Clinical trials: Pain Modulation
Muscle Stretching Exercises, Pain Threshold
Muscle Stretching - the Potential Role of Endogenous Pain Inhibitory Modulation on Stretch Tolerance
This study investigates the influence of a remote, painful stimulus on stretch tolerance. Half of the participants will receive a conditioning painful stimulus following static stretching while the other half will rest quietly.
- Trial name
- NCT03713788
- Testing
- Cold pressor test
- Where
- Denmark
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University College of Northern Denmark
Headache, Migraine
Effect of Transmagnetic Stimulation on Conditioned Pain Modulation (CPM)
While some indications of the neural circuits involved in the Conditioned Pain Modulation (CPM) process are now available, there is still need to clarify what parts of the brain are essential for this process, whether the…
- Trial name
- NCT01501045
- Testing
- TMS system MagPro x100, Tonica Elektronik A/S, Denmark
- Where
- Israel
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Migraine
Investigation and Modulation of the Mu-Opioid Mechanisms in Migraine (in Vivo)
This study investigates whether non-invasive brain stimulation, given for 20 minutes/once per day for ten days (M-F) can reduce migraine pain.
- Trial name
- NCT02964741
- Testing
- Active Comparator
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Sleep Apnea, Chronic Pain Syndrome
Sleep and Pain Sensitivity
This project will assess patients with diagnosed obstructive sleep apnea, to investigate the impact of poor sleep on central pain mechanisms.
- Trial name
- NCT04246294
- Testing
- Continuous Positive Airway Pressure (CPAP)
- Where
- Denmark
- Volunteers
- 6 people
- Sponsor
- Aalborg University
Mechanisms and Modulators of Placebo Analgesia in Healthy Volunteers
The Effect of Oxytocin on Placebo Analgesia: an Experimental Study in Healthy Volunteers
Placebo responses contribute to medical treatment outcome. The purpose of this study is to determine whether a single intranasal application of oxytocin can increase the placebo response in an experimental model of placebo…
- Trial name
- NCT01886014
- Testing
- Oxytocin
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Work-related Illness
Central and Peripheral Sensitization, Pain Mediators in Thumb Pain Among Physiotherapists
The work-related thumb pain is a common problem among physiotherapists which deal with this experience at least once in their life.
- Trial name
- NCT05345496
- Where
- Italy
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Healthy
Pain Inhibitory Effects of a Single Painful Mechanical Stimulus Compared to Multiple and Multiple at Different Locations
The objective is to estimate the effects on pain thresholds of a single painful mechanical stimulus compared to multiple and multiple stimuli at different locations.
- Trial name
- NCT05730179
- Testing
- Mechanical Conditioning stimulus
- Where
- Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Josue Fernandez Carnero
Phantom Limb Pain
Use of Hand Prosthesis With Direct Nerve Stimulation for Treatment of Phantom Limb Pain
Phantom limb pain (PLP) is a frequent consequence of amputation, and it is notoriously difficult to treat. Amputation usually follows traumatic injuries or surgery following vascular diseases, diabetes, osteomyelitis or tumours…
- Trial name
- EPIONE (NCT02506608)
- Testing
- Operation of sensorized hand prosthesis
- Where
- Italy
- Volunteers
- 2 people
- Sponsor
- Paolo Maria Rossini
Arthritis, Rheumatoid, Pain
Pain Modulation in Rheumatoid Arthritis (RA) - Influence of Adalimumab
The purpose of this study is to obtain increased knowledge concerning central pain and fatigue processing in rheumatoid arthritis, and how these conditions are influenced by treatment with Tumor Necrosis Factor (TNF) blockade…
- Conditions
- Arthritis, Rheumatoid, Pain, Fatigue
- Trial name
- PARADE (NCT01197144)
- Testing
- adalimumab
- Where
- 2 sites in Sweden
- Volunteers
- 70 people
- Sponsor
- Karolinska Institutet
Neuropathic Pain
Exploring the Role of the GABAergic Modulation in Pain Transmission in Human
Neuropathic pain affects about 7% of the general population in European countries. Meta-analyses indicate that only a minority of neuropathic pain patients has adequate response to drug therapy and management of neuropathic pain…
- Trial name
- NDMC-101 (NCT03375034)
- Testing
- NDMC 20mg, NDMC60mg, Clonazepam 1.5mg
- Where
- Switzerland
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Jules Desmeules
The Focus of the Study is Healthy Volunteers
Meaning in Music-Based Pain Modulation
The overall goal of this project is to examine the impact of music's meaning on pain. Relationships between trait affect, meaning in life, and subjective qualities of meaningful music will be assessed.
- Trial name
- NCT07036315
- Testing
- Music intervention
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Virginia
Irritable Bowel Syndrome
Irritable Bowel Syndrome (IBS) Functional Magnetic Resonance Imaging (fMRI) With Desipramine
Individuals with irritable bowel syndrome (IBS) may experience abdominal pain as a result of pain signals in the bowel and how these signals are processed in the brain.
- Trial name
- NCT00880594
- Testing
- Desipramine
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Washington University School of Medicine
Motor Activity
Investigating Motor Cortex Processing for Pain Modulation
The purpose of this study is to investigate the effects of different types of interventions (motor learning, somatosensory learning, observation task, mental imagery and tDCS) on the perception of pain and motor cortex…
- Trial name
- NCT01404039
- Testing
- Motor Learning, Somatosensory Learning, Observational Task
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Spaulding Rehabilitation Hospital
Mechanical Neck Pain
The Synergistic Effects of Integrated Neuromuscular Inhibition Technique and Dry Cupping Therapy on Pain Modulation and Functional Recovery on Myofascial Trigger Points of Upper Trapezius
The purpose of the study is to investigate the Synergistic Effects of the Integrated Neuromuscular Inhibition Technique and Dry Cupping Therapy on Pain Modulation and functional recovery on Myofascial Trigger Points of the upper…
- Trial name
- NCT07027644
- Testing
- Dry Cupping Therapy, Integrated Neuromuscular Inhibition Technique, stretching and strengthening exercises
- Where
- Egypt
- Volunteers
- 130 people
- Sponsor
- Beni-Suef University
Pain Perception, Autonomic Nervous System Functioning
Music-based Intervention for the Reduction of Pain
This study aims to compare the impact of listening to frequency-modulated music vs. non-modulated music (both researcher-selected), and to test whether there are differential effects on pain and stress perception.
- Trial name
- MINTREP (NCT02991014)
- Testing
- researcher-selected frequency-modulated music, researcher-selected non-modulated music, participant-selected non-modulated music
- Where
- 2 sites in Austria, Germany
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Chronic Lower Limb Pain
A Safety and Effectiveness Trial of Spinal Cord Stimulation of the Dorsal Root Ganglion for Chronic Lower Limb Pain
The purpose of this study is to evaluate the safety and effectiveness of the AXIUM Neurostimulator System for the treatment of chronic lower limb pain in persons diagnosed with Complex Regional Pain Syndrome (CRPS) or Peripheral…
- Trial name
- ACCURATE (NCT01923285)
- Testing
- AXIUM Neurostimulator System, Control Spinal Cord Stimulation Device
- Where
- 22 sites in United States
- Volunteers
- 152 people
- Sponsor
- Abbott Medical Devices
Healthy Volunteers
Reliability of Measuring Conditioned Pain Modulation With the Nociceptive Withdrawal Reflex
Conditioned pain modulation is the ability of the spine to describe changes in pain perception, if two different painful stimulations take place.
- Trial name
- NCT01636440
- Testing
- Conditioned Pain Modulation
- Where
- Switzerland
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Back Pain
Evaluation of How Different Dosages of Spinal Manipulation Modulate Spinal Stiffness in Participants With Back Pain
This study evaluate the relationships between spinal manipulative therapy dosage (speed and peak force), the resulting modulation of thoracic spinal stiffness and changes in the clinical status in participants with chronic…
- Trial name
- NCT03063177
- Testing
- Spinal manipulative therapy
- Where
- Canada
- Volunteers
- 81 people
- Sponsor
- Université du Québec à Trois-Rivières
Pain, Lumbar Disc Herniation
The Diagnostic and Prognostic Value of Two Quantitative Clinical Tests in Patients With Lumbar Disc Herniation
This study will investigate whether two clinical tests can be used to diagnose and predict the outcome in patients with lumbar disc herniation undergoing surgery and non-surgery treatment.
- Conditions
- Pain, Lumbar Disc Herniation, Back Pain, Spinal Diseases
- Trial name
- NCT03832036
- Testing
- Paraspinal Mapping and Quantitative Sensory Pain Test
- Where
- Denmark
- Volunteers
- 102 people
- Sponsor
- Spine Centre of Southern Denmark
Fibromyalgia
Pain Neuroscience Education, Conditioned Pain Modulation and Emotional Processes in Fibromyalgia
Chronic pain represents a significant public health concern worldwide and is a primary reason why patients seek specialized medical care.
- Trial name
- NEUROPAINFIB (NCT07055971)
- Testing
- Experimental: Pain Neuoescience Education Group, Active Comparator: Biomedical Education Group
- Where
- Spain
- Volunteers
- 46 people
- Sponsor
- Universidad de Granada