Clinical trials: Pain Management and Care
Abdominal Pain, Isolated Extremity Fracture
Morphine or Ketamine for Analgesia
Pain is common in children presenting to the emergency department but is frequently undertreated, leading to both short- and long-term consequences.
- Conditions
- Abdominal Pain, Isolated Extremity Fracture, Pain, Pediatrics
- Trial name
- MoKA (NCT06835504)
- Testing
- Ketamine hydrochloride, Morphine sulphate
- Where
- 8 sites in United States
- Volunteers
- 1,010 people
- Sponsor
- Columbia University
Myalgia of Mastication Muscle
Self-management and Home Exercises for the Treatment of Masticatory Muscle Pain. A Clinical Trial
The objective of this study was to compare the clinical effectiveness of self-management (SM) together with mandibular home exercises (EX) in the treatment of myalgia of the masticatory muscles.
- Trial name
- NCT06054490
- Testing
- Self-management, Home exercises
- Volunteers
- 50 people
- Sponsor
- Universidad Nacional Andres Bello
Opioid Use Disorder (OUD), Chronic Pain
Mindfulness Texting for Medication Adherence and Chronic Pain Management
The goal of this clinical trial is to examine the effects of reminder and mindfulness text messages based on integrated Acceptance and Commitment Therapy and Mindfulness Based Relapse Prevention (ACT+MBRP) on medication adherence…
- Trial name
- MiMA (NCT07711795)
- Testing
- Mindfulness text messages
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of New Mexico
Acute Lymphoblastic Leukemia ALL
Children's Laughter and Fun Yoga as Adjunctive Pain Relief Following Chemotherapy.
The goal of this clinical trial is to learn if a home-based program that combines laughter and fun yoga can help lower pain in children receiving chemotherapy.
- Trial name
- CLAP (NCT07327138)
- Testing
- Laughter and Fun Yoga Program
- Where
- Lebanon
- Volunteers
- 60 people
- Sponsor
- Bahaa Bou Dargham
Analgesia, Sedation
Intranasal Dexmedetomidine for Procedural Pain Management in Elderly Adults in Palliative Care
Dexmedetomidine is allowed in Switzerland for intravenous (IV) medication in the intensive care unit in the adult patient. Its active molecule, Dexmedetomidine (Dex), is a selective and powerful α2-Adrenoreceptors (AR) agonist…
- Conditions
- Analgesia, Sedation, Anxiolysis
- Trial name
- INDEX (NCT03151863)
- Testing
- Opioids, Dexmedetomidine
- Where
- Switzerland
- Volunteers
- 33 people
- Sponsor
- Walid HABRE
Pain, Anesthesia
Impact of Intraoperative Non-invasive Analgesia Monitoring Using Nociception Level Index on Patient Management
This prospective randomised clinical trial aims to assess the impact of intraoperative nociception monitoring using NOL on anesthetic management during major abdominal surgery.
- Conditions
- Pain, Anesthesia, Perioperative Care
- Trial name
- NCT06804434
- Testing
- Lidocaine Intravenous Infusion, NOL
- Where
- Romania
- Volunteers
- 160 people
- Sponsor
- Osoian Cristiana
Palliative Care, Pain
A Study of Sativex® for Pain Relief in Patients With Advanced Malignancy.
The purpose of this study is to determine the effective dose range and to demonstrate a non-effective dose range of Sativex in patients with advanced cancer, who experience inadequate pain relief even though they are on optimized…
- Conditions
- Palliative Care, Pain, Cancer
- Trial name
- SPRAY (NCT00530764)
- Testing
- Sativex Low Dose, Sativex Medium Dose, Sativex High Dose
- Where
- 110 sites in United States, Belgium and 14 more
- Volunteers
- 360 people
- Sponsor
- GW Pharmaceuticals Ltd
Opioid Use, Injury Traumatic
A Pain and Coordination Plan for Reduced Opioid Use After Accidental Injuries
This clinical trial aims to lower the number of people who use opioids and improve the quality of health in patients who have experienced accidental injury by implementing a Pain and Coordination Plan (PAC-plan).
- Conditions
- Opioid Use, Injury Traumatic, Pain, Postoperative
- Trial name
- PAC-plan (NCT06055205)
- Testing
- PAC-plan
- Where
- Norway
- Volunteers
- 271 people
- Sponsor
- University of Oslo
Chronic Pain
Patient Activation to Address Chronic Pain and Opioid Management in Primary Care
Will a primary care-based behavioral intervention for patient activation and engagement and self-management, for patients with chronic pain who are taking opioid pain medication, result in better patient outcomes than Usual Care?
- Trial name
- NCT02290223
- Testing
- Behavioral Based Treatment Model
- Where
- 2 sites in United States
- Volunteers
- 376 people
- Sponsor
- Kaiser Permanente
Back Pain
Erector Spinae Plane Block vs. Usual Care for ED Patients With Mechanical Back Pain
The goal of this clinical trial is to compare the Erector Spinae plane (ESP) block, a nerve block, to usual care in emergency department patients with back pain.
- Trial name
- NCT05982483
- Testing
- Erector Spinae plane block using 20 ml of bupivicaine 0.25%, Usual care
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Island Health
Pain, Pain Acute
The PainSMART Research Program: Evaluating a Pain Education Strategy for Patients Seeking Primary Care Physiotherapy
The goal of this clinical trial is to test the PainSMART-strategy in a population of patients seeking primary care physiotherapy for pain related to muscles, joints and bones, so called musculoskeletal pain.
- Conditions
- Pain, Pain Acute, Pain, Chronic, Self Efficacy
- Trial name
- PainSMART (NCT06187428)
- Testing
- PainSMART-strategy, Usual physiotherapy management
- Where
- 6 sites in Sweden
- Volunteers
- 494 people
- Sponsor
- Kajsa Johansson
Central Nervous System Diseases
Dexmedetomidine in Patients After Intracranial Surgery
Dexmedetomidine is a highly selective a2-adrenoreceptor agonist that produces dose-dependent sedation and analgesia without respiratory depression.
- Trial name
- NCT01445639
- Testing
- Dexmedetomidine, Normal saline
- Where
- China
- Volunteers
- 192 people
- Sponsor
- Capital Medical University
Intensive Care Patients, Pain
The Effect of Acupressure Applied to Icu on Pain and Physiological Parameters
The aim of this experimental study is to determine the effect of acupressure applied to intensive care patients on pain and physiological parameters (blood pressure, heart rate, respiration and oxygen saturation).
- Trial name
- EFFECTOFACU (NCT06271226)
- Testing
- acupressure, control group
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Ondokuz Mayıs University
Analgesia, Critical Illness
Adjuvant Continuous Infusion of Nefopam Versus Standard of Care in Mechanically Ventilated Critically Ill Patients: Randomized Double-blind Controlled Study
The aim of this prospective, randomized, active control, double blinded study is to assess the effect and safety of continuous infusion nefopam in mechanically ventilated ICU patients compared to standard of care.
- Conditions
- Analgesia, Critical Illness, Mechanical Ventilation, Sedation
- Trial name
- NCT05071352
- Testing
- Nefopam, Standard of care in the ICU for assessment and management of pain, sedation, and delirium.
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Palliative Medicine, Pediatric ALL
Paediatric Palliative Care Pain Management in the Community
To describe the the barriers and facilitators experienced by carers and healthcare professionals when managing medicines for pain relief for infants, children, and young people approaching the end of life in out of hospital…
- Trial name
- PARAMOUNT (NCT04519632)
- Testing
- Qualitative study
- Where
- United Kingdom
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Southampton
Analgesia
Pharmacoeconomic Consequences Of Analgesia in the Intensive Care Unit (ICU)
This study will be a multicentre randomized, open-label, phase IIIb study. This study will evaluate two different techniques of sedation: an analgesia based regimen with remifentanil versus a conventional sedation based regimen…
- Trial name
- NCT00436345
- Testing
- Remifentanil, Propofol
- Where
- 6 sites in Italy
- Volunteers
- 39 people
- Sponsor
- GlaxoSmithKline
Ventilator Lung; Newborn
NIPE as an Indicator of Pain in Sedated/Ventilated Patient Under 3 Years-old Hospitalized in Intensive Care Unit
The main objective is to assess correlation between Newborn Infant Parasympathetic Index values and external evaluation by Comfort Behaviour Scale during painful medical cares in sedated intubated children admitted in pediatric…
- Trial name
- NIPE (NCT04195672)
- Testing
- NIPE (MDoloris®) and CBS values
- Where
- France
- Volunteers
- 32 people
- Sponsor
- University Hospital, Lille
Pain Management, Nursing Homes
Improving Pain Management in Nursing Homes: A Research Project to Enhance Care Practices
This study aims to improve the way pain is managed in nursing homes. It focuses on training staff, creating better systems to track pain, and involving residents and their families in decision-making.
- Conditions
- Pain Management, Nursing Homes, Elderly, Pain
- Trial name
- NCT06984042
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Centre Hospitalier de Gonesse
Behavior, Child
Effect of Virtual Reality on Dental Anxiety in Children
The aim of this study is to reduce dental anxiety in children by using virtual reality glasses (VRG) with a special content and innovative interactive methods, to determine the level of stress experienced by patients during…
- Trial name
- NCT05302154
- Testing
- Distraction by dentist, Distraction by cartoon movie, Distraction by virtual reality glasses
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Acute Pain
Rebooting Infant Pain Care: Using Machine Learning and Skin-to-Skin Contact to Exponentially Improve Neonatal Intensive Care Unit Practice
To address the current limitations related to infant pain assessment in the NICU, our international team of knowledge users and health/natural science/engineering/social science researchers have come together to build a machine…
- Trial name
- BabyAIBabyCalm (NCT05579496)
- Where
- 2 sites in Canada, United Kingdom
- Volunteers
- 400 people
- Sponsor
- York University