Clinical trials: Pain, Nerve
Headache Disorders
Occipital Nerve Stimulation to Treat Chronic Headaches
The purpose of this study is to evaluate the safety and efficacy of a implantable device, called the bion(R), in the treatment of chronic headache.
- Trial name
- NCT00205894
- Testing
- bion microstimulator
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Boston Scientific Corporation
Diabetic Neuropathies
An Efficacy and Safety Study of Carisbamate in the Treatment of Nerve Pain in Diabetics
The purpose of this study is to evaluate the safety, tolerability, and efficacy of carisbamate (800 and 1200 mg/day) in patients with diabetic neuropathic pain.
- Trial name
- NCT00870454
- Testing
- Pregabalin 300 mg/d, Carisbamate 800 mg/d, Carisbamate 1,200 mg/d
- Volunteers
- 386 people
- Sponsor
- SK Life Science, Inc.
Failed Back Surgery Syndrome, Post-Laminectomy Syndrome
SENSE (Subcutaneous and Epidural Neuromodulation System Evaluation) Study
The purpose of the study is to demonstrate safety and efficacy of spinal cord stimulation with peripheral nerve field stimulation for the treatment of chronic low back and leg pain.
- Conditions
- Failed Back Surgery Syndrome, Post-Laminectomy Syndrome, Low Back Pain
- Trial name
- SENSE (NCT01990287)
- Testing
- SCS and PNfS, SCS Alone
- Where
- 28 sites in United States
- Volunteers
- 38 people
- Sponsor
- Abbott Medical Devices
Chronic Low Back Pain (CLBP)
SENECA - Smart Therapies for Chronic Pain
This will be a randomized controlled prospective pilot study: The feasibility and usability of VIVO 2nd GEN therapy + Standard-of-Care (SoC) vs. Standard-of-Care alone will be evaluated.
- Trial name
- SENECA (NCT07628179)
- Testing
- VIVO 2nd GEN, Standard-of-Care Multimodal Pain Therapy
- Where
- Austria
- Volunteers
- 44 people
- Sponsor
- Aurimod GmbH
Pain, Neuropathic
P38 Mitogen-activated Protein (Map) Kinase Inhibitor (SB-681323)Study In Patients With Neuropathic Pain
This will be a double-blind, placebo controlled cross-over study. After enrolment and initial assessments, subjects will receive oral SB681323 or matching placebo for 14 days.
- Trial name
- NCT00390845
- Testing
- SB681323
- Where
- 13 sites in Australia, Germany and 2 more
- Volunteers
- 50 people
- Sponsor
- GlaxoSmithKline
Post Herpetic Neuralgia, PHN
A Comparison of EpiCept™ NP-1 Topical Cream vs. Oral Gabapentin in Postherpetic Neuralgia (PHN)
The purpose of this study is to compare EpiCept™ NP-1 Topical Cream (2% ketamine / 4% amitriptyline) vs. Oral Gabapentin in the treatment of Postherpetic Neuralgia (PHN)
- Conditions
- Post Herpetic Neuralgia, PHN, Neuropathy, Nerve Pain
- Trial name
- NCT00475904
- Testing
- EpiCept-NP-1 Cream, Gabapentin Capsules
- Where
- India
- Volunteers
- 360 people
- Sponsor
- EpiCept Corporation
Nerve Block, Upper Extremity Surgery
Ropiclobet for Regional Anesthesia and Post-Operative Pain Control in Upper Extremity Surgery
This is a national, single-center, single-arm, open-label Phase II clinical trial designed to evaluate the efficacy and safety of Ropiclobet, a fixed-dose injectable solution containing Ropivacaine HCl, Betamethasone Sodium…
- Trial name
- NCT07131657
- Testing
- Ropivacaine + Clonidine + Betamethasone
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- PHARMAFINA
Low Back Pain
SMART Clinical Study: Surgical Multi-center Assessment of RF Ablation for the Treatment of Vertebrogenic Back Pain
To evaluate the safety and efficacy of RF ablation using the Intracept Intraosseous Nerve Ablation System to ablate intraosseous nerves for the relief of chronic axial low back pain.
- Trial name
- SMART (NCT01446419)
- Testing
- Intracept Treatment
- Where
- 13 sites in United States
- Volunteers
- 225 people
- Sponsor
- Relievant Medsystems, Inc.
Postoperative Pain
Multicenter Continuous Peripheral Nerve Block Surveillance Study
This two tiered study is a multi-center, open label, surveillance study of the use of continuous nerve blocks with the ON-Q® C-bloc and either nerve stimulator or ultrasound guided continuous nerve block techniques.
- Trial name
- cpnb (NCT00653133)
- Testing
- Ultrasound imaging, Peripheral nerve stimulator
- Where
- 16 sites in United States
- Volunteers
- 1,821 people
- Sponsor
- Halyard Health
Osteoarthritis
Tanezumab In Osteoarthritis Of The Hip Or Knee
The purpose of the study is to test the efficacy and safety of 2 doses of tanezumab compared to oxycodone CR and placebo in patients with osteoarthritis
- Trial name
- NCT00985621
- Testing
- tanezumab 10 mg, tanezumab 5 mg, oxycodone
- Where
- 112 sites in United States, Austria and 5 more
- Volunteers
- 614 people
- Sponsor
- Pfizer
Chronic Low Back Pain
CLBP Single-Arm Long-Term Follow-up Study
This is a prospective, noninterventional, observational post market data collection of long-term effectiveness and satisfaction outcomes for "A Prospective, Open-Label, Single-Arm Study of Intraosseous Basivertebral Nerve…
- Trial name
- NCT05207813
- Testing
- Intracept Procedure
- Where
- 2 sites in United States
- Volunteers
- 42 people
- Sponsor
- Boston Scientific Corporation
Peripheral Neuralgia, Chronic Pain
Clinical Study Of a Micro-Implantable Pulse Generator For The Treatment of Peripheral Neuropathic Pain
This post market study is being conducted to document the comparative effectiveness and safety of peripheral nerve stimulation plus conventional medical management versus conventional medical management alone in the treatment of…
- Trial name
- COMFORT (NCT05287373)
- Testing
- Nalu Neurostimulation System for PNS, conventional medical management
- Where
- 13 sites in United States
- Volunteers
- 89 people
- Sponsor
- Nalu Medical, Inc.
Greater Trochanteric Pain Syndrome, Greater Trochanteric Pain Syndrome of Both Lower Limbs
ReneuRx™ (Nerve Selective Therapy) Utilized in Lateral Hip Pain
The goal of this clinical trial is to evaluate the safety and analgesic performance of the ReneuRx™ device in subjects with moderate to severe chronic lateral hip pain compared to subjects receiving treatment with corticosteroid…
- Conditions
- Greater Trochanteric Pain Syndrome, Greater Trochanteric Pain Syndrome of Both Lower Limbs, Lateral Hip Pain
- Trial name
- RENEU (NCT07568015)
- Testing
- Triamcinolone acetate, ReneuRx
- Where
- 11 sites in United States
- Volunteers
- 100 people
- Sponsor
- Brixton Biosciences, Inc.
Dementia
Placebo-Controlled Crossover Study to Evaluate Donepezil and MK-3134 for Reversal of Cognitive Impairment Associated With Scopolamine Administration (3134-005)(COMPLETED)
The drug, scopolamine, can result in short-term impairments of cognitive function, attention, and memory that resemble those seen in aging and Alzheimer's disease.
- Trial name
- NCT01181310
- Testing
- C: MK-3134 25 mg + Scopolamine 0.5 mg, D: Donepezil 10 mg + Scopolamine 0.5 mg, E: Combo: Donepezil 10 mg + MK-3134 25 mg + Scopolamine 0.5 mg
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Moderate to Severe Chronic Peripheral Neuropathic Pain (PNP) Due to Postherpetic Neuralgia (PHN) or Peripheral Nerve Injury
A Clinical Trial to Investigate Efficacy and Safety of NT 201 Injections Compared With Placebo Injections in Participants Aged 18 Years and Older With Chronic Nerve Pain After Shingles or Nerve Injury
In this clinical trial, participants with nerve pain after shingles or nerve injury will receive injections with NT 201 or placebo. The purpose is to measure the decrease of nerve pain with NT 201 compared to placebo.
- Trial name
- PaiNT (NCT06091020)
- Testing
- IncobotulinumtoxinA
- Where
- 31 sites in Bulgaria, France and 4 more
- Volunteers
- 123 people
- Sponsor
- Merz Therapeutics GmbH
Rheumatoid Arthritis (RA)
Treatment With Auricular Vagus Nerve Stimulation in Rheumatoid Arthritis - the TRAVAGA Study
Purpose and aim The overall aim is to investigate efficacy and safety of a newly developed non-invasive auricular investigational device that electrically stimulates the auricular branch of the vagus nerve to activate the…
- Trial name
- TRAVAGA (NCT06779123)
- Testing
- Transauricular vagus nerve stimulation., transauricular vagus nerve non-stimulation
- Where
- 6 sites in Sweden
- Volunteers
- 128 people
- Sponsor
- taVNS AB