Clinical trials: Pain Severity
Trigeminal Neuralgia
An Efficacy and Safety Study of Basimglurant (NOE-101) in Patients With Trigeminal Neuralgia.
Trigeminal neuralgia (TN), also called "tic douloureux", is the most common form of craniofacial neuropathic pain and is considered the cause of one of the most painful afflictions known in medical practice.
- Trial name
- NCT05217628
- Testing
- Basimglurant
- Where
- 34 sites in United States, Denmark and 6 more
- Volunteers
- 166 people
- Sponsor
- Noema Pharma AG
Cancer Pain
Study to Evaluate Effectiveness and Tolerability of OROS Hydromorphone for Cancer Pain Treatment in Korean Patients
The purpose of this study is to evaluate the effectiveness and tolerability of Once-Daily OROS ("Osmotic Release Oral System" [a controlled release oral medication delivery system in the form of a tablet]) hydromorphone for…
- Trial name
- NCT01621100
- Testing
- OROS hydromorphone
- Where
- 6 sites in South Korea
- Volunteers
- 106 people
- Sponsor
- Janssen Korea, Ltd., Korea
Ankle Sprain
Proof-of-concept Study of NSAID Hydrogel Patch in Treatment of Acute Pain
The safety and the efficacy of the Esflurbiprofen Hydrogel Patch will be assessed in comparing with placebo in the treatment of acute pain due to ankle sprain
- Trial name
- NCT02729207
- Testing
- Esflurbiprofen Hydrogel Patch
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Teikoku Seiyaku Co., Ltd.
Central Neuropathic Pain, Multiple Sclerosis
Safety and Efficacy of AVP-923 in the Treatment of Central Neuropathic Pain in Multiple Sclerosis
The objectives of the study are to evaluate the safety, tolerability, and efficacy of 3 doses of AVP-923 capsules in the treatment of central neuropathic pain in participants with multiple sclerosis.
- Trial name
- PRIME (NCT01324232)
- Testing
- AVP-923-45, AVP-923-30, AVP-923-20
- Where
- 72 sites in United States, Argentina and 3 more
- Volunteers
- 209 people
- Sponsor
- Avanir Pharmaceuticals
Headache
Efficacy of a Single Dose of Aspirin vs. Acetaminophen in Tension Type Headache
The purpose of this trial is to determine if a single, oral dose of a fast release aspirin 1000 mg provides relief compared to acetaminophen 1000 mg and placebo in subjects with tension-type headache pain.
- Trial name
- Tarot Headache (NCT01552798)
- Testing
- Acetylsalicylic acid (Aspirin, BAY1019036), Acetaminophen
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Bayer
Intractable Pain, Back Pain
Prometra's Utilization in Mitigating Pain II
Intrathecal infusion pumps are increasingly used to deliver analgesics for chronic intractable pain. The PUMP II trial is designed to evaluate the ongoing safety and efficacy of the new Prometra® Programmable Pump System for…
- Conditions
- Intractable Pain, Back Pain, Leg Pain, Arm Pain
- Trial name
- (PUMP 2) (NCT00866164)
- Testing
- Prometra Programmable Pump
- Sponsor
- Flowonix Medical
Pain
Open Label Assessment of Long-Term Safety and Utility
The purpose of this study is to monitor the long-term analgesic effectiveness, safety, and utility of oxymorphone ER for the relief of moderate to severe pain due to cancer.
- Trial name
- NCT00904449
- Testing
- Oxymorphone ER
- Volunteers
- 24 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Osteoarthritis, Knee, Degenerative Joint Disease of Knee
Post Marketing Clinical Follow up Study to Evaluate the Performance and Safety of ORTHIX PLUS
This trial is a post marketing clinical follow up study, aiming to evaluate the performance and safety of ORTHIX PLUS for pain relief in patients suffering from osteoarthritis or degenerative joint diseases.
- Trial name
- NCT05348525
- Volunteers
- 54 people
- Sponsor
- Yooyoung Pharmaceutical Co., Ltd.
Acute Pain
Efficacy and Safety of Escócia Association in the Treatment of Acute Pain
The purpose of this study is to evaluate the efficacy and safety of Escócia association in adults with acute pain.
- Trial name
- NCT04666701
- Testing
- Escócia association, Ketorolac Tromethamine, Scopolamine
- Sponsor
- EMS
Ankylosing Spondylitis
16 Week Efficacy and 2 Year Long Term Safety and Efficacy of Secukinumab in Patients With Active Ankylosing Spondylitis
This study will assess the efficacy and safety of secukinumab in patients with active ankylosing spondylitis who are intolerant to or have had an inadequate response to NSAIDs, DMARDs and / or TNFα inhibitor therapy.
- Trial name
- MEASURE 1 (NCT01358175)
- Testing
- Secukinumab (75 mg), Secukinumab (150 mg)
- Where
- 67 sites in United States, Belgium and 12 more
- Volunteers
- 371 people
- Sponsor
- Novartis Pharmaceuticals
Pain, Cancer
Clinical Use and Safety of the Fentanyl Transdermal Therapeutic System (TTS) in the Management of Pain in Patients With Cancer
The purpose of this study is to establish the clinical utility and safety of fentanyl TTS (a transdermal patch delivering the narcotic pain reliever fentanyl) in the treatment of pain in patients with cancer.
- Trial name
- NCT00269763
- Testing
- Fentanyl Transdermal Therapeutic System (TTS)
- Volunteers
- 32 people
- Sponsor
- Alza Corporation, DE, USA
Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS)
Clinical Evaluation of the Efficacy and Safety of a Medical Device in the Form of Rectal Suppositories (Prospidol®) for the Treatment of Symptoms Associated With Chronic Prostatitis/Chronic Pelvic Pain Syndrome.
The goal of this clinical trial is to evaluate whether a medical device is effective and safe in treating chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in adult men.
- Trial name
- NCT07685847
- Testing
- Prospidol suppository
- Where
- 2 sites in Italy
- Volunteers
- 40 people
- Sponsor
- S&R Farmaceutici S.p.A.
Osteoarthritis
Study of Association of Anti-inflammatory and Anti-rheumatic
Phase III Study, double-blind, comparing association of anti-inflammatory and anti-rheumatic in 375 subjects with knee osteoarthritis.
- Trial name
- ZDPC00213 (NCT02448199)
- Testing
- Meloxicam and Glucosamine, Meloxicam, Glucosamine
- Volunteers
- 375 people
- Sponsor
- Zodiac Produtos Farmaceuticos S.A.
Angina Pectoris
To Find the Best Dose of pVGI.1(VEGF2) to Benefit Angina Patients When Given With an Experimental Injection Catheter
The purpose of this study is to determine the optimum effective dose of recombinant plasmid DNA [pVGI.1(VEGF2)] gene therapy administered using an experimental cardiac direct injection catheter (Stiletto™) system needed to…
- Trial name
- NCT00090714
- Testing
- pVGI.1(VEGF2)
- Where
- 35 sites in United States
- Volunteers
- 404 people
- Sponsor
- Corautus Genetics
Migraine Disorders
Occipital Nerve Stimulation (ONS) for Migraine: OPTIMISE
The primary objective of this study is to evaluate the safety and efficacy of occipital nerve stimulation (ONS) using the Boston Scientific Corporation (BSC) Precision™ System in the management of intractable chronic migraine…
- Trial name
- OPTIMISE (NCT01775735)
- Testing
- Occipital nerve stimulator
- Where
- 10 sites in United States
- Volunteers
- 28 people
- Sponsor
- Boston Scientific Corporation
Dental Pain
A Study of ARRY-371797 in Subjects Undergoing Third Molar Extraction
This is a Phase 2 study designed to test the ability of investigational study drug ARRY-371797 to reduce pain either perioperatively or postoperatively in a third molar extraction pain model, and to further evaluate the drug's…
- Trial name
- NCT00542035
- Testing
- ARRY-371797, p38 inhibitor; oral
- Where
- 2 sites in United States
- Volunteers
- 103 people
- Sponsor
- Pfizer
Facet Syndrome of Lumbar Spine
Safety and Initial Feasibility of Using the Neurolyser XR Device for the Treatment of Axial Chronic Low Back Pain
Single arm pilot study to evaluate the safety and initial feasibility of the Neurolyser XR, a high intensity focused ultrasound device, for non-invasive treatment of axial chronic low back pain
- Trial name
- NCT04129034
- Testing
- Neurolyser XR
- Where
- 5 sites in Canada
- Volunteers
- 30 people
- Sponsor
- FUSMobile Inc.
Patellofemoral Pain Syndrome, Anterior Knee Pain Syndrome
Dynamic Quadriceps Muscle Stimulation for Treatment of Patellofemoral Pain
The purpose of this small, pilot study is to evaluate a novel device that uses neuromuscular electrical stimulation to assist quadriceps muscles as a user walks.
- Trial name
- NCT02243332
- Testing
- KneeStim mobile rehabilitation assistance device
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Articulate Labs
Neuropathy
Efficacy of Near Infrared Phototherapy in Type 2 Diabetic Neuropathy
This is a double blind, randomized, placebo-controlled study in which a total of 120 patients will be selected from a broad spectrum group of typical Americans (all demographics including various races and both genders as well as…
- Trial name
- ResearchNIR (NCT02798393)
- Testing
- Infrared Phototherapy
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Healthlight, LLC
Pain
Post-Marketing Surveillance Study on the Safety and Efficacy of Cymbalta (Duloxetine) on Diabetic Peripheral Neuropathic Pain Among Filipino Patients
Primary objective: To estimate the frequency of adverse events, serious and non-serious in Filipino patients with diabetic peripheral neuropathic pain treated with duloxetine 60mg once daily within the study duration of…
- Trial name
- NCT02215798
- Testing
- Cymbalta
- Volunteers
- 269 people
- Sponsor
- Boehringer Ingelheim
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