Clinical trials: Pain Management
Postoperative Pain, Acute, Hemodynamics
Nalbuphine Timing Effects on Hemodynamics and Analgesia in Elderly Patients
In total knee arthroplasty (TKA), the use of a tourniquet and controlled hypotension is common. However, ischemia-reperfusion injury induced by the tourniquet and inappropriate controlled hypotension can lead to cardiac and…
- Conditions
- Postoperative Pain, Acute, Hemodynamics, Total Knee Arthroplasty (TKA)
- Trial name
- TKA (NCT07271849)
- Testing
- Nalbuphine Hydrochloride injection was administered during anesthesia induction., Nalbuphine Hydrochloride injection was administered after cement implantation., Standard general anesthesia regimen ( nalbuphine was not administered throughout the entire anesthesia process.)
- Where
- China
- Volunteers
- 162 people
- Sponsor
- Qianfoshan Hospital
Pain, Acute
Intrathecal Nalbuphine is a Comparable Safer Alternative to Fentanyl for Intraoperative Pain Management During Uterine Exteriorization
In case of cesarean section (CS) delivery, spinal anesthesia is the best anesthetic choice. It is simple to perform with rapid onset of anesthesia and lower incidence of failed block.
- Trial name
- NCT04689217
- Testing
- intrathecal drug injection
- Where
- Egypt
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Cairo University
Cataract
Clinical Study of the Efficacy of the Ophthalmic Emulsion PRO-145 for Inflammation and Pain After Phacoemulsification
objective: To evaluate the efficacy of the ophthalmic emulsion PRO-145 in the treatment of inflammation and pain after phacoemulsification.
- Trial name
- PRO-145/III (NCT03693989)
- Testing
- Difluprednate 0.05%, Prednefrin
- Where
- 5 sites in Mexico
- Volunteers
- 178 people
- Sponsor
- Laboratorios Sophia S.A de C.V.
Complex Regional Pain Syndromes, CRPS
Effect of Delta-9-Tetrahydrocannabinol on the Prevention of Chronic Pain in Patients With Acute CRPS (ETIC-Study)
The purpose of this study is to determine whether application of low dose Delta9-Tetrahydrocannabinol can prevent the development of chronic pain in patients with acute CRPS.
- Trial name
- NCT00377468
- Testing
- Delta9-Tetrahydrocannabinol
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Postoperative Pain
Interscalene Versus Combined Infraclavicular-suprascapular Nerve Blocks
The aim of this trial is to compare the analgesic efficiency and hemi-diaphragmatic paralysis of the standard ultrasound-guided interscalene (ISB) brachial plexus block with the combined use of costoclavicular approach of…
- Trial name
- NCT03628950
- Testing
- ICSSB group, ISB group
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Fayoum University Hospital
Children's Distress During Flu Vaccination
Reducing Children's Distress Towards Flu Vaccinations
Millions of children in North America receive an annual flu vaccination, many of whom are at risk of experiencing severe distress. Children frequently use technologically advanced devices such as computers and cell phones.
- Trial name
- NCT01529021
- Where
- Canada
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Supratentorial Tumors
Comparison of Systemic Opioid (Morphine) and Pre-Incision Bilateral Scalp Nerve Block for Pain Management in Craniotomy Patients
The goal of this randomized controlled clinical trial is to compare the effectiveness of systemic opioids versus pre-incision bilateral scalp nerve block in managing intraoperative noxious stimuli and postoperative pain in adult…
- Trial name
- NCT07425678
- Testing
- Scalp nerve block, Morphine, Lidocaine
- Where
- Pakistan
- Volunteers
- 62 people
- Sponsor
- Aga Khan University
Mammary Cancer
Open Technique Interpectoral Catheter for Postoperative Analgesia in Modified Radical Mastectomy
patients undergoing modified radical mastectomy were divided into two groups. patients in catheter group were placed a catheter with open technique by the surgeon in the pectoral area.
- Trial name
- NCT03204708
- Testing
- catheter, iv analgesia
- Volunteers
- 86 people
- Sponsor
- Istanbul University
Procedural Pain
Intranasal Versus Intravenous Fentanyl For Procedural Analgesia in Preterm Neonates
Pain in neonatal life has profound long-term developmental impacts, so pain control is crucial. The intranasal (IN) route is a minimally invasive method for rapidly delivering fentanyl to provide short-term analgesia and sedation…
- Trial name
- NCT07190625
- Testing
- fentanyl intravenous, Fentanyl intranasal using atomizer, fentanyl intranasal direct
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Ain Shams University
Recovery, Analgesia And Delirium Profiles At Laparoscopic Abdominal and Gynecologic Surgeries With Processed EEG Monitoring
Recovery, Analgesia And Delirium Profiles At Laparoscopic Abdominal and Gynecologic Surgeries With Processed EEG Monitoring
The aim of this study is to evaluate the effects of processed electroencephalogram (pEEG) monitoring on recovery and extubation times, length of stay in the post-anesthesia care unit (PACU), postoperative pain, patient comfort…
- Trial name
- TandRT (NCT07670689)
- Testing
- Bispectral index monitoring
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 136 people
- Sponsor
- Cukurova University
Trauma, Trauma Injury
Liposomal Bupivacaine Intercostal Nerve Block vs Thoracic Epidural for Regional Analgesia in Multiple Rib Fractures
Management of traumatic rib fractures continues to be a challenge for trauma surgeons. Currently, many analgesic options are available to patients suffering from rib fractures.
- Conditions
- Trauma, Trauma Injury, Pain, Acute
- Trial name
- NCT03574376
- Testing
- Bupivacaine Liposome Injection, Bupivacaine
- Where
- United States
- Volunteers
- 258 people
- Sponsor
- Chadrick Evans
Trauma
Pain Control After Trauma
Using Virtual Reality as a form of pain control for trauma patients.
- Trial name
- VRHTrauma (NCT00739076)
- Testing
- Virtual Reality
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- University of Washington
Pain, Constipation
Effect of Lidocaine and Esmolol to Improve the Quality of Recovery
The purpose of this prospective, randomized, double-blinded, active-controlled study is: To assess the effectiveness of systemic administration of lidocaine and esmolol in combination (vs.
- Conditions
- Pain, Constipation, Nausea, Vomiting
- Trial name
- NCT01114997
- Testing
- Lidocaine, Esmolol, Lidocaine + Esmolol (Combo)
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Cedars-Sinai Medical Center
Pain, Postoperative
The Effect of IV Dexamethasone on the Duration of Analgesia of Spinal Anaesthesia for C-Sections at a Jamaican Hospital
Dexamethasone is one of many adjuncts tested to prolong the duration of spinal anesthesia and its analgesic effect. The intent of this, a single-site, double-blinded, randomized controlled trial, is to determine if a single…
- Trial name
- NCT04624360
- Testing
- Dexamethasone
- Where
- Jamaica
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The University of The West Indies
Post Operative Pain Management
Peri-capsular Nerve Group Block Versus Fascia Iliaca Block for Hip Arthroplasty
In this study, the investigator will examine the efficacy of Pericapsular nerve group (PENG) block in hip surgeries as a post-operative pain management technique in comparison with fascia Iliaca block in hip surgeries
- Trial name
- NCT03783247
- Testing
- Pericapsular nerve group block, Fascia Iliaca BLock
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Femoral Neck Fracture
Fascia Iliaca Block in the Emergency Department for Analgesia After Femoral Neck Fracture
Femoral neck fracture is very common in the elderly and can produce severe to moderate pain. As this pathology is not life-threatening, waiting time in the emergency department may be prolonged due to the high number of…
- Trial name
- NCT02433548
- Testing
- Fascia iliaca block
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Postdural Puncture Headache, Epidural Analgesia, Obstetric
A Prospective Cohort Study to Evaluate the Safety, Efficacy, and Usability of the EpiZact Device
The purpose of the study is to learn more about a new device, the EpiZact Epidural Device, that may be helpful for reducing the likelihood of wet tap when a labor epidural is placed.
- Trial name
- NCT06729255
- Testing
- EpiZact-assisted epidural placement
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Oregon Health and Science University
Obesity, Morbid, Surgery
Multimodal Analgesia Effect on Post Surgical Patient
Patients undergoing Bariatric Surgery at the University of California Davis Medical Center will be divided into two groups, one receiving Standard of Care pain control medications vs the second group which will receive…
- Conditions
- Obesity, Morbid, Surgery, Bariatric Surgery Candidate
- Trial name
- NCT04240626
- Testing
- Neurontin, Dilaudid Injectable Product, Marcaine Injectable Product
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, Davis
Pain Management
Regional Anesthesia to Reduce Opioid Use Following Functional Endoscopic Sinus Surgery
Opioids are prescribed for moderate to severe pain disorders; however, there are contraindications and side effects that are common to all opioids.
- Trial name
- NCT03757715
- Testing
- Bupivacaine, Dexamethasone
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Alabama at Birmingham
Cancer
Impact of Therapeutic Osteopathy-hypnosis on Cancer Patients.
Osteopathy is recognized as a beneficial complementary approach for cancer patients. By addressing tissue mobility, circulation, and muscle tension, it helps improve physical comfort, reduce musculoskeletal pain, and foster…
- Trial name
- HYPOSTEO (NCT07860476)
- Testing
- Osteopathy, Hypnosis
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Institut Rafael