Clinical trials: Pain Disorder
Pain, Menstrual, Primary Dysmenorrhea
Music for Pain in Primary Dysmenorrhea
Primary dysmenorrhea is defined as lower abdominal pain that occurs during menses and is not secondary to any type of pelvic disease. It is considered the most common condition in reproductive age women.
- Trial name
- NCT03593850
- Testing
- Music group, Silence Group
- Where
- Colombia
- Volunteers
- 649 people, healthy volunteers welcome
- Sponsor
- Universidad del Rosario
Plantar Fasciitis
Plantar Heel Pain: Multisegment Foot Motion and Muscle Function, FFI Translation, and Evaluation of Treatments
Plantar fasciitis (PF) is a prevalent musculoskeletal condition of plantar heel pain (PHP) that leads to pain, functional limitations, and reduced quality of life, especially among active adults aged 25 to 65.
- Trial name
- NCT03161314
- Testing
- Strengthening exercises, Stretching exercises
- Where
- 2 sites in Thailand
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Post Surgical Ocular Inflammation and Pain
Safety and Efficacy of KPI-121 in Subjects With Postsurgical Inflammation and Pain
The primary objective of the study is to investigate the efficacy and safety of KPI-121 1.0% ophthalmic suspension compared to placebo in subjects who have undergone cataract surgery.
- Trial name
- NCT02793817
- Testing
- KPI-121 1% Ophthalmic Suspension dosed BID, Vehicle of KPI-121 Ophthalmic Suspension dosed BID
- Where
- 35 sites in United States
- Volunteers
- 520 people
- Sponsor
- Kala Pharmaceuticals, Inc.
Migraine
To Evaluate the Blockade of CGRP in Preventing PACAP-38 Induced Migraine-like Attacks With AMG 334 in Migraine Patients
Phase I, Randomized, Parallel-group, Double-Blind, Placebo-Controlled, Single Dose Study to Evaluate the Blockade of CGRP Receptor by AMG 334 in Preventing PACAP-38 Induced Migraine-like Attacks in Migraine Patients.
- Trial name
- NCT02542605
- Testing
- Erenumab, PACAP-38 Challenge Agent
- Where
- 3 sites in United States, Belgium and 1 more
- Volunteers
- 35 people
- Sponsor
- Amgen
Musculoskeletal Pain
Comparing Five Oral Analgesics for Treatment of Acute Pain in the Emergency Department (ED)
This study compares the efficacy of five oral analgesics: 5 mg oxycodone + 325 mg acetaminophen, 5 mg hydrocodone + 300 mg acetaminophen, 30 mg codeine + 300 mg acetaminophen, 400 mg ibuprofen + 1000 mg acetaminophen, and 800 mg…
- Trial name
- NCT03173456
- Testing
- oxycodone/APAP, hydrocodone/APAP, codeine/APAP
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Albert Einstein College of Medicine
Acute Lymphoblastic Leukemia, Neuropathy
Therapeutic Interventions For Pain Induced By Vincristine Treatment For Childhood Acute Lymphoblastic Leukemia (ALL)
Neuropathic pain / peripheral neuropathy (NP/PN) is a known painful complication of vincristine (VCR) therapy; evidence supporting the best treatment plan for pediatric patients is limited.
- Conditions
- Acute Lymphoblastic Leukemia, Neuropathy, Neuropathic Pain
- Trial name
- TINALL (NCT01506453)
- Testing
- gabapentin
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- St. Jude Children's Research Hospital
Pain, Postpartum Depression
Postpartum Perineal Pain After Obstetric Anal Sphincter Injuries
Obstetric anal sphincter injuries (OASIS) encompass both third and fourth degree perineal tears. These tears can have a significant impact on women's quality of life in the short and long term.
- Trial name
- NCT03470675
- Testing
- Epidural saline + IV saline, Epidural morphine 3 mg + IV saline, Epidural morphine 3 mg + IV ketamine 0.3 mg/kg
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Northwestern University
Miscarriage
Virtual Reality in MVA for Miscarriage
We are investigating the use of a virtual reality programme to reduce pain and anxiety experienced during manual vacuum aspiration.
- Trial name
- NCT04466956
- Testing
- Virtual reality
- Where
- 2 sites in United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Barts & The London NHS Trust
Migraine
Efficacy and Tolerability of Rimegepant for the Acute Treatment of Migraine in Adults Unsuitable for Triptan Use
This study is being conducted to evaluate the efficacy and tolerability of rimegepant in a population of adults that are unsuitable for triptan medications due to a previous intolerance, lack of efficacy, or contraindication…
- Trial name
- NCT05509400
- Testing
- Rimegepant
- Where
- 93 sites in United States, Australia and 13 more
- Volunteers
- 813 people
- Sponsor
- Pfizer
Pain, Fibromyalgia
An Efficacy Study of Combination of Tramadol and Acetaminophen Tablets in the Treatment of Participants With Fibromyalgia Pain
The purpose of this study is to evaluate the analgesic effect of combination of tramadol hydrochloride and acetaminophen in participants for treatment of fibromyalgia pain (chronic widespread pain and presence of tender points).
- Trial name
- NCT00766675
- Testing
- Tramadol hydrochloride, Acetaminophen
- Volunteers
- 80 people
- Sponsor
- Johnson & Johnson Taiwan Ltd
Sickle Cell Disease
Home-Based Intervention for Chronic Pain in Adults With Sickle Cell Disease
This project will evaluate AppliedVR's EaseVRx - a multi-modal, skills-based, 8-week, virtual reality, home intervention - in an exploratory randomized controlled trial for self-management of chronic pain among Black, young…
- Trial name
- NCT04906707
- Testing
- EaseVRx, Audio-only version of EaseVRx
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Emory University
Pain, Acute, Pain, Chronic
Development and Validation of a Digital Pain-Reduction Kit for Musculoskeletal Injuries
This study will test the effectiveness of an evidence-based, multi-modal, "digital pain-reduction kit" as a non-pharmacological supplement to managing patients with pain due to musculoskeletal injuries.
- Trial name
- NCT03187132
- Testing
- Digital Pain Reduction Kit, Active Control
- Where
- United States
- Volunteers
- 245 people
- Sponsor
- Cedars-Sinai Medical Center
Osteoarthritis of the Shoulder
SUPARTZ Versus Placebo in Osteoarthritis of the Shoulder
This clinical trial is to determine the safety and effectiveness of three injections of SUPARTZ (sodium hyaluronate) compared with phosphate buffered saline (PBS) for the treatment of glenohumeral osteoarthritis of the shoulder.
- Trial name
- NCT00479687
- Testing
- SUPARTZ®, Phosphate Buffered Saline
- Volunteers
- 300 people
- Sponsor
- Bioventus LLC
Acute Coronary Syndrome
Early Risk Stratification in ED Chest Pain Patients
In the management of adult chest pain patients presenting to an Emergency Department (ED) with suspected acute coronary syndrome (ACS), we aimed to evaluate the diagnostic accuracy of the combined use of a modified Thrombolysis…
- Trial name
- NCT02364271
- Testing
- Thrombolysis in myocardial infarction score, routine blood test for hs-cTnT, HEART score
- Where
- China
- Volunteers
- 602 people
- Sponsor
- Chinese University of Hong Kong
Pectus Excavatum
Prospective Trial: Pain Management After Pectus Excavatum Repair, Epidural Versus PCA
Pectus excavatum, the most common chest wall deformity, occurs in roughly one in 1000 children. Operative repair of the anterior thoracic concavity has transitioned to the minimally invasive approach with substernal bar placement…
- Trial name
- PectusEpiPCA (NCT01863498)
- Testing
- Epidural, PCA
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Children's Mercy Hospital Kansas City
Diabetes, Diabetes Mellitus, Type 1
Investigation of Pain During Subcutaneous Injections With Different Injection Speed and Volume Combinations
This trial is conducted in Europe. The aim of this trial is to assess and describe the pain in relation to subcutaneous (under the skin) injection of different combinations of injection speed and volume with respect to acceptance…
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Delivery Systems
- Trial name
- NCT01680328
- Testing
- 19 injections, sodium chloride 0.9% solution
- Where
- Germany
- Volunteers
- 82 people
- Sponsor
- Novo Nordisk A/S
Obstructive Sleep Apnea
A Pilot Study of Biomarkers in Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is common and is a risk factor for postoperative complications, including respiratory and cardiac events and delirium.
- Trial name
- Cytokine OSA (NCT02325687)
- Testing
- Lumbar Puncture (Standard-of-Care)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Hospital for Special Surgery, New York
Rotator Cuff Tear
Rotator Cuff Repair Using Standard Double Row Technique With Platelet Rich Fibrin Membrane vs. Standard Double Row Technique
This study is a single-blind, randomized study evaluating the 6 month and 2 year outcomes of patients treated with arthroscopic rotator cuff repair using one of two techniques.
- Trial name
- RCRPRFM (NCT02256891)
- Testing
- PRFM, Double Row
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- HealthPartners Institute
Migraine, Migraine With Aura
A Study of a Melatonin Receptor Agonist to Prevent Migraine
The purpose of this study is to see if ramelteon will reduce the number of migraine headaches over a 12 week period. The safety and tolerability of ramelteon will also be evaluated. Ramelteon has been approved by the U.S.
- Conditions
- Migraine, Migraine With Aura, Migraine Without Aura
- Trial name
- NCT00739024
- Testing
- Ramelteon
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Swedish Medical Center
Low Back Pain, Osteoarthritis
Long-term Open-Label Safety Study to Evaluate EN3409
The purpose of the long-terms study is to evaluate the safety, tolerability, and analgesic efficacy of EN3409 in subjects with moderate to severe chronic pain requiring continuous around-the-clock opioid analgesia for an extended…
- Conditions
- Low Back Pain, Osteoarthritis, Neuropathic Pain
- Trial name
- NCT01755546
- Testing
- EN3409
- Where
- 57 sites in United States
- Volunteers
- 304 people
- Sponsor
- BioDelivery Sciences International
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