Clinical trials: Pain Severity
Bowel Dysfunction, Constipation
Long-Term Safety Evaluation Of Treatment Of Constipation Due To Opioids Being Taken For Persistent Non-Cancer Pain
Adults who are taking opioid therapy for persistent non-cancer pain and have resulting opioid-induced bowel dysfunction (OBD) will be randomized (1:1) to alvimopan or placebo.
- Trial name
- NCT00241722
- Testing
- Alvimopan
- Where
- 227 sites in United States, Australia and 15 more
- Volunteers
- 805 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Tonsillectomy
Safety and Efficacy of Intravenous Ibuprofen for Treatment of Pain in Pediatric Patients Undergoing Tonsillectomy
The hypothesis is that a single, pre-operative dose of intravenous ibuprofen will significantly reduce post-operative fentanyl use compared to placebo.
- Trial name
- NCT01332253
- Testing
- Intravenous ibuprofen, Normal Saline
- Where
- 6 sites in United States
- Volunteers
- 161 people
- Sponsor
- Cumberland Pharmaceuticals
Healthy, Peripheral Neuropathic Pain
Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD), Food-effect of TRK-750
This is an exploratory, randomised, double-blind, placebo-controlled, Phase I study to assess the safety, tolerability, pharmacokinetics, pharmacodynamics and food-effect of single and multiple, ascending oral doses of TRK-750 in…
- Trial name
- NCT03346330
- Testing
- TRK-750
- Where
- United Kingdom
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Toray Industries, Inc
Peripheral Neuropathy, Antineoplastic Combined Chemotherapy Protocols
Evaluation of the Efficacy of Cesamet™ for the Treatment of Pain in Patients With Chemotherapy-Induced Neuropathy
This study was designed to evaluate the safety and efficacy of Cesamet™ in controlling pain in subjects experiencing pain due to chemotherapy-induced neuropathic pain in patients with cancer.
- Trial name
- NCT00380965
- Testing
- Cesamet™ (nabilone)
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- NEMA Research, Inc.
Acute Pain, Dysmenorrhea
Observational Prospective Study to Evaluate AEs, Risk Factors and Drug Utilization of BUSCAPINA COMPOSITUM N in Adults From Metropolitan Lima
What AE occur in routine clinical practice, what is the incidence of AE and Adverse Drug Reaction, how many patients present with AE symptoms related to a potential liver injury.
- Trial name
- NCT02910167
- Testing
- Hyoscine n-butylbromide, Paracetamol
- Where
- Peru
- Volunteers
- 360 people
- Sponsor
- Boehringer Ingelheim
Pain
A Single Dose Escalation Trial of HRS-2129 in Healthy Subjects
The study is being conducted to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics in healthy subjects, and to evaluate the food effect on pharmacokinetics of HRS-2129.
- Trial name
- NCT06619392
- Testing
- HRS-2129
- Where
- China
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
Cancer
Immediate-Release Oxycodone Capsules Study in Cancer Pain
The efficacy of dose titration of OxyNorm™(Oxycodone) immediate-release capsules versus morphine immediate-release tablets in the treatment of cancer pain.
- Trial name
- NCT01675622
- Testing
- Oxycodone, Morphine
- Volunteers
- 242 people
- Sponsor
- Mundipharma (China) Pharmaceutical Co. Ltd
Neuralgia
EMONO for the Treatment of Peripheral Neuropathic Pain
To assess the effect of 3 consecutive days of one-hour administration of Nitrous Oxide/Oxygen 50%/50% (EMONO) versus placebo as Oxygen/Nitrogen 22%/78% (synthetic medical air), in add-on therapy to chronic analgesic treatments…
- Trial name
- ProtoTOP (NCT02957851)
- Testing
- Medical Air, EMONO
- Where
- 22 sites in France, Germany
- Volunteers
- 287 people
- Sponsor
- Air Liquide Santé International
Episodic Migraine
A Study Evaluating the Effectiveness of AMG 334 Injection in Preventing Migraines in Adults Having Failed Other Therapies
The purpose of this study is to determine if AMG 334 is effective in treating migraines in patients who have failed other preventive migraine treatments.
- Trial name
- NCT03096834
- Testing
- AMG334 (70 mg) Pre-Filled Syringe (PFS)
- Where
- 59 sites in Australia, Austria and 14 more
- Volunteers
- 246 people
- Sponsor
- Novartis Pharmaceuticals
Post-Operative Pain, Acute Pain
Clinical Study to Evaluate the Effectiveness, Safety, and Tolerability of Oxymorphone Immediate Release (IR) Oral Liquid in Post Surgical Pediatric Subjects
The purpose of the study is to evaluate the efficacy, tolerability, safety and pharmacokinetics of Oxymorphone HCl as an analgesic for acute moderate to severe post-operative pain in pediatric subjects.
- Trial name
- NCT02687451
- Testing
- Oxymorphone HCl
- Where
- 3 sites in United States
- Volunteers
- 28 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Plantar Fasciitis
Topical Phytoterpenes for Plantar Fasciitis
Randomized controlled trial of mixture of essential oils containing tea tree oil, rosemary, clove, pepper, in a formulation with skin permeation enhancers including limonene for the treatment of plantar fasciitis in adult men and…
- Trial name
- NCT05467631
- Testing
- Topical oil application
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Center for Biomedical Research, Inc.
Pain
OxyNorm® Capsules (Immediate-Release) Pharmacokinetic (PK) Study
A Single Dose PK Study of OxyNorm® immediate-release capsules 5, 10, and 20mg, and a multiple-dose PK Study of OxyNorm® immediate-release capsules 10mg in Chinese patients with pain.It will be a single center, open label…
- Trial name
- NCT01643772
- Testing
- Oxycodone hydrochloride
- Where
- China
- Volunteers
- 61 people
- Sponsor
- Mundipharma (China) Pharmaceutical Co. Ltd
Mild to Moderate Chronic Low Back Pain
The Efficacy of the no!no!Back for Chronic Low Back Pain
This pilot study is designed to evaluate the efficacy of the no!no!Back continuous passive motion device in relieving of mild to moderate non-specific low back pain.
- Trial name
- LBP-1 (NCT01620281)
- Testing
- no!no!Back
- Where
- Israel
- Volunteers
- 36 people
- Sponsor
- Radiancy
Pain
A Study of Whether 3 New Oral Formulations of a Strong Pain Killer Release the Same Amount of Drug Into the Body as the Marketed Medication
To determine whether three new oral formulations of a strong pain killer release the drug into the body in a similar pattern as the already marketed reference capsule formulation with or without food
- Trial name
- NCT02446561
- Testing
- MRXXX, MR1XXX, MR2XXX
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Mundipharma Research Limited
Intractable Neuropathic Pain, Pain
Spinal Cord Stimulation (SCS) for Neuropathic Pain of Back or Lower Extremity
The primary objective of this study is to compare the efficacy and patient preference for spinal cord stimulation (SCS) using the Precision device with the electrode array placed at T7 versus placement at T8.
- Conditions
- Intractable Neuropathic Pain, Pain, Back Pain, Lower Extremity Pain
- Trial name
- NCT00399841
- Testing
- Precision for Spinal Cord Stimulation
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Boston Scientific Corporation
Haemorrhoidectomy
A Randomised Controlled Trial of the Use of Topical Metronidazole (10%) to Reduce Pain After Haemorrhoidectomy
The purpose of this study is to determine whether metronidazole 10% ointment , applied topically three times a day in and around the anus, on the reduction of pain following haemorrhoidectomy.
- Trial name
- NCT00774722
- Testing
- Metronidazole
- Where
- 5 sites in United Kingdom
- Volunteers
- 59 people
- Sponsor
- S.L.A. Pharma AG
Pain, Chronic Pain
Observational Study of the Impact of Genetic Testing on Healthcare Decisions and Care in Interventional Pain Management
The purpose of this study is to evaluate the impact of genetic testing on healthcare decisions and patient outcomes in interventional pain management clinical care.
- Conditions
- Pain, Chronic Pain, Back Pain, Nociceptive Pain
- Trial name
- MOSAIC (NCT02485795)
- Testing
- Observational
- Where
- 31 sites in United States
- Volunteers
- 50,000 people
- Sponsor
- Proove Bioscience, Inc.
Back Pain
Effectiveness of a Digital Health Application for Subacute and Chronic Back Pain (Relevis)
This clinical trial with 276 patients with subacute or chronic back pain aims to investigate the effectiveness of the unguided digital therapeutic relevis for patients with subacute or chronic back pain.
- Trial name
- APRICOT (NCT06221956)
- Testing
- relevis
- Where
- Germany
- Volunteers
- 276 people
- Sponsor
- Gaia AG
Cardiac Arrythmias, Unstable Angina
CardioSenseSystem Compared Study Regarding Efficacy and Safety in the Monitoring of ECG
This is a prospective, controlled, comparative clinical trial of a new ECG monitoring system CardioSenseSystem prior CE marking.
- Conditions
- Cardiac Arrythmias, Unstable Angina, Heart Valve Disorders, Disorder of Aorta
- Trial name
- NCT03610529
- Testing
- CardioSenseSystem, Philips Intellivue
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Novosense AB
Post Operative Pain
A Single-dose Open-Label Study to Assess the Safety and Preliminary Efficacy of PRF 110 in Open Herniorrhaphy Surgery
LNP is new extended release (ER) oily solution formulation of ropivacaine that is intended for local infiltration into surgical wounds.
- Trial name
- NCT01681966
- Testing
- PRF110- oily solution (Ropivacaine)
- Where
- 3 sites in Israel
- Volunteers
- 15 people
- Sponsor
- PainReform LTD
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