Clinical trials: Pain, Perioperative
Acute Pain, Hyperalgesia
IV Acetaminophen as an Adjunct Analgesic in Cardiac Surgery
Patients undergoing cardiac surgery experience significant postoperative pain, which may impact postoperative outcomes. The aim of this single center, double-blind, randomized, placebo controlled trial is to determine if…
- Trial name
- CarDolMev (NCT01544062)
- Testing
- IV acetaminophen
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of Washington
Perioperative Pain
Effect of Dexamethasone Shortly Before Surgery on the Intraoperative Dose of Remifentanil
This explorative post hoc analysis included patients randomized in the DEX-2-TKA trial (NCT03506789) who were operated under general anesthesia with remifentanil and propofol.
- Trial name
- NCT05002361
- Testing
- Dexamethasone, Isotonic saline
- Where
- 5 sites in Denmark
- Volunteers
- 94 people
- Sponsor
- Naestved Hospital
Pain, Hip Fractures
Comparison Effects of Two Regional Anesthetic Technique on Pain During High Risk Hip Fracture Surgery
In this study, our is to compare effect of lumbosacral plexus and sacral plexus + suprainguinal fascia iliaca plane block on perioperative pain via analgesia nociceptive index monitor on high-risk patients undergoing hip fracture…
- Conditions
- Pain, Hip Fractures, Perioperative Analgesia
- Trial name
- NCT05862922
- Testing
- Analgesia Nosiception İndex Monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- TC Erciyes University
Cervical Cancer Stage IB2, Cervical Cancer Stage IIa
Minimally Invasive Radical Hysterectomy Using Endoscopic Stapler in Stage IB2 or IIA1 Cervical Cancer
This study is a multicenter, open-label, non-inferiority, randomized controlled, investigator-initiated clinical trial comparing the efficacy and safety of open radical hysterectomy versus minimally invasive radical hysterectomy…
- Trial name
- SOLUTION2 (NCT07256977)
- Testing
- Open radical hysterectomy, Minimally invasive radical hysterectomy
- Where
- South Korea
- Volunteers
- 494 people
- Sponsor
- Seoul National University Hospital
Systemic Inflammatory Response Syndrome, Postoperative Pain, Acute
Opioid Free Anaesthesia-Analgesia Strategy on Surgical Stress and Immunomodulation in Elective VATS-Lobectomy for NSCLC
Lobectomy is a major, high-risk surgical procedure that in addition to one-lung ventilation (OLV) exerts a potent surgical stress response.
- Conditions
- Systemic Inflammatory Response Syndrome, Postoperative Pain, Acute, Postoperative Pain, Chronic, Infections Postoperative
- Trial name
- NCT05172739
- Testing
- Opioid-Based Anesthesia-Analgesia Strategy, Opioid-free Anesthesia-Analgesia Strategy
- Where
- Greece
- Volunteers
- 70 people
- Sponsor
- University of Crete
Pain
Erector Spinae Plane Block for Carotid Endarterectomy
The purpose of this study is to test the hypothesis that erector spinae plane block will decrease intraoperative local anesthetic and postoperative analgesic consumption in patients undergoing carotid endarterectomy.
- Trial name
- NCT04224844
- Testing
- Erector spinae plane block, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Antalya Training and Research Hospital
Degenerative Joint Disease of Shoulder
Cryoneurolysis of the Suprascapular Nerve for Perioperative Pain Control After Receiving a Reverse Total Shoulder Arthroplasty (RTSA)
The main purpose of this research is to find out if a treatment called cryoneurolysis can reduce pain after reverse total shoulder replacement surgery. This treatment uses cold to temporarily block a nerve in the shoulder.
- Trial name
- NCT07125833
- Testing
- Cryoneurolysis, No cryoneurolysis
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- North Texas Medical Research Institute, PLLC
Supratentorial Tumors
Comparison of Systemic Opioid (Morphine) and Pre-Incision Bilateral Scalp Nerve Block for Pain Management in Craniotomy Patients
The goal of this randomized controlled clinical trial is to compare the effectiveness of systemic opioids versus pre-incision bilateral scalp nerve block in managing intraoperative noxious stimuli and postoperative pain in adult…
- Trial name
- NCT07425678
- Testing
- Scalp nerve block, Morphine, Lidocaine
- Where
- Pakistan
- Volunteers
- 62 people
- Sponsor
- Aga Khan University
Postoperative Pain
Perioperative Use of Gabapentin To Decrease Narcotic Requirements in Spinal Fusion
Blinded study using oral gabapentin in load pre-operative (15mg/kg) and maintenance 5mg/kg three times a day (TID) for 5 days or discharge, Patient Controlled Analgesia (PCA) morphine and placebo group with similar pills, also…
- Trial name
- NCT00726999
- Testing
- Gabapentin, Morphine
- Volunteers
- 63 people
- Sponsor
- Medical College of Wisconsin
Anxiety
Perioperative Pregabalin Use, Rehabilitation, Pain Outcomes and Anxiety Following Hip Surgery
Pain prior to surgery is of particular concern in patients undergoing total hip arthroplasty (THA) since it is the most important predictor of pain and poor function 2-3 years after surgery.
- Trial name
- RCT (NCT00762099)
- Testing
- Pregabalin
- Where
- Canada
- Volunteers
- 184 people
- Sponsor
- Sunnybrook Health Sciences Centre
Neuropathic Pain
Efficacy of Perioperative Pregabalin in Reducing the Incidence of Chronic Neuropathic Pain and Postthoracotomy Syndrome.
This study is designed to assess: 1. The impact of taking perioperative pregabalin on the incidence of chronic neuropathic pain and postthoracotomy syndrome at 3 months in patients who have undergone a thoracotomy with a thoracic…
- Trial name
- NCT00967135
- Testing
- Pregabalin
- Where
- Canada
- Volunteers
- 110 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Hyperalgesia, Pain, Postoperative
DNA Methylation and Perioperative Pain Treatment
In the last few years much attention has been paid to hyperalgesia induced by opioids, which represents a clinically significant condition following acute and chronic exposure to opioids.
- Trial name
- MEDAPO (NCT02938455)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Bologna
Persistent Postoperative Pain
Avoid With Locoregional Analgesia Persistant Postoperative Pain In Children
Persistent postoperative pain is a substantial pain (scores 4-10 using a 0-10 numeric scale) that develops 3 months after surgery. Persistent postoperative pain can be a problem even in ambulatory surgery.
- Trial name
- AWA3PASIC (NCT06271174)
- Testing
- Carbocaine, Profofol and/or Suxaméthonium and/or Sévoflurane
- Where
- France
- Volunteers
- 208 people
- Sponsor
- Nantes University Hospital
Complex Obstetric Surgery, Perioperative Pain Management
COMFORT Trial: Complex Obstetric Management With Focused Regional Transversus Abdominis Plane Block
To assess the effect of intraoperative transversus abdominis plane (TAP) blocks on the amount of opioid pain medications expressed as morphine milliequivalents (MME) used postoperatively in patients who have undergone cesarean…
- Conditions
- Complex Obstetric Surgery, Perioperative Pain Management, Cesarean Delivery, Postoperative Pain Control
- Trial name
- COMFORT (NCT06925152)
- Testing
- Bupivicaine intervention arm
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Tennessee
Vasectomy, Pain
Perioperative Virtual Reality Intervention for Pain and Anxiety During Vasectomies
The goal of this clinical trial is to learn if a virtual reality (VR) program (TRIPP) can reduce pain, anxiety, and distress in adult men (aged 18+) undergoing a vasectomy under local anesthesia.
- Conditions
- Vasectomy, Pain, Anxiety, Virtual Reality
- Trial name
- NCT07055178
- Testing
- Virtual reality (VR) guided meditation therapy, Treatment as usual
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Post-Surgical Pain
Perioperative ACT-Based Clinical Hypnosis for Opioid Weaning
This randomized-controlled trial (RCT) will evaluate the effectiveness of a pain psychology intervention -- consisting of a hybrid of acceptance and commitment therapy (ACT) and clinical hypnosis intervention -- in reducing…
- Trial name
- NCT03730350
- Testing
- Clinical Hypnosis
- Where
- Canada
- Volunteers
- 92 people
- Sponsor
- University Health Network, Toronto
Participants' Pain,Quality of Life and Hospital Satisfaction
The Effect of "Adjacent Bed Effect" Induced by Anxiety on the Perioperative Period of Patients With Chocolate Cyst of Ovary
The "adjacent bed effect" caused by anxiety leads to poor recovery of participants after ovarian chocolate cyst surgery, including pain and quality of life, and affects participant satisfaction with the hospital.
- Trial name
- NCT06215482
- Where
- China
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Head and Neck Cancer, Acute Pain
Perioperative Gabapentin Use In Head And Neck Mucosal Surgery Patients
Patient satisfaction with healthcare is increasingly being utilized as a metric to reflect provider and hospital quality of care.
- Conditions
- Head and Neck Cancer, Acute Pain, Postoperative Pain
- Trial name
- GABA (NCT02926573)
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- Washington University School of Medicine
Uterine Fibroids (UF)
Ultrasound-Guided Stellate Ganglion Block Plus Propofol for Perimenopausal Insomnia With Anxiety
Laparoscopic myomectomy is a commonly performed minimally invasive gynecologic procedure. However, surgical trauma, tracheal intubation, and pneumoperitoneum may induce pronounced perioperative stress responses, resulting in…
- Trial name
- SGB-PROP-PIA (NCT07384468)
- Testing
- Ultrasound-Guided Stellate Ganglion Block
- Where
- China
- Volunteers
- 233 people
- Sponsor
- Xiaochen Ji
Colorectal Cancer
Effect of Lidocaine on Postoperative Pain in Elderlypatients Undergoing Colorectal Cancer Surgery
Patients who meet the enrollment criteria will be randomized 1:1 to the lidocaine group or placebo group.
- Trial name
- NCT05920980
- Testing
- lidocaine
- Where
- China
- Volunteers
- 276 people
- Sponsor
- West China Hospital