Clinical trials: Pain, Post Surgical
Ketamine, Morphine
PCA Ketamine-Morphine VS PCA Morphine as Post-Operative Analgesia in Colorectal Surgery
The goal of this clinical trial is to compare the effectiveness of PCA ketamine-morphine versus conventional PCA morphine in postoperative patients undergoing elective laparotomy colorectal surgery under general anaesthesia.
- Trial name
- NCT06021717
- Testing
- Ketamine-Morphine, Morphine
- Where
- Malaysia
- Volunteers
- 60 people
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Postoperative Pain
Dexamethasone Twice for Pain Treatment of Total Knee Arthroplasty
Dexamethasone twice for pain treatment after total knee arthroplasty - A Placebo-controlled, randomised, parallel 3-group multicentre trial of one and two doses of dexamethasone for postoperative treatment
- Trial name
- DEX-2-TKA (NCT03506789)
- Testing
- Dexamethasone
- Where
- 5 sites in Denmark
- Volunteers
- 485 people
- Sponsor
- Naestved Hospital
Endodontic Disease
Effect of Different Irrigation Solutions on Postoperative Pain and Lesion Healing
In this study researchers plan to conduct, three different irrigation solutions that are responsible for the release of growth factors necessary for the success of regenerative endodontic treatments will be used.
- Trial name
- NCT06386991
- Testing
- Using ethylenediaminetetraacetic acid (EDTA), citric acid ((MONO/ANH) and etidronic acid (HEBP) to clean root canals during regenerative endodontic treatments
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Pilonidal Sinus, Wound Healing
ENVELOP: Wound Care Following Pilonidal Sinus Surgery
This is a single-blinded, multicentre, prospective randomised controlled trial (RCT) comparing post-operative and patient-reported outcomes for patients undergoing application of negative-pressure wound therapy (NPWT) after sinus…
- Trial name
- ENVELOP (NCT06647290)
- Testing
- Negative Pressure Wound Therapy, Standard wound care
- Where
- 10 sites in Ireland
- Volunteers
- 200 people
- Sponsor
- Royal College of Surgeons, Ireland
Regional Anesthesia, Video-assisted Thoracoscopic Surgery (VATS)
Ultrasound-Guided Erector Spinae Plane Block Versus Thoracoscopically-Guided Intercostal Nerve Block in Video-Assisted Thoracoscopic Surgery
Effective postoperative pain management is essential after thoracic surgery. Insufficient pain control may impair breathing and coughing, increasing the risk of pulmonary complications such as collapsed lungs (atelectasis) or…
- Conditions
- Regional Anesthesia, Video-assisted Thoracoscopic Surgery (VATS), Erector Spinae Plane Block, Intercostal Nerve Block
- Trial name
- NCT07535697
- Testing
- Anesthesiological, Ultrasound-Guided "Erector Spine Plane Block" (ESPB), Surgical, Thoracoscopically-Guided "Intercostal Nerve Block" (ICNB)
- Where
- Germany
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Sana Klinikum Offenbach
Pain, Postoperative, Child
PECS Study for CIED Implantation Surgery
We aim to determine whether pectoral nerve block (PECS) performed after induction of anesthesia but before surgical incision results less opioid use in the post operative period compared with local infiltration alone in children…
- Conditions
- Pain, Postoperative, Child, Adolescent
- Trial name
- NCT04577690
- Testing
- Bupivacaine 0.25% with epinephrine 1:200000 by PECS block and wound infiltration, Bupivacaine 0.25% with epinephrine 1:200000 by wound infiltration only
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- The Hospital for Sick Children
Postoperative Pain, Hysterectomy
Effectiveness of Thoracoabdominal Nerve Block (M-TAPA) on Postoperative Pain Relief in Laparoscopic Hysterectomy
This study aims to investigate the effectiveness of a specific regional anesthesia technique, the Modified-Thoracoabdominal Nerve Block through a Perichondrial Approach (M-TAPA), on reducing pain after laparoscopic hysterectomy…
- Conditions
- Postoperative Pain, Hysterectomy, Plane Blocks
- Trial name
- NCT07483190
- Testing
- Modified-Thoracoabdominal Nerve Block through a Perichondrial Approach (M-TAPA)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istinye University
Morphine Consumption, Postoperative Pain
Ultrasound-Guided Pericapsular Nerve Group Block for Pain Control After Hip Surgery
This study evaluated whether an ultrasound-guided pericapsular nerve group (PENG) block could reduce pain and morphine use during the first 24 hours after hip surgery.
- Trial name
- NCT07906613
- Testing
- Ultrasound-Guided Pericapsular Nerve Group Block with Bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Cumhuriyet University
Post Operative Pain
Patient Satisfaction and Pain Control Following Reconstructive Vaginal Surgery
The investigators hypothesize that patient controlled analgesia (PCA) provides superior pain relief and patient satisfaction when compared to scheduled intravenous analgesia following vaginal reconstructive surgery.
- Trial name
- NCT01442818
- Testing
- Dilaudid PCA, Dilaudid IV Scheduled
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- TriHealth Inc.
Postoperative Pain, Analgesic Consumption
Analgesic Consumption in the Early Postoperative Period: A Prospective Observational PACU Study
Postoperative pain remains a significant clinical challenge that directly affects patient recovery, functional outcomes, and overall quality of care.
- Conditions
- Postoperative Pain, Analgesic Consumption, Pain Management
- Trial name
- NCT07547618
- Testing
- Observational Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 254 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Pain After Extracorporeal Shock Wave Lithotripsy, Palmitoylethanolamide
Palmitoylethanolamide vs Ibuprofen for Pain After ESWL
Pain after extracorporeal shock wave lithotripsy (ESWL), a non-surgical procedure used to treat kidney stones, is common and is usually treated with non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen.
- Trial name
- NCT07316660
- Testing
- Palmitoylethanolamide (PEA), Ibuprofen (Brufen®)
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Benha University
Mammoplasty, Postoperative Pain
Study of EXPAREL in Patients Undergoing Breast Augmentation
This is a Phase 4, prospective, open-label, non-randomized, sequential study with two treatment groups differing only in the technique used for EXPAREL administration (instillation or infiltration).
- Trial name
- NCT01582490
- Testing
- Instillation - EXPAREL, Infiltration - EXPAREL
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Irreversible Pulpitis, Root Canal Treatment
Simultaneous Working Length Detection Methods
Precise knowledge of the apical construction, which determines the end of the area for canal preparation and filling, is essential for the success of root canal treatment and the management of postoperative pain.
- Trial name
- NCT06507982
- Testing
- EWL, SWL, RWL
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
The Effect of Local Aplication of Cayanoacrylate Tissue Adhesives on Improving the Healing
Cyanoacrylate Tissue Adhesives Versus Silk Suture at the Palatal Donor Site of Sub Epithelial Connective Tissue Graft
Subepithelial connective tissue grafts (CTG) are considered the gold standard procedure with proven clinical success when it comes to gingival augmentation aims to to improve periodontal health, which can enhance the long-term…
- Trial name
- NCT04780360
- Testing
- Cayanoacrylate tissue adhesives, Silk suture
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Diseases of Mitral Valve, Aortic Valve Disorder
Comparison of the Local Anaesthetics Articaine and Bupivacaine in Treatment of Acute Sternum Pain After Heart Surgery
The purpose of this study is to examine the wound infusion of articaine for treatment of acute post-sternotomy pain in a placebo-controlled manner using a prospective and randomized design and an active control (bupivacaine)
- Conditions
- Diseases of Mitral Valve, Aortic Valve Disorder, Atrial Septal Defects, Intracardiac Myxoma
- Trial name
- NCT01536717
- Testing
- Articaine hydrochloride 2% solution, Sodium Chloride
- Where
- 2 sites in Finland
- Volunteers
- 36 people
- Sponsor
- Helsinki University Central Hospital
Total Knee Arthroplasty
NEUROCUPLE™ in TKA Patients to Enhance Pain Management
This is a randomized (1:1) placebo-controlled clinical trial to determine the feasibility and effectiveness of 30-day application of NEUROCUPLE™ patch for pain reduction and opioid consumption following TKA.
- Trial name
- NCT06460350
- Testing
- NEUROCUPLE™ Patch
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- nCap Medical
Phantom Limb
Cognitive Behavior Therapy (CBT) and Mirror Training for Phantom Limb Pain
The goal of this study is to test whether a combination of cognitive-behavior therapy and mirror training reduces phantom limb pain for veterans with amputations.
- Trial name
- NCT00731614
- Testing
- Cognitive Behavioral Therapy and Mirror Retraining, Supportive therapy, Mirror retraining
- Where
- 3 sites in United States
- Volunteers
- 59 people
- Sponsor
- VA Office of Research and Development
Chronic Postoperative Pain
Placebo Effect In Spinal Cord Electrical Stimulation for Pain
Objective: To evaluate if spinal cord stimulation (SCS) performs better than placebo (no stimulation) in the long term to reduce persistent neuropathic leg pain refractory to medication and other conservative treatments in…
- Trial name
- PISCES (NCT06585033)
- Testing
- Spinal cord stimulation
- Where
- 4 sites in Netherlands, Norway and 1 more
- Volunteers
- 50 people
- Sponsor
- Sahlgrenska University Hospital
Rotator Cuff Tear, Postoperative Pain
Oral Ketorolac for Arthroscopic Rotator Cuff Repair
1. The investigators aim to examine the use of IV and oral ketorolac as an adjunctive agent to the standard of care pain protocol for postoperative pain control following arthroscopic rotator cuff repair. 2.
- Trial name
- NCT03967847
- Testing
- Ketorolac
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University Hospitals Cleveland Medical Center
Irreversible Pulpitis, Postoperative Pain
Evaluation of Trans-mucosal Bio-adhesive Discs of Diclofenac Potassium on the Anesthetic Success and Postoperative Pain in Patients With Symptomatic Irreversible Pulpitis: A Randomized Clinical Trial
The aim of the proposed study is to compare the effect of single dose of Diclofenac Potassium premedication as trans-mucosal bio-adhesive discs versus placebo on the effectiveness of the inferior alveolar nerve block and…
- Trial name
- NCT04585438
- Testing
- Diclofenac Potassium
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Cairo University
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