Clinical trials: Pain, Post Surgical
Pain
Evaluation of Dexmedetomidine on Post-operative Narcotic Requirements and Pain Scores in Bariatric Patients
The purpose of the study is to determine whether a single bolus dose of dexmedetomidine administered during bariatric surgery has any effect on the amount of narcotic pain medications required by an individual after surgery.
- Trial name
- NCT02604940
- Testing
- Dexmedetomidine, Normal Saline
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- West Virginia University
Non-obstructive Azoospermia
Gabapentin for Post-Operative Pain Control and Narcotic Reduction in Scrotal Surgery
The use of non-narcotic multi-modal analgesia to be used in the pre-operative, peri-operative and post-operative period to reduce or potentially eliminate narcotic usage following scrotal surgery.
- Trial name
- NCT04230980
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Weill Medical College of Cornell University
Pain, Obesity
Ketamine Effect After Laparoscopic Gastric Reduction: A Randomized, Double-Blinded, Placebo Controlled Study
Laparoscopic surgery for gastric reduction is frequently associated with high levels of postoperative pain. Postoperative pain is very often treated with opioids.
- Conditions
- Pain, Obesity, Hypoxia
- Trial name
- NCT01997515
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Northwestern University
Pain, Postoperative, Urethral Stricture
Efficacy of Opioid-limiting Pain Management Protocol in Men Undergoing Urethroplasty
The investigator's study aims to see if an enhanced recovery regimen of pain medications before and during surgery will decrease the use and risk of opioid pain medications as well as improve pain control in anterior…
- Trial name
- NCT03859024
- Testing
- Oxycodone, Acetaminophen, Gabapentin
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Alabama at Birmingham
Rotator Cuff Tear
The Effect of EXPAREL® on Postsurgical Pain, and the Use of Narcotics
Patients undergoing shoulder rotator cuff surgery in an outpatient setting are the focus of this study. The purpose of this study is to determine if the product EXPAREL® can be used as a safe alternative in shoulder surgery to…
- Trial name
- NCT03290196
- Testing
- EXPAREL 1.3 % in 20 ML Injection
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Andrews Research & Education Foundation
Postsurgical Pain
Study in Subjects Undergoing Complete Abdominoplasty
Phase 2, single center, randomized, double-blind, placebo-controlled, parallel design study of CA-008 vs. placebo in subjects undergoing an elective C-ABD under general anesthesia supplemented with a bupivacaine hydrochloride…
- Trial name
- NCT03789318
- Testing
- CA-008 5 mg, Bupivacaine Hydrochloride, Hydromorphone
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Concentric Analgesics
ACL, ACL Injury
Acupuncture ACL (Anterior Cruciate Ligament)
Acupuncture research in regards to PONV has been fairly well established, however, studies about perioperative pain control and acupuncture are a little more murky.
- Conditions
- ACL, ACL Injury, Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Rupture
- Trial name
- NCT03711734
- Testing
- Acupuncture + Standard of Care
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Breast Neoplasm Female, Postoperative Pain Management
PECS II vs. MTP for Analgesia After MRM
This randomized controlled study aims to compare the analgesic efficacy of the ultrasound-guided modified pectoral nerve block (PECS II) and the midpoint transverse process to pleura (MTP) block in female patients undergoing…
- Trial name
- NCT06187909
- Testing
- PECS II BLOCK, MTP BLOCK
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Ain Shams University
Inflammation Corneal, Pain, Postoperative
OCS-01 in Treating Inflammation and Pain in Post-cataract Patients
The DX-216 trial is a randomized, double-masked, placebo (vehicle)-controlled study evaluating the efficacy and safety of two doses of OCS-01 compared to vehicle in the treatment of inflammation and pain following cataract…
- Trial name
- SKYGGN (NCT04130802)
- Testing
- OCS-01 - Dexamethasone Cyclodextrin Nanoparticle Ophthalmic Suspension 1.5% mg/mL
- Where
- 4 sites in United States
- Volunteers
- 153 people
- Sponsor
- Oculis
Total Shoulder Arthroplasty
Exparel for Total Shoulder Arthroplasty
The primary objective of this study is to determine if Exparel leads to better pain scores at 24, 48 and 72 hours after Total Shoulder Arthroplasty (TSA) compared to a pain pump.
- Trial name
- NCT04364867
- Testing
- Exparel, Pain Pump
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Norton Healthcare
Postoperative Pain, Breast Cancer
Administration of Ketamine to Prevent the Post-operative Pain
The surgery of breast cancer is responsible for post-operative pain, needing in about 30% some morphine consumption; like that, the association of ketamine with general anaesthesia may decrease morphine's use and so its adverse…
- Trial name
- KETAMINE (NCT00210210)
- Testing
- Ketamine, Saline solution
- Where
- France
- Volunteers
- 230 people
- Sponsor
- Institut Bergonié
Quadratus Lumborum Block, Surgical Wound Infiltration
Surgeon Infiltration QL Block Comparison
The purpose of this study is to learn if using a Quadratus Lumborum (QL) plane injection technique (also called a "nerve block") that numbs the nerves going to the abdominal area improve pain control after surgery compared to…
- Trial name
- NCT03496610
- Testing
- Liposomal Bupivicaine, QL Block
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Duke University
Postoperative Pain
Does Ultrasound Improve Procedural Time in the Lateral Popliteal Approach to the Sciatic Nerve in Obese Patients
Ultrasound have been shown to improve the time needed to locate and block nerves in the non obese population. However, its utility is still unknown in the obese population.
- Trial name
- NCT01579747
- Testing
- Ultrasound, Nerve stimulation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of New Mexico
Postoperative Pain
Open-Label Safety and Tolerability Study of Oxymorphone for Acute Postoperative Pain in Pediatric Subjects.
When post-operative parenteral analgesia is discontinued, oral dosing with study medication may begin once the subject has developed a moderate level of pain as defined by a 100 mm VAS (pain intensity score greater than or equal…
- Trial name
- NCT00801398
- Testing
- Oxymorphone IR
- Where
- 11 sites in United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Postoperative Pain
A Safety and Effectiveness Study of SABER®-Bupivacaine for Pain Following Shoulder Surgery
This is a research study testing SABER-Bupivacaine (an experimental pain-relieving medication). SABER-Bupivacaine is designed to continuously deliver bupivacaine, a common local anesthetic, for a few days in order to treat local…
- Trial name
- NCT00818363
- Testing
- SABER-Bupivacaine
- Where
- 9 sites in Australia, New Zealand
- Volunteers
- 60 people
- Sponsor
- Durect
Colorectal Surgery, Pain, Postoperative
Intrathecal Opioids for Colorectal Resection
This research study is being done to determine the optimal dose of spinal morphine and hydromorphone in patients undergoing minimally-invasive (i.e., surgery performed through small entry sites and using cameras) colorectal…
- Conditions
- Colorectal Surgery, Pain, Postoperative, Analgesic, Opioid
- Trial name
- NCT04752033
- Testing
- Morphine, Hydromorphone
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Mayo Clinic
Postoperative Pain, Acute Pain
Pharmacokinetic, Efficacy and Safety Study of Tapentadol Oral Solution in Children With Postoperative Pain
To find out if a drug called tapentadol administered by mouth safely relieves pain in children. Look at the amount of tapentadol in the blood after a single oral dose.
- Trial name
- NCT01729728
- Testing
- Tapentadol
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Grünenthal GmbH
Postoperative Pain
Bilateral Continuous Erector Spinae Blocks for Post-Sternotomy Pain Management
To evaluate the efficacy of bilateral continuous erector spinae blocks (BESB) for postoperative analgesia in children and adolescents undergoing cardiac surgical procedures via sternotomy in the Early Recovery After Surgery…
- Trial name
- NCT04567407
- Testing
- Bilateral erector spinae blocks using ropivacaine
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Analgesia, Obstetrical, Coagulation Defect; Postpartum
IV Ketorolac on Platelet Function Post-Cesarean Delivery
Cesarean delivery has become the most common surgical procedure in the US. Non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to improve the quality of post-cesarean analgesia and markedly reduce opioid consumption.
- Conditions
- Analgesia, Obstetrical, Coagulation Defect; Postpartum, Nonsteroidals (NSAIDs)Toxicity, Postpartum Hemorrhage
- Trial name
- KetoPltAgg (NCT03805607)
- Testing
- Ketorolac Tromethamine 30 MG/ML
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Post Ocular Surgical Inflammation and Pain
Phase 3 Study Evaluating Safety and Efficacy of OTX-DP for Treatment of Ocular Inflammation and Pain After Cataract Surgery
To evaluate the safety and efficacy of OTX-DP as a sustained release drug (dexamethasone) depot when placed in the canaliculus of the eyelid for the treatment of post-surgical inflammation and pain in subjects who have undergone…
- Trial name
- NCT02034019
- Testing
- Dexamethasone, Punctum Plug
- Where
- United States
- Volunteers
- 247 people
- Sponsor
- Ocular Therapeutix, Inc.