Clinical trials: Pain Assessment
Coronary Artery Disease, Atherosclerosis, Coronary
Safety and Effectiveness of the Orsiro Sirolimus Eluting Coronary Stent System in Subjects With Coronary Artery Lesions
The objective of this study is to assess the safety and efficacy of the Orsiro Sirolimus Eluting Coronary Stent System in the treatment of subjects with up to three native de novo or restenotic (standard PTCA only) coronary…
- Conditions
- Coronary Artery Disease, Atherosclerosis, Coronary, Myocardial Ischemia, Ischemic Heart Disease
- Trial name
- BIOFLOW-V (NCT02389946)
- Testing
- Orsiro DES, Xience DES
- Where
- 92 sites in United States, Australia and 11 more
- Volunteers
- 1,334 people
- Sponsor
- Biotronik, Inc.
Venous Leg Ulcer
Evaluation of Pain Associated With the Removal of Wound Dressing During Care of Venous Leg Ulcer. Comparison of the Efficacy and Safety of Two Dressings Urgotul and TulleGras
Evaluation of the non-inferiority of TulleGras M.S.® versus Urgotul® in pain associated with removal of wound dressing during care of venous leg ulcer
- Trial name
- NCT02104180
- Testing
- Urgotul, TulleGras M.S.
- Where
- 27 sites in France
- Volunteers
- 62 people
- Sponsor
- Mylan Inc.
Postoperative Pain
PAIN - Postoperative Analgesia INvestigation
The purpose of this study is to assess the efficacy of the intraoperative injection of prolonged acting (liposomal) bupivacaine in postoperative pain control after truncal surgical incisions.
- Trial name
- PAIN (NCT02111746)
- Testing
- Exparel, Bupivacaine hydrochloride, Patient Controlled Analgesia (PCA)
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- The University of Texas Health Science Center, Houston
Anesthesia, Local, Pain
Evaluation of the Dental Vibe Injection Comfort System
This study investigated the Dental Vibe Injection Comfort System (DV), developed to lessen anesthesia pain through pulsed vibration, a form of counter-stimulation.
- Trial name
- DVRCT (NCT04971941)
- Testing
- Dental Vibe
- Volunteers
- 60 people
- Sponsor
- Harvard Medical School (HMS and HSDM)
Lower Back Pain
A Study to Evaluate Two Formulations of Carisoprodol in Subjects With Musculoskeletal Spasm of the Lower Back
The purpose of this study is to determine if two sustained released formulations of carisoprodol are more effective than placebo.
- Trial name
- NCT00671502
- Testing
- Carisoprodol SR
- Where
- 68 sites in United States
- Volunteers
- 840 people
- Sponsor
- Meda Pharmaceuticals
HIV Infections
Pain and Sensory Changes Assessment in HIV+ Patients
There are about 42 million people in the world afflicted with HIV or AIDS with about 1 million patients in the US. The epidemiology of orofacial pain has been reported extensively in the literature, yet the prevalence severity…
- Trial name
- NCT00422695
- Where
- United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Dentistry of New Jersey
Computer + Fluency, Computer Only
Evaluation of a Computerized Opioid Overdose Prevention Program
Unintentional fatal drug overdose (OD) is now the 2nd leading cause of accidental death in the general population. Fatal OD from opioid analgesics specifically has increased over 400% between 1999 and 2008, and nonfatal overdose…
- Conditions
- Computer + Fluency, Computer Only, Treatment as Usual
- Trial name
- NCT02040077
- Testing
- Computer + Fluency, Computer Only, Treatment as Usual
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Johns Hopkins University
Osteoarthritis of the Knee or Hip
Long-Term Safety and Efficacy Study of Fasinumab in Patients With Pain Due to Osteoarthritis (OA) of the Knee or Hip
The primary objective of the study is to describe the safety and tolerability of fasinumab, including adverse events of special interest (AESIs), in patients with pain due to radiographically-confirmed OA of the knee or hip.
- Trial name
- FACT LTS & OA (NCT02683239)
- Testing
- Fasinumab
- Where
- 149 sites in United States, Bulgaria and 19 more
- Volunteers
- 5,331 people
- Sponsor
- Regeneron Pharmaceuticals
Chronic Migraine or Episodic Migraine
Study to Evaluate the Efficacy and Safety of AMG 301 in Migraine Prevention
To evaluate the effect of AMG 301 compared to placebo on the change from the baseline period in monthly migraine days in subjects with migraine.
- Trial name
- NCT03238781
- Testing
- AMG 301
- Where
- 49 sites in United States, Austria and 6 more
- Volunteers
- 343 people
- Sponsor
- Amgen
Musculoskeletal Pain, Pain, Chronic
NEPAL (Neuromodulatory Examination of Pain and Mobility Across the Lifespan)
Musculoskeletal pain represents the leading cause of disability worldwide. It has been traditionally attributed to peripheral mechanisms, but peripheral damage, inflammation, and psychological factors have failed to significantly…
- Trial name
- NEPAL (NCT02488863)
- Testing
- MRI Neuroimaging, Quantitative Sensory Testing, Questionnaires
- Where
- 4 sites in United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of Florida
Endometriosis
Extension to Study on Efficacy and Safety of Linzagolix for the Treatment of Endometriosis-associated Pain
The primary objective of this extension study is to assess the maintenance of efficacy of linzagolix administered orally once daily for up to an additional 6 months (for up to 12 months of treatment in total) in women who have…
- Trial name
- EDELWEISS 5 (NCT04372121)
- Testing
- 75 mg linzagolix tablet, 200 mg linzagolix tablet, Add-back capsule (E2 1 mg / NETA 0.5 mg)
- Where
- 25 sites in United States, Canada and 1 more
- Volunteers
- 30 people
- Sponsor
- Kissei Pharmaceutical Co., Ltd.
Pain
Study Evaluating A Novel Ibuprofen Formulation In The Treatment Of Dental Pain
This study will compare the analgesic efficacy of a single-dose of a novel ibuprofen formulation to placebo and acetaminophen in the treatment of post-surgical dental pain following "wisdom" tooth (third molar) removal.
- Trial name
- NCT01216163
- Testing
- Novel Ibuprofen, Acetaminophen
- Where
- United States
- Volunteers
- 218 people
- Sponsor
- Pfizer
Pain
Study to Evaluate the OrthoCor Active System for Pain Relief
This is a prospective, multi-center, randomized, pivotal study to evaluate the OrthoCor Active System in individuals prescribed its use in comparison with the standard of care intervention for pain relief.
- Trial name
- NCT05244187
- Testing
- OrthoCor Active System
- Where
- 5 sites in United States
- Volunteers
- 120 people
- Sponsor
- Caerus Corporation
Irritable Bowel Syndrome
Study to Evaluate the Efficacy and Safety of Vibegron Administered Orally for 12 Weeks to Women With Irritable Bowel Syndrome
This study will evaluate the efficacy and safety of vibegron, a beta-3 adrenergic receptor (β3-AR) agonist, in the treatment of pain associated with irritable bowel syndrome (IBS) due to IBS with predominant diarrhea (IBS-D) or…
- Trial name
- NCT03806127
- Testing
- Vibegron
- Where
- 41 sites in United States
- Volunteers
- 222 people
- Sponsor
- Urovant Sciences GmbH
Laparoscopic Surgery
Labetalol and Esmolol: Vital Signs and Post Operative Pain Management
This study proposes to investigate the effects of labetalol or esmolol on managing the vital signs (like blood pressure and heart rate) during surgery, on pain management, and on the later recovery after surgery.
- Trial name
- NCT01114971
- Testing
- Fentanyl, Labetalol, Esmolol
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Cedars-Sinai Medical Center
Thalassemia
Assessment of Pain in People With Thalassemia Who Are Treated With Regular Blood Transfusions
Thalassemia is an inherited blood disorder that can result in mild to severe anemia. Regular blood transfusions, which refresh the healthy red blood cell supply, are one treatment for thalassemia.
- Trial name
- NCT00872833
- Where
- 9 sites in United States, Canada
- Volunteers
- 32 people
- Sponsor
- Carelon Research
Chronic Low Back Pain
Virtual Reality Therapy for Chronic Low Back Pain
This study will test the efficacy of an evidence-based virtual reality (VR) therapy program as a non-pharmacological supplement for the management of chronic lower back pain.
- Trial name
- NCT04409353
- Testing
- Distraction-Based VR, Skills-Based VR, Activity Tracker
- Where
- United States
- Volunteers
- 413 people
- Sponsor
- Cedars-Sinai Medical Center
Moderate-to-severe Acute Pain
Open-Label Safety and Efficacy of the Sufentanil Sublingual Tablet 30 mcg for Acute Pain
To evaluate the safety and efficacy of sufentanil tablet (ST) 30 mcg in the management of moderate-to-severe acute pain in patients in an emergency room (ER) setting.
- Trial name
- NCT02447848
- Testing
- sufentanil sublingual 30 mcg tablet
- Where
- 3 sites in United States
- Volunteers
- 76 people
- Sponsor
- Talphera, Inc
Stable Angina
Efficacy of Topical Capsaicin Cream for Stable Angina
The purpose of this study is to test the hypothesis that application of topical capsaicin in patients with stable angina will result in improved exercise tolerance and reduced cardiac ischemia.
- Trial name
- TOPCAP (NCT01231750)
- Testing
- Capsaicin
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Neal Weintraub
Nerve Pain
A Study To Assess The Ability Of A Crossover Study Design To Detect The Efficacy Of Pregabalin In Post-Traumatic Neuropathic Pain Patients
The purpose of this study is to assess whether a cross-over type study design in post-traumatic neuropathic patients can be used to assess the activity of potential analgesic agents
- Trial name
- NCT00654940
- Testing
- Pregabalin (Lyrica)
- Where
- 5 sites in Canada, Sweden
- Volunteers
- 25 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.