Clinical trials: Pain Severity
Degenerative Joint Disease of Knee, Osteoarthritis
A Randomized Controlled Trial for Partial Knee Arthroplasty
This is a prospective, multi-center, two-arm, randomized, controlled post-market study to evaluate and compare the clinical accuracy of component placement in robotic-assisted UKA and that of traditional methods.
- Conditions
- Degenerative Joint Disease of Knee, Osteoarthritis, Traumatic Arthritis, Varus Deformity
- Trial name
- NCT05037734
- Testing
- Persona Partial Knee System
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Zimmer Biomet
Chest Tube Removal
Effect of Cold Application on Patient's Pain and Vital Signs During Chest Tube Removal.
In this study, the effect of cold application used during and after chest tube removal on pain and vital signs in infants and children in the 0-3 age group will be examined.
- Trial name
- NCT05046834
- Testing
- cold application, cold application until 13.6 C
- Where
- Turkey (Türkiye)
- Sponsor
- Muğla Sıtkı Koçman University
Oral Contraceptive, Headache
Effect of a New Oral Contraceptive Pill on Hormone Related Symptoms Such as Pelvic Pain and Headache
The aim of the present study is to investigate whether women taking a new combined oral contraceptive pill (SH T00658ID, estradiol valerate/dienogest) experience fewer hormone withdrawal-associated symptoms such as pelvic pain or…
- Conditions
- Oral Contraceptive, Headache, Pelvic Pain
- Trial name
- NCT00778609
- Testing
- EV/DNG (Qlaira, BAY86-5027)
- Where
- 63 sites in Australia, Finland and 7 more
- Volunteers
- 449 people
- Sponsor
- Bayer
Postoperative Pain, Inflammation
Assessment of the Operative Course in Connection With Removal of Lower Third Molars
The aim of this study is to compare postoperative complications after removal of lower third molars using two different types of anaesthetics and two different treatments against swelling and inflammation (methylprednisolone and…
- Trial name
- NCT00805298
- Testing
- methylprednisolone, xyloplyin adrenalin, marcain adrenalin
- Where
- Denmark
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Low Back Pain
Effect of Core Stability Exercises and Russian Electrical Stimulation in Non-specific Low Back Pain
Brief Summary: Low back pain (LBP) is an important public health problem due to the increasing world population and aging. In chronic LBP, exercise therapy is among the first-line treatments.
- Trial name
- NCT06495099
- Testing
- Russian electrical stimulation
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Deraya University
Neovascular Age-related Macular Degeneration, Diabetic Macular Edema
Effect on Pain and Inflammation With DEXTENZA Treatment in Patients Undergoing Intravitreal Anti-VEGF Injections
This is an investigator initiated prospective open-label, within-patient, masked, randomized study in patients with neovascular AMD, DME, or RVO undergoing bilateral anti-VEGF injections.
- Conditions
- Neovascular Age-related Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion
- Trial name
- DETeR (NCT04563299)
- Testing
- Dextenza 0.4Mg Ophthalmic Insert, Prednisolone Acetate
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Retina Vitreous Associates of Florida
Opioid-use Disorder
Pain, Inflammation and Opioid Craving
The goal of this study is to investigate the association between response to pain and opioid craving in people with opioid use disorder.
- Trial name
- NCT04190563
- Testing
- Pain De-Catastrophizing, Pain Education
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Mclean Hospital
Pain Management After Surgery
Evaluation of the Effect of Virtual Reality Application on Postoperative Pain and Anxiety in Women Aged 50-70
Surgical interventions, while significant milestones in patients\' physical recovery processes, can be a major source of concern for patients due to postoperative pain, which is also an important component of postoperative…
- Trial name
- Pain (NCT06436014)
- Testing
- Providing VR experience
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Osmaniye Korkut Ata University
Healthy, Tooth Extraction
Prostanoid Levels After Medication to Prevent Pain Following Third Molar (Wisdom Tooth) Extraction
This study will evaluate how well different medications work to relieve pain following third molar (wisdom tooth) extraction. Scientists believe that hormone-like substances called prostanoids contribute to pain following oral…
- Trial name
- NCT00078104
- Testing
- Extraction of wisdom teeth
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Pain Management
Impact of Breast Milk on Cortical Pain Response in Newborns
Background:Newborns are exposed to painful procedures for many different reasons in the first days of their life. If pain is not relieved effectively in these newborns, neurodevelopmental and behavioral problems may occur in the…
- Trial name
- NCT05961904
- Testing
- Breastmilk
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Chronic Neck Pain, Autonomic Nervous System
Autonomic Nervous System Dysregulation in People With Chronic Neck Pain
The goal of this observational study is to investigate heart rate variability in different positions and in response to isometric hand-grip test in people with non-specific chronic neck pain as compared with healthy controls.
- Trial name
- NCT06554704
- Testing
- Isometric hand grip test
- Where
- Taiwan
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- National Yang Ming Chiao Tung University
Shoulder Pain, Shoulder Injuries
Finnish Imaging of Shoulder Trauma
The FIMAGE-Trauma study is an extension of the FIMAGE study and aims to answer the question if rotator cuff tears found on shoulder imaging after a shoulder injury are caused by the index trauma or are rather incidental findings.
- Conditions
- Shoulder Pain, Shoulder Injuries, Rotator Cuff Tears, Glenoid Labrum Tear
- Trial name
- FIMAGE-T (NCT05800184)
- Where
- 4 sites in Finland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Asymptomatic Apical Periodontitis
Sonic Irrigation Activation for Postoperative Pain After Root Canal Treatment
This randomized controlled clinical trial will evaluate whether sonic activation of the root canal irrigant using the EndoActivator system reduces postoperative pain after root canal treatment compared with conventional syringe…
- Trial name
- VAS (NCT07847333)
- Testing
- Sonic Irrigation Activation Using EndoActivator, Conventional Syringe Irrigation
- Volunteers
- 176 people
- Sponsor
- Saidu College of Dentistry
Sexual Pain Disorders, Postmenopausal Symptoms
Sexual Penetration Pain in Postmenopausal Women: A Topical Botanical Drug Treatment
This study will evaluate the use of topical 5 or 10% sinecatechins, a botanical drug derived from green tea for the alleviation of sexual pain in the area around the vaginal opening (the vulvar vestibule), that is a main source…
- Conditions
- Sexual Pain Disorders, Postmenopausal Symptoms, Vulvovaginal Atrophy, Female Sexual Dysfunction
- Trial name
- NCT03682601
- Testing
- 5% sinecatechins ointment, 10% sinecatechins ointment
- Where
- 4 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- GTO Pharmaceutical, LLC
Urinary Incontinence, Urinary Incontinence, Urge
Prophylactic Analgesia for Bladder Botox Injections
The goal of this clinical trial is to learn more about using phenazopyridine (Pyridium) for pain control during bladder onabotulinumtoxinA ("botox") injections for surgical management of overactive bladder (OAB) for patients at…
- Conditions
- Urinary Incontinence, Urinary Incontinence, Urge, Overactive Bladder
- Trial name
- NCT06514430
- Testing
- Phenazopyridine, 1% lidocaine with sodium bicarbonate
- Where
- United States
- Sponsor
- Montefiore Medical Center
Low Back Pain
Effect of Visceral Osteopathic Manipulations on Low Back Pain
Forty female patients with age ranging from 30-40 years old were suffering from low back pain due to visceral dysfunctions participated in this study. They were recruited from a private clinic.
- Trial name
- NCT04822428
- Testing
- Osteopathic manipulation
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Neck Pain, Musculoskeletal Manipulations
Effects of Radial Shock Waves Therapy in the Treatment of Neck Pain
The aim of this study is to assess the effects of radial shock wave therapy in neck pain. For this objective, subjects recruited will be allocated in an experimental group or a placebo group.
- Conditions
- Neck Pain, Musculoskeletal Manipulations, Extracorporeal Shockwave Therapy
- Trial name
- NCT04495465
- Testing
- Radial Shock Wave Therapy, Manual Therapy
- Where
- Spain
- Volunteers
- 68 people
- Sponsor
- University of Jaén
Chronic Pain, Trauma
Influence of Trauma on Pain Area and Widespreadness in Chronic Pain Patients
It is well known that patients suffering from chronic pain report higher levels of pain, anxiety, and depression if they have experienced a traumatic event. However, little is know about pain area and widespreadness.
- Trial name
- NCT05190367
- Where
- Germany
- Volunteers
- 914 people
- Sponsor
- Hannover Medical School
Shoulder Injury
Ropivacaine Block Alone or With Perineural or Systemic Dexamethasone for Pain in Shoulder Surgery
Pre-operative perineural injection of dexamethasone mixed with local anesthetic in peripheral nerve blockade for orthopedic surgery has been shown to prolong the length of analgesia, improve visual analog pain scores, decrease…
- Trial name
- NCT01450007
- Testing
- Ropivacaine, Dexamethasone, Normal saline
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Mayo Clinic
Trigeminal Neuralgia
Trial for Treatment Refractory Trigeminal Neuralgia
The purpose of this study is to evaluate the efficacy of BHV3000 compared to placebo for subjects with treatment refractory Trigeminal Neuralgia as measured by a 2-point or greater reduction in the average Numeric Pain Rating…
- Trial name
- NCT03941834
- Testing
- Rimegepant
- Where
- 20 sites in United States
- Volunteers
- 65 people
- Sponsor
- Pfizer
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