenac, Tramadol Hydrochloride Plus Acetaminophen
- Volunteers
- 143 people
- Sponsor
- Janssen Korea, Ltd., Korea
Knee Osteoarthritis, Knee Pain Chronic
Lyophilized and Micronized Particulate Human Amniotic and Umbilical Cord (TTAX03) for KL Grade 3-4 Knee OA
It is hypothesized that a single Intra-articular Injection of TTAX03, 100mg in 2mL of saline, will have more benefit with respect to the proportion of responders 12 weeks post-injection than an equal volume of saline, based on…
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Knee Arthritis
- Trial name
- NCT05079035
- Testing
- TTAX03, Saline
- Where
- 10 sites in United States
- Volunteers
- 90 people
- Sponsor
- BioTissue Holdings, Inc
Chronic Pain
Study to Evaluate the Efficacy and Safety of Hydrocodone Bitartrate Extended-Release Tablets (CEP-33237) for Relief of Moderate to Severe Pain in Patients With Osteoarthritis or Low Back Pain Who Require Opioid Treatment for an Extended Period of Time
The primary objective of this study is to evaluate efficacy of hydrocodone extended-release (ER) tablets compared with placebo in alleviating moderate to severe pain in patients with osteoarthritis or low back pain as assessed by…
- Trial name
- NCT01240863
- Testing
- Hydrocodone ER
- Where
- 73 sites in United States
- Volunteers
- 391 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Knee Osteoarthritis
A Study to Compare Levels of Capsaicin After Intra-Articular Injection and Topical Application in Patients With Painful Knee Osteoarthritis
This is a Phase 1b, open-label, two-period, randomized crossover study in adult male and female participants with painful knee osteoarthritis.
- Trial name
- NCT03576508
- Testing
- CNTX-4975-05, Qutenza, Lidocaine (without epinephrine)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Centrexion Therapeutics
Chronic Pain, Anxiety
Phase II Trial of Nu-V3 Non-Invasive Nerve Stimulation Device for Chronic Pain, Anxiety, Depression, Sleeplessness
This Nu-V3 clinical study is a randomized, phase II, open-label study evaluating the Nu-V3 cranial nerve stimulation treatment device in patients with chronic pain, anxiety, depression, and/or sleeplessness.
- Conditions
- Chronic Pain, Anxiety, Depression, Sleeplessness
- Trial name
- Nu-V3P2RCT (NCT05394545)
- Testing
- Nu-V3
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Nu-Life Solutions
Osteoarthritis
Osteoarthritis Bedside Testing Kit
Develop and test a bedside testing kit for evaluating pain and symptoms of osteoarthritis
- Trial name
- NCT00794651
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Analgesic Solutions
Osteoarthritis, Knee
A Study To Investigate Whether PF-04457845 Is Effective In Treating Pain, Is Safe And Tolerable In Patients With Osteoarthritis Of The Knee
Inactivation of the FAAH (Fatty Acid Amide Hydrolase) enzyme has been shown to relieve pain and inflammation in animal studies. PF-04457845 has been shown to inactivate the FAAH enzyme in animals and healthy human volunteers.
- Trial name
- NCT00981357
- Testing
- PF-04457845, Naproxen
- Where
- 7 sites in United States, Canada and 1 more
- Volunteers
- 76 people
- Sponsor
- Pfizer
Knee Osteoarthritis
Comparison Between Mobithron® and Crystalline Glucosamine Sulphate in Patients With Knee Osteoarthritis
Knee osteoarthritis is a common degenerative joint disorder that causes pain, functional limitation, and reduced quality of life.
- Trial name
- NCT07717957
- Testing
- Mobithron®, Crystalline Glucosamine Sulphate
- Where
- Malaysia
- Volunteers
- 34 people
- Sponsor
- BREGO Life Sciences