Clinical trials: Pain Assessment
Pain
Evaluation of the Excretion of Suzetrigine Into Breast Milk in Healthy Lactating Female Participants
The purpose of the study is to evaluate the pharmacokinetics (PK) of suzetrigine (SUZ) and its active metabolite in breast milk of lactating female participants.
- Trial name
- NCT07378865
- Testing
- Suzetrigine
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Vertex Pharmaceuticals Incorporated
Pain, Chronic, Facet Joint Pain
Offset Mechanisms in Evaluation of Lumbar Medial Branch Blocks
This study examines the relationship between central nervous system (CNS) mechanisms of pain inhibition and the pain relief that occurs following a lumbar medial branch block (MBB).
- Conditions
- Pain, Chronic, Facet Joint Pain, Pain, Procedural, Analgesia
- Trial name
- OMEGA (NCT05961800)
- Testing
- Cutaneous Probe, Quantitative Sensory Testing, Computer Tasks
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Pittsburgh
Dental Extraction
Etoricoxib Versus Ibuprofen in Third Molar Extraction Pain
The aim of this study is to evaluate the analgesic efficacy of etoricoxib compared with a well known and widely used non-steroid antinflammatory drug, ibuprofen, in third molar extraction pain.
- Trial name
- NCT00855777
- Testing
- etoricoxib, ibuprofen
- Volunteers
- 110 people
- Sponsor
- Universita di Verona
Dental Implant Exposure Using Diode Laser
Using Diode Laser in 2nd Stage of Implant.
Dental Implants that are teeth replacements usually place with two stages. In the second stage the implant fixture, (which is the body that inserted in the bone is exposed to place the artificial tooth), is exposed using surgical…
- Trial name
- NCT06213467
- Testing
- diode laser 940nm
- Where
- Iraq
- Volunteers
- 15 people
- Sponsor
- University of Baghdad
Failed Back Surgery Syndrome (FBSS), Persistent Spinal Pain Syndrome Type 2 (PSPS-T) Lower Spine
Evaluation of Medication Tapering on the Sensitivity of the Spinal Cord Using Closed-Loop Spinal Cord Stimulation (Pilot Study)
This pilot study investigates the effects of reducing pain medication including opioids and anticonvulsants, on spinal cord sensitivity during closed-loop spinal cord stimulation (SCS).
- Conditions
- Failed Back Surgery Syndrome (FBSS), Persistent Spinal Pain Syndrome Type 2 (PSPS-T) Lower Spine, Neurophysiological Sensitivity to Spinal Cord Stimulation
- Trial name
- ECAP-MED Pilot (NCT07502612)
- Testing
- Spinal Cord Stimulation with Evoke Closed-Loop System
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Brai²n
Inguinal Hernia
Pain and Quality of Life After Inguinal Hernia Repair
This study aims to explore the difference in outcomes relating to pain and quality of life after open, laparoscopic, and robotic-assisted inguinal hernia repair.
- Trial name
- PREPARE (NCT04074200)
- Testing
- Open Inguinal Hernia Repair, Laparoscopic Inguinal Hernia Repair, Robotic-Assisted Inguinal Hernia Repair
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- Intuitive Surgical
Forearm Fracture, Radius Fractures
Pain Palliation in Forearm Fractures in the Emergency Department
The aim is to evaluate the success of reduction procedures and pain palliation in patients with forearm fractures undergoing reduction under procedural sedation-analgesia (PSA) and ultrasound (US)-guided infraclavicular nerve…
- Conditions
- Forearm Fracture, Radius Fractures, Ulnar Fracture
- Trial name
- NCT06588907
- Testing
- Bupivacaine Hydrochloride, Ketamine
- Where
- Turkey (Türkiye)
- Volunteers
- 85 people
- Sponsor
- Ankara Etlik City Hospital
Chroinc Pain, PET
Targeted Translocator Protein PET Imaging Evaluate Neuroinflammation of the Chronic Pain Patients
Chronic pain is a major public health issue, which seriously affects patients' quality of life. Neuroinflammation is an important mechanism resulting in chronic pain.
- Conditions
- Chroinc Pain, PET, Microglial Activation
- Trial name
- NCT06701734
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Weibing Miao, PhD
Pain After Total Knee Arthroplasty, Pain, Postoperative
Comparison of BiFeS + ACB and IPACK + ACB Block Combinations for Postoperative Pain After Total Knee Arthroplasty
This prospective observational study will compare the postoperative analgesic efficacy of two multimodal regional anesthesia combinations routinely used after total knee arthroplasty (TKA) performed under spinal anesthesia.
- Conditions
- Pain After Total Knee Arthroplasty, Pain, Postoperative, Arthroplasty, Replacement, Knee
- Trial name
- NCT07231692
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Karabuk University
Healthy Participants
A Study of Two Formulations (Both Refrigerated and Room Temperature) Using an Autoinjector Device in Healthy Participants
The main purpose of the study is to assess the injection site pain intensity of two formulations using prefilled autoinjector device in healthy participants.
- Trial name
- NCT05154968
- Testing
- Sodium chloride, Citrate buffer, Mannitol
- Where
- Canada
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Chronic Pain, Acute Pain
Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA
This study relies on the use of a smartphone application (SOMA) that the investigators developed for tracking daily mood, pain, and activity status in acute pain, chronic pain, and healthy controls over four months.The primary…
- Conditions
- Chronic Pain, Acute Pain, Post Operative Pain, Fibromyalgia, Primary
- Trial name
- NCT05754190
- Testing
- SOMA pain manager smartphone application
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Brown University
Chronic Illness, Opioid Use
Characteristics and Clinical Implications of a Clinical Decision Support System
The investigators propose to study the feasibility, acceptability, usability and outcomes of a new clinical decision support system for clinicians of opioid therapy in the context of specialist palliative care for serious chronic…
- Conditions
- Chronic Illness, Opioid Use, Palliative Care
- Trial name
- NCT03295097
- Testing
- Clinical Decision Support System
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Hospice of Henderson County, Inc.
Fibromyalgia
Effects of a Physical Exercise Program on Patients Affected With Fibromyalgia
Physical activity has been used for a number of years in the treatment of fibromyalgia (FM). The main objective of this study is to compare the effects of physical activity on two groups of women diagnosed with fibromyalgia (FM)…
- Trial name
- NCT04031391
- Testing
- Physical activity
- Where
- Spain
- Volunteers
- 48 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Nerve Pain
Objective Assessment of Sensory Nerve Fiber Sensitivity
This pilot study utilizes a unique technology to determine nerve fiber sensitivity. This will allow us to determine whether this method and device can discern changes in pain intensity and type, which is predicated on differing…
- Trial name
- NCT03596489
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Julia Finkel
Self Efficacy
The Examination of Relationship Between Self-Efficacy in People With Chronic Low Back Pain
Self-efficacy is defined as a person's confidence or belief that one can achieve a certain behavioral or cognitive state. Self-efficacy is one of the most important assesment parameters in the self-management model.
- Trial name
- NCT05614674
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Suleyman Demirel University
Symptomatic Irreversible Pulpitis
Pulpotomy in Mature Permanent Molars Using Biodentine Versus MTA
The aim of this study is to compare treatment outcomes of pulpotomy in mature permanent teeth using Biodentine versus MTA regarding postoperative pain and success rate.
- Trial name
- NCT03890835
- Testing
- MTA Pulpotomy., Biodentine Pulpotomy
- Volunteers
- 70 people
- Sponsor
- Cairo University
Chest Pain, Stable Angina Pectoris, CCS Class I to III
Randomized Evaluation of Patients With Stable Angina Comparing Diagnostic Examinations
This randomized, controlled, diagnostic, multicenter trial will compare two diagnostic imaging pathways--coronary computed tomography angiography (CCTA) and single photon emission tomography (SPECT) myocardial perfusion imaging…
- Conditions
- Chest Pain, Stable Angina Pectoris, CCS Class I to III, Angina Equivalent, Coronary Artery Disease
- Trial name
- RESCUE (NCT01262625)
- Testing
- CCTA, SPECT MPI/ICA
- Where
- 3 sites in United States
- Volunteers
- 1,050 people
- Sponsor
- American College of Radiology
Abuses Over-The-Counter/Prescription Medications, Pain, Postoperative
Expectations and Pain Control Advancement In surgeRy: The REPAIR Trial
This is a randomized control trial that aims to evaluate whether patient-centered education, compared to routine education, decreases narcotic consumption without interfering with return to physical activity following hospital…
- Conditions
- Abuses Over-The-Counter/Prescription Medications, Pain, Postoperative, Opioid Use, Physical Activity
- Trial name
- REPAIR (NCT03726476)
- Testing
- Patient centered pre-op education, routine preop education
- Where
- 2 sites in United States
- Volunteers
- 174 people
- Sponsor
- University of New Mexico
Osteoarthritis of the Knee
Study to Assess the Safety of Repeat Administration of FX006 Administered to Patients With Osteoarthritis of the Knee
This is an Open-label Study to Assess the Safety of Repeat Dose of FX006 Administered to Patients with Osteoarthritis (OA) of the Knee
- Trial name
- NCT03046446
- Testing
- FX006 32 mg
- Where
- 17 sites in United States
- Volunteers
- 208 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Delirium, Pain
Pregabalin in the Prevention of Postoperative Delirium and Pain
The purpose of this study is to determine whether administration of pregabalin by mouth immediately preoperatively and three times daily for 3 days after surgery reduces the incidence of delirium postoperatively and improves…
- Trial name
- NCT00819988
- Testing
- Pregabalin, Sugar pill
- Where
- Canada
- Volunteers
- 240 people
- Sponsor
- Ottawa Hospital Research Institute