Clinical trials: Pain Severity
Postoperative Pain, Hysterectomy
Efficacy and Safety of Intravenous Acetaminophen Over 48 Hrs for the Treatment of Post-op Pain After Gynecologic Surgery
This study will be investigating the efficacy and safety administration of multiple doses of intravenous (IV) acetaminophen (IVAPAP) in the 48 hour period following Gynecologic Surgery.
- Trial name
- NCT00399568
- Testing
- IV Acetaminophen
- Where
- 27 sites in United States
- Volunteers
- 331 people
- Sponsor
- Mallinckrodt
Musculoskeletal Disorders, Stress Management
Impact of Barre Stretching Among Dental Hygiene Students
The healthcare profession of dental hygiene can be a highly stressful academic path and occupation. Physical stressors can quickly lead to postural disturbances and musculoskeletal disorders (MSDs) due to instrument grasping…
- Conditions
- Musculoskeletal Disorders, Stress Management, Perceived Stress, Reported Stress
- Trial name
- NCT06279182
- Testing
- Barre Stretching Intervention
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Idaho State University
Chronic Pain
Prospective Assessment of Integrative Therapies for Neuromusculoskeletal Pain (PAIN)
With vast numbers of active-duty members restricted from their specific duties or deemed unfit for deployment because of low back pain, both the mission of the Department of Defense and overall military workflow can be…
- Trial name
- PAIN (NCT07094282)
- Testing
- Acupuncture, myofascial therapy, microcurrent therapy
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- David Moss
Abdominal Pain, Abdominal Cancer
Analgesic Efficacy of Dexmedetomidine Added to Fentanyl in PCEA
Dexmedetomidine if add to patient controlled epidural analgesia for patients undergoing major abdominal cancer surgery may improve its effects.
- Trial name
- NCT03453424
- Testing
- TEA+DEX, TEA
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- South Egypt Cancer Institute
Corneal Abrasion, Eye Trauma
Bandage Contact Lenses for Corneal Abrasions
Two percent of all patients presenting to the Emergency Departments have complaints involving the eye. Corneal abrasions are a common diagnosis with patients with eye pain and often cause significant discomfort.
- Trial name
- NCT03206723
- Testing
- Bandage contact lens, Eyedrop, Hydrocodone
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Low Back Pain, Pain
Workplace Exercises Versus Home-based Exercises on Pain and Function Among Office Workers With Non-specific Low Back Pain
The study was done to investigate the differences between workplace exercises and home-based exercises on pain, function, quality of life, and posture (pelvic inclination angle and lumbar lordotic angle) among office workers with…
- Conditions
- Low Back Pain, Pain, Function, Office Worker
- Trial name
- NCT07297680
- Testing
- Workplace exercise intervention, Home-based exercise intervention, general education and counseling
- Where
- Egypt
- Volunteers
- 57 people
- Sponsor
- Cairo University
Osteoarthritis, Knee
Follow on Extension of XT-150-1-0201
XT-150 safety and efficacy in severe osteoarthritic pain.
- Trial name
- NCT03769662
- Testing
- XT-150
- Where
- Australia
- Volunteers
- 16 people
- Sponsor
- Xalud Therapeutics, Inc.
Temporomandibular Disorders (TMD), Orofacial Pain
Comparing the Effectiveness of Online vs. Face-to-face Physiotherapy for Treating Temporomandibular Disorders
Dentists and physiotherapists have two options for treating these conditions: splint therapy and physiotherapy. Right now, the gold standard is individual physiotherapy, which contains manual therapy and active exercises too.
- Conditions
- Temporomandibular Disorders (TMD), Orofacial Pain, Temporo-mandibular Dysfunction, Temporomandibular Joint and Muscle Disorder
- Trial name
- NCT07474662
- Testing
- Individual physiotherapy, Group physiotherapy, Online physiotherapy
- Where
- 2 sites in Hungary
- Volunteers
- 90 people
- Sponsor
- Semmelweis University
Low Back Pain, Lumbago
Home Program Education for Patients With Low Back Pain
The primary purpose of this study is to assess the effect size of the change in Oswestry Disability Questionnaire (ODQ) score over the 8 week follow-up period between the video based instruction or standard of care hand-out with…
- Conditions
- Low Back Pain, Lumbago, Spinal Instability
- Trial name
- NCT02427438
- Testing
- Video, Handout
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Postherpetic Neuralgia
Efficacy and Safety Study of SLC022 in Treating Pain Associated With Post Herpetic Neuralgia
The purpose of this study is to evaluate the efficacy and safety of SLC022 in treating pain associated with post-herpetic neuralgia (PHN) in recently diagnosed patients.
- Trial name
- NCT00813826
- Testing
- SLC022
- Where
- 19 sites in United States
- Volunteers
- 204 people
- Sponsor
- Solace Pharmaceuticals
Cesarean Delivery
Postoperative Cesarean Delivery Pain Relief; Diclofenac Versus Bupivacaine
This randomized controlled trial, compared postoperative pain score in patient undergoing cesarean delivery between bupivacaine peritoneal and subcutaneous infiltration and diclofenac intramuscular injection
- Trial name
- NCT03039426
- Testing
- Bupivacaine, Diclofenac
- Where
- 2 sites in Thailand
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Healthy
The Effect of Transcranial Direct Current Stimulation of the Primary Motor and Somatosensory Cortex on Pain Thresholds.
The purpose of this study is to investigate the modulatory effect of a novel tDCS configuration on the pain sensitivity in healthy subjects.
- Trial name
- NCT04658485
- Testing
- Active tDCS
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Amputation, Surgical, Amputation, Traumatic
Cryoanalgesia to Treat Phantom Limb Pain Following Above-Knee Amputation
When a limb is severed, pain perceived in the part of the body that no longer exists often develops and is called "phantom limb" pain.
- Conditions
- Amputation, Surgical, Amputation, Traumatic, Phantom Limb Pain, Phantom Pain Following Amputation of Lower Limb
- Trial name
- NCT06071715
- Testing
- ACTIVE cryoneurolysis
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, San Diego
Prostate Cancer
Local Anesthesia for Prostate Biopsy
Title: Local anesthesia for office biopsy of the prostate: effects on pain control, quality of life and surgical intervention. Introduction: Local anesthetic should be administered prior to transrectal needle biopsy of the…
- Trial name
- NCT00422708
- Testing
- Local anesthesia
- Where
- United States
- Volunteers
- 243 people
- Sponsor
- Mayo Clinic
Musculoskeletal Pain, Athletic Injuries
Single Focused Shock Wave in the Release od Delayed Onset Muscle Soreness (DOMS)
The study is a single-center, double blinded, randomized controlled trial aimed to investigate the effects of focused extracorporeal shockwave therapy (fESWT) on Delayed Onset Muscle Soreness (DOMS) of the non-dominant biceps…
- Trial name
- NCT02548208
- Testing
- Verum focused extracorporeal shockwave
- Where
- Germany
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Dr. Johannes Fleckenstein
Vagus Nerve Autonomic Disorder, Heart Rate
Balance, Autonomic Response, and Sensory Modulation to Dosage of Mechanical Vagal Stimulation in Healthy Adults
The vagus nerve (VN) plays a crucial role in regulating vital functions (heart rate, blood pressure, digestion, and immune response) and maintaining communication between internal organs and the brain.
- Conditions
- Vagus Nerve Autonomic Disorder, Heart Rate, Pain, Equilibrium; Disorder, Labyrinth
- Trial name
- BARVANS (NCT06541808)
- Testing
- mechanical Vagus Nerve Stimulation (Low Intensity), mechanical Vagus Nerve Stimulation (Intermediate Intensity), mechanical Vagus Nerve Stimulation (High Intensity)
- Where
- Austria
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Rotator Cuff Repair, Anterior Cruciate Ligament Reconstruction
Ultrasound-Guided Percutaneous Peripheral Nerve Stimulation: A Department of Defense Funded Multicenter Pilot Study
Postoperative pain is usually treated with opioids that have undesirable and sometimes dangerous side effects (e.g., vomiting and respiratory depression)-and yet over 80% of patients still experience inadequate pain relief.
- Conditions
- Rotator Cuff Repair, Anterior Cruciate Ligament Reconstruction, Ankle Arthrodesis or Arthroplasty, Hallux Valgus Correction
- Trial name
- NCT03481725
- Testing
- ACTIVE peripheral nerve stimulation with a percutaneously inserted lead and wearable stimulator (SPR Therapeutics, Cleveland, Ohio)
- Where
- 6 sites in United States
- Volunteers
- 65 people
- Sponsor
- University of California, San Diego
Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD))
The REVEALPLAQUE Study: A pRospEctiVe, multicEnter Study to AnaLyze PLAQUE Using CCTA
This study will evaluate the level of agreement between noninvasive CCTA (coronary computed tomography angiography)-based quantification and characterization of coronary atherosclerosis and invasive IVUS (intravascular…
- Trial name
- REVEALPLAQUE (NCT05138289)
- Testing
- Total Plaque Volume
- Where
- United States
- Volunteers
- 258 people
- Sponsor
- HeartFlow, Inc.
PTSD, Chronic Pain
Ketamine Infusion for Comorbid PTSD and Chronic Pain
The purpose of the study is to investigate the effectiveness of low dose IV ketamine infusion in the treatment of patients with PTSD and comorbid chronic pain.
- Trial name
- NCT04322968
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- VA Ann Arbor Healthcare System
Endometriosis
SPIRIT EXTENSION: Efficacy and Safety Extension Study of Relugolix in Women With Endometriosis-Associated Pain
The purpose of this study is to evaluate the long-term efficacy and safety of relugolix 40 milligram (mg) once daily co-administered with low-dose estradiol (E2) and norethindrone acetate (NETA) for up to 104 weeks on…
- Trial name
- NCT03654274
- Testing
- Relugolix, Estradiol/norethindrone acetate
- Where
- 169 sites in United States, Argentina and 18 more
- Volunteers
- 802 people
- Sponsor
- Myovant Sciences GmbH
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