Clinical trials: Pain Disorder
Sphincter of Oddi Dysfunction
Duloxetine in Patients With Suspected Functional Pancreatic/Biliary Pain (Sphincter of Oddi Dysfunction)
Open-label single center study of duloxetine in patients with SOD who have failed to respond to the standard treatments. This protocol is designed to explore the tolerability and efficacy of Duloxetine in the management of…
- Trial name
- SOD (NCT00471315)
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Medical University of South Carolina
Vulvodynia
Vulvodynia Pain Thresholds
Annotated pain maps will be created showing region and size of areas sensitive to mechanical stimulus in both women affected by vulvar pain and unaffected control patients.
- Trial name
- NCT04461210
- Testing
- Thermographic Imaging and Mechanical Pain Assessment
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Cystitis, Interstitial
Pilot Study Evaluating the Efficacy of Certolizumab Pegol for Interstitial Cystitis
A Randomized, Double-blind, Placebo Controlled Trial of Certolizumab Pegol in Women with Refractory Interstitial Cystitis/Bladder Pain Syndrome
- Trial name
- NCT02497976
- Testing
- Certolizumab pegol
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- ICStudy, LLC
Chronic Pain, Osteoarthritis
A Confirmatory Study of Fentanyl in Participants With Osteoarthritis or Low Back Pain
The purpose of this study is to evaluate efficacy and safety of fentanyl in opioid-naive participants with osteoarthritis (disorder, which is seen mostly in older persons, in which the joints become painful and stuff) or low back…
- Conditions
- Chronic Pain, Osteoarthritis, Low Back Pain
- Trial name
- NCT01008618
- Testing
- Fentanyl
- Where
- 59 sites in Japan
- Volunteers
- 218 people
- Sponsor
- Janssen Pharmaceutical K.K.
Chronic Pain
Veterans' Pain Care Organizational Improvement Comparative Effectiveness Study
Background and significance: Treatment with opioid pain medications (like hydrocodone and morphine) is common for severe pain, but studies show these medications may not always help and can cause serious problems.
- Trial name
- VOICE (NCT03026790)
- Testing
- Medication management, Non-pharmacological pain management, Buprenorphine-Naloxone
- Where
- United States
- Volunteers
- 820 people
- Sponsor
- University of Minnesota
Amputation, Phantom Limb
Naval Medical Center San Diego (NMCSD) - Ambulatory Continuous Peripheral Nerve Blocks for Treatment of Post-Amputation Phantom Limb and Stump Pain
The purpose of this research study is to determine if putting local anesthetic-or numbing medication-through one or two tiny tube(s) placed next to the nerves that go to an amputated limb will decrease phantom limb and/or stump…
- Conditions
- Amputation, Phantom Limb, Stump Pain
- Trial name
- NCT00768248
- Testing
- perineural ropivacaine
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of California, San Diego
Drug Use Disorders, Drug Abuse
Evaluation of a Health Plan Initiative to Mitigate Chronic Opioid Therapy Risks
Background: Sixty million American adults suffer from moderate to severe chronic pain. Of these, 5 to 8 million currently use opioids long-term.
- Conditions
- Drug Use Disorders, Drug Abuse, Drug Addiction, Drug Dependence
- Trial name
- CARE (NCT02224508)
- Volunteers
- 1,588 people
- Sponsor
- Kaiser Permanente
Interstitial Cystitis, Painful Bladder Syndrome
Efficacy and Safety Study of Uracyst to Treat Interstitial Cystitis/Painful Bladder Syndrome
A new device for interstitial cystitis is compared to inactive control to determine if it is safe and effective. The study lasts approximately 7 weeks with a 19-week follow-up period.
- Trial name
- NCT00919113
- Testing
- 2% sodium chondroitin sulfate
- Where
- 20 sites in United States
- Volunteers
- 98 people
- Sponsor
- Watson Pharmaceuticals
Postoperative Pain
Non-invasive Assessment of Immediate Postoperative Analgesia Using Analgesia/Nociception Index (ANI)
The aim of this study is to evaluate the clinical performance on Analgesia/Nociception Index (ANI) in the assessment of immediate postoperative analgesia in PACU in adult patients undergoing general anesthesia.
- Trial name
- NCT01633320
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Hôpital Edouard Herriot
Neuropathic Pain
Intraoral Administration of Botox in Patients With Dentoalveolar Neuropathic Pain
Onabotulinum toxin type A (BoNT-A) is a potent neurotoxin that has been reported to have an effect on afferent (sensory) neurons independent of its action on muscle tone and secretory glands at the periphery.In human studies, the…
- Trial name
- NCT03848143
- Testing
- onabotulinum toxin A
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Isabel Moreno Hay
Pain
"Lidocaine 4% Cream (LMX4) vs Placebo for Pain Due to Lumbar Puncture in Infants 0-60 Days of Age."
The study's hypothesis is LMX4 cream, a topical anesthetic cream, will reduce the pain of infants undergoing Lumbar Puncture (spinal tap).
- Trial name
- NCT00533468
- Testing
- Lidocaine Cream 4%
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- State University of New York at Buffalo
Stable Angina
Aspirin Resistance and Percutaneous Coronary Intervention (PCI)
The objective of this study is to evaluate if aggressive antiplatelet therapy would reduce ischemic events in aspirin (ASA) resistant patients after percutaneous coronary intervention (PCI).
- Trial name
- RESIST (NCT01103440)
- Testing
- Intravenous Glycoprotein inhibitor + ASA, Clopidogrel, Antiplatelet Therapy (ASA, Clopidogrel)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Coronary Heart Disease
Clinical Evaluation of Magnetic Resonance Imaging in Coronary Heart Disease-2
CE-MARC 2 is a randomised controlled trial to determine diagnosis and patient management in patients presenting to outpatient clinics with suspected stable angina.
- Trial name
- CE-MARC2 (NCT01664858)
- Testing
- 3T CMR, SPECT, CT calcium score
- Where
- 6 sites in United Kingdom
- Volunteers
- 1,202 people
- Sponsor
- University of Leeds
Benign Breast Disease, Fibrocystic Disease of Breast
Effects of Tamoxifen in Premenopausal Women With Benign Breast Disease Not at High-Risk of Developing Breast Cancer
The purpose of the study is to determine the efficacy and relapse rate of low dose, short duration treatment with tamoxifen in benign breast disease amenable to hormonal therapy with respect to etiology and estrogen receptor…
- Conditions
- Benign Breast Disease, Fibrocystic Disease of Breast, Fibroadenoma, Mastalgia
- Trial name
- NCT00999921
- Testing
- Tamoxifen, Evening Primrose Oil
- Where
- India
- Volunteers
- 256 people
- Sponsor
- Medical College and Hospital Kolkata
Shoulder Pain
Effectiveness of Biofreeze® on Shoulder Pain and In-office Exercise Performance
Biofreeze® is a topical analgesic, frequently used in the office or given to a patient for home use as a way to mitigate pain during the course of treatment.
- Trial name
- BFShld01 (NCT01827306)
- Testing
- Biofreeze
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Sport and Spine Rehab Clinical Research Foundation
Burns, Wound Care
Comparison of Virtual Reality and Passive Distraction on Burn Wound Care Pain in Adolescents
Relief of severe burn wound care pain may require both medications to relieve pain and non-medication interventions,such as distraction. Little is known about distraction's effectiveness.
- Conditions
- Burns, Wound Care, Pain
- Trial name
- NCT01812655
- Testing
- Virtual Reality, Passive Distraction
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Arkansas
Breast Carcinoma
Fluocinonide Cream in Treating Symptoms of Vaginal Dryness and Painful Sexual Intercourse In Patients With Breast Cancer Undergoing Hormone Therapy
This phase II trial studies how well giving fluocinonide cream works in treating symptoms of vaginal dryness and painful sexual intercourse in patients with breast cancer undergoing hormone therapy.
- Trial name
- NCT01422408
- Testing
- Fluocinonide Cream, Management of Therapy Complications, Questionnaire Administration
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- OHSU Knight Cancer Institute
Adiposity
Kybella With Triamcinolone
This study is to evaluate the efficacy, edema and pain associated with Kybella(TM) injections of the upper neck in the treatment of submental fat with varying low concentrations of triamcinolone acetonide plus low doses of…
- Trial name
- NCT03361176
- Testing
- Injectable sodium deoxycholate, Injectable sodium deoxycholate with Triamcinolone acetate
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Goldman, Butterwick, Fitzpatrick and Groff
Chronic Pain, Neuropathic Pain
Intraoperative Neuromonitoring Recording With a Novel SCS Paddle
The purpose of this study is to demonstrate safety and efficacy of a new spinal cord stimulation paddle electrode which is able to target the dorsal horns, dorsal nerve roots, and dorsal columns.
- Conditions
- Chronic Pain, Neuropathic Pain, Failed Back Surgery Syndrome, Complex Regional Pain Syndromes
- Trial name
- NCT05045625
- Testing
- HD Study Electrode
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Albany Medical College
Osteoarthritis of Knee
Efficacy and Safety of MM-II for Treatment of Knee Pain in Subjects With Symptomatic Knee Osteoarthritis
This is a phase IIb, randomized, double-blind, placebo-controlled study to determine the efficacy and safety of MM-II in subjects with symptomatic knee OA as compared to matching placebo.
- Trial name
- NCT04506463
- Testing
- MM-II dose I, MM-II dose II, MM-II dose III
- Where
- 25 sites in United States, Denmark and 1 more
- Volunteers
- 397 people
- Sponsor
- Sun Pharmaceutical Industries Limited
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