Clinical trials: Pain Perception
Pain
Sedation and Pain (The Effect of IV Sedation on Pain Perception)
The investigators propose to evaluate the potential effect of sedation on pain perception in two ways, by asking for a participant's pain rating(subjective) and by evaluating a subject's brain activation using fMRI(objective).
- Trial name
- NCT00853333
- Testing
- dexmedetomidine, midazolam, propofol
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Pain
Pain Perception With Tenaculum Placement
Randomized controlled trial that compares methods of tenaculum placement during intrauterine device insertion and their effect on pain.
- Trial name
- NCT02969421
- Testing
- Cough method for placement of tenaculum, Slow Tenaculum Placement of tenaculum
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Duke University
Schizophrenia, Major Depression
Past Pain Experience and Perception of Experimental Pain
Differences in pain perception between subjects with and without psychiatric illness may be influenced by the individual experience, and not primarily by the pathology, although the pathological frame may amplify it.The aim of…
- Trial name
- NCT01575912
- Testing
- experimental pain tests
- Where
- France
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Esquirol
Cognitive Pain Control
Real-Time fMRI Feedback Effects on Pain Perception
The purpose of this study is to determine whether real-time functional magnetic resonance imaging may be a viable treatment for chronic pain in the future.
- Trial name
- NCT01588197
- Testing
- Attention/Distraction Strategy, Stimulus Quality/Severity Strategy, Control Strategy
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Motor Activity
Investigating Motor Cortex Processing for Pain Modulation
The purpose of this study is to investigate the effects of different types of interventions (motor learning, somatosensory learning, observation task, mental imagery and tDCS) on the perception of pain and motor cortex…
- Trial name
- NCT01404039
- Testing
- Motor Learning, Somatosensory Learning, Observational Task
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Spaulding Rehabilitation Hospital
Foot Pain
Orthofeet: A Prospective Proof of Concept Trial to Evaluate an Innovative Pain Relief Footwear
The purpose of this prospective randomized crossover study is to evaluate the effectiveness of a new pain relief footwear, Orthofeet, in reducing foot pain and improving daily physical activity.
- Trial name
- NCT05434078
- Testing
- Orthofeet Shoes
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Bijan Najafi, PhD
Pain, Acute, Anesthesia, Local
Variable Perception of Cutaneous Stimulation
Perception of cutaneous sensory stimulation shows a large range of variability across multiple populations. Understanding this variability is critical to medical practice as interpretation of discomfort and pain is critical to…
- Conditions
- Pain, Acute, Anesthesia, Local, Dermatology/Skin - Other
- Trial name
- NCT03467685
- Testing
- Vibratory Anesthetic Device (VAD)
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Acute Pain
Vasopressin and Pain Perception in the Brain
The feeling of pain is not just a sensory experience, but is also influenced by emotions, beliefs and expectations, making pain a highly subjective experience.
- Trial name
- NCT03446456
- Testing
- Arginine vasopressin, Saline, Observational learning
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Healthy
N-of-few Study of Pain Perception
A behavioral study that will examine how pain perception is affected by different types of conditioning and by context, with a few participants and multiple sessions ("N-of-few" design).
- Trial name
- NOF (NCT04664400)
- Testing
- Symbolic conditioning, Conditioning, Instructions
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Trustees of Dartmouth College
Acute Pain
The Influence of Testosterone on Experimental Pain Perception
This trial examined how the administration of exogenous testosterone would influence pain tolerance and other endogenous steroids (i.e. estradiol and progesterone).
- Trial name
- NCT05781685
- Testing
- Testosterone
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Placebo, Expectations
Effects of Expectations on Negative Affect, Perceived Cognitive Effort, and Pain
The investigators administer a functional neuroimaging task to investigate the effect of cue expectancy on participants' self-reported ratings across a variety of affective and cognitive domains.
- Trial name
- NCT05425563
- Testing
- Pain Expectancy Cues, Vicarious Pain Expectancy Cues, Cognitive Effort Expectancy Cues
- Where
- United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Trustees of Dartmouth College
Pain
Effects of Transcranial Direct Current Stimulation on Pain Perception
The purpose of this study is to determine whether a new medical technology can temporarily alter pain perception. The new technology is called Transcranial direct current stimulation (tDCS).
- Trial name
- tDCS-CBT (NCT01860950)
- Testing
- anodal tDCS, cathodal tDCS
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Pain, Surgery
The Possible Correlations Between the Genes Related to Pain Sensation and the Pain Sensitivity in the General Population
Objective: This study was conducted to explore the possible correlation between some gene related to pain sensation and individual basal pain perception and postoperative pain intensity in the general population.
- Trial name
- NCT01950078
- Where
- China
- Volunteers
- 1,533 people, healthy volunteers welcome
- Sponsor
- Xianwei Zhang
Low Back Pain
EMG Activation of Gluteal Musculature During Exercises With and Without Resistance
The gluteus medius (Gmed) and gluteus maximus (Gmax) muscles are important components in the treatment of many lower limb injuries.
- Trial name
- GlutEMG02 (NCT01841216)
- Testing
- Lower Body Exercises with and without resistance
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sport and Spine Rehab Clinical Research Foundation
Anxiety, Pain, Procedural
Lavender Aromatherapy to Decrease Anxiety/Pain Perception During Office Hysteroscopy
Office hysteroscopy is an invaluable practice to treat a myriad of gynecological processes. However, a limiting factor is the perceived pain and anxiety.
- Trial name
- NCT06316934
- Testing
- Lavandula angustifolia, Aura Cacia
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Florida
Pain
The Neurobiology of Expectancy and Pain Perception
This study will use using fMRI (functional Magnetic Resonance Imaging) to elucidate how contextual learning/expectation relieves or aggravates pain experience in the same cohort of subjects and the same study session.
- Trial name
- NCT01575106
- Testing
- Heat pain applied using TSA or CHEPS
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Pain
Double Blinded Randomized Trial Between Lidocaine And Plain Gel For Urethral Straight Catheterization And The Q-Tip Test
The purpose of this study is to compare the pain perception between lidocaine and plain aqueous gel during assessment of postvoid residual volume and the Q-tip test.
- Trial name
- NCT00883103
- Testing
- 2% Lidocaine jelly, Plain aqueous gel
- Where
- United States
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Baystate Medical Center
Pain, Postoperative, Numbness
Lidocaine Versus Bupivacaine in Orthognathic Surgery
In this research study, we want to learn more about the impact of two different local anesthetics (bupivacaine and lidocaine) on patient experience following orthognathic (jaw) surgery.
- Conditions
- Pain, Postoperative, Numbness, Temperature Sensation, Perception of Touch
- Trial name
- NCT06450028
- Testing
- 10 cc of 0.25% bupivacaine hydrochloride with 1:200,000 epinephrine, 6.8 cc of 2% lidocaine hydrochloride with 1:100,000 epinephrine
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Pain
To Measure Pain Perception With Electronic Pressure Algometer of Different Size Probes : a Healthy Subjects Research
This study was conducted to explore the influencing factors, subjects and testers' evaluation about pain measurement with hand-held pressure algometer with different size probes.
- Trial name
- NCT01618942
- Testing
- pressure algometer
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Xianwei Zhang
Infant, Newborn, Infant, Premature
Effect of a Vibratory Stimulus on Mitigating Nociception-specific Responses to Skin Puncture in Neonates
The assessment and treatment of pain in neonates remains a challenge. In an effort to improve the quality of care while limiting opioid-related adverse effects, this study aims to determine the efficacy of a non-pharmacological…
- Conditions
- Infant, Newborn, Infant, Premature, Pain Perception, Pain Measurement
- Trial name
- NCT04050384
- Testing
- Baby GentleStick
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Lance M Relland, MD, PhD