Clinical trials: Pain Intervention
Postoperative Pain
Efficacy and Safety of a Collagen Bupivacaine Implant in Women Following Abdominal Hysterectomy
The purpose of this study is to determine whether the CollaRx Bupivacaine implant is safe and effective in reducing the amount of narcotic pain medication needed to control pain during the first 24 hours after abdominal…
- Trial name
- NCT00624910
- Testing
- Bupivacaine Collagen Sponge (CollaRx®)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Innocoll
Acute Pain
A Single-arm Study Evaluating the Effectiveness and Safety of Suzetrigine (SUZ) for Acute Pain After Selected Surgeries
The purpose of this study is to evaluate the effectiveness, safety, and tolerability of SUZ for acute pain after laparoscopic procedures of the intraperitoneal or retroperitoneal cavities or arthroscopic orthopedic procedures.
- Trial name
- NCT06887959
- Testing
- Suzetrigine
- Where
- 17 sites in United States
- Volunteers
- 47 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Joint Disease
Post Market Clinical Follow-Up Study Protocol for PROFEMUR® TL Modular Femoral Stems
Sponsor is conducting this post market clinical follow-up (PMCF) study to evaluate the safety and efficacy of its total hip arthroplasty (THA) marketed in the European Union (EU) .
- Trial name
- NCT02239783
- Testing
- total hip arthroplasty implant
- Where
- Canada
- Volunteers
- 143 people
- Sponsor
- MicroPort Orthopedics Inc.
Chronic Pain
An Interventional Study to Compare the Efficacy and Tolerability With Targin® in Non-malignant Chronic Pain (GLORY)
Objectives: 1. Objective of main interest To assess the drop-out rate caused by adverse event* after 6 weeks treatment 2. Further objectives To assess the drop-out rate caused by adverse event* after 1 week treatment To assess…
- Trial name
- NCT01811186
- Testing
- Oxycodone/naloxone
- Where
- South Korea
- Volunteers
- 261 people
- Sponsor
- Mundipharma Korea Ltd
Coronary Artery Disease, Myocardial Ischemia
BIOFLOW-III Israel Satellite Registry
BIOTRONIK - SaFety and Performance Registry for a diabetic patient population with the .bimus Eluting Orsiro Stent System Within daily clinical practice - III
- Conditions
- Coronary Artery Disease, Myocardial Ischemia, Diabetes Mellitus Type 1 or 2
- Trial name
- NCT01895712
- Where
- 6 sites in Israel
- Volunteers
- 120 people
- Sponsor
- BIOTRONIK Israel
Pain, Cervical, Discogenic Pain
Evaluation of Efficacy and Safety of Intradiscal Gelified Ethanol in Refractory Cervical Discogenic Pain
The purpose of this study is to assesse safety and efficacy of the Intradiscal Gelified Ethanol for treatment in refractory cervical discogenic pain.
- Trial name
- DISCOCERV (NCT05969392)
- Testing
- Intradiscal Gelified Ethanol (Discogel)
- Where
- 2 sites in Italy
- Volunteers
- 60 people
- Sponsor
- Gelscom SAS
Uterine Fibroids, Bleeding
Study to Evaluate the Safety and Effectiveness of MRgFUS Compared With Myomectomy for the Treatment of Uterine Fibroids
The objective of this trial is to evaluate the safety and efficacy of ExAblate for the treatment of uterine fibroids. Women, seeking treatment for symptomatic uterine leiomyomata will be eligible for the study.Women who agree to…
- Conditions
- Uterine Fibroids, Bleeding, Pelvic Pain
- Trial name
- NCT01328067
- Testing
- Exablate 2100, Myomectomy
- Where
- United Kingdom
- Sponsor
- InSightec
Pain
Evaluation of DEX-IN During Outpatient Procedures
The primary objective of this study is to evaluate the analgesic efficacy of DEX-IN compared with placebo and active control (fentanyl), in subjects undergoing painful outpatient and office based procedures.
- Trial name
- NCT03348423
- Testing
- DEX-IN, Fentanyl
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Baudax Bio
Postoperative Pain, Abdominoplasty Surgery
Cohort 2 (Abdominoplasty) of: A Multi-surgery Assessment of ZYNRELEF (HTX-011)
Cohort 2 (subjects undergoing abdominoplasty) of a Phase 4, randomized, blinded, active-controlled, multicohort study to evaluate HTX-011 compared with bupivacaine HCl in subjects undergoing different surgical procedures See also…
- Conditions
- Postoperative Pain, Abdominoplasty Surgery, Multimodal Analgesia
- Trial name
- AMAZE (NCT06109428)
- Testing
- MMA regimen, ZYNRELEF kit components for administration, HTX-011
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- Heron Therapeutics
Acute Pain, Surgery
Clinical Study to Evaluate Clinical Impact of PGx-Guided Treatment for Patients Undergoing Elective Spinal Surgical Procedures
The purpose of this study is to evaluate the effect of pharmacogenetic (PGx) guided treatment when implemented into the pre-operative process for patients undergoing an elective spinal surgical procedure and requiring…
- Trial name
- NCT02599870
- Testing
- NeuroIDgenetix Test Panel
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- AltheaDx
Chronic Low Back Pain, Leg Pain
MIS MiLIF Versus Open
This study is being undertaken to compare the clinical outcomes of patients that have unilateral posterolateral lumbar interbody fusion using a traditional open approach versus the MiLIF procedure based on the MiCOR Precision…
- Trial name
- NCT00792129
- Testing
- The Atavi System
- Where
- 9 sites in United States
- Volunteers
- 113 people
- Sponsor
- Zimmer Biomet
Breakthrough Pain, Cancer
Efficacy and Tolerability of Intranasal Fentanyl Spray for the Treatment of Breakthrough Pain in Cancer Patients Older Than 18 Years
The aim of the study was to evaluate the safety and efficacy of intranasal fentanyl spray in cancer patients over four weeks, especially during cancer-related breakthrough pain (BTP) attacks.
- Trial name
- GENISIS (NCT00994760)
- Testing
- Instanyl (Intranasal Fentanyl)
- Where
- 168 sites in Germany
- Volunteers
- 131 people
- Sponsor
- Takeda
Low Back Pain
Lumbar Belt Benefit Compared to the Usual Care in the Treatment of Non-specific Low Back Pain
Lumbar belt benefit compared to the usual care in the treatment of non-specific low back pain -an interventional, prospective, multicenter, randomized, open and controlled.study
- Trial name
- LOMBACT (NCT04701073)
- Testing
- LombaStab belt
- Where
- 3 sites in France
- Volunteers
- 168 people
- Sponsor
- Thuasne
Chronic Pain
Fentanyl Sublingual Spray for the Treatment of Acute Procedure-related Pain in a Monitored Setting
Participants will be selected from patients who have been scheduled at the site for treatment of chronic pain without sedation. They will receive either fentanyl sublingual spray or a matching placebo sublingual spray that…
- Trial name
- NCT02138409
- Testing
- Fentanyl Sublingual Spray (FSS)
- Sponsor
- INSYS Therapeutics Inc
Coronary Artery Diseases
BIOFLOW-III VIP Russia Registry Orsiro Stent System
Clinical evaluation of the Orsiro LESS in subjects requiring coronary revascularization with Drug Eluting Stents (DES). Along with it, an explanatory (hypothesis-finding) problem will be investigated, whether the patient's body…
- Trial name
- NCT02247492
- Where
- 7 sites in Russia
- Volunteers
- 200 people
- Sponsor
- Biotronik Russia
Joint Disease
Post Market Clinical Follow-up Study Protocol for DYNASTY® BioFoam® Acetabular Components
Sponsor is conducting this post market clinical follow-up (PMCF) study to evaluate the safety and efficacy of its total hip arthroplasty (THA) components marketed in the European Union (EU) .
- Trial name
- NCT02149667
- Testing
- total hip arthroplasty implant
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- MicroPort Orthopedics Inc.
Breakthrough Cancer Pain
Instanyl® Non-Interventional Study
The aim of this study is to describe the use of Instanyl® (Intranasal fentanyl spray) in the treatment of breakthrough pain (BTP) in cancer patients by success of dose titration and distribution of dose strength.
- Trial name
- INIS (NCT01045603)
- Where
- 65 sites in Denmark, France and 5 more
- Volunteers
- 309 people
- Sponsor
- Takeda
Critical Limb Ischemia, Peripheral Vascular Disease
Study of Remodulin in Patients With Critical Limb Ischemia With No Planned Revascularization Procedures
The purpose of this study is to assess and compare the safety of continuous and daily subcutaneous Remodulin therapy in patients with critical limb ischemia (CLI) with no planned vascular interventional procedures; and to…
- Conditions
- Critical Limb Ischemia, Peripheral Vascular Disease, Foot Ulcers, Rest Leg Pain
- Trial name
- NCT00060996
- Testing
- Remodulin® (treprostinil sodium) Injection
- Where
- 7 sites in United States
- Volunteers
- 30 people
- Sponsor
- United Therapeutics
Oral Surgical Procedures, Pain
Pilot Study to Evaluate the Use of OroScience Topical Oral Wound Emulsion in Post Operative Wound Healing
The purpose of this pilot study is to determine if Topical Oral Wound Emulsion (TOWE) assists with dental wound healing and relieves pain from oral wounds.
- Trial name
- NCT00596141
- Testing
- OroScience Topical Oral Wound Emulsion
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- OroScience, Inc.
Idiopathic Parkinson's Disease
Observational Study With Neupro® to Evaluate the Patient´s Perception of Pain Associated With Parkinson´s Disease
The primary objective of this study is to evaluate the perception of pain associated with Parkinson´s Disease in patients who receive Neupro® for the first time.
- Trial name
- NEUPAD (NCT01606670)
- Where
- 27 sites in Austria, Germany
- Volunteers
- 93 people
- Sponsor
- UCB Pharma GmbH