Clinical trials: Pain Severity
Chronic Pain
Defense Health Agency- Development of a Medical Device Utilizing an EEG-Based Algorithm for the Objective Quantification of Pain
PainQx, with the support of the Department of Defense (Contract #W81XWH-21-C-0034), is conducting a study to collect electroencephalography (EEG) data from people with chronic pain in order to develop algorithms than will…
- Trial name
- PQXDOD1 (NCT05215184)
- Testing
- Zeto WR19 EEG Recording
- Where
- 5 sites in United States
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- PainQx, Inc
Acute Otitis Media
Study to Compare Efficacy and Safety of AR01 to a Placebo Solution for Relief of Pain in Acute Otitis Media (AR01007)
Children ages 2 months to less than 19 years old, who have been diagnosed with a middle ear infection may receive either medicated ear drops (AR01) or glycerin (placebo) ear drops.
- Trial name
- NCT02074007
- Testing
- AR01
- Where
- 21 sites in United States
- Volunteers
- 178 people
- Sponsor
- Arbor Pharmaceuticals, Inc.
Lumbar Facet Joint Pain
Technical Description of Cooled Radiofrequency Ablation of Lumbar Medial Branches for the Treatment of Lumbar Facet Pain
This study aims to develop a technical description of lumbar medial branch ablation using the LumbarCool system. The procedure uses cooled radiofrequency (cooled-RF) technology in treating patients with diagnosed lumbar facet…
- Trial name
- NCT01590004
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mehul Desai
IBS (Irritable Bowel Syndrome), Bloating
A Study Evaluating the Impact of Regular FODMAP-targeting Digestive Enzyme Blend Use on Gastrointestinal Symptoms in Individuals With Self-Reported Bloating
This study is a randomized, double-blind, placebo-controlled, within-individual crossover trial designed to assess the impact of regular use of a consumer-grade FODMAP-targeting digestive enzyme blend (FODZYME®) on…
- Conditions
- IBS (Irritable Bowel Syndrome), Bloating, Abdominal Pain, Gut Health
- Trial name
- NCT07591584
- Testing
- FODMAP-targeting digestive enzyme blend
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Kiwi Health Inc
Moderate to Severe Cyclic Mastalgia
An Open-Label, MultiCenter Evaluation of the Use of Topically Administered FP1198 in Subjects With Pain Associated With Cyclic Mastalgia
The purpose of this study is to determine the safety of topical FP1198 for the treatment of moderate to severe cyclic breast pain (cyclic mastalgia) and to examine the clinical activity of FP1198.
- Trial name
- NCT01105793
- Testing
- Danazol
- Where
- 4 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- FemmePharma Global Healthcare, Inc.
Chronic Low Back Pain, Lumbar Radiculopathy
Low-Dose Naltrexone and Acetaminophen Combination in the Treatment of Chronic Low Back Pain (ANODYNE-4)
Treatment of chronic low-back pain with low-dose naltrexone and acetaminophen combination: a small, randomized, double-Blind, and placebo-controlled clinical trial with an open-label extension for none-responders
- Trial name
- NCT03201393
- Testing
- Low-dose naltrexone and acetaminophen combination
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Allodynic Therapeutics, Inc
Bone Cancer, Bone Metastases
Focused Ultrasound Surgery in the Treatment of Pain Resulting From Metastatic Bone Tumors With the ExAblate 2100 Conformal Bone System
The goal of this prospective, non-randomized, single-arm, phase 2 study is to evaluate the safety and effectiveness of this treatment using this ExAblate conformal system in the treatment of pain resulting from metastatic bone…
- Conditions
- Bone Cancer, Bone Metastases, Pain
- Trial name
- NCT01085565
- Testing
- ExAblate 2100
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- InSightec
Osteoarthritis of the Knee, Pain
A Study to Examine the Efficacy and Safety of REGN5069 in Patients With Pain Due to Osteoarthritis of the Knee
The primary objective of the study is to evaluate the efficacy of REGN5069 compared to placebo in patients with pain due to radiographically-confirmed OA of the knee who have a history of inadequate joint pain relief or…
- Trial name
- NCT03956550
- Testing
- REGN5069
- Where
- 12 sites in United States, Georgia and 3 more
- Volunteers
- 259 people
- Sponsor
- Regeneron Pharmaceuticals
Pain, Intractable, Pain, Chronic
Comparison of DTM™ SCS Therapy Combined With Conventional Medical Management (CMM) to CMM Alone in the Treatment of Intractable Back Pain Subjects Without Previous History of Lumbar Spine Surgery
The purpose of this investigational study is to document the safety, clinical effectiveness and health economic analytics of DTM™ SCS programming delivered through the Intellis™ neurostimulator in subjects with chronic…
- Trial name
- NCT06442410
- Testing
- DTM™ spinal cord stimulation therapy delivered via Intellis™ neurostimulator system, Conventional Medical Management (CMM)
- Where
- 12 sites in Belgium, Germany and 2 more
- Volunteers
- 115 people
- Sponsor
- MedtronicNeuro
Osteoarthritis, Knee
A Study of GW842166 in Adults With Osteoarthritis Pain
The purpose of this study is to determine whether GW842166 is effective in the treatment of osteoarthritis pain of the knee.
- Trial name
- NCT00447486
- Testing
- GW842166
- Where
- 22 sites in Denmark, Germany and 2 more
- Volunteers
- 308 people
- Sponsor
- GlaxoSmithKline
Chronic Pain
Vectors Post Market: A Study to Assess Pain Relief Using Spinal Cord Stimulation
This is a prospective, single-arm, multi-center study evaluating the efficacy of spinal cord stimulation (SCS) therapy for pain relief using high dose (HD) stimulation parameters delivered to neural targets identified during…
- Trial name
- NCT03345472
- Testing
- Spinal Cord Stimulation System
- Where
- 20 sites in United States
- Volunteers
- 175 people
- Sponsor
- MedtronicNeuro
Lumbar Spinal Stenosis
Study Evaluating the Safety and Effectiveness of the FLEXUS(TM) Interspinous Spacer
The purpose of this investigation is to evaluate the safety and effectiveness of the FLEXUS™ Interspinous Spacer as compared to the XSTOP® Spacer for the treatment of patients who are suffering from lumbar spinal stenosis at one…
- Trial name
- NCT01156675
- Testing
- FLEXUS(TM) Interspinous Spacer, XSTOP® Interspinous Spacer
- Where
- United States
- Volunteers
- 215 people
- Sponsor
- Globus Medical Inc
Post Ocular Surgical Inflammation and Pain
Phase 3 Study Evaluating Safety and Efficacy of OTX-DP for Treatment of Ocular Inflammation and Pain After Cataract Surgery
To evaluate the safety and efficacy of OTX-DP as a sustained release drug (dexamethasone) depot when placed in the canaliculus of the eyelid for the treatment of post-surgical inflammation and pain in subjects who have undergone…
- Trial name
- NCT02034019
- Testing
- Dexamethasone, Punctum Plug
- Where
- United States
- Volunteers
- 247 people
- Sponsor
- Ocular Therapeutix, Inc.
Breakthrough Cancer Pain
Effectiveness and Tolerance of Inhaled Fentanyl Aerosol (25µg/Dose) in Chinese Patients With BTcP
Breakthrough cancer pain (BTcP) is a common problem in patients with cancer. This is a phase IIa dose-response and safety study of inhaled fentanyl aerosol (25µg/dose) in Chinese patients with breakthrough cancer pain.
- Trial name
- NCT05531422
- Testing
- Inhaled fentanyl aerosol
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Lee's Pharmaceutical Limited
Abdominal Pain, GI Disorders
Radicle GI Health 24: A Study of Health and Wellness Products on GI Health and Related Health Outcomes
A randomized, double-blind, placebo-controlled study assessing the impact of health and wellness products on GI health and related health outcomes
- Conditions
- Abdominal Pain, GI Disorders, Digestion
- Trial name
- NCT06376695
- Testing
- Radicle GI Health Active Study Product 1.1 Usage, Radicle GI Health Active Study Product 2.1 Usage
- Where
- United States
- Volunteers
- 4,607 people, healthy volunteers welcome
- Sponsor
- Radicle Science
Back Pain
Spinal Cord Stimulation for Chronic and Intractable Back Pain
The purpose of this study is to evaluate the efficacy of spinal cord stimulation (SCS) using the Precision implantable neurostimulation device for chronic and intractable back pain in subjects who are not candidates for surgery…
- Trial name
- NCT00370695
- Testing
- Precision Spinal Cord Stimulation System
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Boston Scientific Corporation
Toothache
Assessing the Analgesic Efficacy of Naproxen Sodium in Postsurgical Dental Pain.
To evaluate the analgesic efficacy of a single, oral dose of a naproxen sodium extended-release tablet, compared to placebo in postsurgical dental pain.
- Trial name
- NCT00720057
- Testing
- Naproxen Sodium ER (BAYH6689)
- Where
- 3 sites in United States
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- Bayer
Irritable Bowel Syndrome
A Study To Investigate The Effect Of PD-217,014 On Abdominal Pain/Discomfort In Patients With IBS.
The purpose of this study is to determine the effectiveness of PD-217,014 in the treatment of abdominal pain/discomfort associated with irritable bowel disease.
- Trial name
- NCT00139672
- Testing
- PD-217,014
- Volunteers
- 330 people
- Sponsor
- Pfizer
Healthy
Study To Assess The Effect Of Gabapentin, Diphenhydramine And Morphine On Cold Pain In Healthy Male Volunteers
Human experimental pain models are useful in understanding the mechanisms underlying clinical pain conditions and can be used to test the analgesic efficacy of drugs used in the management of pain.
- Trial name
- NCT01119222
- Testing
- Gabapentin, Diphenhydramine, Morphine
- Where
- Belgium
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Pfizer
Fibromyalgia
Evaluation of Magnetic Fields to Treat Fibromyalgia
The purpose of this study is to see if a device called the Resonator can help to reduce pain and improve aspects of health and quality of life for people with fibromyalgia.
- Trial name
- NCT01262131
- Testing
- magnetic therapy protocol A, magnetic therapy Protocol B
- Volunteers
- 13 people
- Sponsor
- pico-tesla Magnetic Therapies, LLC
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