Clinical trials: Pain, completed
Healthy
A Relative Bioavailability Study of Acetaminophen 650 mg Extended Release Gelcaps Under Fasting Condition
The study was conducted as an open labeled, balanced, randomized, two-treatment, two-period, two-sequence, single-dose, crossover, bioavailability study comparing acetaminophen extended release gelcaps 650 mg of OHM Laboratories…
- Trial name
- NCT01073709
- Testing
- Acetaminophen
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ranbaxy Laboratories Limited
Urinary Tract Infection
Safety and Efficacy of PP4001 for the Treatment of Symptoms Associated With Uncomplicated Urinary Tract Infection
PP4001 is a medication not yet approved by the US FDA. This is a phase 2, multi-center, randomized, double-blind study of 3 doses of PP4001 versus placebo in the treatment of symptoms associated with uncomplicated urinary tract…
- Trial name
- NCT01406587
- Testing
- PP4001
- Where
- 25 sites in United States
- Volunteers
- 261 people
- Sponsor
- Pinnacle Pharmaceuticals, Inc.
Osteoarthritis, Knee
A Mechanism Based Proof of Concept Study of the Effects of Duloxetine in the Treatment of Patients With Osteoarthritic Knee Pain
Background: Duloxetine provides an analgesic effect of patients with OA. The mode of action of duloxetine is partly believed to act through modulating the descending inhibitory pain pathways from the brainstem towards the spinal…
- Trial name
- NCT04224584
- Testing
- Duloxetine
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Kristian Kjær Petersen
Thalassemia
Assessment of Pain in People With Thalassemia Who Are Treated With Regular Blood Transfusions
Thalassemia is an inherited blood disorder that can result in mild to severe anemia. Regular blood transfusions, which refresh the healthy red blood cell supply, are one treatment for thalassemia.
- Trial name
- NCT00872833
- Where
- 9 sites in United States, Canada
- Volunteers
- 32 people
- Sponsor
- Carelon Research
Labor Pain
Endorphin at Labor Pain and Acupressure
This study was performed to determine the impact of different acupressure procedures, performed on women's hands during labor, on endorphin levels and labor pain perception. The sample consisted of 140 pregnant women.
- Trial name
- NCT04367038
- Testing
- Warm Acupressure, Cold Acupressure , Conventional Acupressure
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Serap ÖZTÜRK ALTINAYAK
Hemorrhoid Pain
Post Hemorrhoidectomy Anorectal Pain
This is a quality assurance trial to evaluate the effectiveness of guided breathing exercises on reducing the symptoms of hemorrhoidal disease in colorectal surgery patients.
- Trial name
- NCT03240185
- Testing
- deep breathing exercises
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Diabetic Polyneuropathy, Sleep Hygiene
The Effect of Sleep Hygiene Education on Sleep Quality and Quality of Life in Patients With Painful Diabetic Polyneuropathy
This randomized controlled study was designed to the effect of sleep hygiene education on sleep quality and quality of life in patients with painful diabetic polyneuropathy The study was conducted between January 2025 and January…
- Conditions
- Diabetic Polyneuropathy, Sleep Hygiene, Pain
- Trial name
- NCT07646743
- Testing
- sleep hygiene education, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Trakya University
Opioid Use, Opioid Prescribing
Variation in Opioid Prescribing and Use for Acute Pain in Diverse Populations
This study will characterize patient pain and opioid use after an initial opioid prescription for acute pain.
- Trial name
- NCT04509115
- Testing
- Short-acting opioid prescription for acute pain
- Where
- 5 sites in United States
- Volunteers
- 1,709 people
- Sponsor
- Yale University
Migraine Without Aura, Headache
Effect of Sumatriptan on Levcromakalim-Induced Symptoms in Individuals With Migraine
The study aims to explore the effects of Sumatriptan on Levcromakalim-induced migraine in individuals with migraine without aura.
- Trial name
- SLIM (NCT05211050)
- Testing
- Levcromakalim, Sumatriptan, Saline
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- Danish Headache Center
Abortion Second Trimester
Overnight Pain Treatment Investigating Opioids vs. Nonopioids
The purpose of this study is to compare maximum pain scores between patients seeking induced abortion and requiring cervical preparation with osmotic dilators.
- Trial name
- OPTION (NCT03545893)
- Testing
- Ibuprofen 600 mg, OxyCODONE 5 Mg Oral Tablet
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Pennsylvania
Pain
Pain Perception With Tenaculum Placement
Randomized controlled trial that compares methods of tenaculum placement during intrauterine device insertion and their effect on pain.
- Trial name
- NCT02969421
- Testing
- Cough method for placement of tenaculum, Slow Tenaculum Placement of tenaculum
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Duke University
Chronic Apical Periodontitis
The Effect of Different Sodium Hypochlorite Concentrations and Activation Techniques on Postoperative Pain
The goal of this clinical trial was to evaluate the effect of different sodium hypochlorite (NaOCl) concentrations and irrigation activation techniques on the intensity of postoperative pain following single-visit root canal…
- Trial name
- NCT07033247
- Testing
- EDDY Sonic Activation System, Passive Ultrasonic Irrigation (PUI)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Cukurova University
Pain Monitoring, Pain Assessment
Intraoperative Analgesia Based on ANI
Osteoarthritis of the knee joint is common and total knee arthroplasty (TKA) is performed in patients with advanced joint degeneration, no response to conservative treatments, severe pain and joint instability.
- Conditions
- Pain Monitoring, Pain Assessment, Opioid Consumption
- Trial name
- NCT06236035
- Testing
- Analgesia nociception index
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Zonguldak Bulent Ecevit University
Digestive Cancer, Gynecological Cancer
Analysis of Chronic Neuropathic Pain Markers in Patients Treated With Oxaliplatin
The role of oxidative stress in the development of oxaliplatin-induced peripheral neuropathy has been previously described in mice and in neuronal cell cultures (Massicot 2013); clinical manifestations and pathophysiological…
- Trial name
- LIPIDOXA (NCT02169908)
- Testing
- Thermotest, von Frey hairs
- Where
- France
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Fondation Hôpital Saint-Joseph
Osteoarthritis Knees
Impact of Blood Flow Restriction and Electrical Stimulation on Postoperative Muscle Atrophy and Pain After Total Knee Arthroplasty
This study investigate the impact of Blood Flow Restriction Training and Electrostimulation Training on postoperative muscle atrophy and pain after elective total knee arthroplasty.
- Trial name
- NCT06944808
- Testing
- BFR + EMS
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital, Bonn
Ozone, Third Molar
Effects of Ozonated Water on Pain, Swelling, Trismus and Quality of Life in Third Molar Surgery
The aim of this study was to evaluate the effect of ozonated water on pain, edema and trismus after third molar removal. Patients were submitted to extraction of lower third molar under irrigation with ozonated water or doubly…
- Conditions
- Ozone, Third Molar, Clinical Trial
- Trial name
- NCT03501225
- Testing
- ozone, water
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Federal University of the Valleys of Jequitinhonha and Mucuri
Chronic Low Back Pain
Comparative Mechanisms of Psychosocial Chronic Pain Treatments
Psychosocial interventions are attractive options for treating chronic low back pain, and many approaches now have strong support for efficacy.
- Trial name
- NCT02133976
- Testing
- cognitive therapy, mindfulness training, behavioral therapy
- Where
- United States
- Volunteers
- 521 people
- Sponsor
- Rush University Medical Center
Fibromyalgia
Emotional Freedom Technique (EFT) on Pain and Stress Levels in Fibromyalgia (FMS)
The main aim of the study was to investigate self-administered emotional to determine the effect of the freedom technique on pain and stress levels. The sub-objectives of the study are as follows: 1.
- Trial name
- EFT-FMS (NCT06391268)
- Testing
- Emotional Freedom Technique (EFT) works on cognitive and energetic levels.
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ege University
Postoperative Pain
Interscalene Versus Combined Infraclavicular-suprascapular Nerve Blocks
The aim of this trial is to compare the analgesic efficiency and hemi-diaphragmatic paralysis of the standard ultrasound-guided interscalene (ISB) brachial plexus block with the combined use of costoclavicular approach of…
- Trial name
- NCT03628950
- Testing
- ICSSB group, ISB group
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Fayoum University Hospital
Pain, Postoperative
Thoracic Paravertebral Block Using Ropivacaine and Dexmedetomidine
The hypothesis of the study is whether dexmedetomidine plus local anesthetic ropivacaine could extend the pain relieve time compared with only ropivacaine when thoracic paravertebral block is performed at the end of…
- Trial name
- NCT02814890
- Testing
- Video-assisted Pneumonectomy, Thoracic paravertebral block
- Where
- China
- Volunteers
- 65 people
- Sponsor
- Jianghui Xu
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