Clinical trials: Pain Tolerance
Healthy
The Effect of Intranasal Oxytocin on Pain Sensitivity and Threshold
Oxytocin is neurohypophysial peptide that acts mainly as a neuromodulator in the brain.The vast majority of basic science studies suggested a large effect of oxytocin in minimizing acute pain.Few studies have demonstrated an…
- Trial name
- NCT02550093
- Testing
- Intervention 1, Washout Period, Intervention 2
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Pain, Peripheral Neuropathy
A Study to Determine the Maintenance of Effect After Long-term Treatment of Sativex® in Subjects With Neuropathic Pain
The purpose of this study is to assess the maintenance of effect after long-term treatment of Sativex® in subjects with neuropathic pain.
- Trial name
- NCT00713817
- Testing
- Sativex®
- Where
- United Kingdom
- Volunteers
- 19 people
- Sponsor
- Jazz Pharmaceuticals
Acute Pain
The Influence of Testosterone on Experimental Pain Perception
This trial examined how the administration of exogenous testosterone would influence pain tolerance and other endogenous steroids (i.e. estradiol and progesterone).
- Trial name
- NCT05781685
- Testing
- Testosterone
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Pain Measurement
Impact on Pain Sensitivity of Clinical Interaction
Pain can currently be quantified using quantitative sensory tests (QSTs). However, we lack knowledge concerning how relational and contextual factors impact these quantitative tests.
- Trial name
- QSTROBOT (NCT04888026)
- Testing
- Quantitative sensory testing
- Where
- 3 sites in Denmark
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Spine Centre of Southern Denmark
Chronic Low-back Pain
Deep Tissue Massage in Office Workers With Chronic Low Back Pain
The main objective of the study was to assess the impact of deep tissue massage on subjective and objective parameters in a group of office workers with chronic low back pain.
- Trial name
- NCT05690178
- Testing
- Deep Tissue Massage
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Poznan University of Physical Education
Knee Osteoarthritis
Pilot Study of Therapy With Hylan G-F 20 Exercise Capacity
Osteoarthritis of the knee is a degenerative joint disease that involves degradation of the joint. Symptoms include joint tenderness, pain, stiffness, locking, and occasionally an effusion.
- Trial name
- CORT (NCT01810848)
- Testing
- Hylan G-F 20, Control
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- OhioHealth
Vulvodynia
Vulvodynia Pain Thresholds
Annotated pain maps will be created showing region and size of areas sensitive to mechanical stimulus in both women affected by vulvar pain and unaffected control patients.
- Trial name
- NCT04461210
- Testing
- Thermographic Imaging and Mechanical Pain Assessment
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Low Back Pain
Immediate Effect of Dry Needling of the Lumbar Multifidus on Pain Sensitivity In A Healthy Population
The goal of this interventional study is to test the effects of trigger point dry needling to the low back in a healthy population.
- Trial name
- NCT05845697
- Testing
- Trigger point dry needling
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Florida
Sickle Cell Anemia
Pressure Pain Tolerance in Relation to Balance and Strength in Children
Sickle cell disease (SCD) is the most frequent life-threatening genetic hemoglobinopathy in the world and occurs due to the synthesis of abnormal hemoglobin S (HbS).Cells with sickle cell hemoglobin are stiff and sticky.
- Trial name
- NCT06529874
- Testing
- Pressure pain tolerance measurement using Digital Pressure Algometer, Balance assessment using HUMAC balance system, Lower limb muscular strength using Lafayette hand held dynamometer
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Adly A Adam
Myofascial Trigger Point, Gastrocnemius Muscle
Effects of Myofascial Induction Pressure Pain Threshold in Trigger Points of the Proximal Muscles of Gastrocnemius
In the present study we will test the effects of myofascial induction technique in the muscles close to the application in the gastrocnemius muscle.
- Conditions
- Myofascial Trigger Point, Gastrocnemius Muscle, Manual Therapy, Pain Threshold
- Trial name
- NCT06499493
- Testing
- Myofascial induction in gastrocnemius muscle
- Where
- Spain
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Mayuben Private Clinic
Migraine Disorder, Low Back Pain
Sleep Hygiene Education to Improve Sleep in Chronic Migraine and Back Pain
The goal of this clinical trial is to learn whether sleep hygiene education can improve sleep quality and reduce pain in adults with migraine and/or chronic lower back pain.
- Conditions
- Migraine Disorder, Low Back Pain, Chronic Pain, Sleep Disorder (Disorder)
- Trial name
- NCT07425964
- Testing
- Sleep Hygiene Education
- Volunteers
- 100 people
- Sponsor
- Aalborg University
Hamstring Muscle Tightness, Muscle Strength
The Effects of Instrument-Assisted Soft Tissue Mobilization in Sedentary Individuals With Hamstring Tightness
The aim of this study will be to investigate and compare the effects of static stretching exercise, Instrument Assisted Soft Tissue Mobilization (IASTM), and functional IASTM techniques on hamstring muscle shortness, pain…
- Conditions
- Hamstring Muscle Tightness, Muscle Strength, Pain Threshold
- Trial name
- NCT07091383
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Cyprus International University
Pain Threshold, Mood
Comparison of the Analgesic Effects of Dronabinol and Smoked Marijuana in Daily Marijuana Smokers
The following study is designed to determine the analgesic efficacy of smoked marijuana (0, 1.98, and 3.56% THC) and oral THC (0, 10, and 20 mg) in the Cold-Pressor Test (CPT), a laboratory model of pain which has predictive…
- Trial name
- NCT00743119
- Testing
- Inactive marijuana (0% THC), Low dose Dronabinol, High dose Dronabinol
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Hand Joint Discomfort, Hand Joint Dysfunction
Effect and Tolerance of Standardized Exclusive Dry Extracts of Curcuma Longa and of Boswellia Serrata Among People With Hand Joint Discomfort and Dysfunction
The objective of the study is to evaluate the effect and tolerance of standardized exclusive dry extracts of Curcuma longa (CURTIL03) and of Boswellia serrata (BOSTIL01) among people with hand joint discomfort and dysfunction.
- Trial name
- FLEXOA (NCT05570123)
- Testing
- Flexofytol Forte
- Where
- Belgium
- Volunteers
- 180 people
- Sponsor
- Tilman S.A.
Shoulder Pain
Manual Therapy in Chronic Shoulder Pain Treatment
Background: Passive oscillatory mobilizations are often employed by physiotherapists to reduce shoulder pain and increase function. However, there is little data about the neurophysiological effects of these mobilizations.
- Trial name
- NCT03416556
- Testing
- Mobilization to the glenohumeral joint, The manual contact condition, No-contact condition
- Where
- Spain
- Volunteers
- 31 people
- Sponsor
- University of Alcala
Autonomic Nervous System Modulation, Pain Perception
Pain Perception and the Autonomic Nervous System
In this study, we want to investigate how pain processing and sensation are related to a certain part of the nervous system, the so-called autonomic nervous system.
- Conditions
- Autonomic Nervous System Modulation, Pain Perception, Pain Sensitivity, Central Sensitization
- Trial name
- NCT06667895
- Testing
- respiratory gated taVNS, random burst stimulation, continuous stimulation
- Where
- Switzerland
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Schweinhardt Petra
Trigger Point Pain, Myofascial
IONTOPHORESIS Versus Ultrasound in Mechanical Neck Pain
to investigate the effects of Magnesium Sulphate Iontophoresis versus High Power Pain Threshold Ultrasound on pain, function and range of motion on active MTrPs found in the upper trapezius.
- Trial name
- NCT05474898
- Testing
- Magnesium Sulphate Iontophoresis +conventional therapy, High- Power Pain Threshold Ultrasound +conventional therapy, conventional theapy
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
Pain
Influence of Pain on Exercise-induced Hypoalgesia
The purpose of this study is to investigate how acute pain induced by hypertonic saline prior to exercise influence the magnitude of exercise-induced hypoalgesia after a 3 min isometric wallsquat exercise in healthy subjects.
- Trial name
- NCT04354948
- Testing
- Pain (hypertonic saline), No pain (Hypotonic saline)
- Where
- Denmark
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Neck Pain
Thoracic Manipulation and Mobilization for Neck Pain
The purpose of this randomized clinical trial was to examine the widespread effects of thoracic spine thrust manipulation and thoracic non-thrust mobilization on pressure pain sensitivity and neck pain intensity in patients with…
- Trial name
- NCT02051478
- Testing
- Thoracic mobilization, Thoracic manipulation
- Where
- Spain
- Volunteers
- 55 people
- Sponsor
- Universidad Rey Juan Carlos
Breast Cancer, Chronic Pain
Effect of Chemotherapy on Pain Sensitivity and Patient-reported Symptoms
Many breast cancer survivors report chronic pain that develops or worsens following chemotherapy. The impact of chemotherapy on the development of chronic pain is uncertain.
- Trial name
- NCT01983982
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Michigan