Clinical trials: Pain Severity
Effects of the Elements
Effect of Removal of Double Antibiotic Paste on Post Operative Pain
Recruited patients with necrotic pulp after application of double antibiotic paste are assigned to group (XP Endo Finisher file) and group( Passive ultrasonic irrigation) and group (conventional syringe irrigation with side…
- Trial name
- NCT04327453
- Testing
- double antibiotic paste with XP-endo Finisher file, double antibiotic paste with Irrisafe Ultrasonic tip, double antibiotic paste with side vented needle
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Minia University
Arthritis, Rheumatoid
Milnacipran in the Treatment of Widespread, Non-Joint Pain in Rheumatoid Arthritis
The purpose of this study is to determine whether milnacipran reduces widespread, non-joint pain in patients with rheumatoid arthritis (RA).
- Trial name
- NCT01207453
- Testing
- Milnacipran
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Brigham and Women's Hospital
Pain, Hemodynamic Instability
The Effect of Virtual Reality Glasses on Pain Level and Hemo-Dynamic Variables After Open Heart Surgery
In this study, between 1 January 2025 - 1 June 2025, who met the inclusion and exclusion criteria, a total of 82 patients who are on the 2nd or 3rd day after the surgery and who are hospitalized in the cardiovascular surgery…
- Trial name
- Virtual (NCT05585853)
- Testing
- virtual reality
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Mersin University
Pain
Duration of Skin Numbing Effect Created by the S-Caine™ Peel
S-Caine™ Peel (lidocaine 7% and tetracaine 7% cream) is a new skin numbing cream made of lidocaine and tetracaine. The purpose of this study is to evaluate and measure the length of time the S-Caine Peel numbs the skin, when…
- Trial name
- NCT00110253
- Testing
- S-Caine™ Peel (lidocaine and tetracaine cream 7%/7%)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- ZARS Pharma Inc.
Pancreatic Cancer Pain
EUS Guided Celiac Neurolysis
Hypothesis: Direct CGN enhances neurolytic drug delivery into celiac ganglia and increases the efficacy of neurolysis and subsequent pain control and survival in patients with pancreatic carcinoma.
- Trial name
- NCT01615653
- Testing
- EUS
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Mayo Clinic
Pain, Acute, Edema
Lornoxicam Versus Etodolac After Third Molar Surgery
Our study aimed to compare the effect of lornoxicam and etodolac on postoperative pain, edema and trismus following lower third molar extraction
- Conditions
- Pain, Acute, Edema, Trismus
- Trial name
- NCT05679453
- Testing
- Lornoxicam 8 Mg Oral Tablet
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
Pulpitis - Irreversible, Vitamin D Deficiency
Effect of Vitamin D on Postoperative Pain in Symptomatic Irreversible Pulpitis
Vitamin D deficiency (VDD) is a prevalent global health concern that has been linked to altered pain perception through its effects on inflammatory pathways, nociceptor activity, and neurotrophic signaling.
- Trial name
- NCT07579637
- Testing
- Vitamin D3
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Future University in Egypt
Cardiovascular Surgery, Pain, Postoperative
Sternal Block With Liposomal Bupivacaine vs. Saline Prior to Incision in Cardiac Surgery
The purpose of this study is to find out what effects (good and bad) that the study medicine called "liposomal bupivacaine" has on subjects that are undergoing a sternotomy.
- Conditions
- Cardiovascular Surgery, Pain, Postoperative, Block
- Trial name
- NCT04333095
- Testing
- Liposomal bupivacaine, Normal Saline Flush, 0.9% Injectable Solution_#1
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Baylor Research Institute
Syncope, Vasovagal, Pain Intensity
Safety/Efficacy Study of Local Anesthetic Prior to Femoral Artery Sheath Removal
This randomized controlled trial will examine the impact of local anesthetic on the frequency of vasovagal reactions and the patients perception of pain during femoral arterial sheath removal after percutaneous coronary…
- Trial name
- NCT00465439
- Testing
- Subcutaneous Lidocaine 2% (Xylocaine) without epinephrine
- Where
- Canada
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Post-operative Pain, Quadriceps Muscle Strength
Ultrasound Guided Adductor Canal Versus Femoral Nerve Blocks for Anterior Cruciate Ligament Reconstruction in Pediatrics
Both Ultrasound guided Adductor Canal Block ( ACB) and Femoral Nerve Block (FNB) has been used to provide postoperative analgesia for knee surgeries.
- Trial name
- NCT03053401
- Testing
- Adductor Canal Block, Femoral Nerve Block, Ultrasound
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Akron Children's Hospital
Physical Functioning, Musculoskeletal Pain
Personalized Exercise Counseling to Promote Workability
The study design is a 2-arm randomized controlled trial with 6-month intervention period and follow-up at 6, 12 and 24 months among blue-color workers of Nokia City with reduced work ability and high number of musculoskeletal…
- Conditions
- Physical Functioning, Musculoskeletal Pain, Quality of Life, Physical Activity
- Trial name
- PEC-Nokia (NCT03854201)
- Testing
- Personalized Exercise Counseling (PEC)
- Where
- Finland
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- UKK Institute
Post Operative Pain
Does the Application of a Bilateral-dual Transverse Abdominal Plane (TAP)Block Have an Influence on Lung Function?
TAP-block (Transverse Abdominal Plane) block is a method of regional anesthesia used after abdominal surgery. The method is often applied ultra-sound guided.
- Trial name
- NCT01254812
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Pain, Postoperative; Anesthesia, Regional
Analgesic Efficacy of Ultrasound Guided Paravertebral Block in Percutaneous Nephrolithotomy Patients
The aim of this study is to investigate the analgesic effects of thoracal paravertebral block in the patients undergoing percutaneous nephrolitotomy. Paravertebral block was applied to the study group.
- Trial name
- NCT04406012
- Testing
- paravertebral block
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Eskisehir Osmangazi University
Pain, Chronic, Sleep
Sleep, Pain and Stress in Adolescents With Persistent Pain
The main aim is the gain information of sleep structures in adolescents with persistent pain. Also to study simple interventions to support their sleep and pain management.
- Trial name
- PedPainSleep (NCT05677412)
- Testing
- suggestive relaxation, Neutral story
- Where
- Finland
- Volunteers
- 20 people
- Sponsor
- Helsinki University Central Hospital
Pain
Effectiveness of Analgesia in Total Knee Arthroplasty
The purpose of this study is to compare the analgesic effectiveness of three techniques: the femoral nerve block, intraarticular infiltration or a combination of both in the control of pain in total knee arthroplasty (KA).
- Trial name
- ATR-2011 (NCT01304212)
- Testing
- several drugs: morphine chloride,ropivacaine,epinephrine,ketorolac, ropivacaine,morphine chloride,epinephrine,ketorolac, ropivacaine
- Where
- Spain
- Volunteers
- 137 people
- Sponsor
- Jose Antonio Bernia Gil
Metastatic Cancer
Ibuprofen or Morphine in Treating Pain in Patients Undergoing Pleurodesis for Malignant Pleural Effusion
RATIONALE: Morphine and ibuprofen help lessen pain caused by pleurodesis. It is not yet known whether one drug is more effective than the other in lessening pleurodesis-related pain or whether the size of the chest drain tube…
- Trial name
- NCT00644319
- Testing
- ibuprofen, morphine sulfate, management of therapy complications
- Where
- United Kingdom
- Volunteers
- 320 people
- Sponsor
- Oxford University Hospitals NHS Trust
Interventions Pain
The Effects on Pain of Acupressure and Foot Reflexology Before Heel Lancing in Newborns
This study aimed to determine the effects of foot reflexology and acupressure on the KI3 and St36 points on pain during interventions when these procedures were administered before heel lancing in term newborns.
- Trial name
- NCT04643730
- Testing
- Acupressure methods, Foot Reflexology Methods, Control Grup
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Eskisehir Osmangazi University
Pain, Postoperative
Pain After Tonsillectomy Study
Pain is a common experience in childhood. Healthy children can undergo up to 20 painful procedures by the age of 5. Moreover, millions of children undergo surgery (e.g., tonsillectomies) each year, which is commonly linked to…
- Trial name
- PAT (NCT03538730)
- Testing
- Memory Reframing
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Postpartum
Effects of Manual Lymph Drainage on Breast Engorgement in Postpartum Period.
There have been many studies on the treatment of breast engorgement, there is a lack of research comparing the effectiveness of manual lymph drainage with massage.
- Trial name
- NCT06168630
- Testing
- Manual lymph drainage, Control group
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Pain, Depression
Stepped Care for Depression and Musculoskeletal Pain
This study will evaluate the effectiveness of a stepped care approach in treating depression and reducing pain.
- Trial name
- NCT00118430
- Testing
- Stepped Care, Antidepressants, Usual Care
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Indiana University
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