Clinical trials: Pain Acute
Hernia
Assessment and Prevention of Acute Post-herniotomy Pain
The aim of the study is the assessment and management of Acute Post-herniotomy Pain using two different therapeutical protocols per os: ketorolac versus association of acetaminophene+tramadol.
- Trial name
- PTSM04APHP (NCT01345162)
- Testing
- Ketorolac postoperative, postoperative Patrol, intraoperative analgesia
- Where
- 2 sites in Italy
- Volunteers
- 200 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Acute Post-surgical Pain
Co-crystal E-58425 vs Tramadol and Celecoxib for Moderate to Severe Acute Pain After Bunionectomy. Phase III Clinical Trial.
This is a Phase 3, randomized, double-blind, controlled, parallel-group, multicenter clinical trial with co-crystal E-58425 compared to tramadol, to celecoxib, and to placebo.
- Trial name
- NCT03108482
- Testing
- Co-crystal E-58425 (Tramadol/Celecoxib), Tramadol (Ultram®), Celecoxib (Celebrex®)
- Where
- 5 sites in United States
- Volunteers
- 637 people
- Sponsor
- Esteve Pharmaceuticals, S.A.
Paravertebral Peripheral Nerve Block, Acute Pain Management
Ultrasound-Assisted Paravertebral Block v. Traditional Paravertebral Block For Pain Control
The overall purpose of this research study is to compare the effectiveness of ultrasound assisted paravertebral block placement versus traditional "blind" technique for postoperative analgesia following thoracotomy or visually…
- Trial name
- NCT01949480
- Testing
- Thoracotomy, Video-Assisted Thoracoscopic Surgery (VATS)
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- University of Pittsburgh
Acute Coronary Syndrome
Acute Coronary Syndrome KCMC
The purpose of this study is to develop a quality improvement intervention to address barriers to evidence-based acute coronary syndrome (ACS) care in northern Tanzania.
- Trial name
- NCT04563546
- Testing
- Quality Improvement
- Where
- United States
- Volunteers
- 641 people
- Sponsor
- Duke University
Rib Fracture, Rib Fracture Multiple
Orthosis of Acute Traumatic Rib Fractures Via RibFx Belt for Pain Alleviation and Improved Pulmonary Function
Acute traumatic rib fractures are a common issue for patients of trauma surgeons. They inflict substantial morbidity, the most dreaded and consequential of which are pulmonary complications.
- Conditions
- Rib Fracture, Rib Fracture Multiple, Trauma, Trauma Chest
- Trial name
- RibFx (NCT03846024)
- Testing
- RibFx Orthosis Belt
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Vermont Medical Center
Pain Acute, Acupuncture
Acupuncture for Pain Management During Uterine Aspiration
The proposed study will be a randomized, double blinded, placebo-controlled trial to evaluate the efficacy of auricular acupuncture as adjunct for pain management during abortion.
- Trial name
- NCT03391986
- Testing
- SEIRIN® Pyonex™ Acupuncture Needles, 12 mm Plasters
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Columbia University
Back Pain, Acute Pain
Tolperisone in Acute Muscle Spasm of the Back
This is a double-blind, randomized, placebo-controlled, parallel group study of the efficacy and safety of tolperisone (a non-opioid) or placebo administered as multiple doses three times a day (TID) in approximately 400 male and…
- Conditions
- Back Pain, Acute Pain, Back Spasm Upper Back, Back Strain
- Trial name
- STAR (NCT03802565)
- Testing
- Tolperisone
- Where
- 43 sites in United States
- Volunteers
- 415 people
- Sponsor
- Neurana Pharmaceuticals, Inc.
Post-operative Pain
IV Acetaminophen for Acute Post Operative Pain in C-Section Patients
Post-operative pain management after C-section is an important topic as the number of elective c-sections increases each year. Pain is managed either by giving opioids or by using non-opioids.
- Trial name
- NCT02069184
- Testing
- IV Acetaminophen
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Montefiore Medical Center
Knee Arthroscopy, Acute Pain
"Comparison of Intra-articular of 0.2% Ropivacaine vs. 0.75% Ropivacaine in Postoperative of Knee Arthroscopy"
All patients with acute lesions that attend the orthopedic and trauma center of the ABC medical center are invited to participate in the study.
- Trial name
- ropivacaine (NCT05807945)
- Testing
- Ropivacaine 0.75% Injectable Solution, Ropivacaine 0.2% Injectable Solution
- Where
- Mexico
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Paola M Zamora Munoz
Unilateral Cataract Extraction, Congenital Cataract
A Randomized Study in Children Ages Birth Through Three Years Undergoing Unilateral Cataract Extraction With or Without Lens Replacement
The purpose of this study is to evaluate the effect of OMS302 compared to phenylephrine when administered in irrigation solution during cataract extraction on intraoperative pupil diameter, acute postoperative pain, and safety in…
- Trial name
- ILR7 (NCT02132312)
- Testing
- OMS302, Phenylephrine HCl
- Where
- 11 sites in United States
- Volunteers
- 78 people
- Sponsor
- Omeros Corporation
Postoperative Pain, Acute Pain
Pharmacokinetic, Efficacy and Safety Study of Tapentadol Oral Solution in Children With Postoperative Pain
To find out if a drug called tapentadol administered by mouth safely relieves pain in children. Look at the amount of tapentadol in the blood after a single oral dose.
- Trial name
- NCT01729728
- Testing
- Tapentadol
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Grünenthal GmbH
Major Depressive Disorder
A Study in Depression and Associated Painful Physical Symptoms
The purpose of this study is to find out if 60 mg of duloxetine given once a day by mouth for 8 weeks to patients diagnosed with major depressive disorder, who also report associated painful physical symptoms, is better than…
- Trial name
- NCT01070329
- Testing
- Duloxetine
- Where
- 34 sites in United States, Puerto Rico
- Volunteers
- 527 people
- Sponsor
- Eli Lilly and Company
Sensitivity
Effects of Acute Intermittent Hypoxia on Sensory Function in Healthy Adults
Exposure to acute intermittent hypoxia (AIH) can facilitate of motor output but no studies of sensory effects has been reported.
- Trial name
- SensoryFLO (NCT03283072)
- Testing
- Intervention 1, Intervention 2, Intervention 3
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Florida
Breast Carcinoma
Topical Cryotherapy in Reducing Pain in Patients With Chemotherapy Induced Peripheral Neuropathy or Paclitaxel Induced Acute Pain Syndrome
This randomized pilot clinical trial studies topical cryotherapy (cooling hands and feet with ice bags) in reducing pain in patients with chemotherapy induced peripheral neuropathy or paclitaxel induced acute pain syndrome.
- Trial name
- NCT02640053
- Testing
- Cryotherapy, Paclitaxel, Quality-of-Life Assessment
- Where
- 8 sites in United States
- Volunteers
- 46 people
- Sponsor
- Academic and Community Cancer Research United
Acute Pain
Tramadol/Diclofenac Fixed-dose Combination Phase III Trial in Acute Pain After Third Molar Extraction
This study evaluated a new drug fixed-dose combination tablet (FDC) called tramadol/diclofenac at two different strengths (fixed doses of 25 milligrams [mg] of tramadol and of diclofenac or of 50 mg each).
- Trial name
- NCT03714672
- Testing
- Tramadol/Diclofenac 50/50, Tramadol/Diclofenac 25/25, Tramadol 50
- Where
- 8 sites in Mexico
- Volunteers
- 1,151 people
- Sponsor
- Grünenthal GmbH
Pain
Safety, Tolerability, Analgesic Effect, and Feasibility of Intranasal CT001 in Pediatric Patients
The proposed study aims to investigate the safety, tolerability, analgesic efficacy, and feasibility of intranasal sufentanil/ketamine (CT001) in pediatric participants attending an acute care (i.e. emergency) setting.
- Trial name
- NCT06364072
- Testing
- CT001
- Where
- 7 sites in Spain, United Kingdom
- Volunteers
- 155 people
- Sponsor
- Cessatech A/S
Hallux Valgus
A Study to Evaluate the Effectiveness and Safety of Tapentadol (CG5503) in the Treatment of Acute Pain From Bunionectomy Compared With Placebo
The purpose of this study is to evaluate the analgesic efficacy and safety of tapentadol immediate-release (IR [CG5503]) for use in the relief of moderate to severe acute pain, compared with placebo, in adult Taiwanese patients…
- Trial name
- NCT01813890
- Testing
- Tapentadol IR 50 mg, Tapentadol IR 75 mg
- Where
- 3 sites in Taiwan
- Volunteers
- 60 people
- Sponsor
- Janssen-Cilag International NV
Hallux Valgus
A Study of Tapentadol Immediate-Release in the Treatment of Patients With Acute Pain From Bunionectomy
The purpose of this study is to demonstrate the efficacy of at least 1 dose of tapentadol IR 50 mg and/or 75 mg versus placebo using the sum of pain intensity difference at 48 hours (SPID48) to measure analgesic effect in Korean…
- Trial name
- NCT01516008
- Testing
- Tapentadol IR 50 mg, Tapentadol IR 75 mg
- Where
- 7 sites in South Korea
- Volunteers
- 353 people
- Sponsor
- Janssen Research & Development, LLC
Acute Migraine
Long-term Safety Study of BHV-3500 (Zavegepant*) for the Acute Treatment of Migraine
The purpose of this study is to evaluate the long-term safety of BHV-3500/vazegepant intranasal in the acute treatment of migraine. BHV-3500, formerly "vazegepant", is now referred to as "zavegepant" (za ve' je pant).
- Trial name
- NCT04408794
- Testing
- Zavegepant (BHV-3500)
- Where
- 67 sites in United States
- Volunteers
- 974 people
- Sponsor
- Pfizer
Acute Pain
IV Acetaminophen as an Analgesic Adjunct
To determine the efficacy of intravenous (IV) acetaminophen as an analgesic adjunct to IV hydromorphone in the treatment of acute severe pain in the elderly Emergency Department (ED) patients.
- Trial name
- NCT02621619
- Testing
- IV acetaminophen + 0.5 mg IV hydromorphone, Normal saline + 0.5 mg IV hydromorphone
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- Montefiore Medical Center