Clinical trials: Pain Control Post Colorectal Surgery
Laparoscopic Colorectal Resection Due to Cancer
The Effects of Optimizing Post-operative Pain Management With Multi Modal Analgesia on Immune Suppression and Oncologic Outcome in Patients Undergoing Laparoscopic Colorectal Surgery
Traditionally, pain control methods based on narcotic analgesics have been used to control severe pain after surgery, but this has resulted in side effects such as vomiting, constipation, dizziness, mental confusion due to drugs…
- Trial name
- NCT03462836
- Testing
- IV ketamine/lidocaine/IV PCA apply, IV PCA only apply
- Where
- South Korea
- Sponsor
- Yonsei University
Post-operative Pain, Colon Cancer
The Effect of Exparel on Post Operative Pain and Narcotic Use After Colon Surgery
The purpose of the study is to evaluate the effect of Exparel on pain control and patient outcome after colon resection. The investigators will evaluate the clinical course of the patients who receive exparel as compared to the…
- Conditions
- Post-operative Pain, Colon Cancer, Diverticulitis
- Trial name
- NCT02052557
- Testing
- Bupivacaine, Bupivacaine liposome suspension
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Des Moines University
Colon Cancer, Rectal Cancer
Compare Preperitoneal Analgesia to Epidural Analgesia for Pain Control After Colon and Rectal Surgery
This is a prospective randomized study of 114 patients. The purpose of this study is to compare the efficacy of two standard methods of analgesia for pain control in patients undergoing elective colon and rectal surgery, as…
- Conditions
- Colon Cancer, Rectal Cancer, Colonic Diverticulosis
- Trial name
- NCT01552226
- Testing
- Continuous Preperitoneal Analgesia, Continuous Epidural Analgesia
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Trinity Health Michigan
Post-Operative Pain
Evaluate the Analgesic Efficacy and Safety of VVZ-149 Injections for Post-Operative Pain Following Laparoscopic Colorectomy
The purpose of this phase 2 study is to evaluate the efficacy and safety of an analgesic drug candidate, VVZ-149 Injections. The study is designed as randomized, double-blind, parallel, placebo-controlled study.
- Trial name
- NCT02992041
- Testing
- VVZ-149 Injections
- Where
- 2 sites in United States
- Volunteers
- 69 people
- Sponsor
- Vivozon, Inc.
Pain, Postoperative, Pain, Abdominal
Optimal Peripheral Nerve Block After Minimally Invasive Colon Surgery
The purpose of the trial is to identify the "most simple non-inferior of three different methods", placebo, laparoscopic assisted transverse abdominal plane block (L-TAP) and ultrasound guided TAP block (US-TAP), using…
- Conditions
- Pain, Postoperative, Pain, Abdominal, Analgesia, Surgery
- Trial name
- OPMICS (NCT04311099)
- Testing
- Active drug, Injection of Ropivacaine - Ultrasound-guided transverse abdominal plane block, Injection of Ropivacaine - Laparoscopic assisted transverse abdominal plane block
- Where
- 5 sites in Denmark
- Volunteers
- 360 people
- Sponsor
- Claus Anders Bertelsen, PhD, MD
Post-Operative Pain
Evaluate the Analgesic Efficacy and Safety of VVZ-149 Injections for Post-Operative Pain Following Colorectal Surgery
The purpose of this Phase 2 study is to evaluate the efficacy and safety of an analgesic drug candidate, VVZ-149 Injections. The study is designed as randomized, double-blind, parallel, placebo-controlled study.
- Trial name
- NCT02489526
- Testing
- VVZ-149 Injections
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Vivozon, Inc.
Rectus Sheath Block, Transversus Abdominis Plane Block
Transversus Abdominis Plane and Rectus Sheath Block for Robotic Colectomy
This study aimed to evaluate the impact of ultrasound-guided bilateral transversus abdominis plane block combined with rectus sheath block on postoperative pain and recovery after robotic colectomy under an enhanced recovery…
- Conditions
- Rectus Sheath Block, Transversus Abdominis Plane Block, Enhanced Recovery After Surgery, Robotic Surgery
- Trial name
- NCT07624916
- Testing
- Ropivacaine, Saline
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Colorectal Cancer, Colorectal Surgery
Peripheral Autonomic Block (BAP) Plus Transversus Abdominis Plane Block (TAP) for Postoperative Analgesia After Minimally Invasive Left-Sided Colorectal Resection (BAPTAP)
Effective postoperative pain management is essential for enhanced recovery after laparoscopic colorectal surgery. This randomized, controlled, double-blind trial will compare conventional postoperative analgesia (intravenous…
- Conditions
- Colorectal Cancer, Colorectal Surgery, Anesthesia, Autonomic Nerve Block
- Trial name
- BAPTAP (NCT07388953)
- Testing
- Minimally Invasive Left-Sided Colorectal Resection, BAPTAP (Peripheral Autonomic Blockade + TAP Block), Trocar/Incision Infiltration
- Where
- Brazil
- Volunteers
- 140 people
- Sponsor
- Faculdade de Ciências Médicas de Minas Gerais
Analgesia, Patient-Controlled, Epidural Analgesia
Intrathecal Morphine Analgesia vs. Continuous Epidural Analgesia vs. Systemic Analgesia in Colorectal Surgery.
The purpose of this study is to determine which postoperative analgesia is optimal after colorectal surgery. The investigators will compare intrathecal morphine, continuous epidural analgesia and standard systemic analgesia.
- Conditions
- Analgesia, Patient-Controlled, Epidural Analgesia, Anesthesia; Spinal, Morphine
- Trial name
- KOLORIT (NCT03007121)
- Testing
- Morphine intrathecal, Bupivacaine + Sufentanil epidural, Morphine intravenous
- Where
- Czechia
- Volunteers
- 75 people
- Sponsor
- Charles University, Czech Republic
Rectal Cancer, Postoperative Pain
Enhanced Recovery After Laparoscopic Colorectal Surgery
Investigators would like to test the effects of spinal anesthesia as an adjunct to general anesthesia in patients undergoing laparoscopic abdominoperineal rectal amputation.
- Trial name
- NCT05406765
- Testing
- Bupivacaine Injection
- Where
- Norway
- Volunteers
- 10 people
- Sponsor
- University Hospital of North Norway
Pain, Postoperative
Effect of Bilateral Erector Spinae Plan Block in Colorectal Surgery
In this study, it was aimed to evaluate the effects erector spina plane block (ESPB) on postoperative opioid consumption in the first 24 hours and pain scores after colorectal surgery.
- Trial name
- NCT05256953
- Testing
- Erector spina plane block + general anesthesia, Only general anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ondokuz Mayıs University
Colorectal Surgery, TAP Blocks
TAP Block Catheters vs Liposomal Bupivacaine for Pain Control After Colorectal Surgery
This is a prospective randomized study designed to compare the pain control from a single shot of liposomal bupivacaine (Exparel) against transversus abominus plane (TAP) catheters with ropivicaine bolus in patients undergoing…
- Trial name
- NCT03080142
- Testing
- Exparel, Ropivacaine
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- University of California, Davis
Colo-rectal Cancer, Anesthesia
The Influence of Type of Anesthesia on Postoperative Pain
The investigators designed a multi-center prospective randomized controlled trial to study the influence of the type of anesthesia on postoperative pain after laparoscopic colorectal cancer surgery.
- Trial name
- NCT04239794
- Testing
- Propofol, Sevoflurane
- Where
- 3 sites in South Korea
- Volunteers
- 468 people
- Sponsor
- Seoul National University Hospital
Abdominal Wall Hernia, Pancreatic Diseases
IV Acetaminophen for Post-Operative Pain Management in Enhanced Recovery After Surgery (ERAS) Population
Number of patients with unsatisfactory pain relief defined as average visual analog scale (VAS) more than 5 with or without requirement of IVPCA for pain relief during the first 48 hours postoperative period will be compared…
- Conditions
- Abdominal Wall Hernia, Pancreatic Diseases, Bowel Disease, Gastric Disease
- Trial name
- NCT03198871
- Testing
- Acetaminophen Injectable Product, Sodium Chloride 0.9%, Intravenous
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Kathirvel Subramaniam
Ibuprofen, Ketorolac
IV Ibuprofen vs Ketorolac in Post Operative Pain in Colorectal Cancer Surgeries in Obese Patient
The aim of this study is to assess the Efficacy of IV Ibuprofen and Ketorolac in the Management of Postoperative Pain in obese patients Following abdominal cancer surgery.
- Conditions
- Ibuprofen, Ketorolac, Colorectal Cancer
- Trial name
- NCT05782608
- Testing
- IV ibuprofen, IV ketorolac
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Postoperative Pain
Evaluation of Preoperative Use of Pregabalin on Postoperative Analgesia After Laparoscopic Colorectal Surgery
The purpose of this study is to evaluate how effective is the preoperative administration of pregabalin 300mg, to attenuate postoperative pain and opioids consumption after laparoscopic colorectal surgery
- Trial name
- NCT01940224
- Testing
- Pregabalin, Morphine
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- Larissa University Hospital
Postoperative Pain
Effect of Transversus Abdominis Plane Block With Compound Lidocaine and Esketamine on Pain After Surgery
Purpose: To explore effects of ultrasound-guided transversus abdominis plane block with compound lidocaine and esketamine on postoperative pain after colorectal cancer surgery.
- Trial name
- NCT05122338
- Testing
- Normal saline, Ropivacaine, Compound lidocaine
- Volunteers
- 160 people
- Sponsor
- Tianjin Medical University General Hospital
Post-operative Pain, Postoperative Nausea
Trial of a Transversus Abdominis Plane (TAP) Block in Laparoscopic Colorectal Surgery
Keyhole surgery for bowel disease has brought great benefits, enabling patients to recover quicker from surgery and so return to normal activities.
- Conditions
- Post-operative Pain, Postoperative Nausea, Postoperative Complications
- Trial name
- NCT00830089
- Testing
- Levobupivicaine 0.25%
- Where
- United Kingdom
- Volunteers
- 66 people
- Sponsor
- University of Nottingham
Postoperative Pain, Postoperative Nausea and Vomiting
A Comparison of Targinact vs. Oxycodone on Gut Function After Colorectal Surgery
Two key requirements for discharge from hospital after major abdominal surgery are adequate oral analgesia and resumption of oral nutrition.
- Trial name
- TACS (NCT02109640)
- Testing
- Targinact, Oxycodone, Laparoscopic segmental colectomy
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University of Edinburgh
Urinary Retention
Early Post-operative Removal of Urethral Catheter in Patients Undergoing Colorectal Surgery With Epidural Analgesia
Patients undergoing colon or rectal surgery will usually have a urinary catheter (silicone tube) placed in the bladder at the time of operating to monitor kidney function during surgery and in the post-surgery period.
- Trial name
- NCT01508767
- Testing
- Removal of urethral catheter
- Where
- Ireland
- Volunteers
- 41 people
- Sponsor
- University College Hospital Galway