Clinical trials: Pain Thresholds
Complex Regional Pain Syndrome Type I of the Upper Limb, Unilateral Limb Pain of Other Origin
Correlation Between 3 Phase Bone Scintigraphy and Pressure Pain Thresholds in Patients With Complex Regional Pain Syndrome (CRPS)
The aim of the study is to investigate the correlation between increased bone metabolism in the 3 phase bone scintigraphy (TPBS) and decreased pressure pain thresholds in patients with complex regional pain syndrome (CRPS) of the…
- Conditions
- Complex Regional Pain Syndrome Type I of the Upper Limb, Unilateral Limb Pain of Other Origin, Healthy Subjects
- Trial name
- NCT01623141
- Testing
- Pressure Pain measurement
- Where
- Germany
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Ruhr University of Bochum
Chronic Pain
rTMS Effects in the Neuromodulation and Pain Threshold of Chronic Myofascial Pain Patients
The purpose of this study is to investigate if rTMS may have a positive impact on pain thresholds and cortical excitability in subjects with chronic musculoskeletal diseases of complex cranio-cervical-mandibular with myofascial…
- Trial name
- NCT01964729
- Testing
- rTMS
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Knee Osteoarthritis, Central Pain Syndrome
Effects of Vagus Nerve Stimulation on Central Pain Sensitivity & Parasympathetic Function in Knee Osteoarthritis
The goal of this clinical trial is to test the feasibility and effectiveness of transcutaneous vagus nerve stimulation (tVNS) to the ear on pain and autonomic function in people with knee osteoarthritis (OA).
- Trial name
- NCT05625178
- Testing
- Transcutaneous vagus nerve stimulation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Texas, El Paso
Histamine, Cowhage
Investigation of the Effects of Sleep Deprivation on Itch and Pain Sensitivity
In This experiment, the investigators would like to test following hypotheses regarding the influence of sleep deprivation on itch: To investigate similarity and differences between itch and pain by comparing the effect of sleep…
- Conditions
- Histamine, Cowhage, Sleep Deprivation
- Trial name
- NCT06081998
- Testing
- Histamine, Cowhage
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Pain Measurement
Impact on Pain Sensitivity of Clinical Interaction
Pain can currently be quantified using quantitative sensory tests (QSTs). However, we lack knowledge concerning how relational and contextual factors impact these quantitative tests.
- Trial name
- QSTROBOT (NCT04888026)
- Testing
- Quantitative sensory testing
- Where
- 3 sites in Denmark
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Spine Centre of Southern Denmark
Total Shoulder Arthroplasty, Postoperative Pain
Total Shoulder Arthroplasty Preoperative Pain Threshold and Association With Postoperative Opioid Consumption
The purpose of this prospective research study is to evaluate the effects of preoperative pain threshold using a pressure algometer and its effects on postoperative patient satisfaction, return to work, and opioid consumption…
- Conditions
- Total Shoulder Arthroplasty, Postoperative Pain, Opioid Use
- Trial name
- NCT06133933
- Testing
- Pain Threshold using algometer/dolorimeter
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- The Cooper Health System
Pain, Tolerance, Oral vs Vaporized THC
PK/PD of Oral and Vaporized Delta-9-Tetrahydrocannabinol (THC) in Older Adults
The overarching goal of this double-blind, placebo-controlled, crossover study is to characterize the pharmacokinetic (PK) and pharmacodynamic (PD) effects of the main analgesic and psychoactive constituent of cannabis, delta-9…
- Conditions
- Pain, Tolerance, Oral vs Vaporized THC, Abuse Liability
- Trial name
- NCT05906511
- Testing
- Dronabinol 5 MG, Dronabinol 10 MG, 2mg Purified THC in an ethanolic solution
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Yale University
Pain Score, Pain Postoperative
Pain Sensitivity Questionnaire Applied in Preoperative Period in Lumpectomy
Objective: The Pain Sensitivity Questionnaire (PSQ) is a clinically valuable tool that has been shown to correlate with various experimental pain sensitivity assessments in healthy individuals and patients with chronic pain.
- Trial name
- Lumpectomy (NCT06928064)
- Testing
- Prediction of Postoperative Pain Severity Using Pain Sensitivity Questionnaire Applied in Preoperative Period in Patients Undergoing Breast-Conserving Surgery (Lumpectomy).
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Myofascial Pain Dysfunction Syndrome, Trigger Points, Myofascial
PRP vs PRP+Betamethasone vs Betamethasone Injection for Upper Trapezius Myofascial Pain
Brief Summary Myofascial pain syndrome (MPS) is a common musculoskeletal condition characterized by active trigger points (TrPs), which are hypersensitive, painful nodules within taut bands of skeletal muscle.
- Conditions
- Myofascial Pain Dysfunction Syndrome, Trigger Points, Myofascial, Trigger Point in Trapezius Muscle
- Trial name
- UMAY-RCT (NCT07547605)
- Testing
- Autologous Platelet-Rich Plasma (PRP), PRP plus Betamethasone, Betamethasone (Diprospan)
- Where
- 2 sites in Cyprus
- Volunteers
- 150 people
- Sponsor
- University of Kyrenia
Healthy Subjects
Comparative Exercise-Induced Hypoalgesia in Upper and Lower Limbs: A Randomized Controlled Trial in Healthy Individuals
This randomized controlled trial with healthy subjects aims to compare exercise-induced hypoalgesia among three groups: one utilizing a lower limb cycle ergometer, another using an upper limb cycle ergometer, and a control group.
- Trial name
- NCT06283186
- Testing
- Aerobic exercise
- Where
- Spain
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centro Universitario La Salle
Healthy Individuals
Effects of Nervous System Mobilization
This study aims to compare the effect of tension neural mobilization versus sliding neural mobilization of the peroneal nerve on the heat and cold threshold, on pressure pain threshold and on flexibility both in the dominant…
- Trial name
- NCT03029260
- Testing
- Neural mobilization - tension., Neural mobilization - gliding
- Where
- Portugal
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Aveiro University
Athletes
Acute Effects of Foam Rolling and Proprioceptive Neuromuscular Facilitation Stretching
This randomized, assessor-blinded, parallel-group comparative trial investigated the acute effects of foam rolling (FR) and proprioceptive neuromuscular facilitation (PNF) stretching used as warm-up strategies in amateur…
- Trial name
- NCT06240013
- Testing
- Foam Rolling, Proprioceptive Neuromuscular Facilitation Stretching
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Intraoperative Hypertension, Pain Threshold
Post SARS-Cov-2 Disease Anesthesia Events
Estimating and recording the rate of occurrence of pulmonary and cardiovascular complications during the perioperative period in patients with past covid infection
- Conditions
- Intraoperative Hypertension, Pain Threshold, Postoperative Pain, Postoperative Hypoxemia
- Trial name
- NCT05252234
- Testing
- Observation of hemodynamic status and post operative pain
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Ain Shams University
Fibromyalgia
Suprathreshold Pressure Pain Stimulation in Fibromyalgia
The purpose of this study is to investigate the induced-pain characteristics after suprathreshold pressure stimulation at different intensities in fibromyalgia subjects, compared with healthy volunteers.
- Trial name
- NCT04047407
- Testing
- Suprathreshold pain stimulation
- Where
- Spain
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Myofascial Pain Syndrome (MPS), Neck Pain
Dual Frequency Low-Level Laser Therapy in Myofascial Trigger Points of Upper Trapezius
The goal of this clinical trial is to determine whether dual frequency low-level laser therapy can reduce pain, improve function, and increase neck movement in patients with myofascial trigger points in the upper trapezius…
- Conditions
- Myofascial Pain Syndrome (MPS), Neck Pain, Myofacial Trigger Points
- Trial name
- DF-LLLT-MTP-UT (NCT07137728)
- Testing
- Red Low-Level Laser Therapy, Infrared Low-Level Laser Therapy, Dual Frequency Low-Level Laser Therapy
- Where
- Pakistan
- Volunteers
- 48 people
- Sponsor
- University of Lahore
Healthy
A Phase 1 Study of FZ008-145 in Healthy Subjects.
The study will be conducted in 5 parts: Part A and Part B (single ascending dose [SAD] in solution formulation and tablet respectively), Part D and Part D2 (cold pressor test [CPT] to evaluate pain tolerance following single…
- Trial name
- NCT06685809
- Testing
- FZ008-145 solution, FZ008-145 Tablet
- Where
- Australia
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Guangzhou Fermion Technology Co., LTD
Temporomandibular Dysfunction (TMD)
Cervical Proprioception, Masticatory Pain Threshold and Craniovertebral Angle in TMD
Temporomandibular disorder (TMD) is a group of conditions involving the masticatory muscles, temporomandibular joint (TMJ), and associated structures of the head, neck, and cervical region.
- Trial name
- NCT07681570
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Whiplash Injuries
Neuroinflammation as a Predictor of Chronicity in Whiplash
Whiplash describes an injury to the neck caused by a rapid movement of the head. It often occurs during a motor vehicle collision, causing considerable pain and distress.
- Trial name
- NCT04940923
- Testing
- MRI
- Where
- 2 sites in United Kingdom
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- University of Sussex
Pain, Neuropathic, Neuropathic Pain
Effect of GSK1014802 on Electrical Hyperalgesia and Threshold Tracking in Healthy Subjects
This study is being conducted to assess the effects of GSK1014802 and a positive control, lidocaine, on tests of peripheral nerve excitability. This will be a double blind, placebo controlled, 4-period cross over study.
- Trial name
- NCT00964288
- Testing
- GSK1014802 low dose, Lidocaine, GSK1014802 high dose
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Biogen
Osteoarthritis
A Single Center 2-way Crossover Study to Investigate the Mechanism of Action of Etoricoxib in Subjects With Osteoarthritis Knee Pain
The purpose of this study is to investigate which pain mechanisms that can be affected by etoricoxib compared to placebo (inactive medication)in subjects with painful knee osteoarthritis af 4 weeks of treatment.
- Trial name
- NCT01619150
- Where
- Denmark
- Volunteers
- 39 people
- Sponsor
- C4Pain