Clinical trials: Pain Disorder
Low Back Pain, Degeneration of Lumbosacral Intervertebral Disc
The Underlying Mechanism of Spinal Manipulative Therapy and the Effect of Pain on Physical Outcome Measures
The purpose of this study is to compare changes in spinal stiffness and back muscle activity between spinal manipulative therapy (SMT) responders, non-responders and asymptomatic participants.
- Conditions
- Low Back Pain, Degeneration of Lumbosacral Intervertebral Disc, Muscle Weakness, Spine Stiffness
- Trial name
- NCT01761838
- Testing
- SMT for low back pain patients, Pain induction (optional), Low back pain participants without SMT
- Where
- Canada
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Pain, Opioid Use
Comparison of Quadratus Lumborum Block Types
This study will compare the quality of analgesia and reduction of opioid use, between standard of care and two groups of local anesthetic blocks in different location in the quadratus lumborum plane, for postoperative pain…
- Conditions
- Pain, Opioid Use, Lumbar Disc Herniation
- Trial name
- NCT04588389
- Testing
- Ropivacaine injection Location 1, Ropivacaine injection Location 2, Multimodal Pharmacological Management
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Massachusetts, Worcester
Post-COVID-19
The Effects of Video-based Yoga Interventions for Patients With Post-corona Virus Disease
Aimed to understand if yoga exercises are superior to posture exercises as an alternative exercise therapy for relieving musculoskeletal pain, improving functional status, and improving quality of life during the post- corona…
- Trial name
- Yoga (NCT05374668)
- Testing
- Video-based Yoga Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 85 people
- Sponsor
- Istinye University
Arterial Occlusive Diseases
High Dose Candesartan Versus Quinapril for Restenosis Prophylaxis After Stent Angioplasty
The study is designed to test the hypothesis that high dose candesartan treatment compared to quinapril is able to reduce intima hyperproliferation and the restenosis rate after stent angioplasty in peripheral occlusive artery…
- Trial name
- NCT00154050
- Testing
- candesartan (drug) or quinapril (drug)
- Where
- Germany
- Volunteers
- 22 people
- Sponsor
- Technische Universität Dresden
Herniated Disc, Low Back Pain
Efficacy of PLDD Versus ESI in the Treatment of Lumbar Radicular Pain
The most common cause of lumbar radicular pain is intervertebral disc herniation with or without pressure on the nerve root, which leads to inflammation and pain.
- Trial name
- NCT05601791
- Testing
- Epidural Steroid Injection, Percutaneous Laser Disc Decompression
- Where
- Croatia
- Volunteers
- 116 people
- Sponsor
- Osijek University Hospital
Myocardial Infarction (MI), Chest Pain Rule Out Myocardial Infarction
The Rule-Out Acute Myocardial Infarction Using Aritifical Intelligence Electrocardiogram (ROMIAE) 2 Trial
This study is to see whether the AI ECG assisted protocol is as safe and efficacious as conventional protocol in early triage of suspected myocardial infarction.
- Trial name
- ROMIAE 2 (NCT07027891)
- Testing
- AI-ECG
- Where
- 12 sites in South Korea
- Volunteers
- 4,670 people
- Sponsor
- CHA University
Musculoskeletal Pain, Work Related Stress
Physiatrist Ergonomic Intervention on Work Related Musculoskeletal Pain in Surgeons
The goal of this randomized control trial is to learn if physical therapy coaching and education improves work-related muscle pain in surgeons more than education alone. The main focuses of this study are to: 1.
- Conditions
- Musculoskeletal Pain, Work Related Stress, Quality of Life, Grip
- Trial name
- NCT05946018
- Testing
- Educational video on ergonomics, Verbal physical therapy coaching sessions
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of Texas Southwestern Medical Center
Bipolar Disorder, Mania
The Efficacy and Safety of AChE Inhibitor Donepezil As Adjunctive Treatment to Mood Stabilizers in Acute Mania
There is a high rate of partial response to standard thymoleptic medication. In this study the investigators want to evaluate the safety and efficacy of donepezil as adjunctive treatment to mood stabilizers in bipolar disorder…
- Trial name
- NCT01191918
- Testing
- Donepezil and Lithium
- Volunteers
- 40 people
- Sponsor
- Shanghai Mental Health Center
Multiple Sclerosis
TakeCharge: Telephone Delivered Self-management Intervention for People With Multiple Sclerosis (MS)
The proposed project will evaluate the efficacy of a telephone-delivered self-management (T-SM) intervention for reducing the impact of secondary conditions in persons with multiple sclerosis (MS), including chronic pain…
- Trial name
- TakeCharge (NCT00944190)
- Testing
- Self-management intervention, Education
- Where
- United States
- Volunteers
- 166 people
- Sponsor
- University of Washington
Sickle Cell Disease, Vaso-occlusive Crisis
A Study of a Single Dose of Inclacumab to Reduce Re-admission in Participants With Sickle Cell Disease and Recurrent Vaso-occlusive Crises
This Phase 3 study will assess the safety and efficacy of a single dose of inclacumab, a P-selectin inhibitor, for a vaso-occlusive crisis (VOC) after an index VOC in participants with sickle cell disease (SCD).
- Conditions
- Sickle Cell Disease, Vaso-occlusive Crisis, Vaso-occlusive Pain Episode in Sickle Cell Disease
- Trial name
- NCT04927247
- Testing
- Inclacumab
- Where
- 59 sites in United States, Brazil and 12 more
- Volunteers
- 72 people
- Sponsor
- Pfizer
Depression, Chronic Pain
Neuromodulation to Facilitate the Effect of Ketamine
application of external neuromodulation along with ketamine infusion.
- Conditions
- Depression, Chronic Pain, Substance Abuse
- Trial name
- TMS/ketamine (NCT01816958)
- Testing
- co-administration of TMS and infused ketamine
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- The Neuroscience Center, LLC
Liver Cancer, Pain Management
Patient Controlled Epidural Analgesia Versus Intravenous Patient Controlled Analgesia for Post-Operative Pain Control in Patients Undergoing Elective Liver Resection
The purpose of this study is to learn whether patient-controlled epidural analgesia (PCEA) is a better method for managing pain after liver resection compared to patient-controlled analgesia (IV PCA).
- Trial name
- NCT02523443
- Testing
- IV PCA, PCEA
- Where
- 3 sites in United States
- Volunteers
- 231 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Hallux Valgus
Foot Orthoses in the Treatment of Painful Hallux Valgus
This randomized pilot feasibility trial will evaluate the feasibility of conducting a full-scale randomized controlled trial comparing custom-made, prefabricated, and sham foot orthoses in people with painful hallux valgus.
- Trial name
- NCT07781735
- Testing
- Podiatric Education, Exercise, Prefabricated foot orthoses
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- Université du Québec à Trois-Rivières
Chronic Pelvic Pain
CPP Among Somali Women in Norway: SCED
Chronic pelvic pain (CPP) in women is a condition associated with negative cognitive, behavioral, sexual and emotional consequences.
- Trial name
- NCT07820176
- Testing
- Multimodal physiotherapy
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- Kristiania University College
Stress Related Disorder, Pain
Analgesia Nociception Index for Pain Monitoring in Intensive Care Units
The aim of this study is to examine the usability of ANI in patients who will be treated in intensive care unit.
- Conditions
- Stress Related Disorder, Pain, Intensive Care Unit Syndrome
- Trial name
- NCT05313789
- Testing
- Analgesia Nociception Index (ANI)
- Volunteers
- 180 people
- Sponsor
- İstanbul Yeni Yüzyıl Üniversitesi
Spastic Hemiplegia
Evaluation of Spasticity, Neuropathic Pain, and Gait Analysis in Stroke Patients Receiving Tolperison Therapy After Botulinum Toxin Injection
Tolperison is an antispastic agent used in the treatment of spasticity. Studies on tolperison are limited, and the literature on its effectiveness against spasticity and neuropathic pain is also limited.
- Trial name
- NCT07482618
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Ayse Guc
Osteoporosis
Analgesic Effects of the Gastrolith, in Osteoporotic Patients Suffering From Recent Skeletal Pain Caused by Vertebral Fractures
This study aims to evaluate the safety and analgesic effect (efficacy) of Gastrolith powder (GASP) on skeletal pain caused by osteoporotic vertebral compression fractures (OVCF) versus placebo, primarily as assessed by the…
- Trial name
- NCT01482858
- Testing
- Gastrolith
- Where
- 5 sites in Israel
- Sponsor
- Amorphical Ltd.
Sciatica, Lumbar Disc Herniation
Electroacupuncture for Insomnia in Patients With Chronic Sciatica Due to Lumbar Disc Herniation: a Randomized Controlled Trial
The goal of this clinical trial is to learn if electroacupuncture can improve sleep in people with chronic sciatica caused by lumbar disc herniation. It will also assess the safety of this treatment.
- Conditions
- Sciatica, Lumbar Disc Herniation, Insomnia
- Trial name
- NCT07576348
- Testing
- Electroacupuncture
- Volunteers
- 114 people
- Sponsor
- Shanghai Yueyang Integrated Medicine Hospital
Pain, Anxiety
Active vs. Passive VR During Office-based ENT Procedures
The purpose of this research is to evaluate whether active virtual reality reduces pain and anxiety more effectively than passive virtual reality during office-based ENT procedures.
- Conditions
- Pain, Anxiety, Chronic Rhinosinusitis (CRS), Nasal Obstruction
- Trial name
- NCT07599826
- Testing
- Passive virtual reality headset or goggles, Active virtual reality headset or goggles
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Cedars-Sinai Medical Center
Physical Therapy, Orthopedic Disorder
EFFECT OF HIGH INTENSITY LASER IN PATELLOFEMORAL PAIN SYNDROME
The aim of this study is to investigate the effectiveness of high-intensity laser therapy on pain and lower extremity function in the treatment of patellofemoral pain syndrome.
- Trial name
- Laser (NCT05075525)
- Testing
- High Intensity Laser Therapy Group, Ultrasound and Transcutaneous Electrical Nerve Stimulation Group, Ultrasound and Interferential Current Stimulation Group
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Istanbul Medipol University Hospital