Clinical trials: Pain Severity
Non-specific Chronic Low Back Pain
Manual Therapy Plus Pain Neuroscience Education With Integrated Motivational Interviewing in Individuals With Non-Specific Chronic Low Back Pain
Non-specific chronic low back pain (NSCLBP) is characterized by persistent back pain that lasts longer than 12 weeks. This clinical trial aims to examine the short-term and long-term effects of adding Pain Neuroscience Education…
- Trial name
- NCT05928975
- Testing
- MT+ PNE with MI, MT, Control
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- International Hellenic University
Palliative Care, Pain Management
Medical Hypnosis and Music for Palliative Care
The goal of this randomized controlled trial is to evaluate the efficacy of a personalized multimodal intervention program (MuzHyp) including hypnosis, music or their combination to improve palliative care at home.
- Conditions
- Palliative Care, Pain Management, Anxiety, Well-being
- Trial name
- MuzhypforPC (NCT05951257)
- Testing
- Personalized multimodal intervention involving hypnosis and/or music
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- Laval University
Chronic Pain, Lumbar Pain Syndrome
BioWave High-frequency Neurostimulation Versus TENS for the Treatment of Chronic Low Back Pain
This will be a multicenter randomized crossover clinical trial comparing the therapeutic efficacy of BioWave therapy versus TENS for the management of chronic low back pain.
- Conditions
- Chronic Pain, Lumbar Pain Syndrome, Low Back Pain
- Trial name
- BioWave (NCT05511181)
- Testing
- BioWave, TENS
- Where
- 4 sites in United States
- Volunteers
- 120 people
- Sponsor
- BioWave Corporation
Functional Gastrointestinal Disorders, Irritable Bowel Syndrome
Does Improving Vagal Tone Increase Mitochondrial Bioenergetics
This study evaluates the effect of auricular neurostimulation on mitochondrial bioenergetics and inflammation through vagal nerve modulation via non-invasive percutaneous electrical nerve field stimulator in children with…
- Conditions
- Functional Gastrointestinal Disorders, Irritable Bowel Syndrome, Dyspepsia, Functional Abdominal Pain Syndrome
- Trial name
- NCT03931330
- Testing
- Percutaneous neurostimulation
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Medical College of Wisconsin
Osteo Arthritis Shoulders
MONOVISC for Shoulder Joint Pain Relief Due to Osteoarthritis
Obtain real world, post market data to confirm the clinical improvement and safety in patients treated with a single injection of MONOVISC for the symptomatic relief of osteoarthritis in the shoulder joint.
- Trial name
- NCT04204265
- Testing
- Monovisc
- Where
- 4 sites in Czechia, Poland
- Volunteers
- 25 people
- Sponsor
- Anika Therapeutics, Inc.
Postoperative Pain, Renal Transplantation
Intravenous Lignocaine Infusion in Laparoscopic Donor Nephrectomy
Background: Administration of morphine as boluses or via a patient controlled analgesic device (PCA) has been the standard practice for donors after nephrectomy.
- Conditions
- Postoperative Pain, Renal Transplantation, Morphine Adverse Reaction
- Trial name
- NCT04052867
- Testing
- Lignocaine, Normal saline
- Where
- Malaysia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Diabetic Peripheral Neuropathic Pain (DPN)
Hyperbaric Oxygen Therapy Versus High Power Laser for Diabetic Neuropathy
The purpose of this study is to compare the clinical effects of Hyperbaric Oxygen Therapy (HBOT) versus High-Intensity Laser Therapy (HPLT) on sensorimotor functions and nerve conduction in patients suffering from painful…
- Trial name
- HBOT-HPLT-DPN (NCT07848867)
- Testing
- Conventional Physiotherapy Program, Hyperbaric Oxygen Therapy, High-Intensity Laser Therapy
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Cairo University
Pharyngitis
Evaluate the Time of Pain Relief of Fast Acting Aspirin Versus Acetaminophen in Subjects Diagnosed With Sore Throat Pain
This study is to evaluate the onset of relief provided by a single, oral dose of fast release aspirin 1000 mg compared to acetaminophen 1000 mg and placebo in subjects with sore throat pain.
- Trial name
- Tarot (NCT01453400)
- Where
- United States
- Volunteers
- 177 people
- Sponsor
- Bayer
Chronic Pain
Study to Evaluate the Efficacy of Dronabinol (Marinol) as Add-On Therapy for Patients on Opioids for Chronic Pain
The purpose of this research study is to determine if Marinol alleviates pain in patients with chronic pain who are currently taking opioids.
- Trial name
- NCT00153192
- Testing
- Marinol (dronabinol)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Brigham and Women's Hospital
Low Back Pain
Effects and Mechanisms of Specific Trunk Exercises in Low Back Pain
Low back pain affects 80% of Americans at some time during their lives. Although recovery usually occurs within 6 months, there is a 50% recurrence within one year's time.
- Trial name
- NCT01611792
- Testing
- Stabilization exercise protocol, Strength and conditioning exercise protocol
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Pain
0.05 mg Versus 0.1 mg Spinal Morphine for Reducing Morphine Requirement After Vaginal Hysterectomy
This study aims to compare the effect of spinal morphine between the dose 0.05 mg and 0.1 mg on the amount of morphine during the first 24 hours postoperative.
- Trial name
- NCT01080911
- Testing
- Morphine
- Where
- Thailand
- Volunteers
- 72 people
- Sponsor
- Mahidol University
Chronic Pancreatitis
EUS-guided Celiac Plexus Block vs. Sham in Chronic Pancreatitis
The aim of this randomized trial is to assess the efficacy of EUS-CPB in the alleviation of abdominal pain in patients with chronic pancreatitis.
- Trial name
- EPOCH (NCT06178315)
- Testing
- EUS-guided celiac plexus block
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Orlando Health, Inc.
Epilepsy, Chronic Pain
Impact of Polymorphisms of OCT2 and OCTN1 on the Kinetic Disposition of Gabapentin in Patients Undergoing Chronic Use
This study aims to evaluate the influence of genetic polymorphisms of OCTN1 and OCT2 and other possible covariates on the kinetic disposition of GAB in patients undergoing GAB chronic treatment.
- Trial name
- NCT02977208
- Testing
- Sparse blood sampling, Urine sampling, DNA extraction
- Where
- Brazil
- Volunteers
- 66 people
- Sponsor
- São Paulo State University
Groin Pain
Adductor Strength in Roller Hockey Athletes
Roller hockey athletes will be recruited along the season and will be examined for adductor strength and other potential groin pain risk factors.
- Trial name
- NCT05273008
- Where
- Spain
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- University of Oviedo
Chronic Migraine
Use of the Tx360 Nasal Applicator in the Treatment of Chronic Migraine
Migraine imposes a substantial burden on patients in terms of diminished daily functioning, quality of life, and financial loss.
- Trial name
- Tx360 (NCT01709708)
- Testing
- Marcaine, Saline
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- Tian Medical Inc.
Post-thoracotomy Pain
Duloxetine Role in Reducing Opioid Consumption After Thoracotomy
A total of 60 patients scheduled for thoracotomy with the aim of excision of pleural or lung cancer, will be randomized by the use of a computer-generated table of random numbers to receive duloxetine 60 mg orally 2 hours before…
- Trial name
- NCT03618225
- Testing
- Oral Duloxetine 60mg
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Sleep Deprivation, Pain
Mechanisms of Sleep Disruption Hyperalgesia
Twenty percent of Americans suffer from chronic pain. Sleep disturbance is similarly prevalent and among the most common and disabling neurobehavioral problems associated with chronic pain.
- Trial name
- ESP2 (NCT01794689)
- Testing
- Morphine, Forced Awakenings, Uninterrupted Sleep
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Coronary Artery Bypass Grafting, Postoperative Pain
Preoperative Pain Neuroscience Education in Patients Undergoing CABG
This randomized controlled trial evaluated the effects of a single preoperative pain neuroscience education (PNE) session on postoperative pain-related outcomes in patients undergoing elective coronary artery bypass grafting…
- Trial name
- PNE-CABG (NCT07783750)
- Testing
- Pain Neuroscience Education
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- İsmail Palalı
Coronary Syndrome
Assessment of New Biomarkers in the Management and Triage of Patients With Chest Pain and Suspicion of Non ST Elevation Acute Coronary Syndrome.
To assess diagnostic and prognostic value of new biomarkers in patients admitted for suspicion of non ST elevation acute coronary syndrome (NSTE ACS).
- Trial name
- NCT00769574
- Testing
- Biological analysis of biomarkers
- Where
- France
- Volunteers
- 143 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Pain, Postoperative
Combination Effects of Pregabalin and Dexmedetomidine on Postoperative Pain
Pregabalin and dexmedetomidine have been introduced to manage postoperative pain. The present study aimed to evaluate the effect of the combination of two drugs on pain relief in patients undergoing total knee or hip arthroplasty…
- Trial name
- NCT03512574
- Testing
- Pregabalin, Dexmedetomidine, Pregabalin and dexmedetomidine
- Where
- South Korea
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Wonkwang University Hospital
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